Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.8247 | 0.8247 |
Onchocerca volvulus | Dual oxidase homolog | 0.0236 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0236 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0236 | 1 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0236 | 1 | 1 |
Onchocerca volvulus | 0.0236 | 1 | 0.5 | |
Echinococcus granulosus | geminin | 0.0205 | 0.8247 | 0.8247 |
Onchocerca volvulus | Peroxidase homolog | 0.0236 | 1 | 0.5 |
Brugia malayi | Peroxidasin | 0.0236 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0236 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0236 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0236 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0236 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.8247 | 0.8247 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0236 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 1 | 1 |
Onchocerca volvulus | 0.0236 | 1 | 0.5 | |
Schistosoma mansoni | peroxidasin | 0.0236 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.0236 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0236 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 1 | 1 |
Onchocerca volvulus | 0.0236 | 1 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0236 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0236 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0236 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0236 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0236 | 1 | 0.5 |
Echinococcus multilocularis | geminin | 0.0205 | 0.8247 | 0.8247 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0236 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0236 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0236 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.122 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.0787 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.