Detailed information for compound 832097

Basic information

Technical information
  • TDR Targets ID: 832097
  • Name: N'-(2-fluorophenyl)-N-(12-oxo-7,8,9,10-tetrah ydro-6H-azepino[2,1-b]quinazolin-2-yl)propane diamide
  • MW: 408.426 | Formula: C22H21FN4O3
  • H donors: 2 H acceptors: 3 LogP: 3.04 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc2c(c1)c(=O)n1c(n2)CCCCC1)CC(=O)Nc1ccccc1F
  • InChi: 1S/C22H21FN4O3/c23-16-6-3-4-7-18(16)26-21(29)13-20(28)24-14-9-10-17-15(12-14)22(30)27-11-5-1-2-8-19(27)25-17/h3-4,6-7,9-10,12H,1-2,5,8,11,13H2,(H,24,28)(H,26,29)
  • InChiKey: RFFQSUWVEPGWQB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N'-(2-fluorophenyl)-N-(12-keto-7,8,9,10-tetrahydro-6H-azepino[2,1-b]quinazolin-2-yl)malonamide
  • C865-0017
  • NCGC00113734-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0217 0.1225 0.1731
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.0413 0.1669
Plasmodium falciparum serine repeat antigen 5 0.0084 0.0413 0.337
Echinococcus granulosus cathepsin b 0.1176 0.7078 1
Brugia malayi hypothetical protein 0.0032 0.0094 0.0132
Loa Loa (eye worm) fibroinase 0.0217 0.1225 0.1731
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0217 0.1225 0.4952
Schistosoma mansoni cathepsin F (C01 family) 0.0217 0.1225 0.1731
Loa Loa (eye worm) hypothetical protein 0.0036 0.0118 0.0167
Giardia lamblia Cysteine protease 0.0084 0.0413 0.1669
Schistosoma mansoni hypothetical protein 0.0039 0.0137 0.0193
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0084 0.0413 0.0583
Loa Loa (eye worm) hypothetical protein 0.0084 0.0413 0.0583
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0193 1
Plasmodium vivax vivapain-1 0.0084 0.0413 0.337
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0008 0.0012
Onchocerca volvulus Cathepsin L homolog 0.0217 0.1225 1
Giardia lamblia Cathepsin B precursor 0.0084 0.0413 0.1669
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0422 0.2474 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0084 0.0413 0.1669
Toxoplasma gondii cathepsin CPL 0.0217 0.1225 0.4952
Schistosoma mansoni carbonic anhydrase-related 0.0081 0.0391 0.0552
Schistosoma mansoni hypothetical protein 0.0018 0.0008 0.0012
Loa Loa (eye worm) hypothetical protein 0.0039 0.0137 0.0193
Toxoplasma gondii hypothetical protein 0.0081 0.0391 0.1579
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0106 0.5505
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.0413 0.1669
Loa Loa (eye worm) cathepsin B 0.0422 0.2474 0.3496
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0081 0.0391 0.0552
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0084 0.0413 0.1669
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0084 0.0413 0.0583
Brugia malayi cathepsin Z-like cysteine proteinase 0.0084 0.0413 0.0583
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0084 0.0413 0.337
Entamoeba histolytica cysteine protease, putative 0.0084 0.0413 0.337
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0084 0.0413 0.1669
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0217 0.1225 0.1225
Brugia malayi Cathepsin L-like precursor 0.0217 0.1225 0.1731
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0217 0.1225 0.4952
Echinococcus multilocularis cathepsin L 0.0084 0.0413 0.0413
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0217 0.1225 0.4952
Loa Loa (eye worm) hypothetical protein 0.0081 0.0391 0.0552
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0084 0.0413 0.0583
Brugia malayi Papain family cysteine protease containing protein 0.0084 0.0413 0.0583
Echinococcus granulosus carbonic anhydrase II 0.0172 0.0947 0.1338
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0217 0.1225 0.4952
Echinococcus granulosus sterol regulatory element binding protein 0.0038 0.0128 0.018
Schistosoma mansoni patched 1 0.0038 0.0128 0.018
Entamoeba histolytica cysteine protease, putative 0.0084 0.0413 0.337
Loa Loa (eye worm) hypothetical protein 0.0088 0.0434 0.0613
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0118 0.613
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0084 0.0413 0.0583
Loa Loa (eye worm) hypothetical protein 0.0036 0.0118 0.0167
Schistosoma mansoni transcription factor LCR-F1 0.0032 0.0094 0.0132
Schistosoma mansoni survival motor neuron protein 0.0043 0.016 0.0226
Entamoeba histolytica cysteine protease, putative 0.0084 0.0413 0.337
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0217 0.1225 0.4952
Echinococcus granulosus Niemann Pick C1 protein 0.0125 0.0664 0.0938
Entamoeba histolytica cysteine protease, putative 0.0084 0.0413 0.337
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0084 0.0413 0.337
Plasmodium falciparum serine repeat antigen 1 0.0084 0.0413 0.337
Onchocerca volvulus 0.0217 0.1225 1
Brugia malayi Papain family cysteine protease containing protein 0.0217 0.1225 0.1731
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0413 0.1669
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0217 0.1225 0.4952
Giardia lamblia Cathepsin B precursor 0.0084 0.0413 0.1669
Plasmodium vivax serine-repeat antigen (SERA) 0.0084 0.0413 0.337
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0106 0.5505
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0217 0.1225 0.1731
Schistosoma mansoni cathepsin F (C01 family) 0.0217 0.1225 0.1731
Schistosoma mansoni cathepsin B (C01 family) 0.0084 0.0413 0.0583
Plasmodium falciparum cysteine proteinase falcipain 1 0.0084 0.0413 0.337
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0084 0.0413 0.337
Brugia malayi Cathepsin L-like precursor 0.0217 0.1225 0.1731
Echinococcus multilocularis cysteine protease 0.0217 0.1225 0.1225
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0172 0.0947 0.1338
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0084 0.0413 0.0583
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0217 0.1225 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0017 0 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.0413 0.1669
Giardia lamblia Cathepsin L precursor 0.0084 0.0413 0.1669
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0247 0.0349
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0084 0.0413 0.1669
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0084 0.0413 0.0583
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0081 0.0391 0.0552
Brugia malayi Papain family cysteine protease containing protein 0.0084 0.0413 0.0583
Echinococcus granulosus cathepsin L cysteine protease 0.0084 0.0413 0.0583
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0217 0.1225 0.4952
Schistosoma mansoni cathepsin C 0.0084 0.0413 0.0583
Echinococcus granulosus cathepsin L 0.0084 0.0413 0.0583
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0172 0.0947 0.1338
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0193 0.078
Echinococcus granulosus GPCR family 2 0.0018 0.0008 0.0012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0217 0.1225 0.4952
Giardia lamblia Cathepsin L-like protease 0.0084 0.0413 0.1669
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0084 0.0413 0.1669
Onchocerca volvulus 0.0217 0.1225 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0217 0.1225 0.4952
Brugia malayi cathepsin L-like precursor 0.0217 0.1225 0.1731
Loa Loa (eye worm) hypothetical protein 0.006 0.0262 0.0371
Brugia malayi Cathepsin L-like precursor 0.0217 0.1225 0.1731
Giardia lamblia Cysteine protease 0.0084 0.0413 0.1669
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0084 0.0413 0.1669
Toxoplasma gondii preprocathepsin c precursor, putative 0.0084 0.0413 0.1669
Entamoeba histolytica cysteine protease, putative 0.0084 0.0413 0.337
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0084 0.0413 0.337
Echinococcus granulosus survival motor neuron protein 1 0.0211 0.1185 0.1675
Trypanosoma brucei cysteine peptidase C (CPC) 0.0422 0.2474 1
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0137 0.0193
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0217 0.1225 0.4952
Schistosoma mansoni hypothetical protein 0.0036 0.0119 0.0169
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0084 0.0413 0.337
Loa Loa (eye worm) hypothetical protein 0.0081 0.0391 0.0552
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0118 0.0965
Plasmodium vivax unspecified product 0.0084 0.0413 0.337
Trypanosoma cruzi major cysteine proteinase, putative 0.0084 0.0413 0.0583
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0081 0.0391 0.0552
Echinococcus granulosus Protein patched homolog 1 0.0038 0.0128 0.018
Onchocerca volvulus 0.0048 0.0193 0.0307
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0128 0.0516
Toxoplasma gondii cathepsin B 0.0422 0.2474 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0084 0.0413 0.0583
Brugia malayi Cathepsin L-like precursor 0.0217 0.1225 0.1731
Loa Loa (eye worm) hypothetical protein 0.0036 0.0118 0.0167
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0081 0.0391 0.0552
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0217 0.1225 0.4952
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0193 0.0273
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0217 0.1225 0.4952
Entamoeba histolytica cysteine protease, putative 0.0084 0.0413 0.337
Echinococcus granulosus expressed conserved protein 0.0082 0.0401 0.0567
Brugia malayi Papain family cysteine protease containing protein 0.0084 0.0413 0.0583
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0193 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0088 0.0434 0.0434
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1176 0.7078 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0084 0.0413 0.0583
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0008 0.0008
Plasmodium falciparum serine repeat antigen 2 0.0084 0.0413 0.337
Entamoeba histolytica cysteine proteinase, putative 0.0217 0.1225 1
Brugia malayi Cathepsin L-like precursor 0.0217 0.1225 0.1731
Entamoeba histolytica cysteine proteinase, putative 0.0084 0.0413 0.337
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0217 0.1225 0.4952
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0217 0.1225 0.4952
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0217 0.1225 0.4952
Plasmodium falciparum serine repeat antigen 4 0.0084 0.0413 0.337
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0084 0.0413 0.0583
Leishmania major cathepsin L-like protease 0.0217 0.1225 0.4952
Loa Loa (eye worm) hypothetical protein 0.0084 0.0413 0.0583
Trypanosoma cruzi cysteine peptidase, putative 0.0217 0.1225 0.1731
Giardia lamblia Cysteine protease 0.0084 0.0413 0.1669
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0422 0.2474 0.3496
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0217 0.1225 0.4952
Schistosoma mansoni hypothetical protein 0.0036 0.0119 0.0169
Entamoeba histolytica cysteine proteinase 2 0.0084 0.0413 0.337
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0217 0.1225 0.4952
Leishmania major cathepsin L-like protease 0.0217 0.1225 0.4952
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0217 0.1225 0.4952
Echinococcus granulosus Niemann Pick C1 protein 0.0088 0.0434 0.0613
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0193 0.078
Echinococcus multilocularis cathepsin b 0.1176 0.7078 0.7078
Onchocerca volvulus 0.006 0.0262 0.0958
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0172 0.0947 0.1338
Loa Loa (eye worm) hypothetical protein 0.0084 0.0413 0.0583
Brugia malayi cathepsin L-like cysteine proteinase 0.0084 0.0413 0.0583
Onchocerca volvulus Cathepsin F homolog 0.0217 0.1225 1
Echinococcus multilocularis expressed conserved protein 0.0082 0.0401 0.0401
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0008 0.0012
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0012
Trypanosoma cruzi cysteine peptidase, putative 0.0217 0.1225 0.1731
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0081 0.0391 0.0552
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0217 0.1225 0.4952
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0084 0.0413 0.1669
Entamoeba histolytica cysteine proteinase, putative 0.0217 0.1225 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0084 0.0413 0.0583
Plasmodium falciparum serine repeat antigen 7 0.0084 0.0413 0.337
Echinococcus multilocularis tumor protein p63 0.0408 0.239 0.239
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0084 0.0413 0.337
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1176 0.7078 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0084 0.0413 0.0583
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0084 0.0413 0.1669
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0172 0.0947 0.1338
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0217 0.1225 0.4952
Echinococcus granulosus carbonic anhydrase 0.0081 0.0391 0.0552
Loa Loa (eye worm) hypothetical protein 0.0046 0.0179 0.0254
Entamoeba histolytica cysteine proteinase, putative 0.0084 0.0413 0.337
Onchocerca volvulus Cathepsin L homolog 0.0084 0.0413 0.2372
Giardia lamblia Cathepsin L precursor 0.0084 0.0413 0.1669
Entamoeba histolytica cysteine protease, putative 0.0084 0.0413 0.337
Toxoplasma gondii cathepsin CPC1 0.0084 0.0413 0.1669
Loa Loa (eye worm) hypothetical protein 0.0217 0.1225 0.1731
Trypanosoma cruzi cysteine peptidase, putative 0.0084 0.0413 0.0583
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0081 0.0391 0.0552
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0217 0.1225 0.4952
Entamoeba histolytica cysteine protease, putative 0.0084 0.0413 0.337
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0262 0.0371
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0084 0.0413 0.1669
Giardia lamblia Cathepsin B precursor 0.0422 0.2474 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0193 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0217 0.1225 0.4952
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0084 0.0413 0.0583
Brugia malayi Papain family cysteine protease containing protein 0.0084 0.0413 0.0583
Loa Loa (eye worm) hypothetical protein 0.0084 0.0413 0.0583
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.0413 0.1669
Trypanosoma cruzi cysteine peptidase, putative 0.0217 0.1225 0.1731
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0217 0.1225 0.4952
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0118 0.613
Brugia malayi fibroinase precursor 0.0084 0.0413 0.0583
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0217 0.1225 0.4952
Giardia lamblia Cathepsin L precursor 0.0084 0.0413 0.1669
Loa Loa (eye worm) hypothetical protein 0.0084 0.0413 0.0583
Mycobacterium ulcerans hypothetical protein 0.0048 0.0193 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0084 0.0413 0.337
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1176 0.7078 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0217 0.1225 0.4952
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0084 0.0413 0.1669
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0008 0.0012
Loa Loa (eye worm) hypothetical protein 0.0048 0.0193 0.0273
Schistosoma mansoni hypothetical protein 0.0036 0.0119 0.0169
Onchocerca volvulus 0.0217 0.1225 1
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0084 0.0413 0.337
Plasmodium falciparum carbonic anhydrase 0.0081 0.0391 0.3187
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0217 0.1225 0.4952
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0118 0.5
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0217 0.1225 0.1225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.0413 0.1669
Entamoeba histolytica cysteine protease, putative 0.0084 0.0413 0.337
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0106 0.5505
Trypanosoma cruzi cruzipain precursor, putative 0.0217 0.1225 0.1731
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0193 1
Echinococcus multilocularis cathepsin L 0.0084 0.0413 0.0413
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0118 0.0965
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0193 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0217 0.1225 0.1731
Giardia lamblia Encystation-specific protease 0.0084 0.0413 0.1669
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0043 0.016 0.0226
Brugia malayi MH2 domain containing protein 0.0106 0.0548 0.0774
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0422 0.2474 0.3496
Plasmodium vivax vivapain-2 0.0217 0.1225 1
Onchocerca volvulus 0.0217 0.1225 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0193 0.078
Giardia lamblia Hypothetical protein 0.0084 0.0413 0.1669
Brugia malayi hypothetical protein 0.0211 0.1185 0.1675
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0217 0.1225 0.4952
Entamoeba histolytica hypothetical protein 0.0032 0.0094 0.0763
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0217 0.1225 0.4952
Echinococcus multilocularis carbonic anhydrase II 0.0172 0.0947 0.0947
Echinococcus granulosus cathepsin l1 0.0217 0.1225 0.1731
Schistosoma mansoni carbonic anhydrase-related 0.0081 0.0391 0.0552
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0193 0.1575
Plasmodium falciparum serine repeat antigen 3 0.0084 0.0413 0.337
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0217 0.1225 0.4952
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0084 0.0413 0.1669
Leishmania major cathepsin L-like protease 0.0217 0.1225 0.4952
Trypanosoma cruzi cysteine proteinase, putative 0.0084 0.0413 0.0583
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0084 0.0413 0.0583
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0193 0.0273
Giardia lamblia Cathepsin B precursor 0.0422 0.2474 1
Brugia malayi CHE-14 protein 0.0038 0.0128 0.018
Plasmodium vivax unspecified product 0.0084 0.0413 0.337
Entamoeba histolytica cysteine protease, putative 0.0084 0.0413 0.337
Echinococcus multilocularis cathepsin L cysteine protease 0.0217 0.1225 0.1225
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0217 0.1225 0.4952
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0193 0.1575
Toxoplasma gondii cathepsin CPC2 0.0084 0.0413 0.1669
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0193 1
Onchocerca volvulus 0.0217 0.1225 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0088 0.0434 0.354
Loa Loa (eye worm) hypothetical protein 0.0217 0.1225 0.1731
Entamoeba histolytica hypothetical protein 0.0032 0.0094 0.0763
Onchocerca volvulus 0.0217 0.1225 1
Brugia malayi Cathepsin L-like precursor 0.0217 0.1225 0.1731
Giardia lamblia Cathepsin L precursor 0.0084 0.0413 0.1669
Brugia malayi Cathepsin L-like precursor 0.0217 0.1225 0.1731
Plasmodium falciparum serine repeat antigen 9 0.0084 0.0413 0.337
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0193 0.1575
Trypanosoma cruzi cysteine protease, putative 0.0084 0.0413 0.0583
Echinococcus multilocularis carbonic anhydrase 0.0081 0.0391 0.0391
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0048 0.0193 0.0273
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0084 0.0413 0.1669
Schistosoma mansoni hypothetical protein 0.0081 0.0391 0.0552
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0193 0.5
Entamoeba histolytica cysteine proteinase, putative 0.0217 0.1225 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0084 0.0413 0.1669
Echinococcus granulosus cysteine protease 0.0084 0.0413 0.0583
Plasmodium vivax vivapain-2 0.0217 0.1225 1
Echinococcus granulosus carbonic anhydrase 0.0081 0.0391 0.0552
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0193 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0391 0.0552
Giardia lamblia Cathepsin B precursor 0.0422 0.2474 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0106 0.5505
Leishmania major cysteine peptidase A (CPA) 0.0217 0.1225 0.4952
Loa Loa (eye worm) MH2 domain-containing protein 0.0106 0.0548 0.0774
Loa Loa (eye worm) hypothetical protein 0.0211 0.1185 0.1675
Plasmodium falciparum serine repeat antigen 8 0.0084 0.0413 0.337
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0084 0.0413 0.1669
Trypanosoma brucei carbonic anhydrase-like protein 0.0172 0.0947 0.3828
Echinococcus multilocularis cysteine protease 0.0217 0.1225 0.1225
Giardia lamblia Cathepsin L-like protease 0.0084 0.0413 0.1669
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0217 0.1225 0.4952
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0247 0.0349
Entamoeba histolytica cysteine protease, putative 0.0084 0.0413 0.337
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0084 0.0413 0.337
Schistosoma mansoni carbonic anhydrase-related 0.0081 0.0391 0.0552
Schistosoma mansoni hypothetical protein 0.0018 0.0008 0.0012
Schistosoma mansoni hypothetical protein 0.0018 0.0008 0.0012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0217 0.1225 0.4952
Loa Loa (eye worm) transcription factor SMAD2 0.0106 0.0548 0.0774
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0217 0.1225 0.4952
Leishmania major cathepsin L-like protease 0.0217 0.1225 0.4952
Brugia malayi cathepsin B-like cysteine proteinase 0.1176 0.7078 1
Leishmania major cathepsin L-like protease 0.0217 0.1225 0.4952
Echinococcus multilocularis cathepsin L cysteine protease 0.0217 0.1225 0.1225
Leishmania major cathepsin L-like protease 0.0217 0.1225 0.4952
Echinococcus multilocularis carbonic anhydrase 0.0081 0.0391 0.0391
Loa Loa (eye worm) hypothetical protein 0.0217 0.1225 0.1731
Brugia malayi cathepsin L precursor 0.0084 0.0413 0.0583
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0217 0.1225 0.4952
Leishmania major cathepsin L-like protease 0.0217 0.1225 0.4952
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0084 0.0413 0.337
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0217 0.1225 0.4952
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0084 0.0413 0.0583
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0008 0.0012
Entamoeba histolytica hypothetical protein 0.0032 0.0094 0.0763
Giardia lamblia Cathepsin L precursor 0.0084 0.0413 0.1669
Plasmodium falciparum cysteine proteinase falcipain 3 0.0217 0.1225 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0084 0.0413 0.337
Loa Loa (eye worm) hypothetical protein 0.0048 0.0193 0.0273
Echinococcus multilocularis carbonic anhydrase 0.0081 0.0391 0.0391
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0413 0.1669
Schistosoma mansoni hypothetical protein 0.0018 0.0008 0.0012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0217 0.1225 0.4952
Loa Loa (eye worm) hypothetical protein 0.1176 0.7078 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0217 0.1225 0.1731
Onchocerca volvulus 0.0217 0.1225 1
Giardia lamblia Cysteine protease 0.0084 0.0413 0.1669
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0038 0.0128 0.018
Schistosoma mansoni hypothetical protein 0.0032 0.0094 0.0132
Echinococcus multilocularis sterol regulatory element binding protein 0.0038 0.0128 0.0128
Schistosoma mansoni hypothetical protein 0.0036 0.0119 0.0169
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0247 0.0349
Entamoeba histolytica cysteine protease, putative 0.0084 0.0413 0.337
Echinococcus granulosus cathepsin b 0.1176 0.7078 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0089 0.0442 0.0625
Loa Loa (eye worm) cysteine protease 0.0217 0.1225 0.1731
Entamoeba histolytica hypothetical protein 0.0084 0.0413 0.337
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0008 0.0012
Leishmania major cathepsin L-like protease 0.0217 0.1225 0.4952
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0422 0.2474 1
Onchocerca volvulus 0.0217 0.1225 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0217 0.1225 0.4952
Giardia lamblia Cathepsin B precursor 0.0084 0.0413 0.1669
Echinococcus multilocularis Niemann Pick C1 protein 0.0125 0.0664 0.0664
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.0413 0.1669
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0084 0.0413 0.0583
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0217 0.1225 1
Echinococcus multilocularis protein patched 0.0038 0.0128 0.0128
Schistosoma mansoni cathepsin F (C01 family) 0.0217 0.1225 0.1731
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0193 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.0413 0.0583
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0172 0.0947 0.1338
Echinococcus granulosus cathepsin l1 0.0217 0.1225 0.1731
Giardia lamblia Cathepsin L precursor 0.0084 0.0413 0.1669
Brugia malayi Cathepsin L-like precursor 0.0217 0.1225 0.1731
Entamoeba histolytica cysteine protease, putative 0.0084 0.0413 0.337
Brugia malayi Papain family cysteine protease containing protein 0.0084 0.0413 0.0583
Loa Loa (eye worm) hypothetical protein 0.0038 0.0128 0.018
Entamoeba histolytica cysteine protease, putative 0.0084 0.0413 0.337
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0032 0.0094 0.0132
Plasmodium falciparum serine repeat antigen 6 0.0084 0.0413 0.337
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0084 0.0413 0.0583
Echinococcus multilocularis cathepsin b 0.1176 0.7078 0.7078
Giardia lamblia Cathepsin B precursor 0.0084 0.0413 0.1669
Entamoeba histolytica cysteine protease, putative 0.0084 0.0413 0.337
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1176 0.7078 1
Plasmodium vivax vivapain-3 0.0084 0.0413 0.337
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0217 0.1225 0.4952
Entamoeba histolytica cysteine proteinase, putative 0.0084 0.0413 0.337
Plasmodium vivax serine-repeat antigen (SERA) 0.0084 0.0413 0.337
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1176 0.7078 1
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0084 0.0413 0.337
Entamoeba histolytica hypothetical protein 0.0032 0.0094 0.0763
Trypanosoma cruzi cysteine peptidase, putative 0.0217 0.1225 0.1731
Entamoeba histolytica cysteine protease, putative 0.0084 0.0413 0.337
Leishmania major carbonic anhydrase-like protein 0.0172 0.0947 0.3828
Echinococcus multilocularis survival motor neuron protein 1 0.0211 0.1185 0.1185
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0084 0.0413 0.1669
Brugia malayi Niemann-Pick C1 protein precursor 0.0088 0.0434 0.0613
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0172 0.0947 0.1338
Entamoeba histolytica cysteine protease, putative 0.0217 0.1225 1
Echinococcus multilocularis protein dispatched 1 0.0043 0.016 0.016
Giardia lamblia Hypothetical protein 0.0084 0.0413 0.1669
Entamoeba histolytica cysteine protease, putative 0.0084 0.0413 0.337
Echinococcus granulosus cathepsin L 0.0084 0.0413 0.0583
Echinococcus granulosus tumor protein p63 0.0408 0.239 0.3376
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0193 0.0273
Loa Loa (eye worm) hypothetical protein 0.0057 0.0247 0.0349
Schistosoma mansoni carbonic anhydrase 0.0081 0.0391 0.0552
Brugia malayi cathepsin F-like cysteine proteinase 0.0084 0.0413 0.0583
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0084 0.0413 0.337
Giardia lamblia Cathepsin B precursor 0.0084 0.0413 0.1669
Echinococcus multilocularis GPCR, family 2 0.0018 0.0008 0.0008
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0084 0.0413 0.337
Loa Loa (eye worm) ctsf protein 0.0217 0.1225 0.1731
Schistosoma mansoni cathepsin S (C01 family) 0.0084 0.0413 0.0583
Loa Loa (eye worm) hypothetical protein 0.0036 0.0118 0.0167
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0193 0.5
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0032 0.0094 0.0094
Onchocerca volvulus Cathepsin L homolog 0.0217 0.1225 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0017 0 0.5
Brugia malayi cathepsin Z-like cysteine proteinase 0.0084 0.0413 0.0583
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0172 0.0947 0.1338
Brugia malayi Cathepsin L-like cysteine proteinase 0.0217 0.1225 0.1731
Echinococcus granulosus cathepsin L cysteine proteinase 0.0217 0.1225 0.1731
Loa Loa (eye worm) carbonic anhydrase 3 0.0172 0.0947 0.1338
Loa Loa (eye worm) hypothetical protein 0.0036 0.0118 0.0167
Echinococcus granulosus cathepsin l cysteine peptidase 0.0217 0.1225 0.1731
Entamoeba histolytica cysteine proteinase 1, putative 0.0084 0.0413 0.337
Echinococcus granulosus carbonic anhydrase 0.0081 0.0391 0.0552
Entamoeba histolytica cysteine protease, putative 0.0084 0.0413 0.337
Schistosoma mansoni hypothetical protein 0.0043 0.016 0.0226
Entamoeba histolytica cysteine protease, putative 0.0084 0.0413 0.337
Onchocerca volvulus 0.0084 0.0413 0.2372
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0084 0.0413 0.0583
Entamoeba histolytica cysteine proteinase, putative 0.0084 0.0413 0.337
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.0413 0.1669
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0193 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.0413 0.1669
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0084 0.0413 0.1669
Trypanosoma cruzi cysteine proteinase, putative 0.0084 0.0413 0.0583
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0084 0.0413 0.0583
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0084 0.0413 0.337
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0084 0.0413 0.1669

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.3162 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Permissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.9441 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.