Detailed information for compound 834939

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 293.385 | Formula: C14H19N3O2S
  • H donors: 1 H acceptors: 3 LogP: 2.16 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(NC(=O)Cn1sc2c(c1=O)c(C)cc(n2)C)C
  • InChi: 1S/C14H19N3O2S/c1-5-9(3)15-11(18)7-17-14(19)12-8(2)6-10(4)16-13(12)20-17/h6,9H,5,7H2,1-4H3,(H,15,18)
  • InChiKey: ZMQRABRWDIPGIO-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0167 0.0699
Schistosoma mansoni hypothetical protein 0.0015 0.0043 0.0191
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0167 0.0699
Brugia malayi hypothetical protein 0.0295 0.2282 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0043 0.0363
Brugia malayi nuclear receptor NHR-88 0.0031 0.0167 0.0712
Loa Loa (eye worm) DR-78 0.0015 0.0037 0.0126
Echinococcus multilocularis geminin 0.0166 0.1249 0.4879
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0043 0.0138
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0167 0.0712
Toxoplasma gondii thioredoxin reductase 0.0042 0.0253 0.0915
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.126 1 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0014 0.0036 0.0108
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0043 0.0168
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.002 0.0046
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0095 0.0678 0.0902
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0043 0.0139
Brugia malayi ecdysteroid receptor 0.0031 0.0167 0.0712
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0188 0.0708
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0126
Loa Loa (eye worm) hypothetical protein 0.0048 0.0305 0.1308
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0167 0.0625
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0015 0.0037 0.0113
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0309 0.1333
Brugia malayi Pre-SET motif family protein 0.0033 0.0188 0.0804
Onchocerca volvulus 0.0032 0.0173 0.0605
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0042 0.0253 0.0305
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.0037 0.0126
Trypanosoma brucei trypanothione reductase 0.0042 0.0253 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0043 0.0139
Echinococcus granulosus nuclear receptor nhr 48 0.0015 0.0037 0.0113
Brugia malayi hypothetical protein 0.0015 0.0037 0.014
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0126
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0167 0.0625
Schistosoma mansoni hypothetical protein 0.0015 0.0043 0.0191
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0188 0.137
Brugia malayi nuclear hormone receptor family member nhr-6 0.0015 0.0037 0.014
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0015 0.0037 0.014
Loa Loa (eye worm) hypothetical protein 0.0028 0.0142 0.0588
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0167 0.0625
Onchocerca volvulus 0.0261 0.2006 0.8773
Brugia malayi steroid hormone receptor 0.0031 0.0167 0.0712
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0167 0.0699
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0167 0.0625
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0167 0.0625
Echinococcus multilocularis GPCR, family 2 0.0015 0.0043 0.0138
Plasmodium vivax thioredoxin reductase, putative 0.0042 0.0253 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0043 0.0155
Leishmania major hypothetical protein, conserved 0.0028 0.0142 0.4894
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0188
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0229 0.1754 0.7678
Schistosoma mansoni hypothetical protein 0.0166 0.1249 1
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0142 0.0513
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0037 0.0113
Loa Loa (eye worm) hypothetical protein 0.0295 0.2282 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0188 0.0708
Loa Loa (eye worm) hypothetical protein 0.0031 0.0167 0.0699
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0142 0.4894
Loa Loa (eye worm) hypothetical protein 0.0015 0.0043 0.0155
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0043 0.0011
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0043 0.0139
Schistosoma mansoni nuclear receptor 0.0015 0.0037 0.0139
Loa Loa (eye worm) pax transcription factor protein 2 0.0234 0.1794 0.7856
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0355 0.2762 0.2736
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0051 0.0188
Schistosoma mansoni zinc finger protein 0.0015 0.0037 0.0139
Brugia malayi nuclear hormone receptor 0.0015 0.0037 0.014
Loa Loa (eye worm) hypothetical protein 0.0031 0.0167 0.0699
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0188 0.137
Brugia malayi CXXC zinc finger family protein 0.0032 0.0173 0.0736
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0037 0.0113
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0167 0.1199
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0167 0.0712
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0167 0.1199
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0037 0.0113
Mycobacterium tuberculosis Probable dehydrogenase 0.0095 0.0678 0.0902
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0015 0.0037 0.0113
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0167 0.0712
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0167 0.1199
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0188 0.0708
Loa Loa (eye worm) hypothetical protein 0.0031 0.0167 0.0699
Schistosoma mansoni nuclear receptor nhr-48 0.0015 0.0037 0.0139
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0051 0.0168
Loa Loa (eye worm) glutathione reductase 0.0042 0.0253 0.1076
Echinococcus multilocularis nuclear receptor nhr 48 0.0015 0.0037 0.0113
Brugia malayi isocitrate dehydrogenase 0.0015 0.0043 0.0169
Echinococcus granulosus tumor protein p63 0.0329 0.2551 1
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0355 0.2762 0.2736
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0105 0.0763 0.1021
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0167 0.0625
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0043 0.0193
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0167 0.0712
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0167 0.0712
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0188
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0167 0.0699
Onchocerca volvulus 0.0033 0.0188 0.0674
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0309 0.1333
Onchocerca volvulus 0.0031 0.0167 0.0581
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0014 0.0036 0.0134
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0188
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0043 0.0363
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0167 0.0712
Brugia malayi tailless protein 0.0015 0.0037 0.014
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0167 0.0712
Loa Loa (eye worm) hypothetical protein 0.0033 0.0188 0.0792
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0167 0.0712
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.0037 0.0126
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0043 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0167 0.0712
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0167 0.0699
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0167 0.0712
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0037 0.014
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.002 0.0046
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0167 0.1199
Schistosoma mansoni cpg binding protein 0.0033 0.0187 0.1361
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0126
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0142 0.4894
Giardia lamblia NADH oxidase lateral transfer candidate 0.0014 0.0036 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0167 0.0699
Echinococcus granulosus GPCR family 2 0.0015 0.0043 0.0138
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0355 0.2762 1
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0905 0.7158 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0043 0.0139
Brugia malayi hypothetical protein 0.0028 0.0142 0.0601
Loa Loa (eye worm) thioredoxin reductase 0.0042 0.0253 0.1076
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0142 0.4894
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0167 0.1199
Onchocerca volvulus 0.0295 0.2282 1
Schistosoma mansoni cpg binding protein 0.0033 0.0187 0.1361
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0015 0.0037 0.0113
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0167 0.1199
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0037 0.0139
Echinococcus granulosus cpg binding protein 0.0033 0.0187 0.0704
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0095 0.0678 0.0902
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0043 0.0168
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0043 0.0363
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0037 0.0113
Echinococcus granulosus thioredoxin glutathione reductase 0.0042 0.0257 0.0979
Mycobacterium tuberculosis Probable reductase 0.0095 0.0678 0.0902
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0167 0.0581
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0186 0.0794
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0037 0.0139
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0305 0.2325
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0167 0.1199
Schistosoma mansoni hypothetical protein 0.0015 0.0043 0.0191
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0167 0.1199
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0015 0.0037 0.0126
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0167 0.0712
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0173 0.0648
Mycobacterium tuberculosis Probable oxidoreductase 0.0105 0.0763 0.1021
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0015 0.0037 0.0139
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0126
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0126
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0051 0.0252
Loa Loa (eye worm) hypothetical protein 0.0049 0.0309 0.1322
Toxoplasma gondii NADPH-glutathione reductase 0.0014 0.0036 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0167 0.0712
Brugia malayi nuclear receptor NHR-67 0.0015 0.0037 0.014
Plasmodium falciparum glutathione reductase 0.0042 0.0253 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0188 0.0681
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0126
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0188 0.137
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0167 0.0712
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0167 0.0625
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0043 0.0363
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0105 0.0763 0.013
Echinococcus granulosus geminin 0.0166 0.1249 0.4879
Brugia malayi ecdysone receptor 0.0015 0.0037 0.014
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0014 0.0036 0.0129
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0037 0.014
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0051 0.0201
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0167 0.0625
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0043 0.0169
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0051 0.0168
Echinococcus multilocularis tumor protein p63 0.0329 0.2551 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0167 0.0699
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0167 0.0699
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0167 0.0625
Brugia malayi Pax transcription factor protein 2 0.0234 0.1794 0.7859
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0051 0.0252
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0167 0.1199
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0037 0.0113
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0015 0.0037 0.0139
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0051 0.0201
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0043 0.0363
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0465 0.3623
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0167 0.0581
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0043 0.0157
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0043 0.0138
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0167 0.0625
Brugia malayi hypothetical protein 0.0016 0.0051 0.0201
Onchocerca volvulus 0.0048 0.0305 0.1197
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0142 0.4894
Brugia malayi nuclear receptor NHR-88 0.0015 0.0037 0.014
Brugia malayi nuclear receptor RXR 0.0016 0.0051 0.0201
Echinococcus multilocularis cpg binding protein 0.0033 0.0187 0.0704
Schistosoma mansoni nuclear receptor 0.0015 0.0037 0.0139
Trichomonas vaginalis mercuric reductase, putative 0.0014 0.0036 0.0177
Brugia malayi hypothetical protein 0.0016 0.0051 0.0201
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0167 0.0625
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0126
Brugia malayi Thioredoxin reductase 0.0042 0.0253 0.1088
Brugia malayi Pre-SET motif family protein 0.0229 0.1754 0.7681
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0167 0.0625
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0095 0.0678 0.0902
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0126
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0043 0.0157
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0167 0.1199
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0167 0.0712
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0043 0.0139
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0095 0.0678 0.0902
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0126
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0167 0.0625
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0043 0.0363
Trichomonas vaginalis set domain proteins, putative 0.0261 0.2006 1
Schistosoma mansoni cpg binding protein 0.0032 0.0173 0.1244
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.126 1 1
Brugia malayi orphan nuclear receptor NR2E1 0.0015 0.0037 0.014
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0408 0.1477
Schistosoma mansoni coup transcription factor 0.0031 0.0167 0.1199
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.126 1 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0015 0.0037 0.0113
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0126
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0188
Loa Loa (eye worm) hypothetical protein 0.0031 0.0167 0.0699
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0309 0.1322
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0167 0.0625
Echinococcus multilocularis thioredoxin glutathione reductase 0.0042 0.0257 0.0979
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0043 0.0363
Trypanosoma cruzi trypanothione reductase, putative 0.0042 0.0253 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0167 0.0625
Schistosoma mansoni hypothetical protein 0.0033 0.0186 0.1351
Brugia malayi nuclear receptor RXR 0.0015 0.0037 0.014
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0173 0.0724
Leishmania major trypanothione reductase 0.0042 0.0253 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0167 0.0712
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0167 0.0581
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0167 0.0712
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0167 0.0625
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0142 0.4894
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0043 0.0155
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0014 0.0036 0.0108
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0167 0.0625
Brugia malayi hypothetical protein 0.0018 0.0063 0.0256
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0355 0.2762 0.3216
Schistosoma mansoni hypothetical protein 0.0015 0.0043 0.0191
Loa Loa (eye worm) hypothetical protein 0.0031 0.0167 0.0699
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0142 0.4894
Loa Loa (eye worm) hypothetical protein 0.0033 0.0186 0.0781
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0167 0.0699
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0167 0.0625
Onchocerca volvulus 0.0234 0.1794 0.7829
Schistosoma mansoni hypothetical protein 0.0166 0.1249 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0188 0.137
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0905 0.7158 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0167 0.0699
Brugia malayi nuclear hormone receptor 0.0031 0.0167 0.0712
Brugia malayi nuclear hormone receptor family member odr-7 0.0015 0.0037 0.014
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0126
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0043 0.0138
Plasmodium vivax glutathione reductase, putative 0.0042 0.0253 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0167 0.0699
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0014 0.0036 0.0129
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0126
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0126
Plasmodium falciparum thioredoxin reductase 0.0042 0.0253 1
Plasmodium vivax SET domain protein, putative 0.0033 0.0188 0.7027
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0105 0.0763 0.1021
Brugia malayi conserved hypotetical protein 0.0015 0.0037 0.014
Brugia malayi hypothetical protein 0.0015 0.0037 0.014
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0043 0.0139
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0167 0.1199
Trichomonas vaginalis glutathione reductase, putative 0.0014 0.0036 0.0177
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0037 0.0113
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0188
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0167 0.1199
Brugia malayi glutathione reductase 0.0042 0.0253 0.1088

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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