Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Glutaredoxin protein 5 | 0.052 | 0.6214 | 0.9448 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0271 | 0.3002 | 0.4564 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0271 | 0.3002 | 0.4564 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0813 | 1 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0 | 0.5 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0271 | 0.3002 | 0.4564 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.0526 | 0.6289 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0813 | 1 | 1 |
Toxoplasma gondii | AGC kinase | 0.0791 | 0.9712 | 1 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0058 | 0.0247 | 0.0376 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0058 | 0.0247 | 0.0376 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0791 | 0.9712 | 0.9712 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0548 | 0.6577 | 0.5109 |
Mycobacterium tuberculosis | Probable glutamine-transport ATP-binding protein ABC transporter GlnQ | 0.0038 | 0 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0046 | 0.0096 | 0.0146 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0271 | 0.3002 | 0.3002 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0271 | 0.3002 | 0.4564 |
Mycobacterium ulcerans | transcriptional regulatory protein | 0.0038 | 0 | 0.5 |
Echinococcus granulosus | NDR protein kinase | 0.0271 | 0.3002 | 0.4564 |
Echinococcus multilocularis | nervana 2 | 0.052 | 0.6214 | 0.9448 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0318 | 0.3607 | 0.5485 |
Echinococcus granulosus | potassium:sodium hyperpolarization activated | 0.0058 | 0.0247 | 0.0376 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0271 | 0.3002 | 0.4564 |
Trichomonas vaginalis | AGC family protein kinase | 0.0813 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0271 | 0.3002 | 0.3002 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0791 | 0.9712 | 0.9712 |
Mycobacterium ulcerans | transmembrane transport protein | 0.0038 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0038 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein Cmr | 0.0038 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0293 | 0.329 | 0.329 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 0.2766 | 0.2766 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0271 | 0.3002 | 0.4564 |
Brugia malayi | Egg laying defective protein 4 | 0.0044 | 0.0075 | 0.0075 |
Giardia lamblia | Kinase, AGC PKA | 0.0526 | 0.6289 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0318 | 0.3607 | 0.5485 |
Echinococcus multilocularis | protein kinase c iota type | 0.0271 | 0.3002 | 0.4564 |
Chlamydia trachomatis | cAMP-dependent protein kinase regulatory subunit | 0.0038 | 0 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0271 | 0.3002 | 0.4564 |
Brugia malayi | Hr1 repeat family protein | 0.0271 | 0.3002 | 0.3002 |
Schistosoma mansoni | atypical protein kinase C | 0.0271 | 0.3002 | 0.4564 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0272 | 0.3015 | 0.3015 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0271 | 0.3002 | 0.4564 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0548 | 0.6577 | 1 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0058 | 0.0247 | 0.0376 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0271 | 0.3002 | 0.4564 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0526 | 0.6289 | 0.9562 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0271 | 0.3002 | 0.4564 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.0038 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0813 | 1 | 1 |
Echinococcus granulosus | protein kinase c iota type | 0.0271 | 0.3002 | 0.4564 |
Echinococcus granulosus | protein kinase C gamma type | 0.0271 | 0.3002 | 0.4564 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0058 | 0.0247 | 0.0376 |
Mycobacterium ulcerans | regulatory protein | 0.0038 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0271 | 0.3002 | 0.4564 |
Trichomonas vaginalis | serine/threonine-protein kinase sgk, putative | 0.0265 | 0.2927 | 0.2927 |
Trichomonas vaginalis | AGC family protein kinase | 0.0813 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0813 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0813 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0813 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0044 | 0.0075 | 0.0115 |
Toxoplasma gondii | protein kinase G AGC kinase family member PKG | 0.0044 | 0.0075 | 0.0078 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0058 | 0.0247 | 0.0376 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0548 | 0.6577 | 0.5109 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0058 | 0.0247 | 0.0376 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0271 | 0.3002 | 0.4564 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0084 | 0.0593 | 0.0901 |
Treponema pallidum | catabolite gene activator (Crp) | 0.0038 | 0 | 0.5 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0058 | 0.0247 | 0.0247 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 0.3002 | 0.3002 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0526 | 0.6289 | 0.9562 |
Treponema pallidum | catabolite gene activator | 0.0038 | 0 | 0.5 |
Plasmodium falciparum | cGMP-dependent protein kinase | 0.0044 | 0.0075 | 0.012 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.0526 | 0.6289 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0271 | 0.3002 | 0.3002 |
Brugia malayi | Cyclic-nucleotide gated cation channel | 0.0058 | 0.0247 | 0.0247 |
Echinococcus granulosus | nervana 2 | 0.052 | 0.6214 | 0.9448 |
Trypanosoma cruzi | Protein kinase B | 0.0548 | 0.6577 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0058 | 0.0247 | 0.0247 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0271 | 0.3002 | 0.3002 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0058 | 0.0247 | 0.0376 |
Echinococcus granulosus | cGMP dependent protein kinase 1 | 0.0044 | 0.0075 | 0.0115 |
Onchocerca volvulus | 0.0038 | 0 | 0.5 | |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0548 | 0.6577 | 1 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0058 | 0.0247 | 0.0376 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0291 | 0.3262 | 0.3262 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0291 | 0.3262 | 0.496 |
Echinococcus granulosus | voltage gated potassium channel | 0.0084 | 0.0593 | 0.0901 |
Entamoeba histolytica | protein kinase 2, putative | 0.0526 | 0.6289 | 0.4697 |
Echinococcus multilocularis | cGMP dependent protein kinase 1 | 0.0044 | 0.0075 | 0.0115 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0271 | 0.3002 | 0.4564 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0271 | 0.3002 | 0.3002 |
Trichomonas vaginalis | AGC family protein kinase | 0.0271 | 0.3002 | 0.3002 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0291 | 0.3262 | 0.3262 |
Leishmania major | protein kinase, putative | 0.0044 | 0.0075 | 1 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0058 | 0.0247 | 0.0247 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0084 | 0.0593 | 0.0593 |
Trichomonas vaginalis | AGC family protein kinase | 0.0813 | 1 | 1 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.0058 | 0.0247 | 0.0376 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0271 | 0.3002 | 0.3002 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0271 | 0.3002 | 0.4564 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0548 | 0.6577 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0038 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0038 | 0 | 0.5 |
Schistosoma mansoni | 60S ribosomal protein L21 | 0.0046 | 0.0096 | 0.0146 |
Echinococcus multilocularis | nervana 2 | 0.052 | 0.6214 | 0.9448 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0038 | 0 | 0.5 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0526 | 0.6289 | 0.9562 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0038 | 0 | 0.5 |
Brugia malayi | protein kinase C II. | 0.0271 | 0.3002 | 0.3002 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0044 | 0.0075 | 0.0115 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0271 | 0.3002 | 0.3002 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0044 | 0.0075 | 0.0115 |
Mycobacterium ulcerans | hypothetical protein | 0.0038 | 0 | 0.5 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0058 | 0.0247 | 0.0376 |
Loa Loa (eye worm) | AGC/PKG protein kinase | 0.0044 | 0.0075 | 0.0075 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0271 | 0.3002 | 0.3002 |
Entamoeba histolytica | protein kinase, putative | 0.0791 | 0.9712 | 0.9589 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0526 | 0.6289 | 0.9562 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0084 | 0.0593 | 0.0901 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0058 | 0.0247 | 0.0247 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.052 | 0.6214 | 0.9448 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0271 | 0.3002 | 0.4564 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0271 | 0.3002 | 0.4564 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0271 | 0.3002 | 0.4564 |
Onchocerca volvulus | 0.0038 | 0 | 0.5 | |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0272 | 0.3015 | 0.3015 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0271 | 0.3002 | 0.4564 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0593 | 0.0593 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.052 | 0.6214 | 0.9448 |
Echinococcus granulosus | cGMP dependent protein kinase 1 | 0.0044 | 0.0075 | 0.0115 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0058 | 0.0247 | 0.0376 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0271 | 0.3002 | 0.4564 |
Echinococcus granulosus | cGMP dependent protein kinase | 0.0044 | 0.0075 | 0.0115 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel alpha 3 | 0.0058 | 0.0247 | 0.0376 |
Schistosoma mansoni | serine/threonine kinase | 0.0271 | 0.3002 | 0.4564 |
Echinococcus multilocularis | expressed conserved protein | 0.0044 | 0.0075 | 0.0115 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0813 | 1 | 1 |
Echinococcus granulosus | cyclic nucleotide gated cation channel alpha 3 | 0.0058 | 0.0247 | 0.0376 |
Mycobacterium ulcerans | hypothetical protein | 0.0038 | 0 | 0.5 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.052 | 0.6214 | 0.9448 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0084 | 0.0593 | 0.0901 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0271 | 0.3002 | 0.4564 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0058 | 0.0247 | 0.0376 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0084 | 0.0593 | 0.0901 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0058 | 0.0247 | 0.0376 |
Echinococcus multilocularis | potassium:sodium hyperpolarization activated | 0.0058 | 0.0247 | 0.0376 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0084 | 0.0593 | 0.0901 |
Treponema pallidum | cyclic nucleotide binding protein | 0.0038 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0247 | 0.0247 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0038 | 0 | 0.5 |
Echinococcus granulosus | nervana 2 | 0.052 | 0.6214 | 0.9448 |
Mycobacterium tuberculosis | Probable conserved transmembrane transport protein | 0.0038 | 0 | 0.5 |
Echinococcus multilocularis | cGMP dependent protein kinase 1 | 0.0044 | 0.0075 | 0.0115 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0291 | 0.3262 | 0.496 |
Trichomonas vaginalis | AGC family protein kinase | 0.0813 | 1 | 1 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0271 | 0.3002 | 0.4564 |
Leishmania major | protein kinase, putative | 0.0044 | 0.0075 | 1 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0271 | 0.3002 | 0.4564 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0548 | 0.6577 | 1 |
Treponema pallidum | cyclic nucleotide binding protein | 0.0038 | 0 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0271 | 0.3002 | 0.3002 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0548 | 0.6577 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0271 | 0.3002 | 0.3002 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.