Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0024 | 1 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0024 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0 | 0.5 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0024 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0024 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0024 | 1 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0024 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0024 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0024 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0024 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.501 | 0.501 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.