Detailed information for compound 833210

Basic information

Technical information
  • TDR Targets ID: 833210
  • Name: N-butyl-N-(furan-2-ylmethyl)-8-methyl-4-oxo-5 H-thieno[4,5-c]quinoline-2-carboxamide
  • MW: 394.487 | Formula: C22H22N2O3S
  • H donors: 1 H acceptors: 3 LogP: 5.19 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCN(C(=O)c1cc2c(s1)c1cc(C)ccc1nc2O)Cc1ccco1
  • InChi: 1S/C22H22N2O3S/c1-3-4-9-24(13-15-6-5-10-27-15)22(26)19-12-17-20(28-19)16-11-14(2)7-8-18(16)23-21(17)25/h5-8,10-12H,3-4,9,13H2,1-2H3,(H,23,25)
  • InChiKey: YYOSHHWOMLJHCJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-butyl-N-(2-furylmethyl)-8-methyl-4-oxo-5H-thieno[4,5-c]quinoline-2-carboxamide
  • N-butyl-N-(2-furylmethyl)-4-keto-8-methyl-5H-thieno[4,5-c]quinoline-2-carboxamide
  • SMR000128322
  • IDI1_006094
  • ChemDiv2_007379
  • MLS000523056

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis hyperpolarization activated cyclic 0.0097 0.0165 0.0199
Trichomonas vaginalis AGC family protein kinase 0.3189 1 1
Schistosoma mansoni serine/threonine protein kinase 0.1062 0.3236 0.4835
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0089 0.014 0.0209
Echinococcus granulosus Protein kinase C brain isozyme 0.1062 0.3236 0.4835
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0087 0.0135 0.0155
Trichomonas vaginalis protein transport protein sec7, putative 0.0089 0.014 0.014
Schistosoma mansoni hypothetical protein 0.0089 0.014 0.0209
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0212 0.0212
Echinococcus multilocularis protein kinase c iota type 0.1062 0.3236 0.481
Trichomonas vaginalis alpha chimerin, putative 0.0089 0.014 0.014
Trypanosoma cruzi hypothetical protein 0.0089 0.014 0.0116
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0112 0.0212 1
Echinococcus multilocularis serine threonine protein kinase 0.1062 0.3236 0.481
Loa Loa (eye worm) hypothetical protein 0.0089 0.014 0.0078
Plasmodium falciparum PH domain-containing protein, putative 0.0089 0.014 0.0121
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0065 0.0062 0.0093
Onchocerca volvulus Putative zinc finger protein 0.0089 0.014 1
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.014 0.014
Brugia malayi protein kinase C II. 0.1062 0.3236 0.3236
Brugia malayi hypothetical protein 0.0089 0.014 0.014
Brugia malayi PH domain containing protein 0.0089 0.014 0.014
Trichomonas vaginalis kinesin light chain, putative 0.0089 0.014 0.014
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.2061 0.6412 0.9576
Leishmania major hypothetical protein, conserved 0.0089 0.014 0.514
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0112 0.0212 0.0151
Trichomonas vaginalis centaurin gamma, putative 0.0089 0.014 0.014
Mycobacterium tuberculosis Conserved protein 0.0065 0.0062 0.5
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0489 0.1411 0.1357
Echinococcus granulosus calcium dependent secretion activator 1 0.0089 0.014 0.0209
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0212 0.0212
Echinococcus multilocularis Oxysterol binding protein 11 0.0089 0.014 0.0161
Echinococcus granulosus oxysterol binding protein 1 0.0089 0.014 0.0209
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0097 0.0165 0.0246
Entamoeba histolytica protein kinase, putative 0.31 0.9718 0.9714
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0065 0.0062 0.0093
Brugia malayi hypothetical protein 0.0286 0.0765 0.0765
Entamoeba histolytica protein kinase, putative 0.0112 0.0212 0.0074
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0112 0.0212 0.0212
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0065 0.0062 0.0062
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0089 0.014 0.0209
Echinococcus multilocularis beta 1 syntrophin 0.0089 0.014 0.0161
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0089 0.014 0.0209
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0212 0.0212
Schistosoma mansoni serine/threonine kinase 0.1062 0.3236 0.4835
Loa Loa (eye worm) hypothetical protein 0.0089 0.014 0.0078
Entamoeba histolytica PH domain containing protein kinase, putative 0.0112 0.0212 0.0074
Trypanosoma cruzi hypothetical protein 0.0089 0.014 0.0116
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0089 0.014 0.0078
Echinococcus granulosus patatin phospholipase domain containing protein 0.0065 0.0062 0.0093
Entamoeba histolytica protein kinase, putative 0.3189 1 1
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0065 0.0062 0.0093
Echinococcus multilocularis rac serine:threonine kinase 0.2149 0.6694 1
Echinococcus granulosus DCC interacting protein 13 beta 0.0089 0.014 0.0209
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0089 0.014 0.0161
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0065 0.0062 0.0062
Mycobacterium ulcerans hypothetical protein 0.0065 0.0062 0.5
Loa Loa (eye worm) hypothetical protein 0.1062 0.3236 0.3194
Loa Loa (eye worm) hypothetical protein 0.0089 0.014 0.0078
Mycobacterium tuberculosis Conserved hypothetical protein 0.0065 0.0062 0.5
Loa Loa (eye worm) hypothetical protein 0.0089 0.014 0.0078
Mycobacterium ulcerans hypothetical protein 0.0065 0.0062 0.5
Echinococcus granulosus cGMP dependent protein kinase 0.0087 0.0135 0.0202
Entamoeba histolytica protein kinase, putative 0.0112 0.0212 0.0074
Echinococcus granulosus neuropeptide s receptor 0.0558 0.1633 0.244
Schistosoma mansoni hypothetical protein 0.0205 0.0508 0.0759
Trypanosoma cruzi hypothetical protein 0.0089 0.014 0.0116
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0456 0.1309 0.1309
Toxoplasma gondii AtPH1 family protein 0.0089 0.014 0.008
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0089 0.014 0.0161
Plasmodium falciparum cGMP-dependent protein kinase 0.0087 0.0135 0.0115
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.2038 0.6339 0.9469
Trichomonas vaginalis AGC family protein kinase 0.1151 0.3519 0.3519
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0212 0.0212
Echinococcus multilocularis DCC interacting protein 13 beta 0.0089 0.014 0.0161
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.014 0.014
Echinococcus granulosus serine:threonine protein kinase N2 0.1062 0.3236 0.4835
Schistosoma mansoni rho gtpase activating protein 0.0089 0.014 0.0209
Entamoeba histolytica PH domain containing protein kinase, putative 0.0112 0.0212 0.0074
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0065 0.0062 0.0062
Mycobacterium ulcerans transcriptional regulatory protein 0.0065 0.0062 0.5
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0089 0.014 0.0209
Entamoeba histolytica protein kinase, putative 0.0112 0.0212 0.0074
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0065 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0089 0.014 0.0078
Loa Loa (eye worm) cytohesin 3 0.0089 0.014 0.0078
Echinococcus granulosus dynamin 1 0.0089 0.014 0.0209
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0212 0.0212
Brugia malayi Hr1 repeat family protein 0.1062 0.3236 0.3236
Echinococcus granulosus hyperpolarization activated cyclic 0.0097 0.0165 0.0246
Loa Loa (eye worm) oxysterol binding protein 0.0089 0.014 0.0078
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0065 0.0062 0.5
Schistosoma mansoni zinc finger protein 0.0089 0.014 0.0209
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0089 0.014 0.014
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0089 0.014 0.0209
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.1062 0.3236 0.3194
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0065 0.0062 0.0093
Brugia malayi PH domain containing protein 0.0089 0.014 0.014
Plasmodium falciparum oxysterol-binding protein, putative 0.0089 0.014 0.0121
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.2061 0.6412 1
Echinococcus granulosus beta 1 syntrophin 0.0089 0.014 0.0209
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0212 0.0212
Trichomonas vaginalis AGC family protein kinase 0.3189 1 1
Echinococcus multilocularis GRB2 associated binding protein 3 0.0089 0.014 0.0161
Schistosoma mansoni voltage-gated potassium channel 0.0533 0.1554 0.2322
Trichomonas vaginalis protein transport protein sec7, putative 0.0089 0.014 0.014
Plasmodium vivax PH domain containing protein 0.0089 0.014 0.0121
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0089 0.014 1
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0087 0.0135 0.0075
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0087 0.0135 0.0155
Trichomonas vaginalis centaurin alpha, putative 0.0089 0.014 0.014
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0456 0.1309 0.1309
Echinococcus granulosus protein kinase c epsilon type 0.1062 0.3236 0.4835
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.1062 0.3236 0.3194
Trichomonas vaginalis centaurin/arf, putative 0.0089 0.014 0.014
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.1039 0.3163 0.3163
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.014 0.014
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0089 0.014 0.0121
Toxoplasma gondii protein kinase domain-containing protein 0.0112 0.0212 0.0155
Schistosoma mansoni survival motor neuron protein 0.0058 0.0042 0.0063
Entamoeba histolytica protein kinase, putative 0.1062 0.3236 0.3141
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0097 0.0165 0.0199
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0065 0.0062 0.0045
Trichomonas vaginalis AGC family protein kinase 0.3189 1 1
Leishmania major folate/biopterin transporter, putative 0.0112 0.0212 1
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0112 0.0212 0.0236
Echinococcus granulosus calcium activated potassium channel 0.0055 0.0032 0.0048
Brugia malayi Plekhf2 protein 0.0089 0.014 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.014 0.014
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0065 0.0062 0.0093
Onchocerca volvulus 0.0065 0.0062 0.2058
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0489 0.1411 0.2108
Entamoeba histolytica PH domain containing protein kinase, putative 0.0112 0.0212 0.0074
Loa Loa (eye worm) hypothetical protein 0.0089 0.014 0.0078
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0097 0.0165 0.0246
Echinococcus multilocularis hyperpolarization activated cyclic 0.0097 0.0165 0.0199
Echinococcus granulosus cytohesin 1 0.0089 0.014 0.0209
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0097 0.0165 0.0246
Brugia malayi Variant SH3 domain containing protein 0.0089 0.014 0.014
Entamoeba histolytica protein kinase 2, putative 0.2061 0.6412 0.6361
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0089 0.014 0.0121
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0112 0.0212 0.0226
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0112 0.0212 1
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0089 0.014 0.0078
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0112 0.0212 0.0226
Echinococcus multilocularis serine:threonine protein kinase N2 0.1062 0.3236 0.481
Echinococcus multilocularis oxysterol binding protein 1 0.0089 0.014 0.0161
Trichomonas vaginalis AGC family protein kinase 0.1062 0.3236 0.3236
Echinococcus multilocularis serine:threonine protein kinase 38 0.1062 0.3236 0.481
Brugia malayi Protein kinase domain containing protein 0.1062 0.3236 0.3236
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0089 0.014 0.0116
Trypanosoma cruzi hypothetical protein 0.0089 0.014 0.0116
Loa Loa (eye worm) hypothetical protein 0.0089 0.014 0.0078
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0112 0.0212 0.0226
Echinococcus multilocularis nervana 2 0.2038 0.6339 0.9467
Echinococcus granulosus Glutaredoxin protein 5 0.2038 0.6339 0.9469
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0089 0.014 0.0161
Echinococcus multilocularis expressed conserved protein 0.0087 0.0135 0.0155
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0089 0.014 0.014
Echinococcus granulosus voltage gated potassium channel 0.0142 0.0307 0.0459
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.014 0.014
Entamoeba histolytica hypothetical protein 0.0112 0.0212 0.0074
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0212 0.0212
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0065 0.0062 0.0093
Mycobacterium leprae Conserved hypothetical protein 0.0065 0.0062 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0065 0.0062 0.0093
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0089 0.014 0.0161
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0065 0.0062 0.0045
Loa Loa (eye worm) hypothetical protein 0.0142 0.0307 0.0247
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0489 0.1411 0.207
Loa Loa (eye worm) hypothetical protein 0.0424 0.1206 0.1151
Schistosoma mansoni growth factor receptor-bound protein 0.0089 0.014 0.0209
Brugia malayi Cyclic-nucleotide gated cation channel 0.0097 0.0165 0.0165
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0112 0.0212 0.0212
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.014 0.014
Schistosoma mansoni serine/threonine protein kinase 0.1062 0.3236 0.4835
Entamoeba histolytica protein kinase, putative 0.3189 1 1
Onchocerca volvulus 0.0089 0.014 1
Schistosoma mansoni serine/threonine protein kinase 0.1062 0.3236 0.4835
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.31 0.9718 0.9716
Schistosoma mansoni goodpasture antigen-binding protein 0.0089 0.014 0.0209
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0089 0.014 0.0209
Schistosoma mansoni hypothetical protein 0.0089 0.014 0.0209
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0097 0.0165 0.0246
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0097 0.0165 0.0199
Echinococcus granulosus protein kinase C gamma type 0.1062 0.3236 0.4835
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0112 0.0212 0.0151
Trichomonas vaginalis AGC family protein kinase 0.3189 1 1
Treponema pallidum cyclic nucleotide binding protein 0.0065 0.0062 0.5
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.2061 0.6412 0.9578
Leishmania major protein kinase, putative 0.0087 0.0135 0.486
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0089 0.014 1
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0112 0.0212 0.0151
Entamoeba histolytica PH domain containing protein kinase, putative 0.2149 0.6694 0.6647
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.014 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0062 0.0062
Trypanosoma cruzi rac serine-threonine kinase, putative 0.2149 0.6694 1
Schistosoma mansoni dynamin 0.0089 0.014 0.0209
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.014 0.014
Loa Loa (eye worm) rho-GTPase-activating 0.0089 0.014 0.0078
Loa Loa (eye worm) AGC/AKT protein kinase 0.3189 1 1
Echinococcus multilocularis calcium dependent secretion activator 1 0.0089 0.014 0.0161
Leishmania major protein kinase, putative 0.0112 0.0212 1
Brugia malayi Cytohesin 3 0.0089 0.014 0.014
Echinococcus multilocularis Pleckstrin y 0.0089 0.014 0.0161
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0089 0.014 0.0209
Echinococcus granulosus myotubularin protein 13 0.0089 0.014 0.0209
Entamoeba histolytica PH domain containing protein kinase, putative 0.0112 0.0212 0.0074
Schistosoma mansoni hypothetical protein 0.0058 0.0042 0.0063
Trichomonas vaginalis hypothetical protein 0.0089 0.014 0.014
Mycobacterium ulcerans hypothetical protein 0.0065 0.0062 0.5
Toxoplasma gondii Oxysterol-binding protein 0.0089 0.014 0.008
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0097 0.0165 0.0246
Schistosoma mansoni dynamin 0.0089 0.014 0.0209
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0142 0.0307 0.0307
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0065 0.0062 0.5
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0212 0.0212
Echinococcus multilocularis Pleckstrin y 0.0089 0.014 0.0161
Leishmania major hypothetical protein, conserved 0.0089 0.014 0.514
Loa Loa (eye worm) hypothetical protein 0.0089 0.014 0.0078
Onchocerca volvulus 0.0089 0.014 1
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.014 0.014
Toxoplasma gondii hypothetical protein 0.0089 0.014 0.008
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0065 0.0062 0.2058
Echinococcus granulosus Pleckstrin y 0.0089 0.014 0.0209
Trichomonas vaginalis centaurin/arf, putative 0.0089 0.014 0.014
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0065 0.0062 0.0093
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0097 0.0165 0.0165
Schistosoma mansoni serine/threonine-protein kinase 0.2149 0.6694 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0142 0.0307 0.0459
Trypanosoma brucei protein kinase, putative 0.0112 0.0212 0.0151
Onchocerca volvulus 0.0065 0.0062 0.2058
Brugia malayi N-terminal motif family protein 0.0065 0.0062 0.0062
Trypanosoma cruzi NIMA-related kinase, putative 0.0112 0.0212 0.0226
Giardia lamblia Kinase, AGC PKA 0.2061 0.6412 1
Echinococcus granulosus oxysterol binding protein 3 0.0089 0.014 0.0209
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.1062 0.3236 0.4835
Toxoplasma gondii hypothetical protein 0.0089 0.014 0.008
Schistosoma mansoni serine/threonine protein kinase 0.1062 0.3236 0.4835
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0089 0.014 0.0121
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0212 0.0212
Treponema pallidum cyclic nucleotide binding protein 0.0065 0.0062 0.5
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0065 0.0062 0.5
Brugia malayi Variant SH3 domain containing protein 0.0089 0.014 0.014
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0112 0.0212 0.0226
Schistosoma mansoni voltage-gated potassium channel 0.0142 0.0307 0.0459
Loa Loa (eye worm) syntrophin-1 0.0089 0.014 0.0078
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0065 0.0062 0.5
Loa Loa (eye worm) hypothetical protein 0.0097 0.0165 0.0103
Mycobacterium ulcerans hypothetical protein 0.0065 0.0062 0.5
Echinococcus multilocularis nervana 2 0.2038 0.6339 0.9467
Leishmania major serine/threonine-protein kinase a, putative 0.0112 0.0212 1
Schistosoma mansoni voltage-gated potassium channel 0.0097 0.0165 0.0246
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0065 0.0062 0.0062
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.2061 0.6412 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0097 0.0165 0.0103
Loa Loa (eye worm) hypothetical protein 0.0089 0.014 0.0078
Echinococcus granulosus pdz domain containing protein 0.0089 0.014 0.0209
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0065 0.0062 0.0045
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0065 0.0062 0.0093
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.0089 0.014 0.0121
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0089 0.014 0.0161
Onchocerca volvulus 0.0089 0.014 1
Brugia malayi PH domain containing protein 0.0089 0.014 0.014
Brugia malayi Egg laying defective protein 4 0.0087 0.0135 0.0135
Brugia malayi PH domain containing protein 0.0089 0.014 0.014
Echinococcus granulosus nervana 2 0.2038 0.6339 0.9469
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0065 0.0062 0.0093
Trypanosoma cruzi hypothetical protein 0.0089 0.014 0.0116
Loa Loa (eye worm) AGC/NDR protein kinase 0.1062 0.3236 0.3194
Entamoeba histolytica hypothetical protein 0.0112 0.0212 0.0074
Echinococcus granulosus cGMP dependent protein kinase 1 0.0087 0.0135 0.0202
Echinococcus multilocularis pleckstrin y domain containing family A 0.0089 0.014 0.0161
Brugia malayi p70 ribosomal S6 kinase beta 0.31 0.9718 0.9718
Schistosoma mansoni hypothetical protein 0.0089 0.014 0.0209
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0112 0.0212 0.0226
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0065 0.0062 0.0045
Entamoeba histolytica PH domain containing protein kinase, putative 0.2149 0.6694 0.6647
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0065 0.0062 0.0093
Schistosoma mansoni voltage-gated potassium channel 0.0142 0.0307 0.0459
Onchocerca volvulus 0.0089 0.014 1
Brugia malayi Dynamin 0.0089 0.014 0.014
Echinococcus multilocularis cytohesin 1 0.0089 0.014 0.0161
Trypanosoma cruzi PH domain containing protein, putative 0.0089 0.014 0.0116
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0212 0.0212
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0089 0.014 0.0078
Echinococcus multilocularis dynamin 1 0.0089 0.014 0.0161
Echinococcus granulosus Oxysterol binding protein 11 0.0089 0.014 0.0209
Schistosoma mansoni hypothetical protein 0.0089 0.014 0.0209
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.014 0.014
Brugia malayi PH domain containing protein 0.0089 0.014 0.014
Echinococcus granulosus pleckstrin y domain containing family A 0.0089 0.014 0.0209
Trypanosoma cruzi rac serine-threonine kinase, putative 0.2061 0.6412 0.9574
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0089 0.014 0.0209
Trypanosoma cruzi PH domain containing protein, putative 0.0089 0.014 0.0116
Brugia malayi MAX-1A 0.0089 0.014 0.014
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.1062 0.3236 0.481
Brugia malayi TBC domain containing protein 0.0089 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0089 0.014 0.0078
Schistosoma mansoni serine/threonine-protein kinase 0.2149 0.6694 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0089 0.014 0.0121
Trichomonas vaginalis centaurin beta, putative 0.0089 0.014 0.014
Echinococcus granulosus NDR protein kinase 0.1062 0.3236 0.4835
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.1062 0.3236 0.3194
Schistosoma mansoni vav2 0.0089 0.014 0.0209
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0212 0.0212
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0042 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.014 0.014
Echinococcus granulosus hyperpolarization activated cyclic 0.0097 0.0165 0.0246
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0065 0.0062 0.0045
Echinococcus multilocularis Pleckstrin y 0.0089 0.014 0.0161
Schistosoma mansoni voltage-gated potassium channel 0.0533 0.1554 0.2322
Loa Loa (eye worm) hypothetical protein 0.0089 0.014 0.0078
Trypanosoma brucei rac serine-threonine kinase, putative 0.3189 1 1
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.1062 0.3236 0.4835
Trypanosoma brucei STE group serine/threonine-protein kinase, putative 0.0068 0.0073 0.001
Echinococcus granulosus cGMP dependent protein kinase 1 0.0087 0.0135 0.0202
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0065 0.0062 0.0093
Echinococcus granulosus Pleckstrin y 0.0089 0.014 0.0209
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0065 0.0062 0.0093
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0089 0.014 0.0209
Echinococcus granulosus Pleckstrin y 0.0089 0.014 0.0209
Echinococcus multilocularis protein kinase c epsilon type 0.1062 0.3236 0.481
Loa Loa (eye worm) AGC/PKG protein kinase 0.0087 0.0135 0.0073
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0097 0.0165 0.0165
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.1062 0.3236 0.4835
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0065 0.0062 0.0093
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.0135 0.0202
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0212 0.0212
Treponema pallidum catabolite gene activator (Crp) 0.0065 0.0062 0.5
Brugia malayi Protein kinase domain containing protein 0.1062 0.3236 0.3236
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0089 0.014 0.0078
Schistosoma mansoni 60S ribosomal protein L21 0.0077 0.0102 0.0153
Brugia malayi PH domain containing protein 0.0089 0.014 0.014
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.1633 0.2403
Echinococcus multilocularis voltage gated potassium channel 0.0142 0.0307 0.0413
Schistosoma mansoni voltage-gated potassium channel 0.0077 0.0102 0.0153
Loa Loa (eye worm) hypothetical protein 0.0089 0.014 0.0078
Entamoeba histolytica protein kinase, putative 0.0112 0.0212 0.0074
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0089 0.014 0.0161
Loa Loa (eye worm) hypothetical protein 0.0286 0.0765 0.0707
Schistosoma mansoni myotubularin-related protein 0.0089 0.014 0.0209
Trypanosoma cruzi NIMA-related kinase, putative 0.0112 0.0212 0.0226
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0089 0.014 0.014
Schistosoma mansoni hypothetical protein 0.0205 0.0508 0.0759
Echinococcus multilocularis oxysterol binding protein 3 0.0089 0.014 0.0161
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0097 0.0165 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.014 0.014
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0212 0.0212
Mycobacterium tuberculosis Conserved hypothetical protein 0.0065 0.0062 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.0135 0.0202
Plasmodium vivax hypothetical protein, conserved 0.0089 0.014 0.0121
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0097 0.0165 0.0246
Onchocerca volvulus Protein melted homolog 0.0089 0.014 1
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0089 0.014 0.014
Mycobacterium ulcerans regulatory protein 0.0065 0.0062 0.5
Mycobacterium ulcerans transmembrane transport protein 0.0065 0.0062 0.5
Schistosoma mansoni oxysterol-binding protein 1 0.0089 0.014 0.0209
Trypanosoma cruzi PH domain containing protein, putative 0.0089 0.014 0.0116
Trichomonas vaginalis AGC family protein kinase 0.3189 1 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0489 0.1411 0.1411
Trypanosoma cruzi hypothetical protein 0.0089 0.014 0.0116
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0212 0.0212
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0212 0.0212
Schistosoma mansoni atypical protein kinase C 0.1062 0.3236 0.4835
Trichomonas vaginalis AGC family protein kinase 0.3189 1 1
Echinococcus multilocularis myotubularin protein 13 0.0089 0.014 0.0161
Schistosoma mansoni syntrophin 0.0089 0.014 0.0209
Echinococcus multilocularis pdz domain containing protein 0.0089 0.014 0.0161
Loa Loa (eye worm) hypothetical protein 0.0089 0.014 0.0078
Echinococcus granulosus oxysterol binding protein 9 0.0089 0.014 0.0209
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0089 0.014 0.0161
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.1062 0.3236 0.481
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.0765 0.1144
Brugia malayi PH domain containing protein 0.0089 0.014 0.014
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0089 0.014 0.0209
Schistosoma mansoni serine/threonine protein kinase 0.1062 0.3236 0.4835
Echinococcus multilocularis serine:threonine protein kinase N2 0.1062 0.3236 0.481
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0089 0.014 0.0161
Echinococcus multilocularis actin binding protein anillin 0.0089 0.014 0.0161
Toxoplasma gondii phosphatidylinositol transfer protein 0.0089 0.014 0.008
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0112 0.0212 0.0151
Trichomonas vaginalis AGC family protein kinase 0.1062 0.3236 0.3236
Schistosoma mansoni serine/threonine protein kinase 0.1062 0.3236 0.4835
Leishmania major protein kinase, putative 0.0087 0.0135 0.486
Brugia malayi Cadps2 protein 0.0089 0.014 0.014
Echinococcus granulosus geminin 0.0205 0.0508 0.0759
Loa Loa (eye worm) hypothetical protein 0.0089 0.014 0.0078
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0112 0.0212 0.0226
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.014 0.014
Trypanosoma cruzi Protein kinase B 0.2149 0.6694 1
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0089 0.014 0.0209
Schistosoma mansoni serine/threonine protein kinase 0.1062 0.3236 0.4835
Treponema pallidum catabolite gene activator 0.0065 0.0062 0.5
Plasmodium falciparum calcium-dependent protein kinase 7 0.0112 0.0212 0.0236
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0089 0.014 0.0078
Echinococcus granulosus protein kinase c iota type 0.1062 0.3236 0.4835
Trypanosoma cruzi PH domain containing protein, putative 0.0089 0.014 0.0116
Brugia malayi PH domain containing protein 0.0089 0.014 0.014
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0065 0.0062 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.014 0.014
Echinococcus granulosus Rho GTPase activating protein 24 0.0089 0.014 0.0209
Loa Loa (eye worm) hypothetical protein 0.0089 0.014 0.0078
Loa Loa (eye worm) AGC/PKN protein kinase 0.1062 0.3236 0.3194
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0212 0.0212
Toxoplasma gondii AGC kinase 0.31 0.9718 1
Echinococcus granulosus serine/threonine protein kinase 0.2149 0.6694 1
Trichomonas vaginalis AGC family protein kinase 0.3189 1 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.014 0.0078
Echinococcus granulosus nervana 2 0.2038 0.6339 0.9469
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0097 0.0165 0.0246
Brugia malayi PH domain containing protein 0.0089 0.014 0.014
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0097 0.0165 0.0199
Schistosoma mansoni hypothetical protein 0.0065 0.0062 0.0093
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0112 0.0212 0.0155
Loa Loa (eye worm) Plekhf2 protein 0.0089 0.014 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.014 0.014
Trypanosoma brucei PH domain containing protein, putative 0.0089 0.014 0.0078
Loa Loa (eye worm) hypothetical protein 0.0089 0.014 0.0078
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0089 0.014 0.0121
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.1633 0.244
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0089 0.014 0.014
Schistosoma mansoni centaurin alpha 0.0089 0.014 0.0209
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.1062 0.3236 0.481
Echinococcus multilocularis Ras associated and pleckstrin y 0.0089 0.014 0.0161
Entamoeba histolytica protein kinase, putative 0.0112 0.0212 0.0074
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0089 0.014 0.014
Brugia malayi Syntrophin-1 0.0089 0.014 0.014
Schistosoma mansoni goodpasture antigen-binding protein 0.0089 0.014 0.0209
Echinococcus multilocularis geminin 0.0205 0.0508 0.0714
Echinococcus multilocularis oxysterol binding protein 9 0.0089 0.014 0.0161
Brugia malayi Dynamin 0.0089 0.014 0.014
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0065 0.0062 0.0062
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0089 0.014 0.0078
Echinococcus granulosus serine threonine protein kinase nrc 0.2061 0.6412 0.9578
Brugia malayi Oxysterol binding protein 0.0089 0.014 0.014
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0089 0.014 0.014
Onchocerca volvulus 0.0089 0.014 1
Echinococcus multilocularis Glutaredoxin protein 5 0.2038 0.6339 0.9467
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0112 0.0212 0.0226
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0089 0.014 0.014
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0089 0.014 0.0116
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.0135 0.0202
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0142 0.0307 0.0413
Echinococcus granulosus GRB2 associated binding protein 3 0.0089 0.014 0.0209
Echinococcus multilocularis Rho GTPase activating protein 24 0.0089 0.014 0.0161
Echinococcus multilocularis Protein kinase C, brain isozyme 0.1062 0.3236 0.481
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0212 0.0212
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0065 0.0062 0.0062
Loa Loa (eye worm) uncoordinated protein 104 0.0089 0.014 0.0078
Schistosoma mansoni zinc finger protein 0.0089 0.014 0.0209
Schistosoma mansoni hypothetical protein 0.0089 0.014 0.0209
Onchocerca volvulus 0.0089 0.014 1
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0097 0.0165 0.0246
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.2038 0.6339 0.9467
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0212 0.0212
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0089 0.014 0.014
Trichomonas vaginalis AGC family protein kinase 0.1062 0.3236 0.3236
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.014 0.014
Loa Loa (eye worm) PH domain-containing protein 0.0089 0.014 0.0078
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0065 0.0062 0.5
Leishmania major protein kinase, putative 0.0112 0.0212 1
Entamoeba histolytica p21-activated kinase 0.0112 0.0212 0.0074
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0065 0.0062 0.0093
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0097 0.0165 0.0246
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0212 0.0212
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0112 0.0212 0.0226
Schistosoma mansoni oxysterol-binding protein 1 0.0089 0.014 0.0209
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0089 0.014 0.0209
Onchocerca volvulus outspread protein homolog 0.0089 0.014 1
Brugia malayi Uncoordinated protein 104 0.0089 0.014 0.014
Brugia malayi Oxysterol-binding protein 0.0089 0.014 0.014
Brugia malayi probable spectrin beta chain 0.0089 0.014 0.014
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0065 0.0062 0.0093
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0089 0.014 0.0116
Onchocerca volvulus 0.0089 0.014 1
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.0765 0.1101
Loa Loa (eye worm) hypothetical protein 0.0089 0.014 0.0078
Trypanosoma cruzi hypothetical protein 0.0089 0.014 0.0116
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.1633 0.2403
Brugia malayi Pleckstrin Homology Domain 0.0089 0.014 0.014
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.1062 0.3236 0.3194

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.2239 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.636 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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