TDR Targets

Basic information

Technical information

TDR Targets ID: 835320
Name: N-(3-diethylaminopropyl)-3,4-dihydro-1H-pyraz ino[4,3-a]benzimidazole-2-carbothioamide
MW: 345.505 | Formula: C18H27N5S
H donors: 0 H acceptors: 1 LogP: 2.3 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCN(CCCN=C(N1CCn2c(C1)nc1c2cccc1)S)CC
InChi: 1S/C18H27N5S/c1-3-21(4-2)11-7-10-19-18(24)22-12-13-23-16-9-6-5-8-15(16)20-17(23)14-22/h5-6,8-9H,3-4,7,10-14H2,1-2H3,(H,19,24)
InChiKey: NUHNUJQHWIBKJD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

MLS000582499
N-[3-(diethylamino)propyl]-3,4-dihydropyrazino[1,2-a]benzimidazole-2(1H)-carbothioamide
SMR000206485

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Trypanosoma cruzi	cysteine peptidase, putative	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0124	0.044
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0075	0.0069
Echinococcus granulosus	chromobox protein 1	0.0069	0.0705	0.0705
Onchocerca volvulus		0.003	0.0243	0.0474
Onchocerca volvulus		0.0011	0.0016	0.003
Leishmania major	cathepsin L-like protease	0.002	0.0124	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0194	0.0193
Brugia malayi	phosphofructokinase	0.0107	0.1166	0.1165
Schistosoma mansoni	thyroid hormone receptor	0.0134	0.1489	0.1489
Leishmania major	cathepsin L-like protease	0.002	0.0124	0.0098
Echinococcus granulosus	chromobox protein 2	0.0011	0.0016	0.0016
Plasmodium vivax	vivapain-2	0.002	0.0124	0.2715
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0016	0.0036
Plasmodium vivax	SET domain protein, putative	0.0029	0.0234	0.525
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0011	0.0016	0.0036
Leishmania major	cathepsin L-like protease	0.0077	0.0807	0.0782
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0016	0.0015
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.002	0.0124	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0016	0.0015
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0106	0.1156	0.8837
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0075	0.0069
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	0.0842	1	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0035	0.0034
Brugia malayi	hypothetical protein	0.0011	0.0018	0.0017
Onchocerca volvulus		0.002	0.0124	0.0241
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.011	0.011
Loa Loa (eye worm)	CYP4Cod1	0.0012	0.0027	0.0026
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0011	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0018	0.0017
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0011	0.0016	0.0083
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0807	0.0801
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0001	0.0001
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0343	0.1258
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0047	0.044	0.044
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0047	0.044	0.2985
Schistosoma mansoni	hypothetical protein	0.0019	0.011	0.011
Echinococcus multilocularis	Protein lozenge	0.0055	0.0538	0.0538
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0014	0.0051	0.0051
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0029	0.0229	1
Loa Loa (eye worm)	ctsf protein	0.002	0.0124	0.0123
Trypanosoma cruzi	cysteine peptidase, putative	0.002	0.0124	0.0118
Echinococcus multilocularis	neuropeptide s receptor	0.0457	0.5365	0.5365
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.006	0.0599	0.0574
Echinococcus granulosus	intermediate filament protein	0.0027	0.02	0.02
Trypanosoma cruzi	cytochrome P450, putative	0.0012	0.0027	0.002
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0016	0.0036
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.011	0.011
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0124	0.044
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0124	0.044
Echinococcus granulosus	cathepsin L cysteine proteinase	0.002	0.0124	0.0124
Echinococcus granulosus	cathepsin L cysteine protease	0.001	0.0007	0.0007
Schistosoma mansoni	coup transcription factor	0.001	0.0001	0.0001
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0229	0.083
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0124	0.044
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.001	0.0007	0.0007
Onchocerca volvulus	Cathepsin L homolog	0.002	0.0124	0.0241
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.002	0.0124	0.2715
Loa Loa (eye worm)	helicase	0.0011	0.0016	0.0015
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0124	0.1369	0.1369
Onchocerca volvulus		0.002	0.0124	0.0241
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0001	0.0001
Echinococcus multilocularis	6 phosphofructokinase	0.0107	0.1166	0.1166
Echinococcus multilocularis	chromobox protein 1	0.0069	0.0705	0.0705
Plasmodium vivax	hypothetical protein, conserved	0.0011	0.0016	0.0223
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0016	0.0075	0.0069
Echinococcus granulosus	cysteine protease	0.001	0.0007	0.0007
Toxoplasma gondii	phosphofructokinase PFKII	0.0029	0.0229	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0044	0.0043
Echinococcus granulosus	lamin dm0	0.0027	0.02	0.02
Echinococcus granulosus	flap endonuclease 1	0.0026	0.0189	0.0189
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0029	0.0229	0.1406
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0011	0.0016	0.0036
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0016	0.0036
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0229	0.083
Schistosoma mansoni	hypothetical protein	0.0041	0.0376	0.0376
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0124	0.1016
Brugia malayi	Valyl-tRNA synthetase	0.0011	0.0016	0.0015
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.011	0.0109
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0229	0.083
Onchocerca volvulus		0.0014	0.0044	0.0084
Schistosoma mansoni	cathepsin F (C01 family)	0.0014	0.0044	0.0044
Brugia malayi	Papain family cysteine protease containing protein	0.001	0.0007	0.0006
Schistosoma mansoni	chromobox protein	0.0069	0.0705	0.0705
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0038	0.0343	0.0669
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0234	0.0234
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.011	0.0109
Echinococcus multilocularis	lamin dm0	0.0027	0.02	0.02
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0011	0.0016	0.0016
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0011	0.0016	0.0016
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0124	0.1369	0.1369
Loa Loa (eye worm)	6-phosphofructokinase	0.0107	0.1166	0.1165
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0229	0.083
Plasmodium vivax	thioredoxin reductase, putative	0.0047	0.044	1
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0001	0.0001
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0124	0.044
Mycobacterium tuberculosis	Probable dehydrogenase	0.0106	0.1156	0.8837
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0012	0.0024	0.0023
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0234	0.0234
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0014	0.0053	0.0053
Echinococcus multilocularis	fructose 1,6 bisphosphatase 1	0.0842	1	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0605	0.0604
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0124	0.044
Loa Loa (eye worm)	phosphofructokinase	0.0107	0.1166	0.1165
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0011	0.0016	0.0015
Plasmodium falciparum	cysteine proteinase falcipain 3	0.002	0.0124	0.2715
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0014	0.0051	0.005
Plasmodium falciparum	thioredoxin reductase	0.0016	0.0075	0.158
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	0.0842	1	1
Echinococcus multilocularis	netrin receptor unc 5	0.0014	0.0051	0.0051
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0011	0.0016	0.0036
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0124	0.044
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0011	0.0016	0.0016
Schistosoma mansoni	chromobox protein	0.0011	0.0016	0.0016
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0106	0.1156	0.8837
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0378	0.1389
Leishmania major	cysteine peptidase A (CPA)	0.002	0.0124	0.0098
Onchocerca volvulus	Cathepsin L homolog	0.002	0.0124	0.0241
Schistosoma mansoni	thyroid hormone receptor	0.0134	0.1489	0.1489
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0016	0.0075	0.0424
Onchocerca volvulus		0.0436	0.5116	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0016	0.0075	0.0069
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0124	0.044
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.002	0.0124	0.044
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0807	0.0801
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0118	0.1299	1
Schistosoma mansoni	chromobox protein	0.0011	0.0016	0.0016
Brugia malayi	Cathepsin L-like precursor	0.0014	0.0044	0.0043
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0075	0.0069
Brugia malayi	6-phosphofructokinase	0.0107	0.1166	0.1165
Onchocerca volvulus		0.0011	0.0016	0.003
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0107	0.1166	0.116
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.011	0.011
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0001	0.0001
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0001	0.0001
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.001	0.0007	0.0007
Echinococcus multilocularis	cathepsin L cysteine protease	0.002	0.0124	0.0124
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0452	0.0451
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.002	0.0124	0.0124
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0016	0.0075	0.0048
Brugia malayi	CHD4 protein	0.0011	0.0016	0.0015
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0072	0.0752	0.0752
Schistosoma mansoni	chromobox protein	0.0069	0.0705	0.0705
Onchocerca volvulus		0.0041	0.0369	0.072
Loa Loa (eye worm)	glutathione reductase	0.0047	0.044	0.0439
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	0.0807	0.0801
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0011	0.0016	0.0016
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0229	0.083
Schistosoma mansoni	lamin	0.0027	0.02	0.02
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0807	0.0801
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.011	0.011
Brugia malayi	Cathepsin L-like precursor	0.002	0.0124	0.0123
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.011	0.0109
Brugia malayi	Cathepsin L-like precursor	0.002	0.0124	0.0123
Plasmodium vivax	hypothetical protein, conserved	0.0011	0.0016	0.0223
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0011	0.0016	0.0036
Brugia malayi	Cytochrome P450 family protein	0.0012	0.0027	0.0026
Echinococcus granulosus	thioredoxin glutathione reductase	0.0047	0.044	0.044
Echinococcus granulosus	Chromobox protein 3	0.0011	0.0016	0.0016
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0016	0.0036
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0378	0.0737
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0124	0.044
Echinococcus granulosus	GPCR family 2	0.0019	0.011	0.011
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0124	0.044
Echinococcus multilocularis	chromobox protein 1	0.0069	0.0705	0.0705
Brugia malayi	6-phosphofructokinase	0.0107	0.1166	0.1165
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0124	0.044
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0124	0.1016
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0134	0.1489	0.1489
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0807	0.0801
Loa Loa (eye worm)	hypothetical protein	0.003	0.0243	0.0242
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0001	0.0001
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0016	0.0075	0.158
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0011	0.0016	0.0223
Plasmodium falciparum	thioredoxin reductase	0.0047	0.044	1
Brugia malayi	Thioredoxin reductase	0.0047	0.044	0.0439
Trichomonas vaginalis	chromobox protein, putative	0.0069	0.0705	0.2611
Onchocerca volvulus		0.0027	0.02	0.039
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0011	0.0016	0.0036
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.02	0.0199
Trichomonas vaginalis	phosphofructokinase, putative	0.0107	0.1166	0.4336
Brugia malayi	Cathepsin L-like precursor	0.002	0.0124	0.0123
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0001	0.0001
Echinococcus granulosus	Chromo domain	0.0011	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0343	0.0342
Plasmodium vivax	6-phosphofructokinase, putative	0.0029	0.0229	0.5117
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0016	0.0036
Leishmania major	cathepsin L-like protease	0.0077	0.0807	0.0782
Mycobacterium tuberculosis	Probable oxidoreductase	0.0118	0.1299	1
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0208	0.0754
Onchocerca volvulus	Cathepsin F homolog	0.002	0.0124	0.0241
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.0124	0.0123
Echinococcus granulosus	chromobox protein 1	0.0069	0.0705	0.0705
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0221	0.0221
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0014	0.0044	0.0043
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0011	0.0016	0.0083
Plasmodium vivax	6-phosphofructokinase, putative	0.0029	0.0229	0.5117
Brugia malayi	Flap endonuclease-1	0.0026	0.0189	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0376	0.0375
Onchocerca volvulus		0.002	0.0124	0.0241
Brugia malayi	Cathepsin L-like precursor	0.002	0.0124	0.0123
Brugia malayi	glutathione reductase	0.0047	0.044	0.0439
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0016	0.0075	0.158
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0035	0.0035
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0011	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0044	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0208	0.0754
Echinococcus granulosus	6 phosphofructokinase	0.0107	0.1166	0.1166
Schistosoma mansoni	lozenge	0.0055	0.0538	0.0538
Trypanosoma cruzi	sedoheptulose-1,7-bisphosphatase, putative	0.0313	0.3644	0.364
Schistosoma mansoni	hypothetical protein	0.0047	0.0452	0.0452
Echinococcus granulosus	death domain containing protein	0.0014	0.0051	0.0051
Onchocerca volvulus		0.0233	0.2682	0.5242
Plasmodium vivax	vivapain-2	0.002	0.0124	0.2715
Echinococcus multilocularis	chromobox protein 2	0.0011	0.0016	0.0016
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0343	0.1258
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0124	0.044
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0011	0.0016	0.0036
Echinococcus granulosus	cathepsin l1	0.0014	0.0044	0.0044
Entamoeba histolytica	phosphofructokinase, putative	0.0107	0.1166	1
Schistosoma mansoni	flap endonuclease-1	0.0023	0.016	0.016
Brugia malayi	Papain family cysteine protease containing protein	0.001	0.0007	0.0006
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0107	0.1166	0.8918
Brugia malayi	Cathepsin L-like precursor	0.0014	0.0044	0.0043
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0599	0.5023
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0014	0.0044	0.014
Trichomonas vaginalis	flap endonuclease-1, putative	0.0026	0.0189	0.0683
Brugia malayi	Protein cec-1.	0.0011	0.0016	0.0015
Onchocerca volvulus	Netrin receptor homolog	0.0014	0.0051	0.0099
Echinococcus granulosus	cathepsin l cysteine peptidase	0.002	0.0124	0.0124
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.0075	0.0069
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0001	0.0001
Trypanosoma cruzi	trypanothione reductase, putative	0.0047	0.044	0.0434
Loa Loa (eye worm)	cytochrome P450 family protein	0.0012	0.0027	0.0026
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0107	0.1166	0.0695
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0029	0.0229	0.5117
Loa Loa (eye worm)	thioredoxin reductase	0.0047	0.044	0.0439
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0016	0.0075	0.0424
Toxoplasma gondii	6-phosphofructokinase	0.0029	0.0229	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0016	0.0015
Brugia malayi	intermediate filament protein	0.0027	0.02	0.0199
Echinococcus multilocularis	cathepsin L	0.001	0.0007	0.0007
Onchocerca volvulus		0.002	0.0124	0.0241
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0124	0.044
Echinococcus granulosus	lamin	0.0027	0.02	0.02
Onchocerca volvulus		0.0047	0.0452	0.0881
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0011	0.0016	0.0016
Echinococcus granulosus	fructose 16 bisphosphatase 1	0.0842	1	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0234	0.0234
Trichomonas vaginalis	phosphofructokinase, putative	0.0107	0.1166	0.4336
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0026	0.0189	0.0183
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0075	0.0069
Leishmania major	ATP-dependent phosphofructokinase	0.0107	0.1166	0.1142
Loa Loa (eye worm)	hypothetical protein	0.0027	0.02	0.0199
Loa Loa (eye worm)	6-phosphofructokinase	0.0107	0.1166	0.1165
Loa Loa (eye worm)	hypothetical protein	0.006	0.0605	0.0604
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0106	0.1156	0.8837
Echinococcus granulosus	Ankyrin	0.0014	0.0053	0.0053
Entamoeba histolytica	hypothetical protein	0.0011	0.0016	0.0083
Trichomonas vaginalis	chromobox protein, putative	0.0011	0.0016	0.0036
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0605	0.0604
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0016	0.0075	0.0075
Onchocerca volvulus		0.002	0.0124	0.0241
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.002	0.0124	0.0123
Toxoplasma gondii	NADPH-glutathione reductase	0.0016	0.0075	0.0059
Echinococcus granulosus	survival motor neuron protein 1	0.0233	0.2676	0.2676
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0011	0.0016	0.0036
Plasmodium vivax	heterochromatin protein 1, putative	0.0011	0.0016	0.0223
Brugia malayi	Death domain containing protein	0.0014	0.0051	0.005
Entamoeba histolytica	cysteine proteinase, putative	0.0014	0.0044	0.0323
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0001	0.0001
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0807	0.0801
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0001	0.0001
Brugia malayi	Cathepsin L-like precursor	0.002	0.0124	0.0123
Trichomonas vaginalis	phosphofructokinase, putative	0.0107	0.1166	0.4336
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.023	0.2647	0.2646
Echinococcus granulosus	cathepsin l1	0.002	0.0124	0.0124
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.02	0.0199
Echinococcus multilocularis	survival motor neuron protein 1	0.0233	0.2676	0.2676
Brugia malayi	Heterochromatin protein 1	0.0069	0.0705	0.0704
Loa Loa (eye worm)	hypothetical protein	0.002	0.0124	0.0123
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0001	0.0001
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0234	0.0234
Entamoeba histolytica	cysteine protease, putative	0.002	0.0124	0.1016
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0029	0.0229	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0124	0.044
Leishmania major	cathepsin L-like protease	0.0077	0.0807	0.0782
Trypanosoma cruzi	trypanothione reductase, putative	0.0016	0.0075	0.0069
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0014	0.0044	0.014
Trypanosoma brucei	cytochrome P450, putative	0.0012	0.0027	0.002
Schistosoma mansoni	6-phosphofructokinase	0.0107	0.1166	0.1166
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0075	0.5
Trichomonas vaginalis	phosphofructokinase, putative	0.0107	0.1166	0.4336
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0001	0.0001
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0011	0.0016	0.0083
Trypanosoma cruzi	major cysteine proteinase, putative	0.0061	0.0609	0.0603
Schistosoma mansoni	lamin	0.0027	0.02	0.02
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.001	0.0007	0.0007
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0029	0.0229	0.1914
Trypanosoma cruzi	sedoheptulose-1,7-bisphosphatase, putative	0.0313	0.3644	0.364
Brugia malayi	Cytochrome P450 family protein	0.0012	0.0027	0.0026
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.002	0.0124	0.044
Schistosoma mansoni	hypothetical protein	0.0019	0.011	0.011
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0016	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0233	0.2676	0.2676
Schistosoma mansoni	fructose-16-bisphosphatase-related	0.0842	1	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0075	0.5
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0016	0.0015
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0118	0.1299	1
Schistosoma mansoni	hypothetical protein	0.0019	0.011	0.011
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0011	0.0016	0.0036
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0016	0.0036
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0001	0.0001
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0016	0.0075	0.0059
Schistosoma mansoni	ankyrin 23/unc44	0.0014	0.0051	0.0051
Echinococcus multilocularis	Chromobox protein 3	0.0011	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0051	0.005
Echinococcus granulosus	cathepsin L	0.001	0.0007	0.0007
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0124	0.044
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0016	0.0075	0.0074
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0001	0.0001
Echinococcus multilocularis	GPCR, family 2	0.0019	0.011	0.011
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0016	0.0015
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0124	0.044
Trypanosoma brucei	sedoheptulose-1,7-bisphosphatase	0.0313	0.3644	0.364
Echinococcus granulosus	neuropeptide receptor A26	0.0457	0.5365	0.5365
Trypanosoma cruzi	cruzipain precursor, putative	0.0077	0.0807	0.0801
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0107	0.1166	0.116
Brugia malayi	Pre-SET motif family protein	0.0205	0.2341	0.234
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0075	0.0069
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0001	0.0001
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0029	0.0229	0.5117
Trichomonas vaginalis	chromobox protein, putative	0.0011	0.0016	0.0036
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0807	0.0801
Trypanosoma brucei	fructose-1,6-bisphosphatase	0.0842	1	1
Trichomonas vaginalis	chromobox protein, putative	0.0011	0.0016	0.0036
Brugia malayi	chromobox protein homolog 3	0.0038	0.0343	0.0342
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0026	0.0189	0.0183
Plasmodium falciparum	glutathione reductase	0.0016	0.0075	0.158
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0205	0.2341	0.234
Echinococcus multilocularis	cysteine protease	0.002	0.0124	0.0124
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0052	0.0051
Loa Loa (eye worm)	flap endonuclease-1	0.0026	0.0189	0.0188
Echinococcus multilocularis	cathepsin L cysteine protease	0.002	0.0124	0.0124
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.006	0.0599	0.0599
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0229	0.083
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0378	0.1389
Onchocerca volvulus		0.002	0.0124	0.0241
Brugia malayi	Protein kinase domain containing protein	0.0014	0.0051	0.005
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0001	0.0001
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0016	0.0075	0.0424
Leishmania major	cathepsin L-like protease	0.002	0.0124	0.0098
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0807	0.0801
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0807	0.0801
Brugia malayi	cathepsin L-like precursor	0.0014	0.0044	0.0043
Loa Loa (eye worm)	fructose-1,6-bisphosphatase	0.0842	1	1
Brugia malayi	M-phase phosphoprotein, mpp8	0.0011	0.0016	0.0015
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.0075	0.0069
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0072	0.0752	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0012	0.003	0.0029
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	0.0807	0.0801
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0014	0.0051	0.0051
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0016	0.0075	0.0048
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0041	0.0369	0.0369
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0011	0.0016	0.0036
Onchocerca volvulus		0.002	0.0124	0.0241
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0011	0.0016	0.0036
Toxoplasma gondii	fructose-bisphospatase II	0.0842	1	1
Loa Loa (eye worm)	CHromoDomain protein family member	0.0011	0.0016	0.0015
Trichomonas vaginalis	hypothetical protein	0.0011	0.0016	0.0036
Schistosoma mansoni	6-phosphofructokinase	0.0107	0.1166	0.1166
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0234	0.0234
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0599	0.5023
Leishmania major	cathepsin L-like protease	0.002	0.0124	0.0098
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0807	0.0801
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0011	0.0016	0.0036
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0011	0.0016	0.0016
Echinococcus multilocularis	lamin	0.0027	0.02	0.02
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0016	0.0075	0.0048
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0452	0.0452
Brugia malayi	hypothetical protein	0.0436	0.5116	0.5116
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0599	0.5023
Brugia malayi	Associated with TFs and helicases family protein	0.0011	0.0016	0.0015
Schistosoma mansoni	netrin receptor unc5	0.0014	0.0051	0.0051
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0016	0.0036
Entamoeba histolytica	phosphofructokinase, putative	0.0107	0.1166	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0012	0.0027	0.0026
Trichomonas vaginalis	glutathione reductase, putative	0.0016	0.0075	0.0256
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0001	0.0001
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0026	0.0189	0.0173
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.002	0.0124	0.2715
Toxoplasma gondii	sedoheptulose-1,7-bisphosphatase	0.0313	0.3644	0.3634
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0016	0.0075	0.0075
Trypanosoma brucei	trypanothione reductase	0.0047	0.044	0.0434
Toxoplasma gondii	thioredoxin reductase	0.0047	0.044	0.0425
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0124	0.044
Entamoeba histolytica	Flap nuclease, putative	0.0026	0.0189	0.1575
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0016	0.0075	0.158
Trichomonas vaginalis	set domain proteins, putative	0.0233	0.2681	1
Plasmodium falciparum	chromodomain-helicase-DNA-binding protein 1 homolog, putative	0.0011	0.0016	0.0223
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0106	0.1156	0.8837
Trichomonas vaginalis	chromobox protein, putative	0.0069	0.0705	0.2611
Echinococcus multilocularis	Chromo domain	0.0011	0.0016	0.0016
Schistosoma mansoni	hypothetical protein	0.0019	0.011	0.011
Brugia malayi	follicle stimulating hormone receptor	0.023	0.2647	0.2646
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0016	0.0075	0.0069
Loa Loa (eye worm)	cysteine protease	0.002	0.0124	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0019	0.011	0.0109
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0026	0.0189	0.0163
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0011	0.0016	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0436	0.5116	0.5116
Giardia lamblia	Flap structure-specific endonuclease	0.0026	0.0189	0.7439
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0001	0.0001
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0605	0.0604
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0001	0.0001
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0016	0.0036
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.007	0.0727	0.072
Loa Loa (eye worm)	runx1	0.0055	0.0538	0.0537
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0376	0.0375
Plasmodium falciparum	heterochromatin protein 1	0.0011	0.0016	0.0223
Entamoeba histolytica	hypothetical protein	0.0011	0.0016	0.0083
Toxoplasma gondii	aldehyde dehydrogenase	0.006	0.0599	0.0584
Entamoeba histolytica	hypothetical protein	0.0011	0.0016	0.0083
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0124	0.0124
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.006	0.0599	0.4283
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0035	0.0035
Onchocerca volvulus		0.0027	0.02	0.039
Plasmodium vivax	flap endonuclease 1, putative	0.0026	0.0189	0.4212
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0029	0.0229	0.0213
Echinococcus multilocularis	Ankyrin	0.0014	0.0053	0.0053
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0001	0.0001
Schistosoma mansoni	intermediate filament proteins	0.0027	0.02	0.02
Echinococcus multilocularis	neuropeptide receptor A26	0.0457	0.5365	0.5365
Trypanosoma cruzi	cytochrome P450, putative	0.0012	0.0027	0.002
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0599	0.0599
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0124	0.0124
Brugia malayi	Pre-SET motif family protein	0.0029	0.0234	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0012	0.003	0.0029
Plasmodium falciparum	flap endonuclease 1	0.0026	0.0189	0.4212
Loa Loa (eye worm)	heterochromatin protein 1	0.0069	0.0705	0.0704
Trichomonas vaginalis	mercuric reductase, putative	0.0016	0.0075	0.0256
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0001	0.0001
Brugia malayi	Uncoordinated protein 44	0.0014	0.0051	0.005
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0075	0.0069
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0016	0.0036
Trichomonas vaginalis	Heterochromatin protein, putative	0.0011	0.0016	0.0036
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0124	0.044
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.006	0.0599	0.0599
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0016	0.0075	0.158
Plasmodium falciparum	glutathione reductase	0.0047	0.044	1
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0599	0.0599
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0118	0.1299	1
Entamoeba histolytica	phosphofructokinase, putative	0.0107	0.1166	1
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0012	0.0024	0.0023
Brugia malayi	SET domain containing protein	0.0012	0.0029	0.0028
Leishmania major	trypanothione reductase	0.0047	0.044	0.0415
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0029	0.0229	0.083
Toxoplasma gondii	fructose-bisphospatase I	0.0313	0.3644	0.3634
Loa Loa (eye worm)	fibroinase	0.002	0.0124	0.0123
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0124	0.044
Echinococcus granulosus	neuropeptide s receptor	0.0457	0.5365	0.5365
Leishmania major	cathepsin L-like protease	0.002	0.0124	0.0098
Plasmodium vivax	glutathione reductase, putative	0.0047	0.044	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	0.0807	0.0801
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0807	0.0801
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0001	0.0001
Mycobacterium ulcerans	6-phosphofructokinase	0.0107	0.1166	1
Loa Loa (eye worm)	hypothetical protein	0.0436	0.5116	0.5116
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0001	0.0001
Echinococcus multilocularis	flap endonuclease 1	0.0026	0.0189	0.0189
Leishmania major		0.0842	1	1
Schistosoma mansoni	hypothetical protein	0.0014	0.0051	0.0051
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.002	0.0124	0.0124
Schistosoma mansoni	hypothetical protein	0.0124	0.1369	0.1369
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0011	0.0016	0.0036
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0124	0.044
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0016	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0234	0.0233
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0234	0.0234
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0107	0.1166	1
Echinococcus multilocularis	musashi	0.0027	0.02	0.02
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0029	0.0229	1
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0016	0.0075	0.0069
Mycobacterium tuberculosis	Probable reductase	0.0106	0.1156	0.8837
Brugia malayi	Cathepsin L-like precursor	0.002	0.0124	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0044	0.0043
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0014	0.0051	0.005
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0001	0.0001
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0234	0.0218
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0124	0.044
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0807	0.0801
Brugia malayi	hypothetical protein	0.0233	0.2676	0.2676
Echinococcus multilocularis	cysteine protease	0.002	0.0124	0.0124
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0052	0.0051
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.02	0.0199
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0001	0.0001
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0016	0.0075	0.0048
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0001	0.0001
Schistosoma mansoni	hypothetical protein	0.0011	0.0016	0.0016
Echinococcus granulosus	netrin receptor unc 5	0.0014	0.0051	0.0051
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0124	0.044
Toxoplasma gondii	cathepsin CPL	0.002	0.0124	0.0108
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0124	0.044
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0053	0.0052

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	2.2387 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	6.5733 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1476 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent))]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1557743
Search by Saint Jude

Bibliographic References

No literature references available for this target.

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Detailed information for compound 835320