Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0368 | 0.0368 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0368 | 0.0368 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 0.4004 | 0.4004 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.3115 | 0.778 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.3115 | 0.3115 |
Echinococcus multilocularis | muscleblind protein | 0.0144 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.3115 | 0.778 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0368 | 0.0368 |
Brugia malayi | nuclear hormone receptor | 0.0011 | 0.0368 | 0.0368 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.4004 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0011 | 0.0368 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0011 | 0.0368 | 0.0918 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0011 | 0.0368 | 0.0368 |
Brugia malayi | RNA binding protein | 0.0061 | 0.4004 | 0.4004 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0011 | 0.0368 | 0.0368 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0368 | 0.0368 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0011 | 0.0368 | 0.0918 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.3115 | 0.778 |
Brugia malayi | nuclear receptor NHR-88 | 0.0011 | 0.0368 | 0.0368 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.3115 | 0.3115 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0011 | 0.0368 | 0.0368 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0368 | 0.0368 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0011 | 0.0368 | 0.0918 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.3115 | 0.3115 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 0.4004 | 0.4004 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0368 | 0.0368 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0368 | 0.0918 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0011 | 0.0368 | 0.0918 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0368 | 0.0368 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0011 | 0.0368 | 0.0368 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0011 | 0.0368 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.4004 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.3115 | 0.3115 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0368 | 0.0918 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0368 | 0.0368 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0011 | 0.0368 | 0.0368 |
Echinococcus granulosus | FTZ F1 alpha | 0.0011 | 0.0368 | 0.0368 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0368 | 0.0368 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0368 | 0.0368 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.4004 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0011 | 0.0368 | 0.0368 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0368 | 0.0368 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0368 | 0.0368 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0011 | 0.0368 | 0.0368 |
Schistosoma mansoni | nuclear hormone receptor | 0.0011 | 0.0368 | 0.0918 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 0.4004 | 0.4004 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0368 | 0.0368 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0011 | 0.0368 | 0.0918 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0011 | 0.0368 | 0.0368 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0368 | 0.0368 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0011 | 0.0368 | 0.0368 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.4004 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0011 | 0.0368 | 0.0368 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0368 | 0.0368 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0368 | 0.0368 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0368 | 0.0368 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0368 | 0.0368 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0011 | 0.0368 | 0.0368 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0368 | 0.0368 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0368 | 0.0368 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0011 | 0.0368 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.0144 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0061 | 0.4004 | 0.4004 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0368 | 0.0368 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0368 | 0.0368 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0368 | 0.0368 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0368 | 0.0368 |
Schistosoma mansoni | coup transcription factor | 0.0011 | 0.0368 | 0.0918 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0011 | 0.0368 | 0.0918 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0011 | 0.0368 | 0.0918 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0368 | 0.0368 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0368 | 0.0368 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0368 | 0.0368 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 0.4004 | 0.4004 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0368 | 0.0368 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0144 | 1 | 1 |
Onchocerca volvulus | 0.0011 | 0.0368 | 0.5 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.3115 | 0.3115 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0368 | 0.0368 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0368 | 0.0368 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0368 | 0.0368 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 0.4004 | 0.4004 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0368 | 0.0368 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0368 | 0.0368 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0011 | 0.0368 | 0.0368 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.4004 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0368 | 0.0368 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.3115 | 0.3115 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 0.4004 | 0.4004 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0011 | 0.0368 | 0.0918 |
Brugia malayi | steroid hormone receptor | 0.0011 | 0.0368 | 0.0368 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0011 | 0.0368 | 0.0368 |
Brugia malayi | ecdysteroid receptor | 0.0011 | 0.0368 | 0.0368 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0368 | 0.0368 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0011 | 0.0368 | 0.0918 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0368 | 0.0368 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.