Detailed information for compound 834320

Basic information

Technical information
  • TDR Targets ID: 834320
  • Name: 4-tert-butyl-N-[[3-(3-methylphenyl)-1,2,4-oxa diazol-5-yl]methyl]-N-propan-2-ylbenzamide
  • MW: 391.506 | Formula: C24H29N3O2
  • H donors: 0 H acceptors: 3 LogP: 5.63 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc(c1)c1noc(n1)CN(C(=O)c1ccc(cc1)C(C)(C)C)C(C)C
  • InChi: 1S/C24H29N3O2/c1-16(2)27(23(28)18-10-12-20(13-11-18)24(4,5)6)15-21-25-22(26-29-21)19-9-7-8-17(3)14-19/h7-14,16H,15H2,1-6H3
  • InChiKey: JUQHPFORXONKHW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-tert-butyl-N-isopropyl-N-[[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]benzamide
  • 4-tert-butyl-N-[[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]-N-propan-2-yl-benzamide
  • STK300457

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cytochrome P450 family protein 0.0029 0.087 0.079
Brugia malayi Cathepsin L-like precursor 0.0178 0.6669 0.664
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0264 1 1
Echinococcus granulosus cytochrome P450 2K1 0.0019 0.0499 0.0476
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0197 0.7418 0.7412
Brugia malayi Papain family cysteine protease containing protein 0.0052 0.1784 0.1712
Entamoeba histolytica cysteine proteinase 2 0.0138 0.5115 0.4054
Loa Loa (eye worm) hypothetical protein 0.0197 0.7418 0.7394
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.1784 0.1784
Entamoeba histolytica cysteine protease, putative 0.0138 0.5115 0.4054
Plasmodium vivax unspecified product 0.0086 0.3082 0.1579
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0264 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0264 1 1
Brugia malayi Cytochrome P450 family protein 0.0019 0.0499 0.0416
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0264 1 1
Entamoeba histolytica cysteine protease, putative 0.0138 0.5115 0.4054
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0019 0.0499 0.5
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0019 0.0499 0.5
Onchocerca volvulus 0.0264 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0264 1 1
Leishmania major cathepsin L-like protease 0.0264 1 1
Schistosoma mansoni cathepsin S (C01 family) 0.0052 0.1784 0.1765
Onchocerca volvulus Cathepsin L homolog 0.0264 1 1
Leishmania major cathepsin L-like protease 0.0264 1 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0197 0.7418 0.7282
Toxoplasma gondii preprocathepsin c precursor, putative 0.0052 0.1784 0.1353
Schistosoma mansoni cpg binding protein 0.003 0.0913 0.0891
Loa Loa (eye worm) hypothetical protein 0.001 0.0121 0.0031
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.2083 0.2064
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0052 0.1784 0.1784
Echinococcus multilocularis 0.0019 0.0499 0.0476
Entamoeba histolytica cysteine protease, putative 0.0138 0.5115 0.4054
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0138 0.5115 0.5103
Plasmodium vivax vivapain-3 0.0138 0.5115 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0264 1 1
Echinococcus multilocularis cathepsin b 0.0197 0.7418 0.7412
Loa Loa (eye worm) hypothetical protein 0.0052 0.1784 0.1709
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.1784 0.1353
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.087 0.0786
Plasmodium vivax unspecified product 0.0138 0.5115 0.4054
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0019 0.0499 0.5
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0052 0.1784 0.1709
Plasmodium vivax vivapain-2 0.0264 1 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0052 0.1784 0.1765
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0264 1 1
Onchocerca volvulus 0.0264 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.6669 0.6669
Entamoeba histolytica cysteine protease, putative 0.0138 0.5115 0.4054
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0091 0.0067
Toxoplasma gondii cathepsin CPL 0.0264 1 1
Echinococcus multilocularis cathepsin L 0.0138 0.5115 0.5103
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0264 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0052 0.1784 0.1712
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0264 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0052 0.1784 0.1765
Entamoeba histolytica cysteine proteinase, putative 0.0264 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.1784 0.1709
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0264 1 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0264 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.1784 0.1784
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0264 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.1784 0.1709
Trypanosoma cruzi cysteine proteinase, putative 0.0138 0.5115 0.4858
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.1784 0.1784
Leishmania major cathepsin L-like protease 0.0264 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0264 1 1
Mycobacterium leprae Conserved hypothetical protein 0.0019 0.0499 0.5
Onchocerca volvulus 0.0264 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0061 0.2113 0.2041
Brugia malayi Papain family cysteine protease containing protein 0.0138 0.5115 0.5072
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0052 0.1784 0.1765
Entamoeba histolytica cysteine protease, putative 0.0138 0.5115 0.4054
Echinococcus multilocularis cathepsin L cysteine protease 0.0264 1 1
Schistosoma mansoni cathepsin C 0.0052 0.1784 0.1765
Entamoeba histolytica cysteine protease, putative 0.0138 0.5115 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.1784 0.1784
Echinococcus multilocularis cathepsin L cysteine protease 0.0264 1 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0178 0.6669 0.6494
Leishmania major cathepsin L-like protease 0.0264 1 1
Leishmania major cathepsin L-like protease 0.0264 1 1
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0019 0.0499 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0052 0.1784 0.1784
Echinococcus multilocularis cathepsin b 0.0197 0.7418 0.7412
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.1784 0.1784
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.5115 0.4858
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0138 0.5115 0.4858
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0264 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.1784 0.1709
Toxoplasma gondii cathepsin CPC2 0.0052 0.1784 0.1353
Trypanosoma cruzi cysteine protease, putative 0.0138 0.5115 0.4858
Loa Loa (eye worm) hypothetical protein 0.0178 0.6669 0.6639
Loa Loa (eye worm) hypothetical protein 0.0052 0.1784 0.1709
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0019 0.0499 0.5
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0264 1 1
Entamoeba histolytica cysteine protease, putative 0.0138 0.5115 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0138 0.5115 0.4054
Brugia malayi cathepsin L-like cysteine proteinase 0.0052 0.1784 0.1712
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0264 1 1
Onchocerca volvulus Cathepsin L homolog 0.0264 1 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0052 0.1784 0.1712
Giardia lamblia Cathepsin B precursor 0.0097 0.3527 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0264 1 1
Brugia malayi Cathepsin L-like precursor 0.0264 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.1784 0.1784
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0264 1 1
Loa Loa (eye worm) hypothetical protein 0.0178 0.6669 0.6639
Trypanosoma cruzi cruzipain precursor, putative 0.0264 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0052 0.1784 0.1765
Trypanosoma cruzi cysteine peptidase, putative 0.0138 0.5115 0.4858
Onchocerca volvulus 0.0264 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0097 0.3527 0.3511
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0019 0.0499 0.5
Entamoeba histolytica cysteine proteinase, putative 0.0264 1 1
Schistosoma mansoni cytochrome P450 0.0019 0.0499 0.0476
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0138 0.5115 0.5103
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0264 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.1784 0.1784
Loa Loa (eye worm) CYP4Cod1 0.0029 0.087 0.0786
Trypanosoma cruzi cysteine peptidase, putative 0.0264 1 1
Brugia malayi fibroinase precursor 0.0052 0.1784 0.1712
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0264 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.1784 0.1784
Schistosoma mansoni cathepsin F (C01 family) 0.0178 0.6669 0.6661
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0052 0.1784 0.1784
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.1784 0.1784
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0264 1 1
Brugia malayi Cytochrome P450 family protein 0.0029 0.087 0.079
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0019 0.0499 0.5
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0019 0.0499 0.5
Toxoplasma gondii cathepsin B 0.0097 0.3527 0.3187
Trypanosoma cruzi cytochrome P450, putative 0.0029 0.087 0.039
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0019 0.0499 0.5
Giardia lamblia Cathepsin B precursor 0.0097 0.3527 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0086 0.3082 0.3021
Onchocerca volvulus 0.0264 1 1
Trypanosoma cruzi cruzipain precursor, putative 0.0086 0.3082 0.2718
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0264 1 1
Entamoeba histolytica cysteine protease, putative 0.0138 0.5115 0.4054
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0264 1 1
Brugia malayi cathepsin B-like cysteine proteinase 0.0197 0.7418 0.7395
Plasmodium vivax vivapain-1 0.0138 0.5115 0.4054
Trypanosoma brucei cytochrome P450, putative 0.0029 0.087 0.039
Echinococcus multilocularis cathepsin L 0.0052 0.1784 0.1765
Trypanosoma cruzi cytochrome P450, putative 0.0029 0.087 0.039
Entamoeba histolytica cysteine proteinase, putative 0.0138 0.5115 0.4054
Onchocerca volvulus 0.0264 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0052 0.1784 0.1765
Echinococcus multilocularis cysteine protease 0.0264 1 1
Echinococcus granulosus cathepsin b 0.0197 0.7418 0.7412
Leishmania major cathepsin L-like protease 0.0264 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0052 0.1784 0.1784
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0264 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.1784 0.1784
Plasmodium falciparum cysteine proteinase falcipain 3 0.0264 1 1
Schistosoma mansoni cpg binding protein 0.0028 0.0851 0.0829
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0264 1 1
Onchocerca volvulus 0.0264 1 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0019 0.0499 0.5
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0197 0.7418 0.7412
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0851 0.0766
Echinococcus granulosus cathepsin l cysteine peptidase 0.0264 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0138 0.5115 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0264 1 1
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0019 0.0499 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.1784 0.1784
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0264 1 1
Onchocerca volvulus Cathepsin L homolog 0.0052 0.1784 0.1021
Onchocerca volvulus Cathepsin F homolog 0.0264 1 1
Loa Loa (eye worm) hypothetical protein 0.0178 0.6669 0.6639
Brugia malayi CXXC zinc finger family protein 0.0028 0.0851 0.0771
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0097 0.3527 0.3187
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0019 0.0499 0.5
Schistosoma mansoni cathepsin F (C01 family) 0.0264 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.1784 0.1709
Loa Loa (eye worm) cysteine protease 0.0264 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0264 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0264 1 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.1834 0.1405
Echinococcus multilocularis cpg binding protein 0.003 0.0913 0.0891
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0264 1 1
Echinococcus granulosus cysteine protease 0.0138 0.5115 0.5103
Brugia malayi cathepsin Z-like cysteine proteinase 0.0052 0.1784 0.1712
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0019 0.0499 0.5
Trypanosoma brucei cysteine peptidase C (CPC) 0.0097 0.3527 0.3187
Brugia malayi Papain family cysteine protease containing protein 0.0138 0.5115 0.5072
Loa Loa (eye worm) ctsf protein 0.0264 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0264 1 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0019 0.0499 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0264 1 1
Brugia malayi Cathepsin L-like precursor 0.0264 1 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0097 0.3527 0.3187
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0052 0.1784 0.1709
Brugia malayi cytochrome P450 0.0019 0.0499 0.0416
Trypanosoma cruzi cysteine peptidase, putative 0.0264 1 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0052 0.1784 0.1765
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.5115 0.5115
Entamoeba histolytica cysteine protease, putative 0.0138 0.5115 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0197 0.7418 0.7412
Entamoeba histolytica cysteine protease, putative 0.0264 1 1
Brugia malayi Cytochrome P450 family protein 0.0061 0.2113 0.2044
Echinococcus granulosus cathepsin L 0.0052 0.1784 0.1765
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0052 0.1784 0.1765
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0019 0.0499 0.5
Entamoeba histolytica cysteine protease, putative 0.0138 0.5115 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0264 1 1
Brugia malayi cathepsin L-like precursor 0.0178 0.6669 0.664
Plasmodium falciparum cysteine proteinase falcipain 1 0.0138 0.5115 0.4054
Brugia malayi Papain family cysteine protease containing protein 0.0264 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0052 0.1784 0.1784
Brugia malayi Cathepsin L-like cysteine proteinase 0.0178 0.6669 0.664
Brugia malayi Cathepsin L-like precursor 0.0264 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0052 0.1784 0.1709
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0029 0.087 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0052 0.1784 0.1784
Schistosoma mansoni cpg binding protein 0.003 0.0913 0.0891
Brugia malayi Cathepsin L-like precursor 0.0264 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.5115 0.5115
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0019 0.0499 0.5
Brugia malayi Papain family cysteine protease containing protein 0.0052 0.1784 0.1712
Entamoeba histolytica cysteine proteinase, putative 0.0178 0.6669 0.5946
Echinococcus granulosus cpg binding protein 0.003 0.0913 0.0891
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0091 0.0067
Entamoeba histolytica cysteine protease, putative 0.0138 0.5115 0.4054
Brugia malayi Cathepsin L-like precursor 0.0178 0.6669 0.664
Loa Loa (eye worm) hypothetical protein 0.0086 0.3082 0.3018
Echinococcus multilocularis cysteine protease 0.0264 1 1
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0019 0.0499 0.5
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0052 0.1784 0.1765
Toxoplasma gondii cathepsin CPC1 0.0052 0.1784 0.1353
Schistosoma mansoni cathepsin F (C01 family) 0.0264 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.087 0.0786
Schistosoma mansoni cathepsin s 0.0086 0.3082 0.3065
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.5115 0.4858
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0264 1 1
Brugia malayi Cathepsin L-like precursor 0.0264 1 1
Leishmania major cytochrome p450-like protein 0.0029 0.087 0.039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.6669 0.6669
Loa Loa (eye worm) hypothetical protein 0.0086 0.3082 0.3018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0264 1 1
Leishmania major cathepsin L-like protease 0.0264 1 1
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0019 0.0499 0.5
Loa Loa (eye worm) hypothetical protein 0.0264 1 1
Mycobacterium leprae putative cytochrome p450 0.0019 0.0499 0.5
Echinococcus granulosus cathepsin L cysteine protease 0.0138 0.5115 0.5103
Entamoeba histolytica cysteine proteinase, putative 0.0138 0.5115 0.4054
Entamoeba histolytica cysteine protease, putative 0.0138 0.5115 0.4054
Loa Loa (eye worm) fibroinase 0.0264 1 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.1784 0.1353
Onchocerca volvulus 0.0178 0.6669 0.636
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0052 0.1784 0.1784
Trypanosoma cruzi cysteine proteinase, putative 0.0138 0.5115 0.4858
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0264 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0264 1 1
Schistosoma mansoni hypothetical protein 0.0019 0.0499 0.0476
Trypanosoma cruzi cysteine peptidase, putative 0.0264 1 1
Echinococcus granulosus cathepsin b 0.0197 0.7418 0.7412
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.3082 0.2718
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0264 1 1
Entamoeba histolytica cysteine protease, putative 0.0138 0.5115 0.4054
Loa Loa (eye worm) hypothetical protein 0.0086 0.3082 0.3018
Brugia malayi Cathepsin L-like precursor 0.0086 0.3082 0.3021
Leishmania major cysteine peptidase A (CPA) 0.0264 1 1
Onchocerca volvulus 0.0052 0.1784 0.1021
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0086 0.3082 0.3021
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0019 0.0499 0.5
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0086 0.3082 0.3018
Loa Loa (eye worm) cathepsin B 0.0097 0.3527 0.3467
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0052 0.1784 0.1784
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0264 1 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0052 0.1784 0.1712
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0264 1 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0138 0.5115 0.4054
Brugia malayi cathepsin Z-like cysteine proteinase 0.0052 0.1784 0.1712
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0052 0.1784 0.1765
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0264 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0264 1 1
Plasmodium vivax vivapain-2 0.0264 1 1
Echinococcus granulosus cathepsin L 0.0138 0.5115 0.5103
Schistosoma mansoni cathepsin B (C01 family) 0.0052 0.1784 0.1765
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0264 1 1
Echinococcus granulosus cathepsin l1 0.0264 1 1
Brugia malayi cathepsin L precursor 0.0052 0.1784 0.1712
Leishmania major cathepsin L-like protease 0.0264 1 1
Giardia lamblia Cathepsin B precursor 0.0097 0.3527 1
Loa Loa (eye worm) cytochrome P450 0.0019 0.0499 0.0412
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0138 0.5115 0.5103
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0097 0.3527 0.3527
Echinococcus granulosus cathepsin l1 0.0178 0.6669 0.6661
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0264 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0197 0.7418 0.7412
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0019 0.0499 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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