Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cytochrome P450 family protein | 0.0075 | 0.2822 | 0.2822 |
Leishmania major | cytochrome p450-like protein | 0.0075 | 0.2822 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0882 | 0.0882 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0882 | 0.0882 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0184 | 1 | 1 |
Plasmodium falciparum | transporter, putative | 0.0031 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0075 | 0.2822 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0882 | 0.0882 |
Loa Loa (eye worm) | serotonin transporter b | 0.0184 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0882 | 0.0882 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0882 | 0.0882 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0882 | 0.0882 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0075 | 0.2822 | 0.2822 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0031 | 0 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0075 | 0.2822 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0882 | 0.0882 |
Echinococcus multilocularis | serotonin transporter | 0.0184 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0882 | 0.0882 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0184 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0075 | 0.2822 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0031 | 0 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0075 | 0.2822 | 0.2822 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0075 | 0.2822 | 0.2822 |
Toxoplasma gondii | hypothetical protein | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0184 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 1 | 1 |
Plasmodium falciparum | amino acid transporter, putative | 0.0031 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0031 | 0 | 0.5 |
Plasmodium vivax | amine transporter, putative | 0.0031 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0075 | 0.2822 | 0.5 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0184 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1422 | 0.1422 |
Onchocerca volvulus | 0.0184 | 1 | 1 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0882 | 0.0882 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0031 | 0 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.0184 | 1 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0184 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0075 | 0.2822 | 0.2822 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.