TDR Targets

Basic information

Technical information

TDR Targets ID: 831882
Name: N'-(3-methylsulfanylphenyl)-N-(12-oxo-7,8,9,1 0-tetrahydro-6H-azepino[2,1-b]quinazolin-2-yl )propanediamide
MW: 436.527 | Formula: C23H24N4O3S
H donors: 2 H acceptors: 3 LogP: 3.45 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CSc1cccc(c1)NC(=O)CC(=O)Nc1ccc2c(c1)c(=O)n1c(n2)CCCCC1
InChi: 1S/C23H24N4O3S/c1-31-17-7-5-6-15(12-17)24-21(28)14-22(29)25-16-9-10-19-18(13-16)23(30)27-11-4-2-3-8-20(27)26-19/h5-7,9-10,12-13H,2-4,8,11,14H2,1H3,(H,24,28)(H,25,29)
InChiKey: PYSFCQGRNAGABP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N'-[3-(methylthio)phenyl]-N-(12-oxo-7,8,9,10-tetrahydro-6H-azepino[2,1-b]quinazolin-2-yl)propanediamide
N-(12-keto-7,8,9,10-tetrahydro-6H-azepino[2,1-b]quinazolin-2-yl)-N'-[3-(methylthio)phenyl]malonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0028	0.013	0.0793
Trichomonas vaginalis	pc-MYB2, putative	0.002	0.007	0.0193
Trichomonas vaginalis	pc-MYB2, putative	0.002	0.007	0.0193
Mycobacterium tuberculosis	Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA	0.0976	0.7159	1
Brugia malayi	hypothetical protein	0.0015	0.0032	0.0196
Loa Loa (eye worm)	thioredoxin reductase	0.0042	0.0235	0.1426
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0096	0.0634	0.0886
Echinococcus granulosus	thioredoxin glutathione reductase	0.0043	0.0239	0.2045
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0015	0.0031	0.0141
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.013	0.4894
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0119	0.0724
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0015	0.0031	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0119	0.0724
Mycobacterium ulcerans	3-phosphoshikimate 1-carboxyvinyltransferase	0.0383	0.2763	0.2763
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0031	0.0155	0.0944
Brugia malayi	Thioredoxin reductase	0.0042	0.0235	0.1426
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0031	0.0155	0.1329
Schistosoma mansoni	hypothetical protein	0.0013	0.0016	0.0134
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0065	0.0405	0.3468
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0119	0.0724
Brugia malayi	Animal haem peroxidase family protein	0.0027	0.0119	0.0724
Schistosoma mansoni	nuclear receptor	0.0015	0.0032	0.0276
Onchocerca volvulus		0.0031	0.0155	0.0665
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0015	0.0031	0.0141
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0034	0.0174	0.0629
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0174	0.1489
Brugia malayi	Nuclear hormone receptor-like 1	0.0017	0.0045	0.0276
Loa Loa (eye worm)	DR-78	0.0015	0.0032	0.0196
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0015	0.0031	0.0262
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.002	0.007	0.0193
Brugia malayi	conserved hypotetical protein	0.0015	0.0032	0.0196
Onchocerca volvulus	Protein ultraspiracle homolog	0.0031	0.0155	0.0665
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0113	0.0685
Schistosoma mansoni	hypothetical protein	0.0168	0.1167	1
Leishmania major	cytochrome p450-like protein	0.0019	0.0064	0.0295
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0017	0.0045	0.0276
Onchocerca volvulus	Peroxidasin homolog	0.0027	0.0119	0.0469
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0005	0.0041
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.002	0.007	0.0193
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0017	0.0045	0.0389
Brugia malayi	nuclear hormone receptor family member odr-7	0.0015	0.0032	0.0196
Plasmodium vivax	SET domain protein, putative	0.0034	0.0174	0.7027
Brugia malayi	Animal haem peroxidase family protein	0.0027	0.0119	0.0724
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0143	0.0984	0.0984
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0015	0.0031	0.0141
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0031	0.0155	0.0944
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0015	0.0032	0.0196
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.0405	0.1868
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0031	0.0155	0.1329
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0293	0.2096	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0015	0.0031	0.0141
Brugia malayi	Peroxidasin	0.0027	0.0119	0.0724
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0293	0.2096	1
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0015	0.0032	0.0276
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0025	0.0107	0.015
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0031	0.0155	0.1329
Loa Loa (eye worm)	animal heme peroxidase	0.0027	0.0119	0.0724
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0031	0.0155	0.0944
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0019	0.0064	0.0064
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0293	0.2096	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0031	0.0155	0.0944
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0155	0.0944
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0031	0.0155	0.0944
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0015	0.0032	0.0276
Schistosoma mansoni	thyroid hormone receptor	0.0031	0.0155	0.1329
Loa Loa (eye worm)	animal heme peroxidase	0.0027	0.0119	0.0724
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0015	0.0032	0.0276
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0043	0.0238	0.1099
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0096	0.0634	0.0886
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0293	0.2096	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0031	0.0155	0.1329
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0119	0.0724
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0015	0.0031	0.0141
Brugia malayi	Cytochrome P450 family protein	0.0029	0.0139	0.0848
Mycobacterium tuberculosis	Probable oxidoreductase	0.0107	0.0714	0.0997
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0014	0.0025	0.0092
Brugia malayi	hypothetical protein	0.0018	0.0057	0.0345
Giardia lamblia	Fructose-bisphosphate aldolase	0.0293	0.2096	1
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.002	0.0071	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0032	0.0196
Leishmania major	hypothetical protein, conserved	0.0028	0.013	0.0601
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0096	0.0634	0.0886
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0031	0.0155	0.1329
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0032	0.0196
Brugia malayi	hypothetical protein	0.0015	0.0032	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0119	0.0724
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0045	0.0276
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.013	0.0601
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0155	0.0944
Loa Loa (eye worm)	animal heme peroxidase	0.0027	0.0119	0.0724
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0143	0.0984	0.1374
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0015	0.0032	0.0276
Brugia malayi	nuclear receptor NHR-88	0.0031	0.0155	0.0944
Mycobacterium ulcerans	thioesterase	0.0023	0.0092	0.0092
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0015	0.0031	0.0141
Brugia malayi	hypothetical protein	0.0027	0.0119	0.0724
Brugia malayi	photoreceptor-specific nuclear receptor	0.0031	0.0155	0.0944
Toxoplasma gondii	LsmAD domain-containing protein	0.0028	0.013	0.0472
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0065	0.0405	0.2462
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE	0.0016	0.0038	0.0053
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.0405	0.1868
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0143	0.0985	0.4544
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0107	0.0714	0.0997
Brugia malayi	Nuclear hormone receptor E75	0.0015	0.0032	0.0196
Onchocerca volvulus		0.0026	0.0113	0.0435
Brugia malayi	nuclear hormone receptor	0.0015	0.0032	0.0196
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0065	0.0405	0.1868
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0143	0.0984	0.1374
Loa Loa (eye worm)	cytochrome P450 family protein	0.0019	0.0064	0.0389
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0096	0.0634	0.0886
Toxoplasma gondii	NADPH-glutathione reductase	0.0015	0.0031	0.0111
Onchocerca volvulus		0.0027	0.0119	0.0469
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0119	0.0724
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0155	0.0944
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.002	0.007	0.0193
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	0.0027	0.012	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0119	0.0724
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	0.0039	0.0208	0.029
Echinococcus granulosus	peroxidasin	0.0027	0.0119	0.102
Giardia lamblia	Myb 1-like protein	0.002	0.0071	0.0196
Brugia malayi	F/Y-rich N-terminus family protein	0.0011	0.0004	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0045	0.0276
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0025	0.0107	0.0107
Echinococcus granulosus	nuclear receptor nhr 48	0.0015	0.0032	0.0276
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	0.002	0.0067	0.0094
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0107	0.0714	0.0997
Mycobacterium ulcerans	polyketide synthase Pks13	0.0039	0.0208	0.0208
Plasmodium falciparum	thioredoxin reductase	0.0042	0.0235	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0029	0.0139	0.0848
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0045	0.0276
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0025	0.0107	0.015
Echinococcus granulosus	cpg binding protein	0.0034	0.0173	0.1481
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0045	0.0276
Plasmodium falciparum	glutathione reductase	0.0042	0.0235	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0032	0.0196
Onchocerca volvulus		0.0027	0.0119	0.0469
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0031	0.0155	0.0944
Schistosoma mansoni	zinc finger protein	0.0015	0.0032	0.0276
Schistosoma mansoni	nuclear receptor	0.0015	0.0032	0.0276
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0015	0.0032	0.0276
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	0.0025	0.0107	0.015
Onchocerca volvulus		0.0027	0.0119	0.0469
Loa Loa (eye worm)	cytochrome P450 family protein	0.0019	0.0064	0.0389
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0031	0.0155	0.1329
Mycobacterium ulcerans	polyketide synthase	0.0027	0.012	0.012
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0043	0.0239	0.2045
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	0.0027	0.012	0.0167
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0031	0.0155	0.0944
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0025	0.0107	0.015
Trichomonas vaginalis	C-MYB, putative	0.002	0.007	0.0193
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	0.0025	0.0107	0.015
Brugia malayi	Animal haem peroxidase family protein	0.0027	0.0119	0.0724
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0032	0.0196
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0031	0.0155	0.1329
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0096	0.0634	0.0886
Plasmodium vivax	thioredoxin reductase, putative	0.0042	0.0235	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0028	0.013	0.0601
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0015	0.0032	0.0196
Schistosoma mansoni	nuclear hormone receptor	0.0015	0.0032	0.0276
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0027	0.012	0.012
Toxoplasma gondii	hypothetical protein	0.0049	0.0285	0.103
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0031	0.0155	0.0944
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0015	0.0031	0.0111
Echinococcus multilocularis	ecdysone induced protein 78C	0.0031	0.0155	0.1329
Schistosoma mansoni	peroxidasin	0.0027	0.0119	0.102
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0065	0.0405	0.2462
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0031	0.0155	0.1329
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0032	0.0196
Mycobacterium tuberculosis	Conserved hypothetical protein	0.016	0.1105	0.1544
Treponema pallidum	fructose-bisphosphate aldolase	0.0293	0.2096	0.2071
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0015	0.0032	0.0276
Schistosoma mansoni	nuclear hormone receptor	0.0015	0.0032	0.0276
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0015	0.0031	0.0141
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0232	0.1645	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0031	0.0155	0.1329
Trichomonas vaginalis	MYB3r3, putative	0.002	0.007	0.0193
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0293	0.2096	1
Onchocerca volvulus	Bile acid receptor homolog	0.0031	0.0155	0.0665
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0031	0.0155	0.1329
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0143	0.0985	0.4544
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0031	0.0155	0.1329
Brugia malayi	Animal haem peroxidase family protein	0.0027	0.0119	0.0724
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0119	0.0724
Onchocerca volvulus		0.015	0.1033	0.5408
Brugia malayi	Cytochrome P450 family protein	0.0019	0.0064	0.0389
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0031	0.0155	0.1329
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0031	0.0155	0.1329
Brugia malayi	Cytochrome P450 family protein	0.0019	0.0064	0.0389
Schistosoma mansoni	cpg binding protein	0.0032	0.0159	0.1365
Echinococcus multilocularis	transcription factor Dp 1	0.0038	0.0202	0.1728
Echinococcus granulosus	transcription factor Dp 1	0.0038	0.0202	0.1728
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0031	0.0155	0.0944
Brugia malayi	Pre-SET motif family protein	0.0232	0.1645	1
Trypanosoma cruzi	cytochrome P450, putative	0.0019	0.0064	0.0295
Mycobacterium tuberculosis	Polyketide synthase Pks12	0.0027	0.012	0.0167
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0015	0.0031	0.0141
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0303	0.2168	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0119	0.0724
Trichomonas vaginalis	MYB, putative	0.002	0.0071	0.0196
Loa Loa (eye worm)	CYP4Cod1	0.0019	0.0064	0.0389
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0015	0.0032	0.0196
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0031	0.0155	0.0944
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0155	0.0944
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	0.0027	0.012	0.0167
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0031	0.0155	0.1329
Schistosoma mansoni	thyroid hormone receptor	0.0031	0.0155	0.1329
Onchocerca volvulus		0.0264	0.1882	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0031	0.0155	0.1329
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0174	0.1057
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0011	0.0002	0.0011
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0293	0.2096	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0015	0.0031	0.0141
Loa Loa (eye worm)	blistered cuticle protein 3	0.0027	0.0119	0.0724
Onchocerca volvulus	Peroxidase homolog	0.0027	0.0119	0.0469
Echinococcus multilocularis	peroxidasin	0.0027	0.0119	0.102
Echinococcus granulosus	FTZ F1 alpha	0.0031	0.0155	0.1329
Brugia malayi	ecdysone receptor	0.0015	0.0032	0.0196
Echinococcus multilocularis	cpg binding protein	0.0034	0.0173	0.1481
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0015	0.0032	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0032	0.0196
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.013	0.0601
Leishmania major	mitochondrial DNA polymerase beta	0.0303	0.2168	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0119	0.0724
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0065	0.0405	0.1652
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.0405	0.1868
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0031	0.0155	0.0665
Loa Loa (eye worm)	fatty acid synthase	0.0027	0.0123	0.075
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0303	0.2168	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0031	0.0155	0.0944
Plasmodium vivax	ataxin-2 like protein, putative	0.0028	0.013	0.4894
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0015	0.0031	0.0043
Onchocerca volvulus		0.0048	0.0277	0.1322
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0031	0.0155	0.0944
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0015	0.0031	0.0031
Brugia malayi	nuclear receptor NHR-88	0.0015	0.0032	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0246	0.1493
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsE	0.0016	0.0038	0.0038
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0015	0.0031	0.0141
Plasmodium vivax	glutathione reductase, putative	0.0042	0.0235	1
Chlamydia trachomatis	phosphoshikimate 1-carboxyl vinyltransferase	0.0383	0.2763	0.2741
Loa Loa (eye worm)	animal heme peroxidase	0.0027	0.0119	0.0724
Brugia malayi	Blistered cuticle protein 3	0.0027	0.0119	0.0724
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.002	0.007	0.0193
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0015	0.0032	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0119	0.0724
Onchocerca volvulus	Fatty acid synthase homolog	0.005	0.0289	0.1391
Toxoplasma gondii	Myb family DNA-binding domain-containing protein	0.002	0.0071	0.0257
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0155	0.0944
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0155	0.0944
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0032	0.0196
Schistosoma mansoni	cpg binding protein	0.0034	0.0173	0.1481
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0015	0.0032	0.0276
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0015	0.0031	0.0141
Wolbachia endosymbiont of Brugia malayi	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.136	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0031	0.0155	0.1329
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0052	0.0307	0.1417
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0032	0.0196
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0031	0.0155	0.1329
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0031	0.0155	0.1329
Loa Loa (eye worm)	steroid hormone receptor	0.0031	0.0155	0.0944
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0031	0.0155	0.1329
Brugia malayi	nuclear receptor NHR-67	0.0015	0.0032	0.0196
Mycobacterium ulcerans	polyketide synthase	0.0025	0.0107	0.0107
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0032	0.016	0.1368
Mycobacterium leprae	Probable polyketide synthase Pks1	0.0027	0.012	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0119	0.0724
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0155	0.0944
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0015	0.0032	0.0276
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0174	0.1489
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0015	0.0031	0.0141
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0065	0.0405	0.3468
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	0.002	0.007	0.0098
Echinococcus granulosus	geminin	0.0168	0.1167	1
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0065	0.0405	0.3468
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	0.002	0.0067	0.0067
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0025	0.0107	0.0107
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0015	0.0031	0.0141
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0015	0.0031	0.0031
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	0.0027	0.012	0.0167
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0143	0.0985	0.4544
Toxoplasma gondii	thioredoxin reductase	0.0042	0.0235	0.0849
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0293	0.2096	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0034	0.0174	0.1489
Schistosoma mansoni	hypothetical protein	0.0168	0.1167	1
Onchocerca volvulus	Dual oxidase homolog	0.0027	0.0119	0.0469
Mycobacterium leprae	Polyketide synthase Pks13	0.0039	0.0208	0.029
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0031	0.0155	0.0944
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0015	0.0031	0.0141
Mycobacterium tuberculosis	Probable polyketide synthase Pks9	0.0016	0.0038	0.0053
Trichomonas vaginalis	set domain proteins, putative	0.0264	0.1882	0.8966
Treponema pallidum	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.136	1	1
Schistosoma mansoni	nuclear hormone receptor	0.0031	0.0155	0.1329
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0042	0.0235	0.0328
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.002	0.007	0.0193
Mycobacterium tuberculosis	Polyketide synthase Pks2	0.0027	0.012	0.0167
Echinococcus granulosus	histone lysine methyltransferase setb	0.0034	0.0174	0.1489
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0031	0.0155	0.1329
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0174	0.1489
Brugia malayi	Nuclear hormone receptor-like 1	0.0031	0.0155	0.0944
Mycobacterium tuberculosis	Polyketide synthase Pks13	0.0039	0.0208	0.029
Schistosoma mansoni	nuclear receptor nhr-48	0.0015	0.0032	0.0276
Trypanosoma brucei	trypanothione reductase	0.0042	0.0235	0.1082
Echinococcus multilocularis	nuclear receptor nhr 48	0.0015	0.0032	0.0276
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0026	0.0113	0.0685
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0015	0.0031	0.0031
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0293	0.2096	1
Schistosoma mansoni	coup transcription factor	0.0031	0.0155	0.1329
Mycobacterium tuberculosis	Probable polyketide synthase Pks15	0.0011	0.0005	0.0007
Loa Loa (eye worm)	glutathione reductase	0.0042	0.0235	0.1426
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0032	0.0159	0.0969
Brugia malayi	hypothetical protein	0.0028	0.013	0.0793
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0013	0.0016	0.0134
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	0.0027	0.012	0.0167
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0015	0.0031	0.0262
Toxoplasma gondii	type I fatty acid synthase, putative	0.002	0.0067	0.0244
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0017	0.0045	0.0389
Brugia malayi	Animal haem peroxidase family protein	0.0027	0.0119	0.0724
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0032	0.0196
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0031	0.0155	0.0944
Brugia malayi	glutathione reductase	0.0042	0.0235	0.1426
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0005	0.0041
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0015	0.0031	0.0141
Mycobacterium ulcerans	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.136	1	1
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.0025	0.0107	0.0651
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0015	0.0031	0.0141
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0293	0.2096	1
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0043	0.0238	0.1099
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.005	0.0289	0.176
Mycobacterium tuberculosis	Probable thioesterase TesA	0.0023	0.0092	0.0129
Schistosoma mansoni	peroxidasin	0.0027	0.0119	0.102
Mycobacterium ulcerans	polyketide synthase Pks9	0.0016	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0032	0.0196
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0034	0.0174	0.1489
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	0.0018	0.0054	0.0197
Mycobacterium tuberculosis	Probable dehydrogenase	0.0096	0.0634	0.0886
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0155	0.0944
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0017	0.0045	0.0389
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0031	0.0155	0.1329
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0031	0.0155	0.0944
Brugia malayi	hypothetical protein	0.015	0.1033	0.6278
Onchocerca volvulus		0.0034	0.0174	0.0766
Toxoplasma gondii	type I fatty acid synthase, putative	0.0027	0.012	0.0433
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0062	0.038	0.1376
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0015	0.0031	0.0141
Echinococcus multilocularis	FTZ F1 alpha	0.0031	0.0155	0.1329
Brugia malayi	steroid hormone receptor	0.0031	0.0155	0.0944
Onchocerca volvulus	Peroxidase homolog	0.0027	0.0119	0.0469
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0032	0.0196
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0031	0.0155	0.0944
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	0.002	0.0069	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0119	0.0724
Loa Loa (eye worm)	hypothetical protein	0.015	0.1033	0.6278
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0031	0.0155	0.1329
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0107	0.0714	0.0997
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.013	0.4894
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0293	0.2096	1
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0015	0.0031	0.0186
Mycobacterium ulcerans	thioesterase TesA	0.0023	0.0092	0.0092
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0026	0.0113	0.0157
Mycobacterium tuberculosis	Probable reductase	0.0096	0.0634	0.0886
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0013	0.0016	0.0134
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0034	0.0174	0.1489
Onchocerca volvulus		0.0032	0.0159	0.0687
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.002	0.007	0.0193
Trichomonas vaginalis	C-MYB, putative	0.002	0.007	0.0193
Brugia malayi	Nuclear hormone receptor-like 1	0.0017	0.0045	0.0276
Echinococcus granulosus	ecdysone induced protein 78C	0.0031	0.0155	0.1329
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0031	0.0155	0.0944
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	0.0027	0.012	0.012
Mycobacterium ulcerans	hypothetical protein	0.016	0.1105	0.1105
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.002	0.0071	0.0196
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0031	0.0155	0.0944
Brugia malayi	hypothetical protein	0.0017	0.0045	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0119	0.0724
Trichomonas vaginalis	MYB72, putative	0.002	0.007	0.0193
Brugia malayi	nuclear hormone receptor	0.0031	0.0155	0.0944
Brugia malayi	nuclear receptor RXR	0.0017	0.0045	0.0276
Loa Loa (eye worm)	histone methyltransferase	0.0011	0.0005	0.0029
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0017	0.0045	0.0389
Trypanosoma brucei	cytochrome P450, putative	0.0019	0.0064	0.0295
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0031	0.0155	0.0944
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0025	0.0107	0.0107
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0031	0.0155	0.1329
Brugia malayi	nuclear receptor RXR	0.0015	0.0032	0.0196
Brugia malayi	hypothetical protein	0.0017	0.0045	0.0276
Schistosoma mansoni	cpg binding protein	0.0034	0.0173	0.1481
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0303	0.2168	1
Brugia malayi	CXXC zinc finger family protein	0.0032	0.0159	0.0969
Brugia malayi	orphan nuclear receptor NR2E1	0.0015	0.0032	0.0196
Brugia malayi	Nuclear hormone receptor E75	0.0015	0.0032	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0032	0.0196
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0015	0.0032	0.0276
Mycobacterium leprae	PROBABLE THIOESTERASE TESA	0.0023	0.0092	0.0129
Leishmania major	trypanothione reductase	0.0042	0.0235	0.1082
Echinococcus multilocularis	geminin	0.0168	0.1167	1
Brugia malayi	ecdysteroid receptor	0.0031	0.0155	0.0944
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0045	0.0276
Echinococcus granulosus	thyroid hormone receptor alpha	0.0015	0.0032	0.0276
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0043	0.0238	0.1099
Loa Loa (eye worm)	nuclear hormone receptor	0.0015	0.0032	0.0196
Trypanosoma cruzi	cytochrome P450, putative	0.0019	0.0064	0.0295
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0043	0.0238	0.1099
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0031	0.0155	0.0944
Mycobacterium leprae	PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA	0.0976	0.7159	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0032	0.0196
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0025	0.0107	0.0107
Loa Loa (eye worm)	acyl carrier protein	0.0013	0.0016	0.0097
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.002	0.0067	0.0067
Onchocerca volvulus	Chorion peroxidase homolog	0.0027	0.0119	0.0469
Brugia malayi	Pre-SET motif family protein	0.0034	0.0174	0.1057
Toxoplasma gondii	shikimate dehydrogenase substrate binding domain-containing protein	0.0383	0.2763	1
Brugia malayi	Steroid receptor seven-up type 2	0.0031	0.0155	0.0944
Mycobacterium leprae	probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS	0.0383	0.2763	0.386
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0011	0.0002	0.0011
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0069	0.0434	0.3718
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0018	0.0107
Onchocerca volvulus	Peroxidasin homolog	0.0027	0.0119	0.0469
Brugia malayi	tailless protein	0.0015	0.0032	0.0196
Trypanosoma cruzi	trypanothione reductase, putative	0.0042	0.0235	0.1082
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0015	0.0032	0.0196

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 831882