TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 579.667 | Formula: C29H33N5O6S
H donors: 3 H acceptors: 5 LogP: 4.43 Rotable bonds: 16
Rule of 5 violations (Lipinski): 2
SMILES: O=C(N[C@@H]1CCN(C1=O)NC(=O)c1csc(n1)[C@@H](NC(=O)OCc1ccccc1)CC(C)C)OCc1ccccc1
InChi: 1S/C29H33N5O6S/c1-19(2)15-23(32-29(38)40-17-21-11-7-4-8-12-21)26-30-24(18-41-26)25(35)33-34-14-13-22(27(34)36)31-28(37)39-16-20-9-5-3-6-10-20/h3-12,18-19,22-23H,13-17H2,1-2H3,(H,31,37)(H,32,38)(H,33,35)/t22-,23+/m1/s1
InChiKey: XDBSXQQREUKNAC-PKTZIBPZSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin K	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin K	329 aa	349 aa	33.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0016	0.0892
Loa Loa (eye worm)	UDP galactose 4'-epimerase	0.005	0.0162	0.1125
Loa Loa (eye worm)	phosphatidylinositol glycan anchor biosynthesis protein	0.0053	0.0182	0.1261
Loa Loa (eye worm)	hypothetical protein	0.013	0.0661	0.4581
Mycobacterium leprae	Isocitrate lyase	0.0268	0.1529	0.1372
Brugia malayi	UDP galactose 4'-epimerase	0.005	0.0162	0.2455
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0016	0.0892
Leishmania major	P-type ATPase, putative	0.0049	0.0156	0.859
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0045	0.0128	0.7016
Echinococcus multilocularis	Tetracycline resistance leader peptide, TetL	0.0049	0.0156	0.0982
Schistosoma mansoni	transmemberane protein	0.0254	0.1443	1
Leishmania major	cathepsin L-like protease	0.0027	0.0016	0.0892
Echinococcus granulosus	sarco:endoplasmic reticulum calcium ATPase	0.0045	0.0128	0.0781
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0016	0.0892
Echinococcus multilocularis	sodium:potassium transporting ATPase subunit	0.0254	0.1443	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0016	0.0892
Brugia malayi	Uncharacterized LmbE-like protein, COG2120 containing protein	0.0053	0.0182	0.2752
Leishmania major	cathepsin L-like protease	0.0027	0.0016	0.0892
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0016	0.0892
Loa Loa (eye worm)	sodium/potassium-transporting ATPase subunit alpha	0.0112	0.0548	0.3801
Giardia lamblia	UDP-glucose 4-epimerase	0.0048	0.0151	0.0442
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0016	0.0892
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0016	0.0892
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0254	0.1443	1
Echinococcus granulosus	nervana 2	0.021	0.1167	0.8066
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0016	0.0892
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0016	0.0892
Echinococcus multilocularis	nervana 2	0.0254	0.1443	1
Trichomonas vaginalis	UDP-glucose 4-epimerase, putative	0.005	0.0162	0.8923
Entamoeba histolytica	calcium-transporting P-type ATPase, putative	0.0049	0.0156	0.8567
Schistosoma mansoni	ATPase	0.0045	0.0128	0.0781
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0016	0.0892
Trypanosoma cruzi	cruzipain precursor, putative	0.0027	0.0016	0.0892
Trypanosoma cruzi	calcium-transporting ATPase, putative	0.0031	0.0044	0.2403
Plasmodium vivax	N-acetylglucosaminylphosphatidylinositol deacetylase, putative	0.0053	0.0182	1
Mycobacterium leprae	PROBABLE CATION-TRANSPORTER ATPASE I CTPI	0.0107	0.052	0.0344
Schistosoma mansoni	ATPase	0.0045	0.0128	0.0781
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0254	0.1443	1
Leishmania major	calcium-transporting ATPase, putative	0.0049	0.0156	0.859
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0016	0.0892
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0016	0.0892
Echinococcus multilocularis	N acetylglucosaminyl phosphatidylinositol	0.0053	0.0182	0.1161
Mycobacterium tuberculosis	Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase)	0.1562	0.9665	1
Loa Loa (eye worm)	calcium ATPase	0.0025	0.0003	0.0021
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0016	0.0892
Brugia malayi	Probable calcium-transporting ATPase KIAA0703	0.0031	0.0044	0.0661
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0049	0.0156	0.859
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0392	0.2718
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0016	0.0892
Toxoplasma gondii	N-acetylglucosaminylphosphatidylinositol deacetylase	0.0053	0.0182	1
Mycobacterium leprae	PROBABLE ISOCITRATE LYASE AceA (ISOCITRASE) (ISOCITRATASE) (ICL)	0.0571	0.3436	0.3314
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.0254	0.1443	1
Echinococcus multilocularis	plasma membrane calcium transporting ATPase	0.0049	0.0156	0.0982
Trypanosoma cruzi	calcium motive p-type ATPase, putative	0.0049	0.0156	0.859
Brugia malayi	E1-E2 ATPase family protein	0.0029	0.0029	0.0433
Leishmania major	cathepsin L-like protease	0.0027	0.0016	0.0892
Giardia lamblia	Glucosamine-6-phosphate isomerase, putative	0.0053	0.0182	0.1018
Entamoeba histolytica	N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase, putative	0.0053	0.0182	1
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0016	0.0245
Trypanosoma cruzi	UDP-galactose 4-epimerase	0.005	0.0162	0.8923
Trypanosoma brucei	vacuolar-type Ca2+-ATPase 1	0.0045	0.0128	0.7016
Schistosoma mansoni	Na+/K+ transporting ATPase subunit alpha	0.013	0.0661	0.452
Toxoplasma gondii	calcium-translocating P-type ATPase, PMCA-type protein	0.0045	0.0128	0.7016
Brugia malayi	calcium ATPase	0.0025	0.0003	0.0046
Echinococcus multilocularis	Na+:K+ ATPase alpha subunit	0.013	0.0661	0.452
Echinococcus granulosus	Ca2 transporting ATPase plasma membrane	0.0049	0.0156	0.0982
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0016	0.0892
Schistosoma mansoni	plasma membrane calcium-transporting atpase	0.0049	0.0156	0.0982
Loa Loa (eye worm)	ctsf protein	0.0027	0.0016	0.0112
Echinococcus granulosus	calcium transporting ATPase type 2C member	0.0049	0.0156	0.0982
Trypanosoma cruzi	N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative	0.0053	0.0182	1
Trypanosoma cruzi	calcium motive p-type ATPase, putative	0.0049	0.0156	0.859
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0016	0.0892
Leishmania major	cathepsin L-like protease	0.0027	0.0016	0.0892
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0045	0.0128	0.7016
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0016	0.0892
Trypanosoma brucei	calcium motive p-type ATPase, putative	0.0049	0.0156	0.859
Trichomonas vaginalis	NAD dependent epimerase/dehydratase, putative	0.005	0.0162	0.8923
Echinococcus multilocularis	sarco:endoplasmic reticulum calcium ATPase	0.0045	0.0128	0.0781
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0045	0.0128	0.6965
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0016	0.0892
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0016	0.0245
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0045	0.0128	0.6965
Echinococcus multilocularis	nervana 2	0.021	0.1167	0.8066
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0027	0.0016	0.0112
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0045	0.0128	0.7016
Entamoeba histolytica	plasma membrane calcium ion-transporting ATPase, putative	0.0029	0.0029	0.1432
Mycobacterium ulcerans	isocitrate lyase AceAb	0.0571	0.3436	0.3426
Echinococcus granulosus	plasma membrane calcium transporting ATPase	0.0049	0.0156	0.0982
Loa Loa (eye worm)	hypothetical protein	0.008	0.0351	0.2437
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0027	0.0016	0.0892
Plasmodium falciparum	calcium-transporting ATPase	0.0049	0.0156	0.8452
Mycobacterium tuberculosis	Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl)	0.0571	0.3436	0.3545
Brugia malayi	Sodium/potassium-transporting ATPase alpha chain, putative	0.0112	0.0548	0.8297
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0027	0.0016	0.0892
Echinococcus granulosus	nervana 2	0.0254	0.1443	1
Onchocerca volvulus		0.0125	0.0632	0.4319
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0053	0.0182	0.0173
Echinococcus multilocularis	Ca2+ transporting ATPase plasma membrane	0.0049	0.0156	0.0982
Entamoeba histolytica	UDP-glucose 4-epimerase, putative	0.005	0.0162	0.8905
Schistosoma mansoni	calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump)	0.0049	0.0156	0.0982
Mycobacterium tuberculosis	N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase)	0.0053	0.0182	0.0173
Mycobacterium ulcerans	metal cation transporter p-type ATPase a	0.0125	0.0632	0.0618
Mycobacterium ulcerans	metal cation-transporting p-type ATPase F, CtpF	0.0049	0.0156	0.0141
Echinococcus granulosus	N acetylglucosaminyl phosphatidylinositol	0.0053	0.0182	0.1161
Trypanosoma brucei	calcium-translocating P-type ATPase	0.0049	0.0156	0.859
Plasmodium falciparum	non-SERCA-type Ca2+ -transporting P-ATPase	0.0049	0.0156	0.8452
Mycobacterium tuberculosis	Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl)	0.0571	0.3436	0.3545
Leishmania major	cathepsin L-like protease	0.0027	0.0016	0.0892
Trypanosoma cruzi	plasma membrane Ca2+ ATPase	0.0045	0.0128	0.7016
Trypanosoma brucei	N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase	0.0053	0.0182	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0016	0.0892
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0016	0.0112
Leishmania major	cysteine peptidase A (CPA)	0.0027	0.0016	0.0892
Trypanosoma cruzi	N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative	0.0053	0.0182	1
Schistosoma mansoni	na+/k+ atpase alpha subunit	0.013	0.0661	0.452
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0016	0.0892
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0016	0.0892
Leishmania major	cathepsin L-like protease	0.0027	0.0016	0.0892
Echinococcus granulosus	sodium:potassium transporting ATPase subunit	0.0254	0.1443	1
Leishmania major	cathepsin L-like protease	0.0027	0.0016	0.0892
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0016	0.0892
Echinococcus multilocularis	calcium transporting atpase	0.0049	0.0156	0.0982
Mycobacterium ulcerans	N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB	0.0053	0.0182	0.0167
Toxoplasma gondii	UDP-glucose 4-epimerase	0.005	0.0162	0.8923
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0045	0.0128	0.7016
Trichomonas vaginalis	glucosamine-6-phosphate isomerase, putative	0.0053	0.0182	1
Trypanosoma cruzi	plasma membrane Ca2+ ATPase	0.0045	0.0128	0.7016
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0045	0.0128	0.7016
Leishmania major	calcium-translocating P-type ATPase	0.0045	0.0128	0.7016
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0045	0.0128	0.7016
Schistosoma mansoni	sodium / potassium ATPase beta chain	0.021	0.1167	0.8066
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0016	0.0892
Toxoplasma gondii	sarco/endoplasmic reticulum Ca2+-ATPase	0.0049	0.0156	0.859
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0016	0.0892
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.021	0.1167	0.8066
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.0016	0.0738
Trichomonas vaginalis	cation-transporting ATPase fungi, putative	0.0045	0.0128	0.7016
Loa Loa (eye worm)	cysteine protease	0.0027	0.0016	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0254	0.1443	1
Loa Loa (eye worm)	Na,K-ATPase alpha subunit	0.013	0.0661	0.4581
Mycobacterium tuberculosis	Isocitrate lyase Icl (isocitrase) (isocitratase)	0.0571	0.3436	0.3545
Loa Loa (eye worm)	hypothetical protein	0.0254	0.1443	1
Giardia lamblia	Potassium-transporting ATPase alpha chain 1	0.013	0.0661	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0016	0.0892
Trichomonas vaginalis	NAD dependent epimerase/dehydratase, putative	0.005	0.0162	0.8923
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0016	0.0245
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0016	0.0245
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0016	0.0892
Loa Loa (eye worm)	calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type	0.0031	0.0044	0.0303
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.021	0.1167	0.8066
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0049	0.0156	0.859
Schistosoma mansoni	calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump)	0.0049	0.0156	0.0982
Echinococcus granulosus	calcium transporting atpase	0.0049	0.0156	0.0982
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0016	0.0892
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0016	0.0892
Trypanosoma brucei	calcium-transporting ATPase, putative	0.0031	0.0044	0.2403
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0254	0.1443	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0016	0.0892
Schistosoma mansoni	N-acetylglucosaminyl-phosphatidylinositol de-n-acetylase	0.0053	0.0182	0.1161
Entamoeba histolytica	glucosamine-6-phosphate isomerase, putative	0.0053	0.0182	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0016	0.0892
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0045	0.0128	0.6965
Brugia malayi	Papain family cysteine protease containing protein	0.0027	0.0016	0.0245
Echinococcus multilocularis	calcium transporting ATPase type 2C member	0.0049	0.0156	0.0982
Mycobacterium ulcerans	isocitrate lyase Icl	0.0571	0.3436	0.3426
Schistosoma mansoni	UDP-glucose 4-epimerase	0.005	0.0162	0.1024
Echinococcus granulosus	nervana 2	0.0254	0.1443	1
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0016	0.0245
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0016	0.0892
Echinococcus multilocularis	nervana 2	0.0254	0.1443	1
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0254	0.1443	1
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.021	0.1167	0.8066
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.0016	0.0738
Echinococcus multilocularis	UDP glucose 4 epimerase	0.005	0.0162	0.1024
Leishmania major	calcium motive p-type ATPase, putative	0.0049	0.0156	0.859
Loa Loa (eye worm)	fibroinase	0.0027	0.0016	0.0112
Toxoplasma gondii	plasma membrane-type Ca(2+)-ATPase A1 PMCAA1	0.0049	0.0156	0.859
Mycobacterium ulcerans	mycothiol conjugate amidase Mca	0.1616	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0016	0.0892
Leishmania major	vacuolar-type Ca2 -ATPase, putative	0.0045	0.0128	0.7016
Echinococcus granulosus	Na:K ATPase alpha subunit	0.013	0.0661	0.452
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.0254	0.1443	1
Leishmania major	vacuolar-type Ca2 -ATPase, putative	0.0045	0.0128	0.7016
Leishmania major	udp-glc 4-epimerase, putative	0.0048	0.0151	0.8313
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0016	0.0892
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0479	0.3321
Brugia malayi	Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type	0.0049	0.0156	0.2364
Schistosoma mansoni	calcium-transporting atpase 2 (atpase 2)	0.0049	0.0156	0.0982
Trypanosoma brucei	vacuolar-type Ca2+-ATPase, putative	0.0045	0.0128	0.7016
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0016	0.0892
Toxoplasma gondii	cathepsin CPL	0.0027	0.0016	0.0892
Brugia malayi	Na,K-ATPase alpha subunit	0.013	0.0661	1
Onchocerca volvulus		0.021	0.1167	0.8066
Trypanosoma cruzi	Calcium ATPase SERCA-like	0.0045	0.0128	0.7016
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0027	0.0016	0.0112
Toxoplasma gondii	P-type ATPase4, putative	0.0049	0.0156	0.859
Trypanosoma brucei	UDP-galactose 4-epimerase	0.0048	0.0151	0.8313
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0016	0.0245
Onchocerca volvulus		0.0254	0.1443	1
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0045	0.0128	0.7016
Trypanosoma brucei	vacuolar-type Ca2+-ATPase 2	0.0045	0.0128	0.7016
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0128	0.0884
Echinococcus granulosus	UDP glucose 4 epimerase	0.005	0.0162	0.1024
Leishmania major	N-acetyl-D-acetylglucosaminylphosphatidylinositol deacetylase	0.0053	0.0182	1
Plasmodium falciparum	N-acetylglucosaminylphosphatidylinositol deacetylase, putative	0.0053	0.0182	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0016	0.0892
Schistosoma mansoni	plasma membrane calcium-transporting atpase	0.0049	0.0156	0.0982
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0044	0.0303
Plasmodium vivax	calcium-transporting ATPase, putative	0.0049	0.0156	0.8452
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0016	0.0892
Entamoeba histolytica	cysteine protease, putative	0.0027	0.0016	0.0738
Plasmodium vivax	P-type ATPase4, putative	0.0049	0.0156	0.8452
Leishmania major	cathepsin L-like protease	0.0027	0.0016	0.0892
Echinococcus multilocularis	nervana 2	0.021	0.1167	0.8066
Echinococcus granulosus	plasma membrane calcium transporting ATPase 2	0.0049	0.0156	0.0982
Trypanosoma cruzi	UDP-galactose 4-epimerase, putative	0.005	0.0162	0.8923
Brugia malayi	haloacid dehalogenase-like hydrolase family protein	0.0025	0.0003	0.0046
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0016	0.0892
Echinococcus granulosus	nervana 2	0.021	0.1167	0.8066
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0016	0.0892
Brugia malayi	Membrane calcium atpase protein 3	0.0049	0.0156	0.2364

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 330 nM	Compound was tested for its inhibitory activity against human osteoclast cathepsin K	ChEMBL.	10450951
Ki (binding)	= 330 nM	Compound was tested for its inhibitory activity against human osteoclast cathepsin K	ChEMBL.	10450951

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 83340