Detailed information for compound 83215

Basic information

Technical information
  • TDR Targets ID: 83215
  • Name: 8-[2-[2-methyl-4-(2-nitrophenyl)piperazin-1-y l]ethyl]-8-azaspiro[4.5]decane-7,9-dione
  • MW: 414.498 | Formula: C22H30N4O4
  • H donors: 0 H acceptors: 4 LogP: 3.09 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CN(CCN1CCN1C(=O)CC2(CC1=O)CCCC2)c1ccccc1[N+](=O)[O-]
  • InChi: 1S/C22H30N4O4/c1-17-16-24(18-6-2-3-7-19(18)26(29)30)11-10-23(17)12-13-25-20(27)14-22(15-21(25)28)8-4-5-9-22/h2-3,6-7,17H,4-5,8-16H2,1H3
  • InChiKey: NBTWKPSAPGBCCD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 8-[2-[2-methyl-4-(2-nitrophenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione
  • 8-[2-[2-methyl-4-(2-nitrophenyl)piperazino]ethyl]-8-azaspiro[4.5]decane-7,9-quinone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Alpha-1d adrenergic receptor Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Get druggable targets OG5_128924 All targets in OG5_128924
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni amine GPCR Get druggable targets OG5_128924 All targets in OG5_128924
Schistosoma japonicum expressed protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Octopamine receptor, putative Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Alpha-1D adrenergic receptor, putative Get druggable targets OG5_128924 All targets in OG5_128924
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni amine oxidase 0.0069 0.0038 0.0056
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0289 0.0262 0.0637
Plasmodium vivax hypothetical protein, conserved 0.0069 0.0038 0.0533
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0073 0.0042 0.0056
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.4065 0.4101 0.5563
Echinococcus multilocularis Furin 1 0.1597 0.1591 0.2158
Echinococcus multilocularis integrin alpha ps 0.0818 0.08 0.1084
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0154 0.0125 0.0168
Echinococcus granulosus glutamate receptor 2 0.0154 0.0125 0.0168
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0033 0.0002 0.0002
Echinococcus granulosus glutamate receptor subunit protein glur 0.0073 0.0042 0.0056
Brugia malayi transcriptional regulator, Sir2 family protein 0.01 0.007 0.007
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0069 0.0038 0.0533
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.001 0.0145
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0289 0.0262 0.0354
Toxoplasma gondii type I fatty acid synthase, putative 0.0065 0.0034 0.0474
Echinococcus granulosus Furin 1 0.1597 0.1591 0.2158
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0204 0.0176 0.0176
Schistosoma mansoni chromatin regulatory protein sir2 0.01 0.007 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.1308 0.1297 0.3162
Mycobacterium ulcerans Type I modular polyketide synthase 0.0088 0.0058 0.0752
Schistosoma mansoni hypothetical protein 0.0065 0.0034 0.0049
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0074 0.0044 0.0064
Schistosoma mansoni hypothetical protein 0.0118 0.0088 0.0129
Brugia malayi hypothetical protein 0.0074 0.0044 0.0044
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0289 0.0262 0.0637
Loa Loa (eye worm) acyl carrier protein 0.0042 0.0011 0.0011
Brugia malayi Stress-activated protein kinase jnk-1 0.025 0.0222 0.0222
Toxoplasma gondii subtilisin SUB2 0.0289 0.0262 0.3702
Echinococcus multilocularis chromatin regulatory protein sir2 0.0676 0.0655 0.0888
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0094 0.0064 0.0843
Mycobacterium tuberculosis Probable thioesterase TesA 0.0076 0.0046 0.0695
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.007 0.0167
Plasmodium falciparum subtilisin-like protease 2 0.0289 0.0262 0.3702
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0282 0.0255 0.0377
Echinococcus granulosus lysine specific histone demethylase 1A 0.034 0.0314 0.0425
Echinococcus granulosus furin 0.6671 0.675 0.9158
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0034 0.0045
Plasmodium falciparum plasmepsin VII 0.0074 0.0044 0.0609
Onchocerca volvulus 0.0085 0.0055 0.1579
Loa Loa (eye worm) endoprotease bli-4 0.6671 0.675 0.675
Echinococcus multilocularis c Jun NH2 terminal kinase 0.025 0.0222 0.03
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0073 0.0042 0.0056
Echinococcus multilocularis protein kinase c epsilon type 0.0089 0.0059 0.0079
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1597 0.1591 0.3879
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0094 0.0064 0.0976
Toxoplasma gondii aspartyl protease ASP1 0.0111 0.0081 0.1139
Echinococcus granulosus glutamate NMDA receptor subunit 0.0404 0.0379 0.0513
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0125 0.0095 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.1308 0.1297 0.3162
Brugia malayi Protein kinase domain containing protein 0.0032 0.0001 0.0001
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0089 0.0058 0.0892
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0047 0.0016 0.0087
Plasmodium falciparum plasmepsin VI 0.0111 0.0081 0.1139
Trichomonas vaginalis conserved hypothetical protein 0.1308 0.1297 0.3162
Schistosoma mansoni hypothetical protein 0.0073 0.0042 0.0061
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.01 0.007 0.0702
Schistosoma mansoni chromatin regulatory protein sir2 0.0676 0.0655 0.097
Schistosoma mansoni protein kinase 0.0143 0.0114 0.0167
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0154 0.0125 0.0168
Giardia lamblia High cysteine membrane protein Group 2 0.2469 0.2478 1
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.0664 0.0643 0.5
Echinococcus granulosus integrin alpha ps 0.0882 0.0865 0.1173
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0085 0.0055 0.0055
Brugia malayi Integrin alpha pat-2 precursor 0.1623 0.1618 0.1618
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0289 0.0262 0.0637
Mycobacterium ulcerans polyketide synthase Pks9 0.0057 0.0026 0.0255
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0111 0.0081 0.1139
Echinococcus multilocularis dna polymerase kappa 0.0041 0.001 0.0013
Loa Loa (eye worm) hypothetical protein 0.0117 0.0087 0.0087
Schistosoma mansoni glutamate receptor kainate 0.0135 0.0106 0.0155
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0088 0.0058 0.0887
Mycobacterium tuberculosis Conserved hypothetical protein 0.0069 0.0038 0.0584
Mycobacterium ulcerans transcriptional regulator NrdR 0.0061 0.0031 0.0321
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0088 0.0058 0.0887
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0052 0.0022 0.0305
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.01 0.007 0.0093
Loa Loa (eye worm) hypothetical protein 0.0209 0.0181 0.0181
Brugia malayi transcriptional regulator, Sir2 family protein 0.01 0.007 0.007
Trypanosoma cruzi UDP-galactopyranose mutase 0.0069 0.0038 0.0406
Plasmodium vivax aspartyl protease, putative 0.0074 0.0044 0.0609
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0204 0.0175 0.2373
Loa Loa (eye worm) hypothetical protein 0.6671 0.675 0.675
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.0726 0.0706 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0088 0.0058 0.0887
Loa Loa (eye worm) hypothetical protein 0.0068 0.0037 0.0037
Echinococcus multilocularis protoporphyrinogen oxidase 0.0069 0.0038 0.0051
Echinococcus granulosus neuroendocrine convertase 2 0.4202 0.424 0.5753
Echinococcus granulosus membrane bound transcription factor site 1 0.0289 0.0262 0.0354
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0072 0.0041 0.0623
Schistosoma mansoni hypothetical protein 0.0065 0.0034 0.0049
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0069 0.0038 0.0446
Leishmania major subtilisin-like serine peptidase 0.0289 0.0262 0.3513
Brugia malayi AMP-binding enzyme family protein 0.0085 0.0055 0.0055
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0289 0.0262 0.0354
Schistosoma mansoni hypothetical protein 0.1308 0.1297 0.1921
Echinococcus multilocularis integrin alpha 3 0.1197 0.1185 0.1607
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0069 0.0038 0.0446
Mycobacterium ulcerans polyketide synthase Pks13 0.0133 0.0104 0.1478
Schistosoma mansoni site-1 peptidase (S08 family) 0.0289 0.0262 0.0387
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0289 0.0262 0.0637
Mycobacterium tuberculosis Transcriptional regulatory protein 0.01 0.007 0.1068
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0069 0.0038 0.0446
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0069 0.0038 0.0533
Loa Loa (eye worm) hypothetical protein 0.0098 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0111 0.0081 0.0081
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.0726 0.0706 1
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0111 0.0081 0.0109
Brugia malayi ADAMTS-like protease 0.0165 0.0136 0.0136
Brugia malayi proprotein convertase 2 0.4202 0.424 0.424
Brugia malayi Disintegrin family protein 0.0117 0.0087 0.0087
Loa Loa (eye worm) integrin alpha pat-2 0.2301 0.2308 0.2308
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.0726 0.0706 1
Schistosoma mansoni glutamate receptor AMPA 0.0135 0.0106 0.0155
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0726 0.0706 1
Trypanosoma cruzi prolyl endopeptidase 0.0132 0.0102 0.1324
Plasmodium vivax hypothetical protein, conserved 0.01 0.007 0.0973
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0289 0.0262 0.0637
Echinococcus granulosus integrin alpha ps 0.0392 0.0367 0.0496
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1308 0.1297 0.3162
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.0726 0.0706 0.1044
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0088 0.0058 0.0887
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0289 0.0262 0.0637
Toxoplasma gondii subtilisin SUB4 0.0289 0.0262 0.3702
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.0726 0.0706 1
Schistosoma mansoni glutamate receptor kainate 0.0135 0.0106 0.0155
Onchocerca volvulus 0.0209 0.0181 0.5257
Schistosoma mansoni hypothetical protein 0.0392 0.0367 0.0542
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0289 0.0262 0.4062
Loa Loa (eye worm) hypothetical protein 0.014 0.011 0.011
Toxoplasma gondii subtilisin SUB9 0.0289 0.0262 0.3702
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0066 0.0035 0.0529
Loa Loa (eye worm) subtilase 0.0289 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0209 0.0181 0.0181
Giardia lamblia Neurogenic locus Notch protein precursor 0.0209 0.0181 0.0463
Loa Loa (eye worm) glutamate receptor 1 0.0135 0.0106 0.0106
Schistosoma mansoni Lysine-specific histone demethylase 1 0.034 0.0314 0.0464
Brugia malayi prolyl oligopeptidase family protein 0.0132 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.049 0.0467 0.0467
Schistosoma mansoni amine oxidase 0.0069 0.0038 0.0056
Trypanosoma brucei DNA polymerase IV, putative 0.0035 0.0003 0.0049
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.017 0.0141 0.0141
Trypanosoma brucei prolyl oligopeptidase, putative 0.0052 0.0022 0.0305
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0676 0.0655 0.9274
Trypanosoma cruzi subtilisin peptidase 0.0289 0.0262 0.3618
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.0726 0.0706 1
Giardia lamblia Tenascin-X 0.0209 0.0181 0.0463
Echinococcus multilocularis membrane bound transcription factor site 1 0.0289 0.0262 0.0354
Loa Loa (eye worm) hypothetical protein 0.0074 0.0044 0.0044
Plasmodium falciparum plasmepsin II 0.0111 0.0081 0.1139
Plasmodium falciparum subtilisin-like protease 3 0.0289 0.0262 0.3702
Brugia malayi hypothetical protein 0.0069 0.0038 0.0038
Schistosoma mansoni integrin alpha-ps 0.049 0.0467 0.069
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.148 0.1473 0.1997
Loa Loa (eye worm) hypothetical protein 0.0805 0.0787 0.0787
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0289 0.0262 0.3974
Brugia malayi Glutamate receptor 2 precursor 0.0135 0.0106 0.0106
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0282 0.0255 0.0377
Giardia lamblia High cysteine protein 0.0209 0.0181 0.0463
Echinococcus granulosus integrin alpha 3 0.1197 0.1185 0.1607
Brugia malayi metalloprotease 0.0078 0.0047 0.0047
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0693 0.0672 0.0911
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4065 0.4101 1
Schistosoma mansoni integrin beta subunit 0.5765 0.5829 0.8635
Leishmania major silent information regulator 2, putative 0.0676 0.0655 0.9262
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0059 0.0028 0.0391
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.0726 0.0706 0.0956
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0289 0.0262 0.3618
Schistosoma mansoni hypothetical protein 0.0065 0.0034 0.0049
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0369 0.0344 0.0508
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0154 0.0125 0.0168
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0289 0.0262 0.4062
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0074 0.0044 0.0044
Schistosoma mansoni protein kinase 0.0143 0.0114 0.0167
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.148 0.1473 0.1997
Trichomonas vaginalis hypothetical protein 0.0209 0.0181 0.0439
Loa Loa (eye worm) reprolysin 0.0282 0.0255 0.0255
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.007 0.0167
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0289 0.0262 0.0387
Brugia malayi hypothetical protein 0.1516 0.151 0.151
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.0664 0.0643 1
Loa Loa (eye worm) apoptosis regulator protein 0.0118 0.0088 0.0088
Loa Loa (eye worm) integrin beta-2 0.9868 1 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0034 0.0034
Schistosoma mansoni chromatin regulatory protein sir2 0.01 0.007 0.0102
Brugia malayi amine oxidase, flavin-containing family protein 0.0098 0.0068 0.0068
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0289 0.0262 0.0637
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0074 0.0044 0.0609
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.0726 0.0706 1
Plasmodium falciparum plasmepsin IV 0.0111 0.0081 0.1139
Trichomonas vaginalis conserved hypothetical protein 0.1308 0.1297 0.3162
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.001 0.0145
Onchocerca volvulus 0.0068 0.0037 0.1064
Echinococcus multilocularis protein jagged 2 0.0209 0.0181 0.0244
Echinococcus multilocularis adam 0.0579 0.0557 0.0754
Echinococcus multilocularis serotonin receptor 0.0162 0.0133 0.018
Schistosoma mansoni integrin alpha 0.1623 0.1618 0.2397
Brugia malayi aspartic protease BmAsp-2, identical 0.0074 0.0044 0.0044
Mycobacterium tuberculosis Probable peptidase 0.0052 0.0022 0.0321
Schistosoma mansoni amine GPCR 0.0215 0.0187 0.0276
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.007 0.0167
Toxoplasma gondii subtilisin SUB7 0.0289 0.0262 0.3702
Mycobacterium ulcerans NAD-dependent deacetylase 0.01 0.007 0.0936
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0133 0.0104 0.1602
Loa Loa (eye worm) hypothetical protein 0.034 0.0314 0.0314
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0078 0.0047 0.0069
Echinococcus multilocularis epidermal growth factor receptor 0.0255 0.0227 0.0307
Onchocerca volvulus 0.0065 0.0034 0.0978
Giardia lamblia Tenascin precursor 0.0209 0.0181 0.0463
Echinococcus granulosus biogenic amine 5HT receptor 0.0162 0.0133 0.018
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0289 0.0262 0.0637
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0074 0.0044 0.0064
Schistosoma mansoni tyrosine kinase 0.0255 0.0227 0.0335
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.6671 0.675 1
Echinococcus granulosus MAM 0.0068 0.0037 0.0049
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0166 0.0136 0.0184
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0133 0.0104 0.1602
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1597 0.1591 0.3879
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.007 0.004 0.0604
Loa Loa (eye worm) hypothetical protein 0.0068 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0068 0.0037 0.0037
Echinococcus multilocularis 0.0069 0.0038 0.0051
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0034 0.0034
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0069 0.0038 0.0533
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0154 0.0125 0.0168
Chlamydia trachomatis protoporphyrinogen oxidase 0.0069 0.0038 0.0117
Schistosoma mansoni serine/threonine protein kinase 0.025 0.0222 0.0328
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0069 0.0038 0.0056
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0057 0.0026 0.0397
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0289 0.0262 0.0637
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.01 0.007 0.0093
Mycobacterium tuberculosis Probable transcriptional regulatory protein NrdR 0.0061 0.0031 0.0461
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.01 0.007 0.0852
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.01 0.007 0.0852
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0154 0.0125 0.0168
Echinococcus multilocularis serotonin receptor 0.0162 0.0133 0.018
Loa Loa (eye worm) hypothetical protein 0.0118 0.0088 0.0088
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0111 0.0081 0.0081
Brugia malayi SWIRM domain containing protein 0.0369 0.0343 0.0343
Echinococcus granulosus adam 0.0579 0.0557 0.0754
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0676 0.0655 0.9284
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0676 0.0655 1
Trichomonas vaginalis hypothetical protein 0.1308 0.1297 0.3162
Echinococcus multilocularis GPCR, family 2 0.0065 0.0034 0.0045
Onchocerca volvulus Prolyl endopeptidase homolog 0.0132 0.0102 0.2962
Mycobacterium leprae Probable polyketide synthase Pks1 0.0094 0.0064 0.0976
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1597 0.1591 0.3879
Brugia malayi hypothetical protein 0.0074 0.0044 0.0044
Brugia malayi Pepsin A precursor 0.0074 0.0044 0.0044
Brugia malayi Furin-like cysteine rich region family protein 0.0255 0.0227 0.0227
Schistosoma mansoni septate junction protein 0.0036 0.0005 0.0006
Trypanosoma brucei SIR2-like protein 4, putative 0.01 0.007 0.0985
Loa Loa (eye worm) hypothetical protein 0.0032 0.0001 0.0001
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.007 0.0167
Toxoplasma gondii histone deacetylase SIR2-like 0.01 0.007 0.0973
Loa Loa (eye worm) hypothetical protein 0.1135 0.1122 0.1122
Trypanosoma cruzi UDP-galactopyranose mutase 0.0069 0.0038 0.0406
Loa Loa (eye worm) hypothetical protein 0.0048 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0051 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0162 0.0133 0.0133
Brugia malayi EGF-like domain containing protein 0.0209 0.0181 0.0181
Echinococcus multilocularis integrin beta 2 0.7281 0.737 1
Giardia lamblia Furin precursor putative serine protease 0.1308 0.1297 0.5099
Plasmodium vivax NAD-dependent deacetylase, putative 0.01 0.007 0.0973
Plasmodium falciparum plasmepsin IX 0.0074 0.0044 0.0609
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0093 0.0062 0.0957
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.0726 0.0706 1
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.001 0.0145
Mycobacterium ulcerans polyketide synthase 0.0094 0.0064 0.0843
Echinococcus multilocularis fibrillin 1 0.021 0.0182 0.0245
Echinococcus multilocularis neuroendocrine convertase 2 0.4202 0.424 0.5753
Plasmodium vivax aspartyl proteinase, putative 0.0111 0.0081 0.1139
Plasmodium falciparum subtilisin-like protease 1 0.0289 0.0262 0.3702
Echinococcus granulosus c-Jun N-terminal kinases 0.025 0.0222 0.03
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0069 0.0038 0.0533
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0143 0.0114 0.0153
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0094 0.0064 0.0976
Plasmodium falciparum plasmepsin III 0.0074 0.0044 0.0609
Echinococcus granulosus nmda type glutamate receptor 0.0166 0.0136 0.0184
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4065 0.4101 1
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.0664 0.0643 1
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1308 0.1297 0.3162
Schistosoma mansoni cathepsin D (A01 family) 0.0205 0.0176 0.026
Brugia malayi neuroendocrine convertase 1 precursor 0.4202 0.424 0.424
Echinococcus granulosus glutamate receptor 2 0.0081 0.0051 0.0067
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0069 0.0038 0.0533
Loa Loa (eye worm) transcriptional regulator 0.0676 0.0655 0.0655
Echinococcus granulosus GPCR family 2 0.0065 0.0034 0.0045
Echinococcus multilocularis integrin alpha ps 0.0392 0.0367 0.0496
Leishmania major sir2-family protein-like protein 0.01 0.007 0.0702
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0117 0.0087 0.0117
Schistosoma mansoni glutamate receptor NMDA 0.0154 0.0125 0.0183
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.001 0.0023
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0132 0.0102 0.1181
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.0726 0.0706 0.0706
Brugia malayi EGF-like domain containing protein 0.0209 0.0181 0.0181
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0289 0.0262 0.0387
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0073 0.0042 0.0056
Brugia malayi angiogenesis inhibito 0.0165 0.0136 0.0136
Echinococcus granulosus fibrillin 2 0.0209 0.0181 0.0244
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.1597 0.1591 0.2356
Echinococcus multilocularis integrin alpha ps 0.0882 0.0865 0.1173
Echinococcus multilocularis serine:threonine protein kinase N2 0.0082 0.0051 0.0068
Loa Loa (eye worm) hypothetical protein 0.0065 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0087 0.0057 0.0057
Plasmodium vivax subtilisin-like serine protease, putative 0.0289 0.0262 0.3702
Mycobacterium ulcerans oxidoreductase 0.0069 0.0038 0.0446
Toxoplasma gondii subtilisin SUB1 0.0289 0.0262 0.3702
Onchocerca volvulus 0.0078 0.0048 0.1362
Mycobacterium leprae Polyketide synthase Pks13 0.0133 0.0104 0.1602
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1308 0.1297 0.3162
Trichomonas vaginalis conserved hypothetical protein 0.1308 0.1297 0.3162
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0289 0.0262 0.3974
Loa Loa (eye worm) hypothetical protein 0.0165 0.0136 0.0136
Plasmodium falciparum transcriptional regulatory protein sir2a 0.01 0.007 0.0973
Loa Loa (eye worm) hypothetical protein 0.0078 0.0047 0.0047
Brugia malayi Reprolysin 0.0165 0.0136 0.0136
Plasmodium falciparum plasmepsin I 0.0111 0.0081 0.1139
Loa Loa (eye worm) hypothetical protein 0.0832 0.0814 0.0814
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0282 0.0255 0.0345
Plasmodium falciparum plasmepsin V 0.0191 0.0162 0.2288
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0052 0.0022 0.0321
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0289 0.0262 0.3974
Mycobacterium ulcerans Type I modular polyketide synthase 0.0088 0.0058 0.0752
Plasmodium falciparum transcriptional regulatory protein sir2b 0.01 0.007 0.0973
Plasmodium falciparum protoporphyrinogen oxidase 0.0069 0.0038 0.0533
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0118 0.0088 0.0129
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0308 0.0281 0.3897
Toxoplasma gondii aspartyl protease ASP5 0.0116 0.0086 0.1214
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0047 0.0016 0.0231
Echinococcus multilocularis 0.5363 0.542 0.7354
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0088 0.0058 0.0887
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.025 0.0222 0.0222
Brugia malayi latrophilin 2 splice variant baaae 0.014 0.011 0.011
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.007 0.0167
Plasmodium vivax plasmepsin IV, putative 0.0111 0.0081 0.1139
Trichomonas vaginalis WD repeat domain, putative 0.0065 0.0034 0.0082
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0089 0.0058 0.0892
Mycobacterium ulcerans dehydrogenase 0.0069 0.0038 0.0446
Echinococcus granulosus protein will die slowly 0.0065 0.0034 0.0045
Echinococcus multilocularis glutamate receptor 2 0.0081 0.0051 0.0067
Schistosoma mansoni biogenic amine (5HT) receptor 0.0162 0.0133 0.0196
Toxoplasma gondii subtilisin SUB10 0.0289 0.0262 0.3702
Brugia malayi EGF-like domain containing protein 0.0209 0.0181 0.0181
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0052 0.0022 0.0162
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.4065 0.4101 0.5563
Echinococcus granulosus dna polymerase kappa 0.0041 0.001 0.0013
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0289 0.0262 0.4062
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.0664 0.0643 1
Echinococcus multilocularis protein will die slowly 0.0065 0.0034 0.0045
Mycobacterium tuberculosis Possible oxidoreductase 0.0069 0.0038 0.0584
Brugia malayi hypothetical protein 0.0047 0.0016 0.0016
Schistosoma mansoni site-1 peptidase (S08 family) 0.0289 0.0262 0.0387
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0289 0.0262 0.0637
Mycobacterium ulcerans thioesterase TesA 0.0076 0.0046 0.0558
Echinococcus multilocularis disintegrin and metalloproteinase 0.0117 0.0087 0.0117
Schistosoma mansoni cathepsin D (A01 family) 0.0205 0.0176 0.026
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0289 0.0262 0.4062
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0289 0.0262 0.0637
Echinococcus multilocularis glutamate receptor 2 0.0135 0.0106 0.0142
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.01 0.007 0.0833
Loa Loa (eye worm) hypothetical protein 0.1516 0.151 0.151
Echinococcus granulosus adam 17 protease 0.0117 0.0087 0.0117
Schistosoma mansoni hypothetical protein 0.0068 0.0037 0.0054
Schistosoma mansoni glutamate receptor kainate 0.0135 0.0106 0.0155
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.001 0.0145
Chlamydia trachomatis glutamine binding protein 0.0093 0.0062 0.0472
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1597 0.1591 0.3879
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0289 0.0262 0.0637
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0289 0.0262 0.4062
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0074 0.0044 0.0064
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0289 0.0262 0.0637
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0118 0.0088 0.0088
Schistosoma mansoni hypothetical protein 0.0065 0.0034 0.0049
Loa Loa (eye worm) hypothetical protein 0.0289 0.0262 0.0262
Schistosoma mansoni glutamate receptor NMDA 0.0404 0.0379 0.056
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.007 0.0167
Echinococcus multilocularis nmda type glutamate receptor 0.0166 0.0136 0.0184
Mycobacterium leprae conserved hypothetical protein 0.0061 0.0031 0.0461
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0118 0.0088 0.0119
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0057 0.0026 0.0255
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0094 0.0064 0.0843
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0289 0.0262 0.0262
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0125 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0209 0.0181 0.0181
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0052 0.0022 0.0162
Loa Loa (eye worm) glutamate receptor 2 0.0135 0.0106 0.0106
Schistosoma mansoni chromatin regulatory protein sir2 0.01 0.007 0.0102
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0111 0.0081 0.0196
Loa Loa (eye worm) transcriptional regulator 0.01 0.007 0.007
Toxoplasma gondii prolyl endopeptidase 0.0132 0.0102 0.1439
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.007 0.0167
Loa Loa (eye worm) hypothetical protein 0.0032 0.0001 0.0001
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0093 0.0062 0.0472
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0676 0.0655 0.1596
Brugia malayi transcriptional regulator, Sir2 family protein 0.0676 0.0655 0.0655
Trichomonas vaginalis conserved hypothetical protein 0.0289 0.0262 0.0637
Loa Loa (eye worm) fatty acid synthase 0.009 0.006 0.006
Schistosoma mansoni hypothetical protein 0.0118 0.0088 0.0129
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0094 0.0064 0.0976
Loa Loa (eye worm) hypothetical protein 0.0369 0.0343 0.0343
Trichomonas vaginalis conserved hypothetical protein 0.0289 0.0262 0.0637
Trypanosoma cruzi oligopeptidase b 0.0052 0.0022 0.0162
Echinococcus multilocularis MAM 0.0068 0.0037 0.0049
Toxoplasma gondii subtilisin SUB6 0.0289 0.0262 0.3702
Mycobacterium ulcerans Type I modular polyketide synthase 0.0088 0.0058 0.0752
Echinococcus multilocularis glutamate receptor 2 0.0154 0.0125 0.0168
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.001 0.0145
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1597 0.1591 0.3879
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.0726 0.0706 0.0706
Loa Loa (eye worm) hypothetical protein 0.01 0.007 0.007
Brugia malayi hypothetical protein 0.0369 0.0344 0.0344
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1597 0.1591 0.3879
Trichomonas vaginalis conserved hypothetical protein 0.1308 0.1297 0.3162
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0074 0.0044 0.0064
Onchocerca volvulus Fatty acid synthase homolog 0.0165 0.0136 0.3935
Loa Loa (eye worm) hypothetical protein 0.034 0.0314 0.0314
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0404 0.0379 0.0513
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.0239 0.0211 0.3269
Giardia lamblia Hypothetical protein 0.0676 0.0655 0.2432
Loa Loa (eye worm) kelch domain-containing protein family protein 0.1536 0.1529 0.1529
Loa Loa (eye worm) hypothetical protein 0.0065 0.0034 0.0034
Toxoplasma gondii histone deacetylase SIR2 0.01 0.007 0.0973
Loa Loa (eye worm) sirtuin 4 0.01 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.015 0.0121 0.0121
Giardia lamblia Neurogenic locus notch-like protein 0.0209 0.0181 0.0463
Schistosoma mansoni protein kinase 0.0143 0.0114 0.0167
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.0726 0.0706 0.0956
Schistosoma mansoni ATP-binding cassette transporter 0.0138 0.0109 0.016
Toxoplasma gondii aspartyl protease ASP3 0.0074 0.0044 0.0609
Brugia malayi Will die slowly protein 0.0065 0.0034 0.0034
Brugia malayi EGF-like domain containing protein 0.0209 0.0181 0.0181
Trichomonas vaginalis conserved hypothetical protein 0.1308 0.1297 0.3162
Echinococcus multilocularis prolyl endopeptidase 0.0132 0.0102 0.0138
Mycobacterium ulcerans thioesterase 0.0076 0.0046 0.0558
Entamoeba histolytica PH domain containing protein kinase, putative 0.0073 0.0042 0.0409
Schistosoma mansoni hypothetical protein 0.0065 0.0034 0.005
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.007 0.0167
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0143 0.0114 0.0153
Toxoplasma gondii type I fatty acid synthase, putative 0.0094 0.0064 0.089
Plasmodium vivax plasmepsin V, putative 0.0191 0.0162 0.2288
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0076 0.0046 0.0695
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0289 0.0262 0.0637
Echinococcus granulosus protein kinase c epsilon type 0.0089 0.0059 0.0079
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0289 0.0262 0.0637
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0209 0.0181 0.0439
Trypanosoma brucei prolyl endopeptidase 0.0132 0.0102 0.145
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0289 0.0262 0.0262
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.007 0.0167
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0074 0.0044 0.0064
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0089 0.0059 0.0059
Trypanosoma brucei oligopeptidase b 0.0052 0.0022 0.0305
Echinococcus multilocularis fibrillin 2 0.0209 0.0181 0.0244
Echinococcus granulosus disintegrin and metalloproteinase 0.0117 0.0087 0.0117
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0088 0.0058 0.0752
Leishmania major UDP-galactopyranose mutase 0.0069 0.0038 0.0248
Mycobacterium leprae Possible secreted protease 0.0289 0.0262 0.4062
Brugia malayi hypothetical protein 0.0068 0.0037 0.0037
Plasmodium vivax aspartyl protease, putative 0.0074 0.0044 0.0609
Giardia lamblia High cysteine protein 0.0209 0.0181 0.0463
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0074 0.0044 0.0064
Brugia malayi aspartic protease BmAsp-1, identical 0.0074 0.0044 0.0044
Trypanosoma cruzi oligopeptidase b 0.0052 0.0022 0.0162
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.01 0.007 0.0833
Toxoplasma gondii subtilisin SUB5 0.0289 0.0262 0.3702
Plasmodium vivax aspartyl protease, putative 0.0074 0.0044 0.0609
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0832 0.0814 0.0814
Giardia lamblia Tenascin-like 0.0209 0.0181 0.0463
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0676 0.0655 0.1596
Loa Loa (eye worm) hypothetical protein 0.0282 0.0255 0.0255
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.001 0.0023
Schistosoma mansoni hypothetical protein 0.0118 0.0088 0.0129
Giardia lamblia Tenascin-37 0.0209 0.0181 0.0463
Loa Loa (eye worm) hypothetical protein 0.0209 0.0181 0.0181
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0088 0.0058 0.0058
Onchocerca volvulus 0.0289 0.0262 0.7619
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0289 0.0262 0.0637
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0074 0.0044 0.0064
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0111 0.0081 0.0119
Loa Loa (eye worm) hypothetical protein 0.2606 0.2617 0.2617
Loa Loa (eye worm) TK/ALK protein kinase 0.0068 0.0037 0.0037
Trypanosoma brucei subtilisin peptidase 0.0289 0.0262 0.371
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0676 0.0655 0.9274
Echinococcus granulosus serine:threonine protein kinase N2 0.0073 0.0042 0.0056
Brugia malayi Subtilase family protein 0.0289 0.0262 0.0262
Mycobacterium ulcerans polyketide synthase 0.0088 0.0058 0.0752
Mycobacterium ulcerans Sir2-like regulatory protein 0.01 0.007 0.0936
Loa Loa (eye worm) transcriptional regulator 0.01 0.007 0.007
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0289 0.0262 0.0637
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0289 0.0262 0.4062
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0132 0.0102 0.015
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0052 0.0021 0.0312
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.01 0.007 0.0093
Schistosoma mansoni chromatin regulatory protein sir2 0.01 0.007 0.0102
Loa Loa (eye worm) metalloprotease 0.0078 0.0047 0.0047
Schistosoma mansoni furin-1 (S08 family) 0.2895 0.2911 0.4312
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0073 0.0042 0.0056
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0094 0.0064 0.0976
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0052 0.0022 0.0321
Toxoplasma gondii subtilisin SUB11 0.0289 0.0262 0.3702
Loa Loa (eye worm) TK/EGFR protein kinase 0.0255 0.0227 0.0227
Trichomonas vaginalis conserved hypothetical protein 0.1308 0.1297 0.3162
Echinococcus multilocularis lysine specific histone demethylase 1A 0.034 0.0314 0.0425
Toxoplasma gondii histone lysine-specific demethylase 0.0069 0.0038 0.0533
Entamoeba histolytica hypothetical protein, conserved 0.01 0.007 0.0833
Onchocerca volvulus 0.0369 0.0343 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0289 0.0262 0.0637
Brugia malayi NAD-dependent deacetylase SIRT1 0.01 0.007 0.007
Trypanosoma brucei unspecified product 0.0035 0.0003 0.0049
Loa Loa (eye worm) WD40 repeat protein 0.0065 0.0034 0.0034
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0052 0.0022 0.0178
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0282 0.0255 0.0345
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0308 0.0281 0.3985
Brugia malayi Calcitonin receptor-like protein seb-1 0.0204 0.0176 0.0176
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.007 0.004 0.0465
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0676 0.0655 0.0888
Toxoplasma gondii hypothetical protein 0.0209 0.0181 0.2555
Plasmodium vivax subtilisin-like protease 2, putative 0.0289 0.0262 0.3702
Brugia malayi Eukaryotic aspartyl protease family protein 0.0074 0.0044 0.0044
Giardia lamblia hypothetical protein 0.0209 0.0181 0.0463
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0289 0.0262 0.0637
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0047 0.0016 0.0087
Plasmodium vivax hypothetical protein, conserved 0.0069 0.0038 0.0533
Loa Loa (eye worm) hypothetical protein 0.0047 0.0016 0.0016
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0117 0.0087 0.0117
Plasmodium falciparum plasmepsin VIII, putative 0.0074 0.0044 0.0609
Loa Loa (eye worm) hypothetical protein 0.0132 0.0102 0.0102
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0289 0.0262 0.0637
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0154 0.0125 0.0168
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.0664 0.0643 0.1567
Loa Loa (eye worm) hypothetical protein 0.0069 0.0038 0.0038
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0693 0.0672 0.0911
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0118 0.0088 0.0119
Schistosoma mansoni memapsin-2 (A01 family) 0.1312 0.1302 0.1927
Loa Loa (eye worm) hypothetical protein 0.0165 0.0136 0.0136
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0085 0.0055 0.0842
Plasmodium vivax subtilisin-like protease 1 0.0289 0.0262 0.3702
Schistosoma mansoni hypothetical protein 0.014 0.011 0.0162
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0073 0.0042 0.0056
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0034 0.0045
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0074 0.0044 0.0064
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0073 0.0042 0.0056
Onchocerca volvulus 0.0068 0.0037 0.1064
Plasmodium falciparum plasmepsin X 0.0074 0.0044 0.0609
Loa Loa (eye worm) hypothetical protein 0.0069 0.0038 0.0038
Brugia malayi protein kinase C II. 0.0089 0.0059 0.0059
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0676 0.0655 0.0888
Schistosoma mansoni chromatin regulatory protein sir2 0.0676 0.0655 0.097
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.001 0.0145
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.01 0.007 0.0093
Echinococcus granulosus prolyl endopeptidase 0.0132 0.0102 0.0138
Echinococcus granulosus epidermal growth factor receptor 0.0255 0.0227 0.0307
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0111 0.0081 0.0109
Schistosoma mansoni glutamate receptor AMPA 0.0135 0.0106 0.0155
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0232 0.0204 0.0301
Brugia malayi Kelch motif family protein 0.1536 0.1529 0.1529
Onchocerca volvulus 0.0159 0.013 0.3767
Trichomonas vaginalis conserved hypothetical protein 0.1308 0.1297 0.3162
Brugia malayi ADAM-TS Spacer 1 family protein 0.0165 0.0136 0.0136
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1276 0.1265 0.1873
Echinococcus granulosus integrin beta 2 0.7281 0.737 1
Trichomonas vaginalis conserved hypothetical protein 0.0289 0.0262 0.0637
Loa Loa (eye worm) proprotein convertase 2 0.1597 0.1591 0.1591
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.001 0.0145
Loa Loa (eye worm) hypothetical protein 0.0162 0.0133 0.0133
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.007 0.004 0.0465
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0046 0.0015 0.0202
Toxoplasma gondii subtilisin SUB12 0.0289 0.0262 0.3702
Loa Loa (eye worm) hypothetical protein 0.0074 0.0044 0.0044
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0093 0.0062 0.0824
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0118 0.0088 0.136
Brugia malayi celfurPC protein 0.5363 0.542 0.542
Brugia malayi Integrin alpha cytoplasmic region family protein 0.1135 0.1122 0.1122
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0676 0.0655 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0289 0.0262 0.0637
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.01 0.007 0.0093
Plasmodium vivax aspartyl proteinase, putative 0.0074 0.0044 0.0609
Loa Loa (eye worm) angiogenesis inhibito 0.0078 0.0047 0.0047
Loa Loa (eye worm) aspartyl protease 6 0.0074 0.0044 0.0044
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.01 0.007 0.0093
Schistosoma mansoni apoptosis regulator bax 0.0118 0.0088 0.0129
Onchocerca volvulus 0.0074 0.0044 0.1254
Schistosoma mansoni integrin alpha-ps 0.0818 0.08 0.1183
Echinococcus multilocularis NMDA receptor 0.0073 0.0042 0.0056
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0154 0.0125 0.0168
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.001 0.0145
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0289 0.0262 0.0637
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0289 0.0262 0.0637
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0094 0.0064 0.0976
Echinococcus granulosus fibrillin 1 0.021 0.0182 0.0245
Schistosoma mansoni hypothetical protein 0.0068 0.0037 0.0054
Echinococcus granulosus chromatin regulatory protein sir2 0.0676 0.0655 0.0888
Mycobacterium ulcerans monoamine oxidase 0.0069 0.0038 0.0446
Brugia malayi Protein kinase domain containing protein 0.0068 0.0037 0.0037
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0132 0.0102 0.015
Schistosoma mansoni dihydroceramide desaturase 0.0117 0.0087 0.0128
Brugia malayi endoprotease bli-4 precursor 0.6671 0.675 0.675
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.001 0.0145
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.001 0.0145
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0289 0.0262 0.0637
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0154 0.0125 0.0168
Echinococcus granulosus lysine specific histone demethylase 1A 0.0069 0.0038 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.1308 0.1297 0.3162
Trichomonas vaginalis conserved hypothetical protein 0.1308 0.1297 0.3162
Trichomonas vaginalis conserved hypothetical protein 0.0289 0.0262 0.0637
Trypanosoma brucei Silent information regulator 2 related protein 3 0.01 0.007 0.0985
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.001 0.0145
Loa Loa (eye worm) hypothetical protein 0.0457 0.0432 0.0432
Schistosoma mansoni chromatin regulatory protein sir2 0.0676 0.0655 0.097
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0037 0.0006 0.0075
Toxoplasma gondii subtilisin SUB8 0.0289 0.0262 0.3702
Brugia malayi Glutamate receptor 1 precursor 0.0135 0.0106 0.0106
Toxoplasma gondii aspartyl protease 0.0074 0.0044 0.0609
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0069 0.0038 0.0584
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.0059 0.0086
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0308 0.0281 0.3897
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0034 0.0034
Onchocerca volvulus 0.0074 0.0044 0.1254
Loa Loa (eye worm) hypothetical protein 0.1231 0.122 0.122
Trichomonas vaginalis conserved hypothetical protein 0.0289 0.0262 0.0637

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) nM In vitro binding affinity towards alpha-1A adrenergic receptor through displacement of [3H]-prazosin in epididymal rat vas deferens. ChEMBL. 15055991
Ki (binding) nM Binding affinity constant against alpha-1B adrenergic receptor of guinea pig spleen. ChEMBL. 15055991
Ki (binding) 0 nM In vitro binding affinity towards alpha-1A adrenergic receptor through displacement of [3H]-prazosin in epididymal rat vas deferens. ChEMBL. 15055991
Ki (binding) 0 nM Binding affinity constant against alpha-1B adrenergic receptor of guinea pig spleen. ChEMBL. 15055991
Ki (binding) = 86.25 nM Binding affinity to human 5-hydroxytryptamine 1A receptor was measured using [3H]-8-hydroxy-2-(di-n-propylamine) tetraline [3H]-8-OH-DPAT) as radioligand ChEMBL. 15055991
Ki (binding) = 86.25 nM Binding affinity to human 5-hydroxytryptamine 1A receptor was measured using [3H]-8-hydroxy-2-(di-n-propylamine) tetraline [3H]-8-OH-DPAT) as radioligand ChEMBL. 15055991
Ki (binding) = 596.93 nM Binding affinity to the adrenergic receptor alpha-1D of rat aorta ChEMBL. 15055991
Ki (binding) = 596.93 nM Binding affinity to the adrenergic receptor alpha-1D of rat aorta ChEMBL. 15055991

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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