Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | dihydrofolate reductase | 0.3906 | 0.1271 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.6705 | 0.6239 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.6705 | 0.6239 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.8824 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.6705 | 0.6239 | 1 |
Brugia malayi | thymidylate synthase | 0.6705 | 0.6239 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.6705 | 0.6239 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.3906 | 0.1271 | 0.2038 |
Brugia malayi | dihydrofolate reductase family protein | 0.3906 | 0.1271 | 0.2038 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.8824 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.319 | 0 | 0.5 |
Onchocerca volvulus | 0.6705 | 0.6239 | 0.5 | |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.8824 | 1 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.6705 | 0.6239 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.8824 | 1 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.6705 | 0.6239 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.6705 | 0.6239 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.3906 | 0.1271 | 0.2038 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.8824 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 125.8925 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.