Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.0377 | 1 | 1 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.016 | 0.3007 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0066 | 0 | 0.5 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0377 | 1 | 1 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.0358 | 0.9389 | 1 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.0358 | 0.9389 | 1 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0377 | 1 | 1 |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.0358 | 0.9389 | 0.5 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.0358 | 0.9389 | 0.5 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.0377 | 1 | 1 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0234 | 0.5389 | 0.3732 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0066 | 0 | 0.5 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0358 | 0.9389 | 1 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.0377 | 1 | 0.5 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0327 | 0.8399 | 0.5 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.016 | 0.3007 | 0.5 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0327 | 0.8399 | 0.5 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.0358 | 0.9389 | 1 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0119 | 0.1679 | 0.0142 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.0358 | 0.9389 | 1 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0377 | 1 | 1 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.0358 | 0.9389 | 0.5 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0358 | 0.9389 | 1 |
Onchocerca volvulus | 0.0066 | 0 | 0.5 | |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0066 | 0 | 0.5 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.0358 | 0.9389 | 1 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.0358 | 0.9389 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.