Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APH1B gamma secretase subunit | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Echinococcus granulosus | gamma secretase subunit aph 1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Schistosoma japonicum | ko:K06172 anterior pharynx defective 1, putative | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0118 | 0 | 0.5 | |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0309 | 0.6256 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0309 | 0.6256 | 0.5 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0296 | 0.5812 | 0.5812 |
Brugia malayi | gamma-secretase subunit aph-1 | 0.0296 | 0.5812 | 0.5812 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0309 | 0.6256 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0424 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0309 | 0.6256 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0424 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0424 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0309 | 0.6256 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0309 | 0.6256 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0424 | 1 | 0.5 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.0296 | 0.5812 | 0.5812 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0424 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0424 | 1 | 1 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.0296 | 0.5812 | 0.5812 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0424 | 1 | 1 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.0296 | 0.5812 | 0.5812 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0424 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0424 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 300 nM | Inhibition of gamma-secretase activity in H4 human neuroglioma cells by measuring amyloid beta production | ChEMBL. | 15050627 |
IC50 (binding) | = 300 nM | Inhibition of gamma-secretase activity in H4 human neuroglioma cells by measuring amyloid beta production | ChEMBL. | 15050627 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.