Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | cysteine proteinase, putative | 0.0484 | 0.1711 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0484 | 0.1711 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0871 | 0.4804 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0871 | 0.4804 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0871 | 0.4804 | 1 |
Echinococcus granulosus | cathepsin b | 0.152 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0556 | 0.2287 | 0.5 |
Onchocerca volvulus | 0.0484 | 0.1711 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0484 | 0.1711 | 0.7479 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.152 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0725 | 0.3638 | 0.3638 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.152 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0484 | 0.1711 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0484 | 0.1711 | 0.7479 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0484 | 0.1711 | 0.7479 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0484 | 0.1711 | 0.7479 |
Brugia malayi | Cathepsin L-like precursor | 0.0338 | 0.0544 | 0.0544 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0871 | 0.4804 | 1 |
Echinococcus multilocularis | cathepsin b | 0.152 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0484 | 0.1711 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0484 | 0.1711 | 0.1711 |
Brugia malayi | Cathepsin L-like precursor | 0.0484 | 0.1711 | 0.1711 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0484 | 0.1711 | 0.7479 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0871 | 0.4804 | 0.4804 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0484 | 0.1711 | 0.7479 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0338 | 0.0544 | 0.238 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0484 | 0.1711 | 0.7479 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0484 | 0.1711 | 0.7479 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0484 | 0.1711 | 0.1711 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0338 | 0.0544 | 0.0544 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0556 | 0.2287 | 0.4761 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0484 | 0.1711 | 0.1711 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0871 | 0.4804 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0484 | 0.1711 | 0.1233 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0338 | 0.0544 | 0.0544 |
Loa Loa (eye worm) | cysteine protease | 0.0484 | 0.1711 | 0.1233 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0484 | 0.1711 | 0.1711 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0484 | 0.1711 | 0.7479 |
Brugia malayi | Cathepsin L-like precursor | 0.0484 | 0.1711 | 0.1711 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0484 | 0.1711 | 0.7479 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0871 | 0.4804 | 0.4804 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0484 | 0.1711 | 0.7479 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0484 | 0.1711 | 0.7479 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0338 | 0.0544 | 0.3182 |
Onchocerca volvulus | 0.0484 | 0.1711 | 1 | |
Onchocerca volvulus | 0.0484 | 0.1711 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0871 | 0.4804 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0484 | 0.1711 | 0.7479 |
Echinococcus multilocularis | cysteine protease | 0.0484 | 0.1711 | 0.1711 |
Loa Loa (eye worm) | hypothetical protein | 0.152 | 1 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0338 | 0.0544 | 0.0544 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0484 | 0.1711 | 0.7479 |
Loa Loa (eye worm) | fibroinase | 0.0484 | 0.1711 | 0.1233 |
Echinococcus multilocularis | cysteine protease | 0.0484 | 0.1711 | 0.1711 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0871 | 0.4804 | 0.4804 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0871 | 0.4804 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0484 | 0.1711 | 0.7479 |
Leishmania major | cathepsin L-like protease | 0.0871 | 0.4804 | 1 |
Leishmania major | cathepsin L-like protease | 0.0871 | 0.4804 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0338 | 0.0544 | 0.0544 |
Echinococcus granulosus | cathepsin l1 | 0.0484 | 0.1711 | 0.1711 |
Loa Loa (eye worm) | hypothetical protein | 0.0484 | 0.1711 | 0.1233 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0484 | 0.1711 | 0.1711 |
Brugia malayi | Cathepsin L-like precursor | 0.0338 | 0.0544 | 0.0544 |
Loa Loa (eye worm) | cathepsin B | 0.0556 | 0.2287 | 0.1843 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0484 | 0.1711 | 0.7479 |
Toxoplasma gondii | cathepsin B | 0.0556 | 0.2287 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0484 | 0.1711 | 0.1233 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0871 | 0.4804 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.152 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.152 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0556 | 0.2287 | 0.5 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0484 | 0.1711 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0556 | 0.2287 | 0.5 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0484 | 0.1711 | 0.1711 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0511 | 0.1927 | 0.1927 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0871 | 0.4804 | 0.4804 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0338 | 0.0544 | 0.238 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.152 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0484 | 0.1711 | 0.1711 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0484 | 0.1711 | 0.1711 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0484 | 0.1711 | 0.7479 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0484 | 0.1711 | 0.7479 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0484 | 0.1711 | 0.7479 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0484 | 0.1711 | 0.1233 |
Onchocerca volvulus | 0.0484 | 0.1711 | 1 | |
Onchocerca volvulus | 0.0484 | 0.1711 | 1 | |
Onchocerca volvulus | 0.0484 | 0.1711 | 1 | |
Onchocerca volvulus | 0.0484 | 0.1711 | 1 | |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0484 | 0.1711 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0484 | 0.1711 | 0.1711 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0484 | 0.1711 | 0.7479 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.152 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0484 | 0.1711 | 0.1711 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0484 | 0.1711 | 0.7479 |
Echinococcus multilocularis | cathepsin b | 0.152 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0556 | 0.2287 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0484 | 0.1711 | 0.7479 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0484 | 0.1711 | 0.1711 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0871 | 0.4804 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0484 | 0.1711 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0484 | 0.1711 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0556 | 0.2287 | 0.2287 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0871 | 0.4804 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0484 | 0.1711 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0484 | 0.1711 | 0.1711 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0871 | 0.4804 | 1 |
Plasmodium vivax | vivapain-2 | 0.0484 | 0.1711 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0484 | 0.1711 | 0.7479 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0556 | 0.2287 | 0.2287 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0484 | 0.1711 | 0.7479 |
Onchocerca volvulus | Cathepsin F homolog | 0.0484 | 0.1711 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0484 | 0.1711 | 0.1711 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0484 | 0.1711 | 0.7479 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0484 | 0.1711 | 0.1711 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0871 | 0.4804 | 1 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0556 | 0.2287 | 0.1864 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.