Detailed information for compound 833673

Basic information

Technical information
  • TDR Targets ID: 833673
  • Name: 5-butylamino-2-[2-(3-methoxyphenyl)ethenyl]-1 ,3-oxazole-4-carbonitrile
  • MW: 297.352 | Formula: C17H19N3O2
  • H donors: 1 H acceptors: 2 LogP: 4.79 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCNc1oc(nc1C#N)C=Cc1cccc(c1)OC
  • InChi: 1S/C17H19N3O2/c1-3-4-10-19-17-15(12-18)20-16(22-17)9-8-13-6-5-7-14(11-13)21-2/h5-9,11,19H,3-4,10H2,1-2H3/b9-8+
  • InChiKey: FNXQZZRXGRBABN-CMDGGOBGSA-N  

Network

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Synonyms

  • 5-butylamino-2-[(E)-2-(3-methoxyphenyl)ethenyl]-1,3-oxazole-4-carbonitrile
  • 5-butylamino-2-[(E)-2-(3-methoxyphenyl)vinyl]oxazole-4-carbonitrile
  • 5-butylamino-2-[2-(3-methoxyphenyl)vinyl]oxazole-4-carbonitrile
  • 5-butylamino-2-[(E)-2-(3-methoxyphenyl)vinyl]-4-oxazolecarbonitrile
  • 5-butylamino-2-[2-(3-methoxyphenyl)vinyl]-4-oxazolecarbonitrile

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus single minded 2 0.004 0.0053 0.0171
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0045 0.0079 0.0322
Plasmodium falciparum glutathione reductase 0.0098 0.035 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0129 0.065
Trichomonas vaginalis mercuric reductase, putative 0.0034 0.0023 0.1405
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.037 0.1732 0.987
Echinococcus granulosus tar DNA binding protein 0.0065 0.0178 0.0892
Echinococcus granulosus geminin 0.0353 0.1643 0.9357
Toxoplasma gondii thioredoxin reductase 0.0098 0.035 0.1216
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1434 0.7139 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0045 0.0079 0.4758
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0079 0.0207
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.0059 0.0204
Schistosoma mansoni survival motor neuron protein 0.0053 0.0122 0.0576
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0045 0.0079 0.0322
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0563 0.2711 0.2694
Brugia malayi PAS domain containing protein 0.0054 0.0124 0.0719
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0045 0.0079 0.1113
Trypanosoma cruzi trypanothione reductase, putative 0.0098 0.035 0.6533
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0325 0.1503 0.8547
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0036 0.0074
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0045 0.0079 0.0415
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0059 0.0204
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0045 0.0079 0.1113
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0062 0.0166 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0059 0.0705
Trypanosoma brucei unspecified product 0.0041 0.0059 0.0705
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0059 0.0035
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0079 0.0207
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0079 0.4758
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0133 0.0524 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0045 0.0079 0.4758
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0045 0.0079 0.0322
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0108 0.061
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0045 0.0079 0.0322
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0045 0.0079 0.1113
Leishmania major cAMP-specific phosphodiesterase, putative 0.0045 0.0079 0.1113
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0133 0.0524 0.2891
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0059 0.0705
Onchocerca volvulus 0.0055 0.0129 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0045 0.0079 0.1113
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0045 0.0079 0.0326
Leishmania major DNA polymerase eta, putative 0.004 0.0052 0.0581
Loa Loa (eye worm) hypothetical protein 0.0181 0.077 0.4389
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0036 0.0075
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.0059 0.0204
Loa Loa (eye worm) transcription factor SMAD2 0.0249 0.1113 0.6392
Echinococcus multilocularis protein patched 0.0055 0.0127 0.0601
Schistosoma mansoni hypothetical protein 0.0037 0.0036 0.0075
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1997 1 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0045 0.0079 0.1113
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0059 0.0705
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0079 0.1113
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0045 0.0079 0.0326
Mycobacterium tuberculosis Probable oxidoreductase 0.025 0.1119 0.154
Schistosoma mansoni aryl hydrocarbon receptor 0.0054 0.0124 0.059
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0079 0.4758
Loa Loa (eye worm) hypothetical protein 0.037 0.1732 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0196 0.1044
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1997 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0059 0.0705
Plasmodium vivax glutathione reductase, putative 0.0098 0.035 1
Plasmodium vivax phosphodiesterase gamma, putative 0.0045 0.0079 0.1703
Echinococcus multilocularis dna polymerase eta 0.0068 0.0196 0.0999
Loa Loa (eye worm) hypoxia-induced factor 1 0.0167 0.0699 0.3973
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0079 0.4758
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0059 0.0705
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0062 0.0166 1
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0079 0.4758
Onchocerca volvulus 0.0053 0.0122 0.909
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0079 0.4758
Schistosoma mansoni patched 1 0.0055 0.0127 0.0609
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0225 0.0991 0.1361
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0178 0.0904
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0079 0.1113
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0133 0.0524 1
Loa Loa (eye worm) hypothetical protein 0.0133 0.0524 0.2954
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0178 0.108
Loa Loa (eye worm) MH2 domain-containing protein 0.0249 0.1113 0.6392
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0079 0.1113
Brugia malayi RNA binding protein 0.0065 0.0178 0.108
Trypanosoma brucei hypothetical protein, conserved 0.0045 0.0079 0.1113
Schistosoma mansoni hypothetical protein 0.0053 0.0122 0.0576
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0079 0.4758
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0036 0.0074
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0225 0.0991 0.1361
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0079 0.4758
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0079 0.1113
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0079 0.4758
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0045 0.0079 0.4758
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0079 0.4758
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0045 0.0079 0.0326
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0079 0.1113
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0045 0.0079 0.0322
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0079 0.0207
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0059 0.0705
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.025 0.1119 0.154
Leishmania major DNA polymerase kappa, putative 0.0041 0.0059 0.0705
Leishmania major hypothetical protein, conserved 0.0045 0.0079 0.1113
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0045 0.0079 0.4758
Trichomonas vaginalis glutathione reductase, putative 0.0034 0.0023 0.1405
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0079 0.4758
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0059 0.0705
Plasmodium falciparum thioredoxin reductase 0.0098 0.035 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0059 0.0705
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0045 0.0079 0.0326
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0079 0.4758
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0059 0.0705
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0178 0.0936
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.0059 0.0705
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0059 0.0705
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0133 0.0524 0.0502
Schistosoma mansoni hypothetical protein 0.0353 0.1643 0.948
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0178 0.0936
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0079 0.0207
Brugia malayi STAT protein, DNA binding domain containing protein 0.0146 0.0591 0.3864
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0034 0.0023 0.004
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0079 0.0207
Loa Loa (eye worm) glutathione reductase 0.0098 0.035 0.1942
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0045 0.0079 0.4758
Echinococcus granulosus thioredoxin glutathione reductase 0.0098 0.035 0.1889
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0059 0.0705
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0059 0.0206
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0079 0.4758
Mycobacterium tuberculosis Probable reductase 0.0225 0.0991 0.1361
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0059 0.0705
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0045 0.0079 0.036
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0059 0.005
Schistosoma mansoni single-minded 0.0054 0.0124 0.059
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0079 0.0207
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0079 0.4758
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0045 0.0079 0.4758
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0045 0.0079 0.0322
Echinococcus granulosus tumor protein p63 0.0375 0.1755 1
Echinococcus multilocularis protein dispatched 1 0.0055 0.0127 0.0601
Loa Loa (eye worm) hypothetical protein 0.0055 0.0127 0.0642
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0178 0.0904
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.037 0.1732 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0108 0.0529
Echinococcus multilocularis transfer RNA-Lys 0.004 0.0053 0.0171
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0059 0.0278
Brugia malayi hypothetical protein 0.0037 0.0036 0.0127
Loa Loa (eye worm) hypothetical protein 0.0045 0.0079 0.036
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0325 0.1503 0.8547
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0325 0.1503 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0045 0.0079 0.4758
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0045 0.0079 0.4758
Brugia malayi hypoxia-induced factor 1 0.0167 0.0699 0.4586
Loa Loa (eye worm) RNA binding protein 0.0065 0.0178 0.0936
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0045 0.0079 0.4758
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.037 0.1732 1
Brugia malayi Thioredoxin reductase 0.0098 0.035 0.2242
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0079 0.0207
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.0052 0.0581
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0045 0.0079 0.0322
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0045 0.0079 0.4758
Plasmodium vivax thioredoxin reductase, putative 0.0098 0.035 1
Echinococcus multilocularis survival motor neuron protein 1 0.0262 0.1183 0.6698
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0045 0.0079 0.1703
Giardia lamblia DINP protein human, muc B family 0.0041 0.0059 0.0206
Mycobacterium ulcerans putative regulatory protein 0.004 0.0053 0.003
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0062 0.0166 0.0835
Brugia malayi glutathione reductase 0.0098 0.035 0.2242
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0079 0.1703
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0045 0.0079 0.4758
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.0059 1
Brugia malayi CHE-14 protein 0.0055 0.0127 0.0741
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0045 0.0079 0.1113
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0563 0.2711 0.2694
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1434 0.7139 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0079 0.0207
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0129 0.0617
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0225 0.0991 0.1361
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0045 0.0079 0.1113
Leishmania major hypothetical protein, conserved 0.0045 0.0079 0.1113
Echinococcus granulosus dna polymerase kappa 0.0041 0.0059 0.0204
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0045 0.0079 0.0415
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0079 0.4758
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0059 0.3529
Brugia malayi ImpB/MucB/SamB family protein 0.0068 0.0196 0.1205
Loa Loa (eye worm) hypothetical protein 0.0262 0.1183 0.6797
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0045 0.0079 0.0326
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0045 0.0079 0.0322
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0045 0.0079 0.4758
Plasmodium falciparum phosphodiesterase delta, putative 0.0045 0.0079 0.1703
Plasmodium falciparum phosphodiesterase gamma, putative 0.0045 0.0079 0.1703
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0133 0.0524 1
Echinococcus granulosus survival motor neuron protein 1 0.0262 0.1183 0.6698
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0098 0.035 0.046
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0178 0.0904
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0045 0.0079 0.0326
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0079 0.0207
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0045 0.0079 0.1113
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0563 0.2711 1
Echinococcus multilocularis tumor protein p63 0.0375 0.1755 1
Brugia malayi hypothetical protein 0.0262 0.1183 0.7845
Echinococcus granulosus Protein patched homolog 1 0.0055 0.0127 0.0601
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0045 0.0079 0.0326
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0045 0.0079 0.1703
Toxoplasma gondii ImpB/MucB/SamB family protein 0.004 0.0052 0.0108
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0079 0.4758
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0079 0.4758
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0127 0.7669
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0062 0.0166 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.025 0.1119 0.0207
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0026 0.0061
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0045 0.0079 0.0415
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0045 0.0079 0.1113
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0079 0.1703
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0079 0.4758
Schistosoma mansoni hypothetical protein 0.0035 0.0026 0.0017
Echinococcus granulosus sterol regulatory element binding protein 0.0055 0.0127 0.0601
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0059 0.0035
Trypanosoma brucei trypanothione reductase 0.0098 0.035 0.6533
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0045 0.0079 0.1113
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0045 0.0079 0.4758
Loa Loa (eye worm) STAT protein 0.0146 0.0591 0.3347
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0059 0.0705
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0045 0.0079 0.1113
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0079 0.4758
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.0059 0.0206
Echinococcus multilocularis sterol regulatory element binding protein 0.0055 0.0127 0.0601
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0079 0.4758
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0045 0.0079 0.0415
Trypanosoma brucei DNA polymerase eta, putative 0.0068 0.0196 0.3457
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0178 0.0892
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.0059 0.0241
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0225 0.0991 0.1361
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0045 0.0079 0.4758
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.0059 0.005
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0045 0.0079 0.0415
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0079 0.0207
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0045 0.0079 0.4758
Loa Loa (eye worm) thioredoxin reductase 0.0098 0.035 0.1942
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0045 0.0079 0.0322
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0045 0.0079 0.4758
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0178 0.0904
Brugia malayi TAR-binding protein 0.0065 0.0178 0.108
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0079 0.0207
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0079 0.0207
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0133 0.0524 0.2929
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0079 0.4758
Schistosoma mansoni hypothetical protein 0.0353 0.1643 0.948
Loa Loa (eye worm) hypothetical protein 0.0045 0.0079 0.036
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0325 0.1503 0.8664
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0079 0.4758
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0079 0.1113
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.037 0.1732 0.987
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0045 0.0079 0.0322
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0133 0.0524 0.2891
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0079 0.0207
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0079 0.1113
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0045 0.0079 0.1113
Brugia malayi bHLH-PAS transcription factor 0.004 0.0053 0.0239
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0079 0.0207
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0108 0.061
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0045 0.0079 0.0326
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0133 0.0524 1
Giardia lamblia hypothetical protein 0.0045 0.0079 0.0326
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0079 0.0207
Loa Loa (eye worm) hypothetical protein 0.0035 0.0026 0.0052
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0079 0.4758
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0178 0.0904
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.037 0.1732 0.987
Echinococcus granulosus Niemann Pick C1 protein 0.0055 0.0127 0.0601
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0079 0.4758
Echinococcus multilocularis thioredoxin glutathione reductase 0.0098 0.035 0.1889
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0059 0.0705
Leishmania major DNA polymerase eta, putative 0.0068 0.0196 0.3457
Giardia lamblia Hypothetical protein 0.0045 0.0079 0.0326
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0079 0.4758
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0079 0.4758
Leishmania major trypanothione reductase 0.0098 0.035 0.6533
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0055 0.0127 0.0642
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0079 0.4758
Loa Loa (eye worm) hypothetical protein 0.0045 0.0079 0.036
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0079 0.1703
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0079 0.0207
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0045 0.0079 0.0326
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.037 0.1732 0.6357
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0079 0.4758
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0563 0.2711 0.2798
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0045 0.0079 0.0326
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0079 0.1703
Echinococcus multilocularis Niemann Pick C1 protein 0.0055 0.0127 0.0601
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0079 0.4758
Echinococcus multilocularis geminin 0.0353 0.1643 0.9357
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0045 0.0079 0.0322
Loa Loa (eye worm) PDE1B protein 0.0045 0.0079 0.036
Brugia malayi hypothetical protein 0.0181 0.077 0.5066
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1997 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0059 0.0705
Loa Loa (eye worm) hypothetical protein 0.0051 0.0108 0.0529
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0055 0.0127 0.0609
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0045 0.0079 0.1703
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.037 0.1732 0.987
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0059 0.3529
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0045 0.0079 0.0322
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0045 0.0079 0.4758
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0045 0.0079 0.0415
Mycobacterium tuberculosis Probable dehydrogenase 0.0225 0.0991 0.1361
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0122 0.0703
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0045 0.0079 0.1113
Echinococcus granulosus dna polymerase eta 0.0068 0.0196 0.0999
Brugia malayi MH2 domain containing protein 0.0249 0.1113 0.7378
Trypanosoma cruzi DNA polymerase eta, putative 0.0068 0.0196 0.3457
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0133 0.0524 0.3409
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0079 0.0207
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0059 0.0705
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0059 0.0705
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0079 0.1113
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.025 0.1119 0.154
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0079 0.4758
Schistosoma mansoni DNA polymerase eta 0.0068 0.0196 0.1013

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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