Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0134 | 0.4217 | 0.5 | |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0116 | 0.3358 | 0.8757 |
Trypanosoma cruzi | p450 reductase, putative | 0.0116 | 0.3358 | 0.5 |
Toxoplasma gondii | diaminopimelate decarboxylase | 0.0134 | 0.4217 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.3358 | 0.2472 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0116 | 0.3358 | 0.8757 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0116 | 0.3358 | 0.4303 |
Mycobacterium ulcerans | diaminopimelate decarboxylase LysA | 0.0134 | 0.4217 | 1 |
Trichomonas vaginalis | ornithine decarboxylase, putative | 0.0134 | 0.4217 | 1 |
Plasmodium falciparum | S-adenosylmethionine decarboxylase/ornithine decarboxylase | 0.0134 | 0.4217 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0251 | 1 | 1 |
Mycobacterium leprae | PROBABLE DIAMINOPIMELATE DECARBOXYLASE LYSA (DAP DECARBOXYLASE) | 0.0052 | 0.0188 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0052 | 0.0188 | 0.0446 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0116 | 0.3358 | 0.4303 |
Mycobacterium tuberculosis | Diaminopimelate decarboxylase LysA (DAP decarboxylase) | 0.0134 | 0.4217 | 0.5 |
Trichomonas vaginalis | diaminopimelate decarboxylase, putative | 0.0134 | 0.4217 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0086 | 0.1859 | 0.4315 |
Schistosoma mansoni | lipoxygenase | 0.0122 | 0.3668 | 1 |
Brugia malayi | flavodoxin family protein | 0.0116 | 0.3358 | 0.2472 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0116 | 0.3358 | 0.7965 |
Trichomonas vaginalis | ornithine decarboxylase, putative | 0.0134 | 0.4217 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0059 | 0.053 | 0.0136 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0122 | 0.3668 | 1 |
Plasmodium vivax | S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative | 0.0134 | 0.4217 | 1 |
Leishmania major | ornithine decarboxylase, putative | 0.0134 | 0.4217 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0116 | 0.3358 | 0.5 |
Trichomonas vaginalis | pyridoxal-dependent decarboxylase, putative | 0.0134 | 0.4217 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0116 | 0.3358 | 0.8757 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0103 | 0.271 | 0.6428 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0116 | 0.3358 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0116 | 0.3358 | 0.8757 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0122 | 0.3668 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0251 | 1 | 1 |
Entamoeba histolytica | ornithine decarboxylase, putative | 0.0134 | 0.4217 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0116 | 0.3358 | 0.5 |
Giardia lamblia | Ornithine decarboxylase | 0.0134 | 0.4217 | 1 |
Brugia malayi | Pyridoxal-dependent decarboxylase, pyridoxal binding domain containing protein | 0.0134 | 0.4217 | 0.3445 |
Trypanosoma brucei | ornithine decarboxylase | 0.0134 | 0.4217 | 1 |
Trichomonas vaginalis | diaminopimelate decarboxylase, putative | 0.0134 | 0.4217 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0116 | 0.3358 | 0.2472 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0072 | 0.1178 | 0.2173 |
Leishmania major | p450 reductase, putative | 0.0116 | 0.3358 | 0.4303 |
Loa Loa (eye worm) | pyridoxal-dependent decarboxylase | 0.0134 | 0.4217 | 0.3445 |
Chlamydia trachomatis | sulfite reductase | 0.0072 | 0.1178 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0116 | 0.3358 | 0.2472 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0116 | 0.3358 | 0.9027 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.