Detailed information for compound 835397

Basic information

Technical information
  • TDR Targets ID: 835397
  • Name: 3-methoxy-N-naphthalen-1-ylbenzamide
  • MW: 277.317 | Formula: C18H15NO2
  • H donors: 1 H acceptors: 1 LogP: 3.98 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)C(=O)Nc1cccc2c1cccc2
  • InChi: 1S/C18H15NO2/c1-21-15-9-4-8-14(12-15)18(20)19-17-11-5-7-13-6-2-3-10-16(13)17/h2-12H,1H3,(H,19,20)
  • InChiKey: OHBKVALAKGKLJH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-methoxy-N-(1-naphthyl)benzamide
  • 3-methoxy-N-naphthalen-1-yl-benzamide
  • MLS001000503
  • SMR000496139
  • BIM-0017442.P001
  • CBMicro_017313
  • Benzamide, N-(1-naphthyl)-3-methoxy-
  • ZINC00209004
  • CDS1_003809
  • DivK1c_004849
  • Oprea1_421705
  • 3-methoxy-N-1-naphthylbenzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0039 0.0044 0.1921
Schistosoma mansoni thyroid hormone receptor 0.0055 0.0074 0.042
Schistosoma mansoni transcription factor btf3 0.0039 0.0044 0.0249
Brugia malayi beta-lactamase family protein 0.0116 0.0196 0.2144
Brugia malayi Nuclear hormone receptor-like 1 0.0055 0.0074 0.078
Trypanosoma brucei hypothetical protein, conserved 0.0116 0.0196 1
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.0503 0.1505
Brugia malayi latrophilin 2 splice variant baaae 0.0112 0.0188 0.2058
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.0503 0.1505
Onchocerca volvulus 0.0116 0.0196 0.1976
Echinococcus granulosus Nuclear hormone receptor HR96 0.0026 0.0017 0.009
Trypanosoma brucei hypothetical protein, conserved 0.0106 0.0176 0.9009
Brugia malayi Latrophilin receptor protein 2 0.0052 0.0069 0.0717
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0271 0.0503 0.5594
Trypanosoma cruzi transcription factor btf3, putative 0.0039 0.0044 0.225
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0055 0.0074 0.042
Echinococcus granulosus tar DNA binding protein 0.0076 0.0117 0.066
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.0118 0.0117
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0106 0.0597
Trypanosoma brucei Enriched in surface-labeled proteome protein 12 0.0106 0.0176 0.9009
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0041 0.1765
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0117 0.0665
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0205 0.1162
Schistosoma mansoni endoplasmin 0.0037 0.0038 0.0218
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0038 0.1936
Loa Loa (eye worm) hypothetical protein 0.0026 0.0017 0.013
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0021 0.0007 0.0334
Loa Loa (eye worm) hypothetical protein 0.0322 0.0605 0.6741
Trichomonas vaginalis protein kinase inhibitor, putative 0.0064 0.0093 0.0263
Trypanosoma cruzi heat shock protein 90, putative 0.0037 0.0038 0.1969
Trypanosoma brucei heat shock protein, putative 0.0037 0.0038 0.1969
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0055 0.0074 0.0414
Brugia malayi CXXC zinc finger family protein 0.0063 0.009 0.096
Brugia malayi Bromodomain containing protein 0.0088 0.0141 0.1527
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0055 0.0074 0.0414
Trypanosoma cruzi Heat shock protein 83, putative 0.0037 0.0038 0.1969
Schistosoma mansoni patched 1 0.0051 0.0067 0.0379
Loa Loa (eye worm) hypothetical protein 0.0026 0.0017 0.013
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0693
Loa Loa (eye worm) hypothetical protein 0.0055 0.0074 0.0774
Echinococcus granulosus heat shock protein 90 0.0037 0.0038 0.0212
Plasmodium falciparum endoplasmin, putative 0.0022 0.001 0.0193
Schistosoma mansoni inositol monophosphatase 0.0036 0.0038 0.0214
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0067 0.0373
Trypanosoma cruzi hypothetical protein, conserved 0.0116 0.0196 1
Mycobacterium leprae conserved hypothetical protein 0.0116 0.0196 0.0361
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0055 0.0074 0.078
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0078 0.0121 0.6202
Echinococcus multilocularis survival motor neuron protein 1 0.0468 0.0895 0.0894
Loa Loa (eye worm) DnaJ domain-containing protein 0.0064 0.0093 0.0988
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0008 0.0005
Leishmania major heat shock protein 83-1 0.0037 0.0038 0.1969
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0026 0.1587
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0038 0.0208
Trichomonas vaginalis heat shock protein, putative 0.0037 0.0038 0.0097
Loa Loa (eye worm) hypothetical protein 0.0026 0.0017 0.013
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0106 0.0176 0.9009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0017 0.0016
Echinococcus multilocularis endoplasmin 0.0029 0.0024 0.0023
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0028 0.0022 0.1113
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0055 0.0074 0.042
Onchocerca volvulus 0.0056 0.0076 0.0659
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0038 0.1936
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0023 0.02
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0106 0.0176 0.9009
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0038 0.1936
Mycobacterium ulcerans esterase/lipase LipP 0.0116 0.0196 0.039
Leishmania major phosphatidylinositol kinase related protein, putative 0.0021 0.0007 0.0338
Brugia malayi hypothetical protein 0.0468 0.0895 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0041 0.0072
Brugia malayi conserved hypotetical protein 0.0026 0.0017 0.0136
Brugia malayi nuclear receptor NHR-88 0.0055 0.0074 0.078
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0117 0.1261
Schistosoma mansoni inositol monophosphatase 0.0036 0.0038 0.0214
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0069 0.0721
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0023 0.003
Loa Loa (eye worm) hypothetical protein 0.0052 0.0069 0.0712
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0023 0.1153
Brugia malayi hypothetical protein 0.0077 0.0118 0.1275
Trypanosoma brucei heat shock protein, putative 0.0037 0.0038 0.1969
Brugia malayi ecdysteroid receptor 0.0055 0.0074 0.078
Toxoplasma gondii heat shock protein HSP90 0.0037 0.0038 0.0066
Schistosoma mansoni alpha-glucosidase 0.0147 0.0257 0.1458
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0052 0.0069 0.0067
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0023 0.003
Loa Loa (eye worm) hypothetical protein 0.0029 0.0023 0.0199
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0042 0.0106
Onchocerca volvulus Bile acid receptor homolog 0.0055 0.0074 0.0633
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.0118 0.067
Giardia lamblia Heat shock protein HSP 90-alpha 0.0029 0.0024 0.4892
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0024 0.0052
Echinococcus granulosus transcription factor btf3 0.0039 0.0044 0.0243
Brugia malayi orphan nuclear receptor NR2E1 0.0026 0.0017 0.0136
Loa Loa (eye worm) nuclear hormone receptor 0.0026 0.0017 0.013
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0042 0.1797
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.0303 0.0302
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0023 0.0132
Loa Loa (eye worm) endoplasmin 0.0037 0.0038 0.0373
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0055 0.0074 0.0414
Schistosoma mansoni hypothetical protein 0.0908 0.1766 1
Trypanosoma brucei heat shock protein, putative 0.0037 0.0038 0.1969
Brugia malayi Muscleblind-like protein 0.0158 0.0278 0.3076
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0023 0.0821
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0041 0.0104
Giardia lamblia Grp94/Hsp90 0.0029 0.0024 0.4892
Echinococcus granulosus survival motor neuron protein 1 0.0468 0.0895 0.5064
Brugia malayi nuclear receptor RXR 0.0029 0.0023 0.0205
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0026 0.1337
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0164 0.0291 0.3213
Brugia malayi Nuclear hormone receptor E75 0.0026 0.0017 0.0136
Loa Loa (eye worm) hypothetical protein 0.0029 0.0023 0.0199
Entamoeba histolytica transcription factor BTF3, putative 0.0039 0.0044 0.1921
Trichomonas vaginalis heat shock protein, putative 0.0022 0.001 0.0012
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0004 0.0016
Loa Loa (eye worm) hypothetical protein 0.0024 0.0014 0.0097
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0117 0.0665
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0055 0.0074 0.0073
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0042 0.2127
Loa Loa (eye worm) hypothetical protein 0.008 0.0124 0.1335
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0023 0.0126
Echinococcus multilocularis serine protein kinase ATM 0.0028 0.0022 0.0021
Schistosoma mansoni hypothetical protein 0.0077 0.0118 0.067
Leishmania major heat shock protein 83-1 0.0037 0.0038 0.1969
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0026 0.0017 0.0016
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0029 0.0024 0.0002
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0021 0.0007 0.0334
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0081 0.0127 0.0717
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0117 0.0116
Entamoeba histolytica hypothetical protein 0.0077 0.0118 0.5728
Leishmania major hypothetical protein, conserved 0.003 0.0026 0.1337
Loa Loa (eye worm) inositol-1 0.0036 0.0038 0.0366
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0055 0.0074 0.078
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0026 0.1337
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0078 0.0121 0.1309
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0041 0.2095
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.0503 0.1505
Schistosoma mansoni alpha glucosidase 0.0038 0.0041 0.0232
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0318 0.0945
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0081 0.0127 0.0717
Echinococcus multilocularis ecdysone induced protein 78C 0.0055 0.0074 0.0073
Loa Loa (eye worm) hypothetical protein 0.0029 0.0023 0.0194
Brugia malayi nuclear hormone receptor 0.0055 0.0074 0.078
Trypanosoma brucei heat shock protein, putative 0.0037 0.0038 0.1969
Mycobacterium ulcerans hypothetical protein 0.0116 0.0196 0.039
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0029 0.0023 0.013
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.0046 0.0255
Leishmania major heat shock protein 83-1 0.0037 0.0038 0.1969
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0026 0.0017 0.013
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0029 0.0024 0.0128
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0042 0.004
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0029 0.0023 0.0199
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.2444 0.4813 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0009 0.0043
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0171 0.0305 0.3365
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0038 0.0037
Brugia malayi Steroid receptor seven-up type 2 0.0055 0.0074 0.078
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.0503 0.1505
Trypanosoma brucei glucosidase, putative 0.0038 0.0041 0.2095
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0023 0.0821
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0021 0.0007 0.0037
Loa Loa (eye worm) hypothetical protein 0.0055 0.0074 0.0774
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0042 0.0414
Echinococcus granulosus Nuclear hormone receptor HR96 0.0026 0.0017 0.009
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0069 0.0068
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0023 0.003
Brugia malayi DnaJ domain containing protein 0.0064 0.0093 0.0994
Onchocerca volvulus Glucosylceramidase homolog 0.0178 0.0318 0.3333
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0021 0.0007 0.0334
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0078 0.0121 1
Trichomonas vaginalis Sialidase-1 precursor, putative 0.1683 0.3303 1
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0106 0.0176 0.9009
Loa Loa (eye worm) hypothetical protein 0.0026 0.0017 0.013
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.0023 0.013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0055 0.0074 0.0774
Loa Loa (eye worm) hypothetical protein 0.0158 0.0278 0.3072
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0012 0.0075
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0055 0.0074 0.042
Echinococcus granulosus thyroid hormone receptor alpha 0.0026 0.0017 0.009
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0028 0.0022 0.0123
Schistosoma mansoni steroid hormone receptor ad4bp 0.0055 0.0074 0.042
Schistosoma mansoni zinc finger protein 0.0026 0.0017 0.0096
Schistosoma mansoni nuclear receptor nhr-48 0.0026 0.0017 0.0096
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0033
Schistosoma mansoni hypothetical protein 0.0052 0.0069 0.0388
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0042 1
Loa Loa (eye worm) hypothetical protein 0.0164 0.0291 0.3209
Loa Loa (eye worm) hypothetical protein 0.0026 0.0017 0.013
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0041 0.0104
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0116 0.0196 0.0395
Trypanosoma brucei heat shock protein, putative 0.0037 0.0038 0.1969
Echinococcus multilocularis dnaJ subfamily C 6 0.0064 0.0093 0.0092
Echinococcus multilocularis tumor protein p63 0.0381 0.0722 0.0721
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0164 0.0291 0.3209
Schistosoma mansoni cellular tumor antigen P53 0.0056 0.0076 0.0433
Entamoeba histolytica hypothetical protein 0.0028 0.0022 0.0781
Brugia malayi nuclear hormone receptor family member odr-7 0.0026 0.0017 0.0136
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0041 0.0104
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0021 0.0007 0.0334
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0078 0.0121 0.6036
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0055 0.0074 0.078
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.0118 0.0664
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0038 0.7912
Plasmodium falciparum basic transcription factor 3b, putative 0.0039 0.0044 0.3166
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.0503 0.1505
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.0012 0.0087
Schistosoma mansoni cpg binding protein 0.0068 0.0102 0.0575
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0007 0.002
Echinococcus multilocularis cpg binding protein 0.0068 0.0102 0.01
Loa Loa (eye worm) hypothetical protein 0.0026 0.0017 0.013
Echinococcus multilocularis nuclear receptor nhr 48 0.0026 0.0017 0.0016
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0078 0.0121 0.0348
Brugia malayi Nuclear hormone receptor E75 0.0026 0.0017 0.0136
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0067 0.0693
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0028 0.0022 0.0191
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0055 0.0074 0.0414
Onchocerca volvulus 0.0116 0.0196 0.1976
Trypanosoma cruzi heat shock protein 85, putative 0.0037 0.0038 0.1969
Loa Loa (eye worm) hypothetical protein 0.0026 0.0017 0.013
Schistosoma mansoni coup transcription factor 0.0055 0.0074 0.042
Brugia malayi Glycosyl hydrolases family 31 protein 0.0171 0.0305 0.3369
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0055 0.0074 0.042
Schistosoma mansoni hypothetical protein 0.0112 0.0188 0.1064
Trypanosoma cruzi target of rapamycin kinase 3 0.0021 0.0007 0.0334
Loa Loa (eye worm) hypothetical protein 0.0052 0.0068 0.0708
Loa Loa (eye worm) hypothetical protein 0.0055 0.0074 0.0774
Loa Loa (eye worm) hypothetical protein 0.0116 0.0196 0.2139
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0052 0.0069 0.0382
Plasmodium vivax basic transcription factor 3b, putative 0.0039 0.0044 0.1911
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0004 0.0022
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0042 0.0408
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0055 0.0074 0.078
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0041 0.0104
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0026 0.0017 0.0096
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0067 0.0066
Trichomonas vaginalis endoplasmin, putative 0.0022 0.001 0.0012
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0106 0.0176 0.9009
Leishmania major heat shock protein 83-1 0.0037 0.0038 0.1969
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0096 0.0155 0.1691
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0029 0.0024 0.1211
Echinococcus granulosus tumor protein p63 0.0381 0.0722 0.4084
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0055 0.0074 0.078
Schistosoma mansoni ap endonuclease 0.0038 0.0042 0.0235
Trypanosoma brucei transcription factor BTF3, putative 0.0039 0.0044 0.225
Echinococcus multilocularis protein dispatched 1 0.0058 0.0081 0.008
Brugia malayi beta-NAC-like protein 0.0039 0.0044 0.0441
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0055 0.0074 0.078
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0055 0.0074 0.078
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0078 0.0121 0.012
Onchocerca volvulus 0.0099 0.0162 0.1602
Trypanosoma brucei heat shock protein 90, putative 0.0037 0.0038 0.1969
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.0945 0.0944
Mycobacterium tuberculosis Probable lipase LipE 0.0116 0.0196 0.0395
Schistosoma mansoni hypothetical protein 0.0052 0.0069 0.0388
Brugia malayi hypothetical protein 0.0026 0.0017 0.0136
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0014 0.0712
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0023 0.0035
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0038 0.0065
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0069 0.039
Loa Loa (eye worm) nuclear receptor NHR-67 0.0026 0.0017 0.013
Schistosoma mansoni hypothetical protein 0.0049 0.0063 0.0358
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.003 0.0016
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.0337 0.1003
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0041 0.0104
Brugia malayi PHD-finger family protein 0.0032 0.0029 0.0268
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0026 0.0017 0.0136
Echinococcus granulosus muscleblind protein 0.0158 0.0278 0.1572
Loa Loa (eye worm) steroid hormone receptor 0.0055 0.0074 0.0774
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0089 0.0087
Loa Loa (eye worm) hypothetical protein 0.0029 0.0023 0.0199
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0081 0.0127 0.0126
Brugia malayi nuclear receptor NHR-67 0.0026 0.0017 0.0136
Schistosoma mansoni bromodomain containing protein 0.0075 0.0114 0.0648
Leishmania major heat shock protein 83-1 0.0037 0.0038 0.1969
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0069 0.0068
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0055 0.0074 0.042
Mycobacterium ulcerans beta-lactamase 0.0116 0.0196 0.039
Schistosoma mansoni hypothetical protein 0.0049 0.0063 0.0358
Onchocerca volvulus 0.0096 0.0155 0.153
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0021 0.0007 0.0031
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0042 0.0229
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0017 0.0096
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0042 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0026 0.0017 0.0016
Leishmania major heat shock protein 83-1 0.0037 0.0038 0.1969
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0055 0.0074 0.078
Echinococcus granulosus heat shock protein 0.0037 0.0038 0.0212
Trypanosoma brucei heat shock protein, putative 0.0037 0.0038 0.1969
Brugia malayi Calcitonin receptor-like protein seb-1 0.0164 0.0291 0.3213
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0026 0.0958
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0023 0.003
Trypanosoma cruzi heat shock protein 90, putative 0.0029 0.0024 0.1211
Brugia malayi steroid hormone receptor 0.0055 0.0074 0.078
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0055 0.0074 0.0414
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0042 0.1782
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0055 0.0074 0.0414
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0318 0.0945
Plasmodium vivax hypothetical protein, conserved 0.0116 0.0196 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.0196 0.2139
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0318 0.0945
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0001 0.0006
Onchocerca volvulus 0.0055 0.0074 0.0633
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0055 0.0074 0.0774
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0026 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0067 0.0183
Trypanosoma cruzi heat shock protein 85, putative 0.0029 0.0024 0.1211
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.0046 0.0045
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0078 0.0121 0.6202
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0078 0.0121 0.6202
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0029 0.0023 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0044 0.0114
Echinococcus multilocularis geminin 0.0908 0.1766 0.1765
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0116 0.0196 0.039
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0033
Echinococcus granulosus histone lysine methyltransferase setb 0.0081 0.0127 0.0712
Schistosoma mansoni heat shock protein 0.0037 0.0038 0.0218
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0117 0.0665
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0069 0.0715
Loa Loa (eye worm) DR-78 0.0026 0.0017 0.013
Leishmania major heat shock protein 83-1 0.0037 0.0038 0.1969
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0055 0.0074 0.0774
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0017 0.009
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0116 0.0196 0.2144
Echinococcus multilocularis muscleblind protein 1 0.0158 0.0278 0.0277
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0055 0.0074 0.0073
Brugia malayi beta-lactamase family protein 0.0116 0.0196 0.2144
Trypanosoma brucei hypothetical protein, conserved 0.0106 0.0176 0.9009
Leishmania major heat shock protein 83-1 0.0037 0.0038 0.1969
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0023 0.02
Onchocerca volvulus Protein ultraspiracle homolog 0.0055 0.0074 0.0633
Brugia malayi RNA binding protein 0.0076 0.0117 0.1267
Entamoeba histolytica hypothetical protein 0.0077 0.0118 0.5728
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.2444 0.4813 1
Brugia malayi Bromodomain containing protein 0.0043 0.0051 0.0525
Brugia malayi hypothetical protein 0.0029 0.0023 0.0205
Loa Loa (eye worm) hypothetical protein 0.0029 0.0023 0.0194
Entamoeba histolytica hypothetical protein 0.0077 0.0118 0.5728
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0023 0.0205
Mycobacterium tuberculosis Conserved protein 0.0116 0.0196 0.0395
Trypanosoma cruzi heat shock protein 85, putative 0.0037 0.0038 0.1969
Loa Loa (eye worm) histone methyltransferase 0.0022 0.0009 0.0038
Mycobacterium tuberculosis Possible penicillin-binding protein 0.074 0.1433 0.297
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0038 0.0062
Echinococcus multilocularis beta LACTamase domain containing family member 0.0116 0.0196 0.0194
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0078 0.0121 0.1304
Loa Loa (eye worm) hypothetical protein 0.0029 0.0023 0.0199
Brugia malayi Pre-SET motif family protein 0.0423 0.0805 0.8996
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0024 0.0052
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0078 0.0121 0.0687
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.0305 0.0304
Echinococcus granulosus cpg binding protein 0.0068 0.0102 0.0569
Trichomonas vaginalis conserved hypothetical protein 0.1683 0.3303 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.0202 0.2207
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0106 0.0105
Echinococcus granulosus dnaJ subfamily B 0.0494 0.0945 0.535
Trypanosoma brucei heat shock protein, putative 0.0037 0.0038 0.1969
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0021 0.0007 0.0031
Mycobacterium tuberculosis Conserved protein 0.0116 0.0196 0.0395
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0007 0.0338
Brugia malayi Inositol-1 0.0036 0.0038 0.0372
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0078 0.0121 0.6202
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0033
Schistosoma mansoni hypothetical protein 0.0052 0.0069 0.0388
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0026 0.1587
Plasmodium vivax heat shock protein 86, putative 0.0037 0.0038 0.1617
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0271 0.0503 0.5597
Mycobacterium ulcerans lipase LipD 0.0116 0.0196 0.039
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0008 0.5
Loa Loa (eye worm) hypothetical protein 0.0116 0.0196 0.2139
Echinococcus multilocularis transcription factor btf3 0.0039 0.0044 0.0043
Schistosoma mansoni retinoic acid receptor RXR 0.0055 0.0074 0.042
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0021 0.0007 0.0334
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0055 0.0074 0.0073
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0052 0.0069 0.0067
Schistosoma mansoni hypothetical protein 0.0096 0.0155 0.0879
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0052 0.0069 0.0717
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0117 0.1267
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0069 0.039
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0067 0.0373
Loa Loa (eye worm) hypothetical protein 0.0055 0.0074 0.0774
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0026 0.0017 0.0016
Leishmania major heat shock protein 83-1 0.0037 0.0038 0.1969
Mycobacterium leprae Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.2444 0.4813 1
Schistosoma mansoni cpg binding protein 0.0063 0.009 0.0511
Mycobacterium tuberculosis Probable hydrolase 0.0116 0.0196 0.0395
Loa Loa (eye worm) hypothetical protein 0.0043 0.0052 0.0521
Echinococcus multilocularis FTZ F1 alpha 0.0055 0.0074 0.0073
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0026 0.0017 0.0016
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0042 0.2127
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0055 0.0074 0.0414
Brugia malayi hypothetical protein 0.0322 0.0605 0.6743
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0026 0.1337
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0023 0.0205
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0117 0.0665
Loa Loa (eye worm) hypothetical protein 0.0055 0.0074 0.0774
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0055 0.0074 0.0073
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0117 0.0665
Loa Loa (eye worm) hypothetical protein 0.003 0.0026 0.0234
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.0503 0.1505
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0028 0.0022 0.1113
Mycobacterium tuberculosis Conserved protein 0.0116 0.0196 0.0395
Trypanosoma brucei heat shock protein 90, putative 0.0037 0.0038 0.1969
Loa Loa (eye worm) hypothetical protein 0.0026 0.0017 0.013
Leishmania major hypothetical protein, conserved 0.0116 0.0196 1
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0202 0.1136
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0042 0.0074
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0041 0.0104
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0004 0.0003
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0106 0.0176 0.9009
Onchocerca volvulus 0.0322 0.0605 0.6504
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0044 0.0114
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0038 0.0095
Loa Loa (eye worm) hypothetical protein 0.0062 0.009 0.0949
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0318 0.0945
Mycobacterium tuberculosis Probable lipase LipD 0.0116 0.0196 0.0395
Loa Loa (eye worm) hypothetical protein 0.0055 0.0074 0.0774
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0055 0.0074 0.0774
Brugia malayi nuclear hormone receptor 0.0026 0.0017 0.0136
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0078 0.0121 0.5883
Brugia malayi nuclear receptor RXR 0.0026 0.0017 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0044 0.0114
Brugia malayi beta-lactamase 0.0116 0.0196 0.2144
Leishmania major phosphatidylinositol 3-kinase, putative 0.0021 0.0007 0.0334
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0023 0.003
Trypanosoma cruzi hypothetical protein, conserved 0.0116 0.0196 1
Loa Loa (eye worm) RNA binding protein 0.0076 0.0117 0.1261
Echinococcus granulosus nuclear receptor nhr 48 0.0026 0.0017 0.009
Brugia malayi Pre-SET motif family protein 0.0062 0.0089 0.0941
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0041 0.0401
Loa Loa (eye worm) hypothetical protein 0.0026 0.0017 0.013
Echinococcus granulosus geminin 0.0908 0.1766 1
Trypanosoma brucei Heat shock protein 83, putative 0.0037 0.0038 0.1969
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0021 0.0007 0.0334
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0007 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0055 0.0074 0.078
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0055 0.0074 0.0633
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0078 0.0121 0.0348
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0078 0.0121 0.1309
Echinococcus granulosus lysosomal alpha glucosidase 0.0171 0.0305 0.172
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0021 0.0007 0.0334
Onchocerca volvulus 0.0062 0.0089 0.0792
Schistosoma mansoni survival motor neuron protein 0.0096 0.0155 0.0879
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0007 0.0014
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0021 0.0007 0.0005
Onchocerca volvulus 0.0482 0.0921 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0116 0.0196 0.0395
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0038 0.0095
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0029 0.0024 0.0037
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0041 0.0226
Schistosoma mansoni heat shock protein 0.0037 0.0038 0.0218
Schistosoma mansoni nuclear hormone receptor 0.0055 0.0074 0.042
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0116 0.0196 0.1107
Brugia malayi Endoplasmin precursor 0.0037 0.0038 0.0379
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0089 0.0171
Trichomonas vaginalis esterase, putative 0.0116 0.0196 0.0573
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0042 0.0069
Echinococcus granulosus serine protein kinase ATM 0.0028 0.0022 0.0117
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0023 0.1153
Loa Loa (eye worm) hypothetical protein 0.0158 0.0278 0.3072
Schistosoma mansoni hypothetical protein 0.0049 0.0063 0.0358
Schistosoma mansoni RAR-like nuclear receptor 0.0055 0.0074 0.042
Loa Loa (eye worm) heat shock protein 90 0.0037 0.0038 0.0373
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0055 0.0074 0.078
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0029 0.0023 0.0022
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0116 0.0196 0.0395
Onchocerca volvulus 0.0029 0.0023 0.0063
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0069 0.0384
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0021 0.0007 0.0334
Schistosoma mansoni hypothetical protein 0.0064 0.0093 0.0528
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0116 0.0196 0.1107
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0078 0.0121 0.0239
Schistosoma mansoni alpha-glucosidase 0.0147 0.0257 0.1458
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0318 0.0945
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0042 0.2127
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0055 0.0074 0.0073
Loa Loa (eye worm) hypothetical protein 0.0116 0.0196 0.2139
Trichomonas vaginalis penicillin-binding protein, putative 0.0116 0.0196 0.0573
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0055 0.0074 0.0073
Loa Loa (eye worm) latrophilin receptor protein 2 0.0052 0.0069 0.0712
Trichomonas vaginalis D-aminoacylase, putative 0.0116 0.0196 0.0573
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0021 0.0007 0.0334
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0055 0.0074 0.0774
Loa Loa (eye worm) hypothetical protein 0.0056 0.0076 0.08
Leishmania major heat shock protein 83-1 0.0037 0.0038 0.1969
Entamoeba histolytica heat shock protein 90, putative 0.0037 0.0038 0.1639
Brugia malayi CHE-14 protein 0.0051 0.0067 0.0699
Trypanosoma cruzi heat shock protein 85, putative 0.0037 0.0038 0.1969
Echinococcus granulosus expressed conserved protein 0.0112 0.0187 0.1055
Schistosoma mansoni hypothetical protein 0.0023 0.0012 0.0068
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0021 0.0007 0.0334
Loa Loa (eye worm) hypothetical protein 0.0046 0.0057 0.058
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0041 0.0407
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0055 0.0074 0.078
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0017 0.0096
Giardia lamblia Heat shock protein HSP 90-alpha 0.0037 0.0038 0.9117
Echinococcus multilocularis heat shock protein 90 0.0029 0.0024 0.0023
Plasmodium falciparum heat shock protein 90 0.0037 0.0038 0.2679
Leishmania major basic transcription factor 3a, putative 0.0039 0.0044 0.225
Plasmodium vivax SET domain protein, putative 0.0062 0.0089 0.4288
Schistosoma mansoni hypothetical protein 0.0494 0.0945 0.5353
Loa Loa (eye worm) hypothetical protein 0.0468 0.0895 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0022 0.0046
Loa Loa (eye worm) hypothetical protein 0.0081 0.0127 0.1365
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0033
Schistosoma mansoni endoplasmin 0.0037 0.0038 0.0218
Entamoeba histolytica hypothetical protein 0.0077 0.0118 0.5728
Trichomonas vaginalis set domain proteins, putative 0.0482 0.0921 0.2773
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0021 0.0007 0.0334
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0318 0.0945
Schistosoma mansoni nuclear receptor 0.0026 0.0017 0.0096
Leishmania major heat shock protein 83-1 0.0037 0.0038 0.1969
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0202 0.02
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0033
Echinococcus multilocularis thyroid hormone receptor alpha 0.0055 0.0074 0.0073
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0078 0.0121 0.1304
Loa Loa (eye worm) hypothetical protein 0.0026 0.0017 0.013
Entamoeba histolytica heat shock protein 90, putative 0.0037 0.0038 0.1639
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0116 0.0196 0.2139
Brugia malayi hypothetical protein 0.0029 0.0023 0.0205
Schistosoma mansoni hypothetical protein 0.0049 0.0063 0.0358
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0055 0.0074 0.078
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0021 0.0007 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0055 0.0074 0.078
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0021 0.0007 0.0005
Leishmania major heat shock protein 83-1 0.0037 0.0038 0.1969
Trichomonas vaginalis D-aminoacylase, putative 0.0116 0.0196 0.0573
Schistosoma mansoni hypothetical protein 0.0052 0.0069 0.0388
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0042 0.2127
Echinococcus granulosus zinc finger protein 0.0026 0.0017 0.0088
Echinococcus granulosus ecdysone induced protein 78C 0.0055 0.0074 0.0414
Brugia malayi photoreceptor-specific nuclear receptor 0.0055 0.0074 0.078
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0023 0.0821
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0041 0.004
Schistosoma mansoni zinc finger protein 0.0026 0.0017 0.0094
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0117 0.1261
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0318 0.0945
Loa Loa (eye worm) hypothetical protein 0.0026 0.0017 0.013
Loa Loa (eye worm) hypothetical protein 0.0055 0.0074 0.0774
Loa Loa (eye worm) hypothetical protein 0.0029 0.0023 0.0194
Brugia malayi hypothetical protein 0.003 0.0026 0.024
Trypanosoma cruzi heat shock protein 90, putative 0.0022 0.0009 0.0445
Echinococcus multilocularis protein patched 0.0051 0.0067 0.0066
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0042 0.2953
Trypanosoma cruzi transcription factor btf3, putative 0.0039 0.0044 0.225
Mycobacterium tuberculosis Probable esterase LipL 0.0116 0.0196 0.0395
Brugia malayi nuclear receptor NHR-88 0.0026 0.0017 0.0136
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.0337 0.1003
Mycobacterium ulcerans hypothetical protein 0.0029 0.0023 0.003
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0041 0.1765
Toxoplasma gondii NAC domain-containing protein 0.0039 0.0044 0.0078
Echinococcus granulosus GPCR family 2 0.0052 0.0069 0.0382
Echinococcus granulosus heat shock protein 90 0.0029 0.0024 0.0128
Toxoplasma gondii ABC1 family protein 0.0116 0.0196 0.0393
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0202 1
Mycobacterium ulcerans heat shock protein 90 0.0029 0.0024 0.0032
Loa Loa (eye worm) ICD-1 protein 0.0039 0.0044 0.0435
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0042 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.003 0.0051
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0069 0.0384
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0078 0.0121 0.0681
Loa Loa (eye worm) hypothetical protein 0.0116 0.0196 0.2139
Echinococcus granulosus dnaJ subfamily C 6 0.0064 0.0093 0.0522
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0023 0.1153
Toxoplasma gondii FATC domain-containing protein 0.0028 0.0022 0.0032
Echinococcus multilocularis muscleblind protein 0.0158 0.0278 0.0277
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0089 0.0501
Brugia malayi hypothetical protein 0.0026 0.0017 0.0136
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0038 0.1936
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0041 0.2095
Schistosoma mansoni thyroid hormone receptor 0.0055 0.0074 0.042
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0023 0.0022
Echinococcus multilocularis zinc finger protein 0.0026 0.0017 0.0016
Leishmania major heat shock protein 83-1 0.0037 0.0038 0.1969
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0041 0.0104
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0026 0.0017 0.009
Echinococcus multilocularis GPCR, family 2 0.0052 0.0069 0.0067
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0026 0.0017 0.0096
Leishmania major heat shock protein 83-1 0.0037 0.0038 0.1969
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0023 0.003
Echinococcus granulosus FTZ F1 alpha 0.0055 0.0074 0.0414
Leishmania major heat shock protein 83-1 0.0037 0.0038 0.1969
Onchocerca volvulus 0.0063 0.009 0.081
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0023 0.003
Loa Loa (eye worm) hypothetical protein 0.0116 0.0196 0.2139
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0423 0.0805 0.8996
Brugia malayi heat shock protein 90 0.0037 0.0038 0.0379
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0052 0.0069 0.0382
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0202 0.2211
Trypanosoma brucei heat shock protein, putative 0.0037 0.0038 0.1969
Leishmania major heat shock protein 83-1 0.0037 0.0038 0.1969
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0024 0.0052
Loa Loa (eye worm) hypothetical protein 0.0026 0.0017 0.013
Echinococcus multilocularis heat shock protein 90 0.0037 0.0038 0.0037
Loa Loa (eye worm) hypothetical protein 0.0029 0.0023 0.0199
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0038 0.0095
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0041 0.0104
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0023 0.0035
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0089 0.0501
Trichomonas vaginalis penicillin-binding protein, putative 0.0116 0.0196 0.0573
Toxoplasma gondii pantoate-beta-alanine ligase 0.2444 0.4813 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0004 0.0022
Brugia malayi nuclear hormone receptor family member nhr-6 0.0026 0.0017 0.0136
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0135 0.0234 0.1325
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0041 0.2095
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.0305 0.0304
Trichomonas vaginalis D-aminoacylase, putative 0.0116 0.0196 0.0573
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0007 0.002
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0042 0.0106
Trichomonas vaginalis conserved hypothetical protein 0.0478 0.0914 0.2752
Schistosoma mansoni ap endonuclease 0.0038 0.0042 0.0235
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0055 0.0074 0.0774
Loa Loa (eye worm) hypothetical protein 0.0026 0.0017 0.013
Onchocerca volvulus 0.0116 0.0196 0.1976
Schistosoma mansoni nuclear receptor 0.0026 0.0017 0.0096
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0081 0.0455
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0009 0.0008
Echinococcus multilocularis expressed conserved protein 0.0112 0.0187 0.0186
Mycobacterium leprae Probable lipase LipE 0.0116 0.0196 0.0361
Loa Loa (eye worm) hypothetical protein 0.0055 0.0074 0.0774
Echinococcus multilocularis heat shock protein 0.0037 0.0038 0.0037
Loa Loa (eye worm) beta-lactamase 0.0116 0.0196 0.2139
Toxoplasma gondii heat shock protein 90, putative 0.0037 0.0038 0.0066
Echinococcus granulosus beta LACTamase domain containing family member 0.0116 0.0196 0.1102
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0023 0.02
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0055 0.0074 0.042
Loa Loa (eye worm) hypothetical protein 0.0112 0.0188 0.2053
Echinococcus granulosus endoplasmin 0.0029 0.0024 0.0128
Brugia malayi TAR-binding protein 0.0076 0.0117 0.1267
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.0303 0.1709
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0021 0.0007 0.0334
Toxoplasma gondii exonuclease III APE 0.0038 0.0042 0.0073
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0041 0.0104
Toxoplasma gondii histone lysine methyltransferase SET1 0.0124 0.0211 0.0426
Brugia malayi tailless protein 0.0026 0.0017 0.0136
Brugia malayi ecdysone receptor 0.0026 0.0017 0.0136
Schistosoma mansoni hypothetical protein 0.0908 0.1766 1
Leishmania major heat shock protein 83-1 0.0037 0.0038 0.1969
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0038 0.1606
Loa Loa (eye worm) CXXC zinc finger family protein 0.0063 0.009 0.0954
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0021 0.0007 0.0334
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0055 0.0074 0.0774
Schistosoma mansoni cpg binding protein 0.0068 0.0102 0.0575
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0069 0.039
Plasmodium vivax endoplasmin, putative 0.0037 0.0038 0.1617

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2239 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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