Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carboxylesterase 5A | 0.0337 | 1 | 1 |
Onchocerca volvulus | 0.0057 | 0 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0337 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0337 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0115 | 0.0115 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0057 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0337 | 1 | 1 |
Onchocerca volvulus | 0.0057 | 0 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0337 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0057 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0115 | 0.0115 |
Onchocerca volvulus | 0.0057 | 0 | 0.5 | |
Onchocerca volvulus | 0.0057 | 0 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0337 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0337 | 1 | 1 |
Onchocerca volvulus | 0.0057 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0337 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0057 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0337 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0337 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0115 | 0.0115 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0057 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0337 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0337 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0057 | 0 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0057 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0115 | 0.0115 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.0795 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.581 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. A Novel Cell-Based Assay to Identify Small Molecules for B -Galactocerebrosidase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.