Detailed information for compound 833892

Basic information

Technical information
  • TDR Targets ID: 833892
  • Name: 7-(3-fluorophenyl)-3-hydroxy-3-(4-methylpheny l)-5-oxo-6,7-dihydro-2H-[1,3]thiazolo[3,2-a]p yridine-8-carbonitrile
  • MW: 380.435 | Formula: C21H17FN2O2S
  • H donors: 1 H acceptors: 3 LogP: 2.74 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1=C2SCC(N2C(=O)CC1c1cccc(c1)F)(O)c1ccc(cc1)C
  • InChi: 1S/C21H17FN2O2S/c1-13-5-7-15(8-6-13)21(26)12-27-20-18(11-23)17(10-19(25)24(20)21)14-3-2-4-16(22)9-14/h2-9,17,26H,10,12H2,1H3
  • InChiKey: VCFVLVIXOJLVFV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-(3-fluorophenyl)-3-hydroxy-3-(4-methylphenyl)-5-oxo-6,7-dihydro-2H-thiazolo[3,2-a]pyridine-8-carbonitrile
  • 7-(3-fluorophenyl)-3-hydroxy-5-keto-3-(4-methylphenyl)-6,7-dihydro-2H-thiazolo[3,2-a]pyridine-8-carbonitrile

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.006 0.0387 0.033
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.099 0.6344
Echinococcus multilocularis orexin receptor type 2 0.006 0.0387 0.033
Echinococcus granulosus somatostatin receptor 0.006 0.0387 0.0608
Loa Loa (eye worm) TYRA-2 protein 0.006 0.0387 0.0711
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.006 0.0387 0.033
Trypanosoma brucei squalene synthase, putative 0.025 0.2875 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.006 0.0387 0.0608
Brugia malayi neuropeptide F receptor 0.006 0.0387 0.0608
Echinococcus granulosus neuropeptide receptor 0.006 0.0387 0.0608
Schistosoma mansoni neuropeptide receptor 0.006 0.0387 0.0608
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0076 0.0595 0.0992
Echinococcus multilocularis somatostatin receptor 0.006 0.0387 0.033
Onchocerca volvulus 0.006 0.0387 0.6189
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.3353 0.5
Brugia malayi Heterochromatin protein 1 0.0068 0.0501 0.0818
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.006 0.0387 0.0711
Onchocerca volvulus 0.006 0.0387 0.6189
Schistosoma mansoni amine GPCR 0.006 0.0387 0.0608
Echinococcus multilocularis neuropeptide receptor 0.006 0.0387 0.033
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Echinococcus granulosus para nitrobenzyl esterase 0.0076 0.0595 0.0992
Schistosoma mansoni peptide (allatostatin)-like receptor 0.006 0.0387 0.0608
Brugia malayi Serotonin/octopamine receptor family protein 7 0.006 0.0387 0.0608
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Onchocerca volvulus 0.0076 0.0595 0.9497
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0387 0.0608
Echinococcus granulosus neuropeptides capa receptor 0.006 0.0387 0.0608
Schistosoma mansoni adenoreceptor 0.006 0.0387 0.0608
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Schistosoma mansoni biogenic amine (dopamine) receptor 0.006 0.0387 0.0608
Schistosoma mansoni hypothetical protein 0.0078 0.0626 0.1051
Echinococcus granulosus orexin receptor type 2 0.006 0.0387 0.0608
Brugia malayi Serotonin receptor 0.006 0.0387 0.0608
Echinococcus granulosus neuropeptide Y receptor 0.006 0.0387 0.0608
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0387 0.0608
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Echinococcus granulosus acetylcholinesterase 0.0448 0.5449 1
Brugia malayi ORL1-like opioid receptor 0.006 0.0387 0.0608
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0387 0.033
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0387 0.0608
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Schistosoma mansoni amine GPCR 0.006 0.0387 0.0608
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0387 0.0608
Schistosoma mansoni biogenic amine (5HT) receptor 0.006 0.0387 0.0608
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3353 1
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0387 0.0608
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.099 0.6344
Brugia malayi AKH receptor 0.006 0.0387 0.0608
Brugia malayi GnHR receptor homolog 0.006 0.0387 0.0608
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.006 0.0387 0.0608
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Toxoplasma gondii thioredoxin reductase 0.0046 0.0214 0.5
Onchocerca volvulus 0.0076 0.0595 0.9497
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.006 0.0387 0.033
Echinococcus multilocularis Squalene phytoene synthase 0.0078 0.0626 0.057
Loa Loa (eye worm) carboxylesterase 0.0448 0.5449 1
Echinococcus granulosus g-protein coupled receptor 0.006 0.0387 0.0608
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.006 0.0387 0.0608
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0214 0.0392
Loa Loa (eye worm) melatonin receptor type 1A 0.006 0.0387 0.0711
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Schistosoma mansoni amine GPCR 0.006 0.0387 0.0608
Echinococcus granulosus neuropeptide FF receptor 2 0.006 0.0387 0.0608
Schistosoma mansoni opsin-like receptor 0.006 0.0387 0.0608
Schistosoma mansoni biogenic amine receptor 0.006 0.0387 0.0608
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.006 0.0387 0.0608
Loa Loa (eye worm) glutathione reductase 0.0046 0.0214 0.0392
Schistosoma mansoni opsin-like receptor 0.006 0.0387 0.0608
Brugia malayi hypothetical protein 0.006 0.0387 0.0608
Onchocerca volvulus 0.006 0.0387 0.6189
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0379 0.0696
Schistosoma mansoni neuropeptide F-like receptor 0.006 0.0387 0.0608
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Echinococcus granulosus neuropeptide receptor 0.006 0.0387 0.0608
Onchocerca volvulus 0.006 0.0387 0.6189
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0076 0.0595 0.1499
Loa Loa (eye worm) neuropeptide F receptor 0.006 0.0387 0.0711
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0214 0.5
Loa Loa (eye worm) hypothetical protein 0.0076 0.0595 0.1091
Brugia malayi hypothetical protein 0.006 0.0387 0.0608
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.1144 0.7604
Schistosoma mansoni opsin-like receptor 0.006 0.0387 0.0608
Brugia malayi hypothetical protein 0.006 0.0387 0.0608
Loa Loa (eye worm) hypothetical protein 0.0076 0.0595 0.1091
Mycobacterium tuberculosis Carboxylesterase LipT 0.0076 0.0595 0.3113
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Brugia malayi chromobox protein homolog 3 0.0038 0.0108 0.009
Echinococcus granulosus sex peptide receptor 0.006 0.0387 0.0608
Onchocerca volvulus 0.006 0.0387 0.6189
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3353 1
Loa Loa (eye worm) carboxylesterase 0.0076 0.0595 0.1091
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Brugia malayi Dopamine receptor protein 2 0.006 0.0387 0.0608
Schistosoma mansoni neuropeptide receptor 0.006 0.0387 0.0608
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.006 0.0387 0.0608
Echinococcus granulosus neuropeptide s receptor 0.006 0.0387 0.0608
Echinococcus granulosus tm gpcr rhodopsin 0.006 0.0387 0.0608
Schistosoma mansoni acetylcholinesterase 0.0076 0.0595 0.0992
Schistosoma mansoni jumonji domain containing protein 0.0075 0.058 0.0965
Echinococcus granulosus g protein coupled receptor 0.006 0.0387 0.0608
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.006 0.0387 0.0608
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.1437 1
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0078 0.0626 0.337
Echinococcus multilocularis BC026374 protein (S09 family) 0.0076 0.0595 0.0538
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.1144 0.7604
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3353 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0387 0.0608
Echinococcus granulosus allatostatin A receptor 0.006 0.0387 0.0608
Schistosoma mansoni biogenic amine receptor 0.006 0.0387 0.0608
Brugia malayi hypothetical protein 0.006 0.0387 0.0608
Trypanosoma cruzi phytoene synthase, putative 0.0078 0.0626 0.155
Onchocerca volvulus 0.006 0.0387 0.6189
Echinococcus granulosus tachykinin peptides receptor 99D 0.006 0.0387 0.0608
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0146 0.2334
Onchocerca volvulus 0.006 0.0387 0.6189
Echinococcus granulosus neuropeptide Y receptor 0.006 0.0387 0.0608
Brugia malayi hypothetical protein 0.0076 0.0595 0.0992
Brugia malayi Melatonin receptor type 1A 0.006 0.0387 0.0608
Schistosoma mansoni chromobox protein 0.0068 0.0501 0.0818
Schistosoma mansoni BC026374 protein (S09 family) 0.0076 0.0595 0.0992
Echinococcus multilocularis neuropeptides capa receptor 0.006 0.0387 0.033
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0387 0.0608
Schistosoma mansoni amine GPCR 0.022 0.2475 0.4481
Schistosoma mansoni myosin xvIII 0.006 0.0387 0.0608
Brugia malayi Carboxylesterase family protein 0.0076 0.0595 0.0992
Loa Loa (eye worm) acetylcholinesterase 1 0.0448 0.5449 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.006 0.0387 0.0608
Brugia malayi hypothetical protein 0.006 0.0387 0.0608
Brugia malayi Tachykinin-like peptides receptor 99D 0.006 0.0387 0.0608
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.006 0.0387 0.0608
Schistosoma mansoni hypothetical protein 0.006 0.0387 0.0608
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.006 0.0387 0.033
Brugia malayi Carboxylesterase family protein 0.0448 0.5449 1
Brugia malayi G protein-coupled receptor F59B2.13 0.006 0.0387 0.0608
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Echinococcus granulosus neuropeptides capa receptor 0.006 0.0387 0.0608
Schistosoma mansoni neuropeptide F-like receptor 0.006 0.0387 0.0608
Echinococcus multilocularis biogenic amine (5HT) receptor 0.006 0.0387 0.033
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.099 0.6344
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Echinococcus granulosus peptide allatostatin:somatostatin 0.006 0.0387 0.0608
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0387 0.033
Mycobacterium tuberculosis Probable reductase 0.0106 0.099 0.6344
Brugia malayi hypothetical protein 0.006 0.0387 0.0608
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0076 0.0595 0.3113
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Brugia malayi gonadotropin-releasing hormone receptor 2 0.006 0.0387 0.0608
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.006 0.0387 0.033
Echinococcus multilocularis chromobox protein 1 0.0068 0.0501 0.0443
Brugia malayi follicle stimulating hormone receptor 0.006 0.0387 0.0608
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0076 0.0595 0.0992
Echinococcus granulosus chromobox protein 1 0.0068 0.0501 0.0818
Onchocerca volvulus 0.006 0.0387 0.6189
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0214 0.0155
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0455
Schistosoma mansoni hypothetical protein 0.006 0.0387 0.0608
Echinococcus multilocularis sex peptide receptor 0.006 0.0387 0.033
Trichomonas vaginalis spcc417.12 protein, putative 0.0076 0.0595 0.1499
Schistosoma mansoni gliotactin 0.0076 0.0595 0.0992
Brugia malayi neuropeptide F receptor 0.006 0.0387 0.0608
Trypanosoma cruzi squalene synthase, putative 0.025 0.2875 1
Brugia malayi Dopamine receptor protein 1 0.006 0.0387 0.0608
Brugia malayi Carboxylesterase family protein 0.0076 0.0595 0.0992
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3353 1
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0387 0.0608
Echinococcus multilocularis neuropeptide receptor A26 0.006 0.0387 0.033
Echinococcus granulosus Squalene phytoene synthase 0.0078 0.0626 0.1051
Brugia malayi RE15519p 0.006 0.0387 0.0608
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.006 0.0387 0.033
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.006 0.0387 0.0608
Echinococcus granulosus tm gpcr rhodopsin 0.006 0.0387 0.0608
Echinococcus multilocularis serotonin receptor 0.006 0.0387 0.033
Echinococcus granulosus BC026374 protein S09 family 0.0076 0.0595 0.0992
Echinococcus granulosus tm gpcr rhodopsin 0.006 0.0387 0.0608
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3353 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.006 0.0387 0.0608
Onchocerca volvulus 0.006 0.0387 0.6189
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.1437 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0595 0.1091
Echinococcus multilocularis neuroligin 0.0076 0.0595 0.0538
Echinococcus multilocularis tachykinin peptides receptor 99D 0.006 0.0387 0.033
Echinococcus granulosus acetylcholinesterase 0.0448 0.5449 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0214 0.0285
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0387 0.0608
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.006 0.0387 0.033
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0387 0.0608
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0831 0.0776
Brugia malayi hypothetical protein 0.006 0.0387 0.0608
Brugia malayi Thioredoxin reductase 0.0046 0.0214 0.0285
Echinococcus granulosus biogenic amine 5HT receptor 0.006 0.0387 0.0608
Brugia malayi G protein-coupled receptor 0.006 0.0387 0.0608
Onchocerca volvulus 0.006 0.0387 0.6189
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0501 0.1209
Schistosoma mansoni neuroligin 3 (S09 family) 0.0076 0.0595 0.0992
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.006 0.0387 0.0608
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0448 0.5449 1
Echinococcus multilocularis fmrfamide receptor 0.006 0.0387 0.033
Plasmodium falciparum thioredoxin reductase 0.0046 0.0214 0.5
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3353 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0387 0.033
Brugia malayi glutathione reductase 0.0046 0.0214 0.0285
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.006 0.0387 0.033
Echinococcus multilocularis neuropeptide receptor 0.006 0.0387 0.033
Echinococcus multilocularis g protein coupled receptor 0.006 0.0387 0.033
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.006 0.0387 0.033
Echinococcus multilocularis g protein coupled receptor 0.006 0.0387 0.033
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.006 0.0387 0.0608
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0501 0.1209
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0076 0.0595 0.3113
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Loa Loa (eye worm) hypothetical protein 0.0448 0.5449 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.006 0.0387 0.0608
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.006 0.0387 0.6189
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.3353 0.5
Brugia malayi G-protein coupled receptor 0.006 0.0387 0.0608
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Brugia malayi Carboxylesterase family protein 0.0448 0.5449 1
Onchocerca volvulus 0.0076 0.0595 0.9497
Loa Loa (eye worm) G-protein coupled receptor 0.006 0.0387 0.0711
Schistosoma mansoni chromobox protein 0.0068 0.0501 0.0818
Onchocerca volvulus 0.006 0.0387 0.6189
Echinococcus granulosus jumonji domain containing protein 0.004 0.0128 0.0126
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0076 0.0595 0.0992
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0387 0.0608
Echinococcus granulosus g protein coupled receptor 0.006 0.0387 0.0608
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Loa Loa (eye worm) hypothetical protein 0.0076 0.0595 0.1091
Brugia malayi putative neuropeptide receptor 0.006 0.0387 0.0608
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.006 0.0387 0.0608
Giardia lamblia Fructose-bisphosphate aldolase 0.0287 0.3353 0.5
Loa Loa (eye worm) hypothetical protein 0.0448 0.5449 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Echinococcus granulosus 7tm_1 domain containing protein 0.006 0.0387 0.0608
Loa Loa (eye worm) carboxylesterase 0.0076 0.0595 0.1091
Onchocerca volvulus 0.0076 0.0595 0.9497
Echinococcus granulosus dro:myosuppressin receptor 0.006 0.0387 0.0608
Schistosoma mansoni growth hormone secretagogue receptor 0.006 0.0387 0.0608
Echinococcus granulosus neuropeptide receptor A26 0.006 0.0387 0.0608
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0387 0.0608
Echinococcus granulosus alpha 1A adrenergic receptor 0.006 0.0387 0.0608
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.006 0.0387 0.0608
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0831 0.1432
Onchocerca volvulus 0.006 0.0387 0.6189
Echinococcus multilocularis acetylcholinesterase 0.0448 0.5449 0.5422
Echinococcus multilocularis G protein coupled receptor 139 0.006 0.0387 0.033
Onchocerca volvulus 0.006 0.0387 0.6189
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Echinococcus multilocularis chromobox protein 1 0.0068 0.0501 0.0443
Echinococcus multilocularis g-protein coupled receptor 0.006 0.0387 0.033
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.1437 1
Schistosoma mansoni neuropeptide receptor 0.006 0.0387 0.0608
Brugia malayi Dopamine receptor 0.006 0.0387 0.0608
Loa Loa (eye worm) hypothetical protein 0.0038 0.0108 0.0198
Echinococcus multilocularis neuropeptide s receptor 0.006 0.0387 0.033
Echinococcus multilocularis g protein coupled receptor 0.006 0.0387 0.033
Brugia malayi hypothetical protein 0.006 0.0387 0.0608
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0387 0.033
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.006 0.0387 0.0608
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0387 0.0608
Schistosoma mansoni neuropeptide receptor 0.006 0.0387 0.0608
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Echinococcus granulosus fmrfamide receptor 0.006 0.0387 0.0608
Brugia malayi hypothetical protein 0.006 0.0387 0.0608
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.006 0.0387 0.033
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.006 0.0387 0.0608
Echinococcus multilocularis serotonin receptor 0.006 0.0387 0.033
Echinococcus multilocularis para nitrobenzyl esterase 0.0076 0.0595 0.0538
Schistosoma mansoni neuropeptide f receptor 76f 0.006 0.0387 0.0608
Echinococcus granulosus hypothetical protein 0.006 0.0387 0.0608
Schistosoma mansoni hypothetical protein 0.006 0.0387 0.0608
Schistosoma mansoni biogenic amine receptor 0.006 0.0387 0.0608
Echinococcus multilocularis dro:myosuppressin receptor 0.006 0.0387 0.033
Plasmodium falciparum glutathione reductase 0.0046 0.0214 0.5
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.006 0.0387 0.0711
Echinococcus multilocularis acetylcholinesterase 0.0448 0.5449 0.5422
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3353 1
Schistosoma mansoni histamine h1 receptor 0.006 0.0387 0.0608
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0387 0.033
Loa Loa (eye worm) hypothetical protein 0.0076 0.0595 0.1091
Echinococcus multilocularis allatostatin A receptor 0.006 0.0387 0.033
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0387 0.033
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0387 0.033
Loa Loa (eye worm) neuropeptide F receptor 0.006 0.0387 0.0711
Onchocerca volvulus Neuropeptide F receptor homolog 0.006 0.0387 0.6189
Brugia malayi Serotonin receptor 0.006 0.0387 0.0608
Plasmodium vivax glutathione reductase, putative 0.0046 0.0214 0.5
Onchocerca volvulus 0.006 0.0387 0.6189
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0501 0.0919
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3353 1
Brugia malayi Carboxylesterase family protein 0.0076 0.0595 0.0992
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Schistosoma mansoni hypothetical protein 0.006 0.0387 0.0608
Leishmania major squalene synthase, putative 0.025 0.2875 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.006 0.0387 0.0608
Trypanosoma cruzi squalene synthase, putative 0.025 0.2875 1
Onchocerca volvulus 0.006 0.0387 0.6189
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0076 0.0595 0.0992
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.099 0.6344
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0078 0.0626 1
Brugia malayi Carboxylesterase family protein 0.0076 0.0595 0.0992
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.006 0.0387 0.0608
Schistosoma mansoni alpha-1 adrenergic receptor 0.006 0.0387 0.0608
Brugia malayi jmjC domain containing protein 0.0094 0.0831 0.1432
Onchocerca volvulus 0.006 0.0387 0.6189
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0387 0.0608
Echinococcus multilocularis G-protein coupled receptor, putative 0.006 0.0387 0.033
Echinococcus multilocularis neuropeptide Y receptor 0.006 0.0387 0.033
Echinococcus multilocularis alpha 1A adrenergic receptor 0.006 0.0387 0.033
Onchocerca volvulus 0.0076 0.0595 0.9497
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0146 0.0117
Echinococcus granulosus thyrotropin releasing hormone receptor 0.006 0.0387 0.0608
Loa Loa (eye worm) G-protein coupled receptor 0.006 0.0387 0.0711
Treponema pallidum fructose-bisphosphate aldolase 0.0287 0.3353 0.5
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Mycobacterium ulcerans phytoene synthase, CrtB 0.0078 0.0626 0.0373
Echinococcus granulosus G protein coupled receptor 139 0.006 0.0387 0.0608
Loa Loa (eye worm) hypothetical protein 0.0076 0.0595 0.1091
Leishmania major hypothetical protein, conserved 0.0078 0.0626 0.155
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.099 0.6344
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Echinococcus granulosus chromobox protein 1 0.0068 0.0501 0.0818
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0108 0.1727
Brugia malayi hypothetical protein 0.006 0.0387 0.0608
Schistosoma mansoni biogenic amine (5HT) receptor 0.006 0.0387 0.0608
Brugia malayi G-protein coupled receptor 0.006 0.0387 0.0608
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0387 0.0608
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0146 0.0117
Brugia malayi larval opioid receptor 0.006 0.0387 0.0608
Loa Loa (eye worm) follicle stimulating hormone receptor 0.006 0.0387 0.0711
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Schistosoma mansoni amine GPCR 0.006 0.0387 0.0608
Brugia malayi putative neuropeptide receptor NPR1 0.006 0.0387 0.0608
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.1144 0.3447
Echinococcus granulosus biogenic amine 5HT receptor 0.006 0.0387 0.0608
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Echinococcus multilocularis neuropeptides capa receptor 0.006 0.0387 0.033
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0076 0.0595 0.0538
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0128 0.0068
Echinococcus multilocularis carboxylesterase 5A 0.0448 0.5449 0.5422
Echinococcus multilocularis fmrfamide receptor 0.006 0.0387 0.033
Schistosoma mansoni biogenic amine (dopamine) receptor 0.006 0.0387 0.0608
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0387 0.033
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.006 0.0387 0.033
Loa Loa (eye worm) hypothetical protein 0.0078 0.0626 0.1149
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.006 0.011
Brugia malayi sulfakinin receptor protein 0.006 0.0387 0.0608
Echinococcus granulosus neuroligin 0.0076 0.0595 0.0992
Onchocerca volvulus 0.006 0.0387 0.6189
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.0711
Echinococcus multilocularis neuropeptide Y receptor 0.006 0.0387 0.033
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.006 0.0387 0.0711
Echinococcus granulosus carboxylesterase 5A 0.0448 0.5449 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.1144 0.7604
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.006 0.0387 0.0711
Echinococcus granulosus serotonin receptor 0.006 0.0387 0.0608
Loa Loa (eye worm) hypothetical protein 0.0076 0.0595 0.1091
Echinococcus granulosus g protein coupled receptor 0.006 0.0387 0.0608
Echinococcus multilocularis neuropeptide FF receptor 2 0.006 0.0387 0.033
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0387 0.0608

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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