Detailed information for compound 834335

Basic information

Technical information
  • TDR Targets ID: 834335
  • Name: 2-(2-bromo-4-methylphenoxy)-N-[(3-phenyl-1,2, 4-oxadiazol-5-yl)methyl]-N-propan-2-ylacetami de
  • MW: 444.322 | Formula: C21H22BrN3O3
  • H donors: 0 H acceptors: 3 LogP: 4.69 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(c(c1)Br)OCC(=O)N(C(C)C)Cc1onc(n1)c1ccccc1
  • InChi: 1S/C21H22BrN3O3/c1-14(2)25(20(26)13-27-18-10-9-15(3)11-17(18)22)12-19-23-21(24-28-19)16-7-5-4-6-8-16/h4-11,14H,12-13H2,1-3H3
  • InChiKey: XETOYOFIINQOSM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(2-bromo-4-methyl-phenoxy)-N-isopropyl-N-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]acetamide
  • 2-(2-bromo-4-methylphenoxy)-N-isopropyl-N-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]acetamide
  • 2-(2-bromo-4-methyl-phenoxy)-N-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]-N-propan-2-yl-ethanamide
  • STK300519
  • BAS 13151395

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus MAM 0.003 0.0549 0.0556
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0136 0.4531 0.4587
Loa Loa (eye worm) hypothetical protein 0.0072 0.2111 0.2111
Schistosoma mansoni nuclear hormone receptor 0.0136 0.4531 0.4338
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0064 0.182 0.1843
Echinococcus multilocularis nuclear receptor nhr 48 0.0064 0.182 0.1843
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0136 0.4531 0.4531
Brugia malayi nuclear hormone receptor family member nhr-6 0.0064 0.182 0.1448
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0136 0.4531 0.4587
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0136 0.4531 0.4587
Echinococcus multilocularis tyrosine protein kinase Blk 0.0041 0.095 0.0962
Loa Loa (eye worm) hypothetical protein 0.0072 0.2111 0.2111
Brugia malayi nuclear hormone receptor 0.0136 0.4531 0.4283
Brugia malayi hypothetical protein 0.0064 0.182 0.1448
Onchocerca volvulus 0.003 0.0549 0.0233
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0072 0.2111 0.1774
Schistosoma mansoni steroid hormone receptor ad4bp 0.0136 0.4531 0.4338
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0064 0.182 0.1843
Loa Loa (eye worm) hypothetical protein 0.0064 0.182 0.182
Brugia malayi Nuclear hormone receptor-like 1 0.0072 0.2111 0.1752
Echinococcus granulosus tyrosine protein kinase Src42A 0.0036 0.0743 0.0752
Schistosoma mansoni tyrosine kinase 0.0063 0.1788 0.1432
Onchocerca volvulus 0.0064 0.182 0.2826
Echinococcus granulosus Nuclear hormone receptor HR96 0.0064 0.182 0.1843
Brugia malayi ecdysteroid receptor 0.0136 0.4531 0.4283
Onchocerca volvulus Bile acid receptor homolog 0.0136 0.4531 0.8358
Schistosoma mansoni tyrosine kinase 0.0069 0.1995 0.1651
Brugia malayi ecdysone receptor 0.0064 0.182 0.1448
Echinococcus granulosus FTZ F1 alpha 0.0136 0.4531 0.4587
Brugia malayi protein-tyrosine kinase 0.0041 0.095 0.0538
Echinococcus multilocularis ecdysone induced protein 78C 0.0136 0.4531 0.4587
Loa Loa (eye worm) nuclear hormone receptor 0.0064 0.182 0.182
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0064 0.182 0.1448
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0064 0.182 0.1467
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0168 0.5743 0.5743
Brugia malayi hypothetical protein 0.0072 0.2111 0.1752
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0045 0.11 0.1114
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0064 0.182 0.1843
Schistosoma mansoni tyrosine kinase 0.0045 0.11 0.0704
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0136 0.4531 0.4587
Loa Loa (eye worm) hypothetical protein 0.0136 0.4531 0.4531
Loa Loa (eye worm) hypothetical protein 0.0027 0.0435 0.0435
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0072 0.2111 0.1774
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0027 0.0435 0.0435
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0136 0.4531 0.4531
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0136 0.4531 0.4283
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0136 0.4531 0.4587
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0136 0.4531 0.8358
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0072 0.2111 0.2137
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0136 0.4531 0.4283
Echinococcus granulosus laminin 0.0027 0.0435 0.0441
Loa Loa (eye worm) steroid hormone receptor 0.0136 0.4531 0.4531
Echinococcus multilocularis protein tyrosine kinase 0.0278 0.9878 1
Onchocerca volvulus Tyrosine kinase homolog 0.0157 0.5336 1
Schistosoma mansoni hypothetical protein 0.003 0.0549 0.0121
Schistosoma mansoni nuclear receptor nhr-48 0.0064 0.182 0.1467
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0064 0.182 0.1843
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0146 0.4908 0.4969
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.095 0.0962
Loa Loa (eye worm) hypothetical protein 0.0072 0.2111 0.2111
Onchocerca volvulus Protein ultraspiracle homolog 0.0136 0.4531 0.8358
Loa Loa (eye worm) hypothetical protein 0.0064 0.182 0.182
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0136 0.4531 0.4338
Brugia malayi Immunoglobulin I-set domain containing protein 0.0168 0.5743 0.5549
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0136 0.4531 0.4283
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0045 0.11 0.1114
Loa Loa (eye worm) TK protein kinase 0.0037 0.0797 0.0797
Brugia malayi Nuclear hormone receptor-like 1 0.0136 0.4531 0.4283
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0136 0.4531 0.4283
Loa Loa (eye worm) hypothetical protein 0.0136 0.4531 0.4531
Schistosoma mansoni thyroid hormone receptor 0.0136 0.4531 0.4338
Loa Loa (eye worm) hypothetical protein 0.0027 0.0435 0.0435
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0136 0.4531 0.4338
Brugia malayi nuclear receptor RXR 0.0064 0.182 0.1448
Echinococcus granulosus tyrosine protein kinase HCK 0.0037 0.0797 0.0806
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0136 0.4531 0.4531
Echinococcus granulosus epidermal growth factor receptor 0.0069 0.1995 0.2019
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0036 0.0743 0.0752
Loa Loa (eye worm) hypothetical protein 0.003 0.0549 0.0549
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0027 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0136 0.4531 0.4531
Schistosoma mansoni zinc finger protein 0.0064 0.182 0.1467
Loa Loa (eye worm) hypothetical protein 0.0064 0.182 0.182
Schistosoma mansoni tyrosine kinase 0.0146 0.4908 0.4737
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0045 0.11 0.1114
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0072 0.2111 0.2111
Schistosoma mansoni nuclear receptor 0.0064 0.182 0.1467
Loa Loa (eye worm) TK protein kinase 0.0041 0.095 0.095
Echinococcus granulosus tyrosine protein kinase Lyn 0.0045 0.11 0.1114
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0136 0.4531 0.4283
Brugia malayi orphan nuclear receptor NR2E1 0.0064 0.182 0.1448
Loa Loa (eye worm) hypothetical protein 0.0136 0.4531 0.4531
Brugia malayi nuclear receptor NHR-88 0.0136 0.4531 0.4283
Brugia malayi Protein kinase domain containing protein 0.0083 0.252 0.218
Brugia malayi Protein kinase domain containing protein 0.0146 0.4908 0.4676
Brugia malayi Nuclear hormone receptor E75 0.0064 0.182 0.1448
Entamoeba histolytica protein kinase, putative 0.0037 0.0797 0.5
Echinococcus multilocularis 0.0019 0.0098 0.0099
Loa Loa (eye worm) hypothetical protein 0.0224 0.7849 0.7849
Schistosoma mansoni coup transcription factor 0.0136 0.4531 0.4338
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0136 0.4531 0.4531
Loa Loa (eye worm) nuclear receptor NHR-67 0.0064 0.182 0.182
Schistosoma mansoni nuclear hormone receptor 0.0064 0.182 0.1467
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0136 0.4531 0.4283
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0136 0.4531 0.4587
Echinococcus granulosus tyrosine kinase 0.0041 0.095 0.0962
Loa Loa (eye worm) hypothetical protein 0.0038 0.0815 0.0815
Echinococcus granulosus protein tyrosine kinase 0.0278 0.9878 1
Echinococcus multilocularis MAM 0.003 0.0549 0.0556
Loa Loa (eye worm) hypothetical protein 0.0136 0.4531 0.4531
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0069 0.1995 0.2019
Loa Loa (eye worm) hypothetical protein 0.0064 0.182 0.182
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0064 0.182 0.2826
Loa Loa (eye worm) hypothetical protein 0.0064 0.182 0.182
Toxoplasma gondii calcium binding egf domain-containing protein 0.0027 0.0435 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.11 0.1114
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0136 0.4531 0.4587
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0072 0.2111 0.2137
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0136 0.4531 0.4531
Schistosoma mansoni tyrosine kinase 0.0146 0.4908 0.4737
Echinococcus multilocularis laminin 0.0027 0.0435 0.0441
Loa Loa (eye worm) TK/FAK protein kinase 0.0281 1 1
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0041 0.095 0.0962
Echinococcus granulosus epidermal growth factor receptor 0.0069 0.1995 0.2019
Onchocerca volvulus 0.0064 0.182 0.2826
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0045 0.11 0.1114
Loa Loa (eye worm) hypothetical protein 0.0136 0.4531 0.4531
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0045 0.11 0.1114
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0136 0.4531 0.4531
Schistosoma mansoni RAR-like nuclear receptor 0.0136 0.4531 0.4338
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0064 0.182 0.1843
Schistosoma mansoni nuclear receptor 0.0064 0.182 0.1467
Echinococcus multilocularis epidermal growth factor receptor 0.0069 0.1995 0.2019
Echinococcus multilocularis Tolloid protein 1 0.0027 0.0435 0.0441
Loa Loa (eye worm) hypothetical protein 0.0064 0.182 0.182
Brugia malayi hypothetical protein 0.003 0.0549 0.0119
Brugia malayi hypothetical protein 0.0064 0.182 0.1448
Loa Loa (eye worm) hypothetical protein 0.0064 0.182 0.182
Echinococcus multilocularis epidermal growth factor receptor 0.0069 0.1995 0.2019
Echinococcus granulosus tyrosine protein kinase Src64B 0.0045 0.11 0.1114
Echinococcus granulosus Tolloid protein 1 0.0027 0.0435 0.0441
Schistosoma mansoni tyrosine kinase 0.0069 0.1995 0.1651
Brugia malayi steroid hormone receptor 0.0136 0.4531 0.4283
Echinococcus multilocularis thyroid hormone receptor alpha 0.0136 0.4531 0.4587
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0136 0.4531 0.4283
Echinococcus multilocularis tyrosine protein kinase HCK 0.0037 0.0797 0.0806
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0064 0.182 0.2826
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0064 0.182 0.182
Loa Loa (eye worm) hypothetical protein 0.0064 0.182 0.182
Schistosoma mansoni tyrosine kinase 0.0045 0.11 0.0704
Schistosoma mansoni retinoic acid receptor RXR 0.0136 0.4531 0.4338
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0045 0.11 0.1114
Toxoplasma gondii calcium binding egf domain-containing protein 0.0027 0.0435 0.5
Loa Loa (eye worm) hypothetical protein 0.0072 0.2111 0.2111
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0136 0.4531 0.4283
Echinococcus multilocularis FTZ F1 alpha 0.0136 0.4531 0.4587
Schistosoma mansoni hypothetical protein 0.003 0.0549 0.0121
Schistosoma mansoni tyrosine kinase 0.0063 0.1788 0.1432
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0136 0.4531 0.4587
Loa Loa (eye worm) TK/EGFR protein kinase 0.0069 0.1995 0.1995
Loa Loa (eye worm) hypothetical protein 0.0064 0.182 0.182
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.11 0.1114
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0146 0.4908 0.4969
Brugia malayi conserved hypotetical protein 0.0064 0.182 0.1448
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.11 0.1114
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0136 0.4531 0.4531
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.11 0.1114
Brugia malayi nuclear hormone receptor family member odr-7 0.0064 0.182 0.1448
Schistosoma mansoni tyrosine kinase 0.0278 0.9878 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.182 0.182
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0136 0.4531 0.4283
Schistosoma mansoni nuclear hormone receptor 0.0064 0.182 0.1467
Schistosoma mansoni tyrosine kinase 0.0063 0.1788 0.1432
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0064 0.182 0.1467
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0136 0.4531 0.4283
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0136 0.4531 0.4587
Brugia malayi Nuclear hormone receptor-like 1 0.0072 0.2111 0.1752
Brugia malayi hypothetical protein 0.0072 0.2111 0.1752
Onchocerca volvulus 0.003 0.0549 0.0233
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0136 0.4531 0.4587
Loa Loa (eye worm) hypothetical protein 0.0027 0.0435 0.0435
Echinococcus multilocularis tyrosine protein kinase Srms 0.0041 0.095 0.0962
Schistosoma mansoni tyrosine kinase 0.0069 0.1995 0.1651
Loa Loa (eye worm) hypothetical protein 0.003 0.0549 0.0549
Schistosoma mansoni thyroid hormone receptor 0.0136 0.4531 0.4338
Brugia malayi nuclear hormone receptor 0.0064 0.182 0.1448
Brugia malayi Nuclear hormone receptor E75 0.0064 0.182 0.1448
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.11 0.1114
Loa Loa (eye worm) hypothetical protein 0.0136 0.4531 0.4531
Echinococcus multilocularis insulin receptor 0.0146 0.4908 0.4969
Brugia malayi Protein kinase domain containing protein 0.026 0.9209 0.9173
Echinococcus granulosus insulin receptor 0.0146 0.4908 0.4969
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0136 0.4531 0.4587
Loa Loa (eye worm) DR-78 0.0064 0.182 0.182
Echinococcus granulosus nuclear receptor nhr 48 0.0064 0.182 0.1843
Loa Loa (eye worm) hypothetical protein 0.0064 0.182 0.182
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0064 0.182 0.1843
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0136 0.4531 0.4338
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0136 0.4531 0.4283
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0136 0.4531 0.4283
Onchocerca volvulus 0.0136 0.4531 0.8358
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0136 0.4531 0.4587
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0064 0.182 0.1843
Loa Loa (eye worm) hypothetical protein 0.0064 0.182 0.182
Loa Loa (eye worm) hypothetical protein 0.0077 0.2313 0.2313
Brugia malayi Furin-like cysteine rich region family protein 0.0069 0.1995 0.163
Brugia malayi nuclear receptor RXR 0.0072 0.2111 0.1752
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0136 0.4531 0.4338
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0045 0.11 0.1114
Loa Loa (eye worm) SRC-1 0.0045 0.11 0.11
Echinococcus granulosus Nuclear hormone receptor HR96 0.0064 0.182 0.1843
Brugia malayi nuclear receptor NHR-88 0.0064 0.182 0.1448
Onchocerca volvulus 0.0149 0.5032 0.938
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0136 0.4531 0.4338
Brugia malayi Steroid receptor seven-up type 2 0.0136 0.4531 0.4283
Echinococcus granulosus tyrosine protein kinase Src42A 0.0045 0.11 0.1114
Loa Loa (eye worm) hypothetical protein 0.0027 0.0435 0.0435
Brugia malayi nuclear receptor NHR-67 0.0064 0.182 0.1448
Loa Loa (eye worm) hypothetical protein 0.0072 0.2111 0.2111
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0136 0.4531 0.4338
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.11 0.1114
Echinococcus granulosus thyroid hormone receptor alpha 0.0064 0.182 0.1843
Echinococcus multilocularis fibrillin 1 0.0027 0.0435 0.0441
Loa Loa (eye worm) hypothetical protein 0.0136 0.4531 0.4531
Echinococcus granulosus tyrosine protein kinase Blk 0.0041 0.095 0.0962
Echinococcus granulosus ecdysone induced protein 78C 0.0136 0.4531 0.4587
Loa Loa (eye worm) hypothetical protein 0.003 0.0549 0.0549
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0136 0.4531 0.4587
Loa Loa (eye worm) hypothetical protein 0.0064 0.182 0.182
Brugia malayi SRC-1 0.0045 0.11 0.0695
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0136 0.4531 0.4283
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0027 0.0435 0.0435
Loa Loa (eye worm) TK/ALK protein kinase 0.026 0.9205 0.9205
Brugia malayi photoreceptor-specific nuclear receptor 0.0136 0.4531 0.4283
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0045 0.11 0.1114
Brugia malayi tailless protein 0.0064 0.182 0.1448
Loa Loa (eye worm) TK/INSR protein kinase 0.0146 0.4908 0.4908

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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