Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | References |
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0029 | 0.0097 | 0.0097 |
Schistosoma mansoni | dihydrofolate reductase | 0.0415 | 1 | 1 |
Onchocerca volvulus | 0.0047 | 0.0552 | 0.5 | |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0415 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0415 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0415 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0415 | 1 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0415 | 1 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0415 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.3426 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0415 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0552 | 0.0552 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.3426 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.3426 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.3426 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0415 | 1 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0159 | 0.3426 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.3426 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 17.3 uM | In vitro inhibitory concentration against rat liver dihydrofolate reductase | ChEMBL. | 9191966 |
IC50 (binding) | = 17.3 uM | In vitro inhibitory concentration against rat liver dihydrofolate reductase | ChEMBL. | 9191966 |
IC50 (binding) | = 18.2 uM | In vitro inhibitory concentration against Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 9191966 |
IC50 (binding) | = 18.2 uM | In vitro inhibitory concentration against Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 9191966 |
Selectivity index (binding) | = 1 | Selectivity index measured as the ratio of IC50 for rat liver DHFR to IC50 for P. carinii DHFR. | ChEMBL. | 9191966 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.