TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 272.299 | Formula: C15H16N2O3
H donors: 0 H acceptors: 2 LogP: 0.96 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: N#CCCN(Cc1cc(=O)oc2c1cc(OC)cc2)C
InChi: 1S/C15H16N2O3/c1-17(7-3-6-16)10-11-8-15(18)20-14-5-4-12(19-2)9-13(11)14/h4-5,8-9H,3,7,10H2,1-2H3
InChiKey: DNKDOSAQPBTSGR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	beta-lactamase	0.0032	0.0382	0.1115
Mycobacterium tuberculosis	Probable amidase AmiA2 (aminohydrolase)	0.0026	0.0291	0.0465
Trypanosoma cruzi	serine peptidase, putative	0.0015	0.0108	0.0266
Trypanosoma brucei	monoglyceride lipase, putative	0.0257	0.4052	1
Mycobacterium tuberculosis	Probable hydrolase	0.0032	0.0382	0.0696
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0014	0.0089	0.0156
Mycobacterium tuberculosis	Probable lipase LipD	0.0032	0.0382	0.0696
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0108	0.0266
Trichomonas vaginalis	D-aminoacylase, putative	0.0032	0.0382	0.0943
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0257	0.4052	1
Schistosoma mansoni	hypothetical protein	0.0014	0.0089	0.0156
Chlamydia trachomatis	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0026	0.0291	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0032	0.0382	0.1115
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0032	0.0382	0.0696
Schistosoma mansoni	hypothetical protein	0.0358	0.5704	1
Toxoplasma gondii	ABC1 family protein	0.0032	0.0382	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0032	0.0382	0.0943
Trypanosoma cruzi	amidase, putative	0.0026	0.0291	0.0718
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0108	0.0314
Onchocerca volvulus		0.0032	0.0382	1
Echinococcus granulosus	abhydrolase domain containing protein 13	0.0015	0.0108	0.0189
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0014	0.0089	0.026
Schistosoma mansoni	amidase	0.0219	0.3429	0.6012
Schistosoma mansoni	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0026	0.0291	0.051
Leishmania major	hypothetical protein, conserved	0.0015	0.0108	0.0266
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0257	0.4052	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0382	0.1115
Echinococcus multilocularis	monoacylglycerol lipase abhd12	0.0015	0.0108	0.0108
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0033	0.0392	0.0721
Trypanosoma cruzi	monoglyceride lipase, putative	0.0257	0.4052	1
Schistosoma mansoni	fatty-acid amide hydrolase	0.0219	0.3429	0.6012
Loa Loa (eye worm)	beta-lactamase	0.0032	0.0382	0.1115
Plasmodium vivax	lysophospholipase, putative	0.0015	0.0108	0.0266
Plasmodium falciparum	esterase, putative	0.0257	0.4052	1
Plasmodium vivax	PST-A protein	0.0015	0.0108	0.0266
Echinococcus granulosus	hormone sensitive lipase	0.0151	0.2329	0.4083
Trichomonas vaginalis	conserved hypothetical protein	0.0257	0.4052	1
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0219	0.3429	0.6012
Schistosoma mansoni	peptidase	0.0015	0.0108	0.0189
Leishmania major	monoglyceride lipase, putative	0.0257	0.4052	1
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0108	0.0266
Plasmodium falciparum	lysophospholipase, putative	0.0015	0.0108	0.0266
Mycobacterium tuberculosis	Conserved protein	0.0032	0.0382	0.0696
Trypanosoma cruzi	cysteine peptidase, putative	0.0033	0.0392	0.0967
Leishmania major	cathepsin L-like protease	0.0033	0.0392	0.0967
Toxoplasma gondii	peptidase S15, putative	0.0015	0.0108	0.2817
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0108	0.0266
Echinococcus granulosus	beta LACTamase domain containing family member	0.0032	0.0382	0.067
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0108	0.0314
Trypanosoma cruzi	hypothetical protein, conserved	0.0032	0.0382	0.0943
Plasmodium falciparum	lysophospholipase, putative	0.0257	0.4052	1
Plasmodium falciparum	prodrug activation and resistance esterase	0.0015	0.0108	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0583	0.17
Brugia malayi	amidase	0.0219	0.3429	1
Echinococcus granulosus	GPCR family 2	0.0014	0.0089	0.0156
Brugia malayi	beta-lactamase family protein	0.0032	0.0382	0.1115
Trichomonas vaginalis	valacyclovir hydrolase, putative	0.0257	0.4052	1
Echinococcus multilocularis	GPCR, family 2	0.0014	0.0089	0.0089
Loa Loa (eye worm)	hypothetical protein	0.003	0.0354	0.1033
Mycobacterium leprae	Probable lipase LipE	0.0032	0.0382	0.0242
Trypanosoma brucei	fatty-acid amide hydrolase, putative	0.0026	0.0291	0.0465
Trypanosoma cruzi	cysteine peptidase, putative	0.0033	0.0392	0.0967
Plasmodium falciparum	exported lipase 1	0.0015	0.0108	0.0266
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0033	0.0392	0.0721
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0015	0.0108	0.0266
Plasmodium falciparum	esterase, putative	0.0015	0.0108	0.0266
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0033	0.0392	0.0721
Mycobacterium tuberculosis	Possible lysophospholipase	0.0257	0.4052	1
Mycobacterium ulcerans	amidase	0.0026	0.0291	0.0465
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0015	0.0108	0.0266
Plasmodium vivax	alpha/beta hydrolase, putative	0.0015	0.0108	0.0266
Plasmodium falciparum	epoxide hydrolase 2	0.0015	0.0108	0.0266
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0015	0.0108	0.0266
Plasmodium vivax	PST-A protein	0.0015	0.0108	0.0266
Plasmodium vivax	PST-A protein	0.0015	0.0108	0.0266
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0015	0.0108	0.0266
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0257	0.4052	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0382	0.1115
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0015	0.0108	0.0266
Brugia malayi	MGC83647 protein	0.0015	0.0108	0.0314
Schistosoma mansoni	family S9 unassigned peptidase (S09 family)	0.0015	0.0108	0.0189
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0032	0.0382	0.067
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0108	0.0266
Leishmania major	cathepsin L-like protease	0.0033	0.0392	0.0967
Trypanosoma cruzi	Serine peptidase, Clan SC, Family S09X, putative	0.0015	0.0108	0.0266
Toxoplasma gondii	esterase/lipase/thioesterase domain-containing protein	0.0015	0.0108	0.2817
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0015	0.0108	0.0266
Plasmodium vivax	hypothetical protein, conserved	0.0015	0.0108	0.0266
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0151	0.2329	0.4083
Plasmodium falciparum	lysophospholipase, putative	0.0257	0.4052	1
Echinococcus granulosus	monoacylglycerol lipase abhd12	0.0015	0.0108	0.0189
Mycobacterium ulcerans	hypothetical protein	0.0257	0.4052	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0033	0.0392	0.0721
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0032	0.0382	0.1115
Wolbachia endosymbiont of Brugia malayi	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0026	0.0291	0.5
Mycobacterium tuberculosis	Probable lipase LipE	0.0032	0.0382	0.0696
Plasmodium vivax	PST-A protein	0.0257	0.4052	1
Schistosoma mansoni	family S9 unassigned peptidase (S09 family)	0.0015	0.0108	0.0189
Trichomonas vaginalis	conserved hypothetical protein	0.0257	0.4052	1
Treponema pallidum	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0026	0.0291	0.5
Brugia malayi	MGC79044 protein	0.0015	0.0108	0.0314
Echinococcus multilocularis	hormone sensitive lipase	0.0151	0.2329	0.2329
Trichomonas vaginalis	penicillin-binding protein, putative	0.0032	0.0382	0.0943
Mycobacterium ulcerans	amidase	0.0026	0.0291	0.0465
Plasmodium falciparum	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0026	0.0291	0.0718
Mycobacterium ulcerans	lipase LipD	0.0032	0.0382	0.0696
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0015	0.0108	0.0266
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0032	0.0382	0.0696
Plasmodium vivax	PST-A protein	0.0015	0.0108	0.0266
Toxoplasma gondii	protein c14orf29, putative	0.0015	0.0108	0.2817
Brugia malayi	latrophilin 2 splice variant baaae	0.003	0.0354	0.1033
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0257	0.4052	1
Plasmodium falciparum	esterase, putative	0.0015	0.0108	0.0266
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0108	0.0266
Plasmodium falciparum	BEM46-like protein, putative	0.0015	0.0108	0.0266
Toxoplasma gondii	hydrolase, alpha/beta fold family protein	0.0015	0.0108	0.2817
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0032	0.0382	0.0382
Onchocerca volvulus		0.0032	0.0382	1
Loa Loa (eye worm)	amidase	0.0026	0.0291	0.0849
Echinococcus granulosus	glutamyl tRNAGln amidotransferase subunit A	0.0026	0.0291	0.051
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0382	0.1115
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0032	0.0382	0.0696
Leishmania major	Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X	0.0015	0.0108	0.0266
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0257	0.4052	1
Leishmania major	hypothetical protein, conserved	0.0015	0.0108	0.0266
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0219	0.3429	0.6012
Trypanosoma cruzi	hypothetical protein, conserved	0.0032	0.0382	0.0943
Mycobacterium leprae	conserved hypothetical protein	0.0032	0.0382	0.0242
Mycobacterium ulcerans	lysophospholipase	0.0257	0.4052	1
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0108	0.0266
Mycobacterium ulcerans	peptide amidase, GatA	0.0026	0.0291	0.0465
Plasmodium vivax	hypothetical protein, conserved	0.0015	0.0108	0.0266
Mycobacterium ulcerans	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0026	0.0291	0.0465
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	0.0257	0.4052	1
Brugia malayi	Latrophilin receptor protein 2	0.0014	0.0089	0.026
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.0015	0.0108	0.0266
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0033	0.0392	0.0721
Trypanosoma cruzi	major cysteine proteinase, putative	0.0026	0.0278	0.0686
Trichomonas vaginalis	D-aminoacylase, putative	0.0032	0.0382	0.0943
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0015	0.0108	0.0266
Schistosoma mansoni	hypothetical protein	0.0358	0.5704	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0033	0.0392	0.0721
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0108	0.0266
Mycobacterium tuberculosis	Probable esterase LipL	0.0032	0.0382	0.0696
Echinococcus granulosus	geminin	0.0358	0.5704	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0108	0.0314
Giardia lamblia	Cgi67 serine protease precursor-like protein	0.0015	0.0108	0.5
Mycobacterium ulcerans	esterase/lipase LipP	0.0032	0.0382	0.0696
Toxoplasma gondii	hypothetical protein	0.0015	0.0108	0.2817
Brugia malayi	Amidase family protein	0.0026	0.0291	0.0849
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0151	0.2329	0.4083
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0044	0.0583	0.17
Trypanosoma cruzi	hydrolase, alpha/beta fold family, putative	0.0015	0.0108	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0108	0.0314
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0015	0.0108	0.0266
Mycobacterium ulcerans	beta-lactamase	0.0032	0.0382	0.0696
Toxoplasma gondii	phospholipase	0.0015	0.0108	0.2817
Mycobacterium ulcerans	amidase	0.0026	0.0291	0.0465
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0015	0.0108	0.0266
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.0015	0.0108	0.0266
Plasmodium vivax	unspecified product	0.0015	0.0108	0.0266
Plasmodium falciparum	alpha/beta hydrolase fold domain containing protein, putative	0.0015	0.0108	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0108	0.0314
Onchocerca volvulus		0.0032	0.0382	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0044	0.0583	0.17
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0204	0.3193	0.7822
Echinococcus multilocularis	Phospholipase carboxylesterase	0.0015	0.0108	0.0108
Entamoeba histolytica	hypothetical protein	0.0015	0.0108	0.0266
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0014	0.0089	0.026
Toxoplasma gondii	hypothetical protein	0.0015	0.0108	0.2817
Toxoplasma gondii	hypothetical protein	0.0015	0.0108	0.2817
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.003	0.0346	0.0853
Trypanosoma brucei	monoglyceride lipase, putative	0.0257	0.4052	1
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0108	0.0266
Mycobacterium tuberculosis	Probable amidase AmiC (aminohydrolase)	0.0026	0.0291	0.0465
Mycobacterium ulcerans	amidase	0.0026	0.0291	0.0465
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0108	0.0266
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0026	0.0291	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0382	0.1115
Echinococcus multilocularis	geminin	0.0358	0.5704	0.5704
Trichomonas vaginalis	penicillin-binding protein, putative	0.0032	0.0382	0.0943
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0382	0.1115
Toxoplasma gondii	hydrolase, alpha/beta fold family protein	0.0015	0.0108	0.2817
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0014	0.0089	0.0089
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0219	0.3429	0.3429
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0033	0.0392	0.0721
Echinococcus granulosus	Phospholipase carboxylesterase	0.0015	0.0108	0.0189
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0032	0.0382	0.0696
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0015	0.0108	0.0266
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0014	0.0089	0.0089
Trypanosoma cruzi	serine peptidase, putative	0.0015	0.0108	0.0266
Mycobacterium tuberculosis	Probable amidase AmiB2 (aminohydrolase)	0.0026	0.0291	0.0465
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0044	0.0583	0.17
Echinococcus multilocularis	abhydrolase domain containing 3	0.0015	0.0108	0.0108
Trypanosoma cruzi	amidase, putative	0.0026	0.0291	0.0718
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.0015	0.0108	0.0266
Schistosoma mansoni	hypothetical protein	0.003	0.0354	0.0621
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0033	0.0392	0.0721
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0033	0.0392	0.0721
Entamoeba histolytica	hypothetical protein	0.0015	0.0108	0.0266
Schistosoma mansoni	hypothetical protein	0.0014	0.0089	0.0156
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0015	0.0108	0.0266
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0257	0.4052	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0033	0.0392	0.0721
Mycobacterium tuberculosis	Possible amidase (aminohydrolase)	0.0026	0.0291	0.0465
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0257	0.4052	1
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0026	0.0291	0.051
Plasmodium falciparum	lysophospholipase, putative	0.0015	0.0108	0.0266
Loa Loa (eye worm)	amidase	0.0026	0.0291	0.0849
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0014	0.0089	0.0156
Echinococcus multilocularis	glutamyl tRNA(Gln) amidotransferase subunit A	0.0026	0.0291	0.0291
Echinococcus granulosus	abhydrolase domain containing 3	0.0015	0.0108	0.0189
Toxoplasma gondii	phospholipase/carboxylesterase	0.0015	0.0108	0.2817
Toxoplasma gondii	hypothetical protein	0.0015	0.0108	0.2817
Brugia malayi	beta-lactamase family protein	0.0032	0.0382	0.1115
Plasmodium vivax	hypothetical protein, conserved	0.0015	0.0108	0.0266
Plasmodium vivax	PST-A protein	0.0015	0.0108	0.0266
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0151	0.2329	0.4083
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0382	0.1115
Brugia malayi	Protein C20orf22	0.0015	0.0108	0.0314
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0015	0.0108	0.0266
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0033	0.0392	0.0721
Plasmodium falciparum	exported lipase 2	0.0015	0.0108	0.0266
Trypanosoma brucei	hypothetical protein, conserved	0.0032	0.0382	0.0696
Plasmodium vivax	lysophospholipase, putative	0.0015	0.0108	0.0266
Brugia malayi	Amidase family protein	0.0026	0.0291	0.0849
Plasmodium vivax	glutamyl-tRNA(Gln) amidotransferase subunit A, putative	0.0026	0.0291	0.0718
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0015	0.0108	0.0266
Plasmodium vivax	hypothetical protein, conserved	0.0032	0.0382	0.0943
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0219	0.3429	0.3429
Plasmodium vivax	alpha/beta hydrolase, putative	0.0015	0.0108	0.0266
Leishmania major	cathepsin L-like protease	0.0033	0.0392	0.0967
Mycobacterium tuberculosis	Conserved protein	0.0032	0.0382	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0089	0.026
Plasmodium vivax	lysophospholipase, putative	0.0015	0.0108	0.0266
Schistosoma mansoni	fatty-acid amide hydrolase	0.0026	0.0291	0.051
Mycobacterium ulcerans	amidase	0.0026	0.0291	0.0465
Schistosoma mansoni	hypothetical protein	0.0014	0.0089	0.0156
Trichomonas vaginalis	esterase, putative	0.0032	0.0382	0.0943
Plasmodium falciparum	alpha/beta-hydrolase, putative	0.0015	0.0108	0.0266
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0015	0.0108	0.0266
Leishmania major	hypothetical protein, conserved	0.0032	0.0382	0.0943
Mycobacterium tuberculosis	Probable amidase AmiD (acylamidase) (acylase)	0.0026	0.0291	0.0465
Brugia malayi	putative amidase	0.0026	0.0291	0.0849
Mycobacterium tuberculosis	Conserved protein	0.0032	0.0382	0.0696
Mycobacterium ulcerans	hypothetical protein	0.0032	0.0382	0.0696
Leishmania major	hypothetical protein, conserved	0.0026	0.0291	0.0718
Trypanosoma cruzi	cruzipain precursor, putative	0.0033	0.0392	0.0967
Trypanosoma cruzi	cysteine peptidase, putative	0.0033	0.0392	0.0967
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0032	0.0382	0.067
Loa Loa (eye worm)	hypothetical protein	0.0151	0.2329	0.6792
Entamoeba histolytica	;Alias	0.0015	0.0108	0.0266
Plasmodium vivax	unspecified product	0.0015	0.0108	0.0266
Plasmodium falciparum	lysophospholipase, putative	0.0257	0.4052	1
Schistosoma mansoni	hypothetical protein	0.0014	0.0089	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0219	0.3429	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 833613