Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0018 | 0.2763 | 0.2803 |
Trichomonas vaginalis | thioredoxin, putative | 0.0009 | 0.0846 | 0.3064 |
Echinococcus granulosus | Thioredoxin fold | 0.0009 | 0.0846 | 0.0846 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0018 | 0.2763 | 0.2803 |
Plasmodium vivax | thioredoxin 1, putative | 0.0009 | 0.0846 | 0.0859 |
Brugia malayi | glutathione reductase | 0.0051 | 0.9855 | 1 |
Treponema pallidum | NADH oxidase | 0.0018 | 0.2763 | 1 |
Trichomonas vaginalis | thioredoxin, putative | 0.0009 | 0.0846 | 0.3064 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0009 | 0.0846 | 0.3064 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0009 | 0.0846 | 0.3064 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0018 | 0.2763 | 0.2803 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0018 | 0.2763 | 0.2803 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0009 | 0.0846 | 0.3064 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.2763 | 0.2803 |
Trichomonas vaginalis | thioredoxin, putative | 0.0009 | 0.0846 | 0.3064 |
Toxoplasma gondii | thioredoxin-like protein TLP1 | 0.0009 | 0.0846 | 0.0859 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0018 | 0.2763 | 0.2803 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0051 | 0.9855 | 1 |
Leishmania major | thioredoxin, putative | 0.0009 | 0.0846 | 0.0859 |
Entamoeba histolytica | thioredoxin, putative | 0.0009 | 0.0846 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0051 | 1 | 1 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0018 | 0.2763 | 0.2803 |
Entamoeba histolytica | thioredoxin, putative | 0.0009 | 0.0846 | 1 |
Leishmania major | trypanothione reductase | 0.0051 | 0.9855 | 1 |
Echinococcus granulosus | thioredoxin mitochondrial | 0.0009 | 0.0846 | 0.0846 |
Toxoplasma gondii | thioredoxin, putative | 0.0009 | 0.0846 | 0.0859 |
Schistosoma mansoni | thioredoxin 2 | 0.0009 | 0.0846 | 0.0846 |
Trichomonas vaginalis | thioredoxin, putative | 0.0009 | 0.0846 | 0.3064 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0018 | 0.2763 | 1 |
Mycobacterium leprae | THIOREDOXIN TRXC (TRX) (MPT46) | 0.0005 | 0.0004 | 0.0013 |
Mycobacterium tuberculosis | Probable thioredoxin TrxB1 | 0.0009 | 0.0846 | 0.0859 |
Trichomonas vaginalis | thioredoxin, putative | 0.0009 | 0.0846 | 0.3064 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0051 | 0.9855 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0018 | 0.2763 | 1 |
Echinococcus multilocularis | thioredoxin 2 | 0.0009 | 0.0846 | 0.0846 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.2763 | 0.2803 |
Echinococcus granulosus | thioredoxin | 0.0009 | 0.0846 | 0.0846 |
Toxoplasma gondii | thioredoxin reductase | 0.0051 | 0.9855 | 1 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0018 | 0.2763 | 0.2803 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.2763 | 0.2803 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0018 | 0.2763 | 1 |
Echinococcus granulosus | thioredoxin 1 | 0.0009 | 0.0846 | 0.0846 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0018 | 0.2763 | 1 |
Treponema pallidum | thioredoxin (trx) | 0.0009 | 0.0846 | 0.3064 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0009 | 0.0846 | 0.3064 |
Trypanosoma cruzi | thioredoxin, putative | 0.0009 | 0.0846 | 0.0859 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0018 | 0.2763 | 1 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0018 | 0.2763 | 0.2803 |
Plasmodium falciparum | thioredoxin 1 | 0.0009 | 0.0846 | 0.0859 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0846 | 0.0859 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.2763 | 0.2803 |
Trichomonas vaginalis | thioredoxin, putative | 0.0009 | 0.0846 | 0.3064 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0018 | 0.2763 | 0.2803 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0051 | 0.9855 | 1 |
Trichomonas vaginalis | thioredoxin, putative | 0.0009 | 0.0846 | 0.3064 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0018 | 0.2763 | 1 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0018 | 0.2763 | 0.2763 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0018 | 0.2763 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0018 | 0.2763 | 1 |
Trichomonas vaginalis | thioredoxin f-type, putative | 0.0009 | 0.0846 | 0.3064 |
Trichomonas vaginalis | thioredoxin f-type, putative | 0.0009 | 0.0846 | 0.3064 |
Trypanosoma brucei | trypanothione reductase | 0.0051 | 0.9855 | 1 |
Trichomonas vaginalis | thioredoxin, putative | 0.0009 | 0.0846 | 0.3064 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.2763 | 0.2803 |
Brugia malayi | thioredoxin | 0.0009 | 0.0846 | 0.0859 |
Trypanosoma brucei | thioredoxin | 0.0009 | 0.0846 | 0.0859 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0018 | 0.2763 | 1 |
Trichomonas vaginalis | thioredoxin m(mitochondrial)-type, putative | 0.0009 | 0.0846 | 0.3064 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0018 | 0.2763 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0018 | 0.2763 | 0.2803 |
Trichomonas vaginalis | thioredoxin, putative | 0.0009 | 0.0846 | 0.3064 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.2763 | 0.2803 |
Loa Loa (eye worm) | glutathione reductase | 0.0051 | 0.9855 | 1 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0018 | 0.2763 | 0.2803 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0018 | 0.2763 | 0.2803 |
Trichomonas vaginalis | thioredoxin m(mitochondrial)-type, putative | 0.0009 | 0.0846 | 0.3064 |
Trichomonas vaginalis | thioredoxin, putative | 0.0009 | 0.0846 | 0.3064 |
Echinococcus multilocularis | thioredoxin 1 | 0.0009 | 0.0846 | 0.0846 |
Echinococcus multilocularis | thioredoxin | 0.0009 | 0.0846 | 0.0846 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0018 | 0.2763 | 0.2763 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0051 | 0.9855 | 1 |
Echinococcus multilocularis | thioredoxin, mitochondrial | 0.0009 | 0.0846 | 0.0846 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0013 | 0.1764 | 0.179 |
Brugia malayi | Thioredoxin reductase | 0.0051 | 0.9855 | 1 |
Trichomonas vaginalis | thioredoxin m(mitochondrial)-type, putative | 0.0009 | 0.0846 | 0.3064 |
Trichomonas vaginalis | thioredoxin, putative | 0.0009 | 0.0846 | 0.3064 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0018 | 0.2763 | 0.2803 |
Mycobacterium ulcerans | thioredoxin TrxC | 0.0009 | 0.0846 | 0.3064 |
Mycobacterium ulcerans | thioredoxin TrxB1 | 0.0009 | 0.0846 | 0.3064 |
Trichomonas vaginalis | thioredoxin, putative | 0.0009 | 0.0846 | 0.3064 |
Plasmodium falciparum | thioredoxin reductase | 0.0018 | 0.2763 | 0.2803 |
Plasmodium falciparum | glutathione reductase | 0.0018 | 0.2763 | 0.2803 |
Trichomonas vaginalis | thioredoxin m(mitochondrial)-type, putative | 0.0009 | 0.0846 | 0.3064 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.2763 | 0.2803 |
Trichomonas vaginalis | thioredoxin f-type, putative | 0.0009 | 0.0846 | 0.3064 |
Mycobacterium ulcerans | thioredoxin TrxB1 | 0.0009 | 0.0846 | 0.3064 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0013 | 0.1764 | 0.179 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.2763 | 0.2803 |
Plasmodium falciparum | thioredoxin reductase | 0.0051 | 0.9855 | 1 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0018 | 0.2763 | 0.2803 |
Wolbachia endosymbiont of Brugia malayi | thioredoxin | 0.0009 | 0.0846 | 0.3064 |
Plasmodium vivax | glutathione reductase, putative | 0.0051 | 0.9855 | 1 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0018 | 0.2763 | 0.2803 |
Onchocerca volvulus | 0.0005 | 0 | 0.5 | |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0018 | 0.2763 | 0.2803 |
Trichomonas vaginalis | thioredoxin, putative | 0.0009 | 0.0846 | 0.3064 |
Trichomonas vaginalis | thioredoxin, putative | 0.0009 | 0.0846 | 0.3064 |
Chlamydia trachomatis | thioredoxin | 0.0009 | 0.0846 | 0.3064 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0018 | 0.2763 | 0.2763 |
Echinococcus granulosus | thioredoxin 2 | 0.0009 | 0.0846 | 0.0846 |
Trichomonas vaginalis | thioredoxin, putative | 0.0009 | 0.0846 | 0.3064 |
Schistosoma mansoni | thioredoxin | 0.0009 | 0.0846 | 0.0846 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0018 | 0.2763 | 0.2803 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0009 | 0.0846 | 0.3064 |
Plasmodium falciparum | glutathione reductase | 0.0051 | 0.9855 | 1 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0018 | 0.2763 | 0.2803 |
Mycobacterium tuberculosis | Thioredoxin TrxC (TRX) (MPT46) | 0.0009 | 0.0846 | 0.0859 |
Trichomonas vaginalis | thioredoxin, putative | 0.0009 | 0.0846 | 0.3064 |
Trichomonas vaginalis | thioredoxin, putative | 0.0009 | 0.0846 | 0.3064 |
Trypanosoma cruzi | thioredoxin, putative | 0.0009 | 0.0846 | 0.0859 |
Entamoeba histolytica | thioredoxin, putative | 0.0009 | 0.0846 | 1 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0018 | 0.2763 | 0.2803 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0018 | 0.2763 | 0.2803 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.