Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0033 | 0.533 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0047 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0026 | 0.3135 | 0.3135 |
Echinococcus granulosus | dna polymerase eta | 0.0047 | 1 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0047 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0033 | 0.533 | 0.4775 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 1 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.002 | 0.1062 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.0047 | 1 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.002 | 0.1062 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.1062 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.3135 | 0.2319 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.3135 | 0.2319 |
Leishmania major | DNA polymerase eta, putative | 0.0047 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.002 | 0.1062 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.3135 | 0.2319 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.1062 | 0.1062 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.002 | 0.1062 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0047 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0033 | 0.533 | 0.4775 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.1062 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.3135 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.3135 | 0.2319 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.3135 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.3135 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.002 | 0.1062 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.002 | 0.1062 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.3135 | 0.2319 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.