Detailed information for compound 835559

Basic information

Technical information
  • TDR Targets ID: 835559
  • Name: N-cyclohexyl-2,6-dimethoxybenzamide
  • MW: 263.332 | Formula: C15H21NO3
  • H donors: 1 H acceptors: 1 LogP: 2.95 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1C(=O)NC1CCCCC1)OC
  • InChi: 1S/C15H21NO3/c1-18-12-9-6-10-13(19-2)14(12)15(17)16-11-7-4-3-5-8-11/h6,9-11H,3-5,7-8H2,1-2H3,(H,16,17)
  • InChiKey: BAFGRWRWSZBARG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-cyclohexyl-2,6-dimethoxy-benzamide
  • Oprea1_652780
  • BIM-0018855.P001
  • A1770/0074991
  • CBMicro_018796

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0426 0.201
Onchocerca volvulus 0.003 0.0148 0.0663
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.0104 0.0098
Plasmodium vivax SET domain protein, putative 0.0032 0.0161 0.7027
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.009 0.0592 0.0821
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0033 0.0214
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0033 0.0249
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0189 0.0812
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0026 0.0116 0.0155
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0153 0.1243
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.2025 1
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.012 0.0547
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0953 0.453
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0027 0.01
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0189 0.0812
Mycobacterium ulcerans beta-lactamase 0.0036 0.0189 0.0183
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0011 0.0006 0.0001
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.009 0.0592 0.0819
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.0116 0.0155
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0011 0.0006 0.0001
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0153 0.0995
Schistosoma mansoni nuclear receptor 0.0014 0.0033 0.0222
Brugia malayi ecdysone receptor 0.0014 0.0033 0.0214
Mycobacterium tuberculosis Probable thioesterase TesA 0.0022 0.009 0.0118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0153 0.0979
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.2095 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.0953 0.453
Schistosoma mansoni cpg binding protein 0.0032 0.016 0.1278
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0153 0.1243
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0976 0.716 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.2025 1
Schistosoma mansoni hypothetical protein 0.0174 0.1212 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0153 0.0979
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0153 0.0979
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0033 0.0249
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0029 0.0139 0.0559
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.0116 0.0154
Loa Loa (eye worm) hypothetical protein 0.0031 0.0153 0.0979
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0029 0.0139 0.0559
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0015 0.0037 0.0031
Mycobacterium tuberculosis Putative ferredoxin reductase 0.009 0.0592 0.0821
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0153 0.0995
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0196
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0014 0.0027 0.02
Plasmodium falciparum glutathione reductase 0.0039 0.0218 1
Giardia lamblia Myb 1-like protein 0.0029 0.014 0.0564
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0022 0.009 0.0117
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0189 0.0183
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0027 0.01
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0196
Loa Loa (eye worm) hypothetical protein 0.0016 0.0046 0.028
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0153 0.0995
Brugia malayi beta-lactamase family protein 0.0036 0.0189 0.1229
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0011 0.0006 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.2025 1
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0153 0.0979
Loa Loa (eye worm) hypothetical protein 0.0155 0.1073 0.6967
Schistosoma mansoni zinc finger protein 0.0014 0.0033 0.0222
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0027 0.01
Brugia malayi ecdysteroid receptor 0.0031 0.0153 0.0995
Brugia malayi Cytochrome P450 family protein 0.002 0.0073 0.0471
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0189 0.0812
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0196
Loa Loa (eye worm) hypothetical protein 0.0036 0.0189 0.1214
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0046 0.0329
Brugia malayi nuclear receptor RXR 0.0014 0.0033 0.0214
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0189 0.1542
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0153 0.1218
Brugia malayi MH2 domain containing protein 0.0116 0.0787 0.5115
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0019 0.0066 0.006
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.012 0.0547
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0153 0.1243
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.1069 0.1486
Brugia malayi Pre-SET motif family protein 0.0032 0.0161 0.1047
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0019 0.0066 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0153 0.0995
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0426 0.2769
Loa Loa (eye worm) hypothetical protein 0.0031 0.0153 0.0979
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0033 0.0249
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0011 0.0006 0.0001
Brugia malayi Cytochrome P450 family protein 0.003 0.0151 0.098
Brugia malayi beta-lactamase 0.0036 0.0189 0.1229
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0189 0.0257
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0189 0.0257
Loa Loa (eye worm) beta-lactamase 0.0036 0.0189 0.1214
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0153 0.1243
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0196
Brugia malayi nuclear hormone receptor 0.0031 0.0153 0.0995
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0014 0.0027 0.0021
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0019 0.0066 0.006
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0033 0.0249
Loa Loa (eye worm) hypothetical protein 0.0016 0.0046 0.028
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0104 0.0098
Onchocerca volvulus 0.0025 0.0109 0.0443
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0153 0.1218
Mycobacterium ulcerans polyketide synthase Pks13 0.0037 0.0201 0.0195
Brugia malayi Thioredoxin reductase 0.0039 0.0218 0.1416
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0355 0.1263
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0073 0.0454
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0046 0.028
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0024 0.0104 0.0138
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.0104 0.0138
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0033 0.0249
Loa Loa (eye worm) hypothetical protein 0.0016 0.0046 0.028
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0405 0.3306
Mycobacterium ulcerans hypothetical protein 0.0154 0.1069 0.1063
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0027 0.01
Onchocerca volvulus 0.0036 0.0189 0.0904
Leishmania major mitochondrial DNA polymerase beta 0.0293 0.2095 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0153 0.1243
Loa Loa (eye worm) hypothetical protein 0.0036 0.0189 0.1214
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0104 0.0098
Leishmania major hypothetical protein, conserved 0.0036 0.0189 0.0876
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.2025 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0011 0.0006 0.0001
Loa Loa (eye worm) CYP4Cod1 0.002 0.0073 0.0454
Brugia malayi steroid hormone receptor 0.0031 0.0153 0.0995
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0033 0.0214
Brugia malayi hypothetical protein 0.0016 0.0046 0.0297
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0153 0.1218
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0033 0.0214
Trichomonas vaginalis MYB3r3, putative 0.0029 0.0139 0.0559
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.012 0.0414
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0161 0.131
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0014 0.0027 0.0075
Treponema pallidum fructose-bisphosphate aldolase 0.0283 0.2025 0.2004
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0153 0.1218
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0033 0.0249
Schistosoma mansoni nuclear receptor 0.0014 0.0033 0.0222
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0046 0.0297
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0231 0.1075
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0033 0.0249
Mycobacterium ulcerans thioesterase TesA 0.0022 0.009 0.0083
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.0027 0.01
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.2025 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0153 0.0995
Brugia malayi beta-lactamase family protein 0.0036 0.0189 0.1229
Loa Loa (eye worm) hypothetical protein 0.0031 0.0153 0.0979
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0153 0.1243
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0014 0.0027 0.01
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0426 0.2757
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0033 0.0222
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0787 0.5106
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0218 1
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0153 0.1243
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.136 1 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.009 0.0592 0.0821
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0153 0.0995
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0013 0.0084
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0013 0.0025 0.0069
Brugia malayi hypothetical protein 0.0014 0.0033 0.0214
Brugia malayi hypothetical protein 0.0014 0.0033 0.0214
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0196
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0153 0.0695
Schistosoma mansoni hypothetical protein 0.0012 0.0013 0.0057
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.009 0.0592 0.0821
Mycobacterium tuberculosis Probable dehydrogenase 0.009 0.0592 0.0821
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0011 0.0006 0.0001
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0025 0.0109 0.0146
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0231 0.1075
Mycobacterium tuberculosis Conserved protein 0.0036 0.0189 0.0257
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0014 0.0027 0.01
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0027 0.01
Brugia malayi glutathione reductase 0.0039 0.0218 0.1416
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.012 0.4894
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0097
Loa Loa (eye worm) acyl carrier protein 0.0012 0.0016 0.0087
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0029 0.014 0.0564
Trichomonas vaginalis esterase, putative 0.0036 0.0189 0.0812
Brugia malayi nuclear receptor NHR-88 0.0031 0.0153 0.0995
Mycobacterium leprae Polyketide synthase Pks13 0.0037 0.0201 0.0273
Brugia malayi hypothetical protein 0.0017 0.0051 0.0334
Onchocerca volvulus 0.0036 0.0189 0.0904
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0033 0.0249
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0189 0.1229
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0153 0.1218
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0189 0.0876
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0153 0.1243
Brugia malayi hypothetical protein 0.0026 0.012 0.0782
Onchocerca volvulus 0.0036 0.0189 0.0904
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0024 0.0104 0.0137
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0011 0.0006 0.0001
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0014 0.0027 0.0021
Brugia malayi Cytochrome P450 family protein 0.002 0.0073 0.0471
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0153 0.1243
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0011 0.0006 0.0001
Leishmania major cytochrome p450-like protein 0.002 0.0073 0.0318
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0153 0.0979
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0046 0.0329
Loa Loa (eye worm) hypothetical protein 0.0032 0.0161 0.1031
Echinococcus multilocularis cpg binding protein 0.0032 0.016 0.1302
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0033 0.0222
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0383 0.2766 0.2761
Loa Loa (eye worm) glutathione reductase 0.0039 0.0218 0.1401
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.0951 0.0946
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.2095 1
Toxoplasma gondii type I fatty acid synthase, putative 0.0026 0.0116 0.0399
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.012 0.0547
Brugia malayi tailless protein 0.0014 0.0033 0.0214
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.0027 0.01
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0153 0.1218
Brugia malayi CXXC zinc finger family protein 0.003 0.0148 0.0959
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0033 0.0222
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0033 0.0249
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0426 0.201
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.0951 0.1321
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0153 0.0995
Onchocerca volvulus 0.0046 0.0268 0.1361
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0218 0.1014
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0189 0.0812
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.136 1 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0153 0.1243
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0046 0.0356
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0153 0.1243
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0033 0.0222
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0426 0.1523
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0153 0.1218
Plasmodium vivax glutathione reductase, putative 0.0039 0.0218 1
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0011 0.0006 0.0001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0027 0.01
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0002 0.0012
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0153 0.1218
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0196
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0153 0.1243
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0025 0.0109 0.0695
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0161 0.1285
Schistosoma mansoni coup transcription factor 0.0031 0.0153 0.1218
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0189 0.1518
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0189 0.0876
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0024 0.0104 0.0677
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.1539 1
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0015 0.0037 0.0045
Echinococcus granulosus thioredoxin glutathione reductase 0.004 0.0222 0.1812
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0231 0.1075
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.0116 0.0154
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0426 0.201
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0026 0.0116 0.0155
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0189 0.0257
Brugia malayi conserved hypotetical protein 0.0014 0.0033 0.0214
Mycobacterium ulcerans polyketide synthase 0.0026 0.0116 0.011
Loa Loa (eye worm) hypothetical protein 0.0016 0.0046 0.028
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0231 0.1075
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0153 0.0995
Brugia malayi nuclear hormone receptor 0.0014 0.0033 0.0214
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0153 0.0995
Loa Loa (eye worm) hypothetical protein 0.0036 0.0189 0.1214
Echinococcus granulosus geminin 0.0174 0.1212 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0189 0.0876
Brugia malayi hypothetical protein 0.0155 0.1073 0.6972
Trichomonas vaginalis MYB, putative 0.0029 0.014 0.0564
Onchocerca volvulus 0.0032 0.0161 0.0742
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0011 0.0006 0.0001
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0189 0.0257
Loa Loa (eye worm) fatty acid synthase 0.0026 0.012 0.0762
Brugia malayi cytochrome P450 0.0011 0.0006 0.004
Loa Loa (eye worm) cytochrome P450 0.0011 0.0006 0.0022
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0011 0.0006 0.0001
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0019 0.0068 0.0088
Loa Loa (eye worm) hypothetical protein 0.0036 0.0189 0.1214
Leishmania major trypanothione reductase 0.0039 0.0218 0.1014
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.0218 0.0297
Loa Loa (eye worm) hypothetical protein 0.0031 0.0153 0.0979
Mycobacterium tuberculosis Probable oxidoreductase 0.01 0.0667 0.0925
Loa Loa (eye worm) hypothetical protein 0.0031 0.0153 0.0979
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0189 0.0257
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0153 0.0995
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0383 0.2766 1
Onchocerca volvulus Fatty acid synthase homolog 0.0048 0.028 0.1432
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0196
Trypanosoma brucei cytochrome P450, putative 0.002 0.0073 0.0318
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0153 0.0979
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0073 0.0318
Giardia lamblia Fructose-bisphosphate aldolase 0.0283 0.2025 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0293 0.2095 1
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0011 0.0006 0.0001
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.1609 0.2242
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0153 0.0979
Toxoplasma gondii hypothetical protein 0.0047 0.0276 0.0977
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0161 0.0562
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0196
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0033 0.0222
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.2025 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0161 0.131
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0153 0.0995
Toxoplasma gondii type I fatty acid synthase, putative 0.0019 0.0066 0.0216
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0151 0.0964
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.2025 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0196
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0196
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.136 1 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0153 0.1243
Mycobacterium leprae Probable lipase LipE 0.0036 0.0189 0.0256
Trichomonas vaginalis C-MYB, putative 0.0029 0.0139 0.0559
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0148 0.1199
Brugia malayi hypothetical protein 0.0016 0.0046 0.0297
Trichomonas vaginalis pc-MYB2, putative 0.0029 0.0139 0.0559
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0011 0.0006 0.0001
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0024 0.0104 0.0138
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0189 0.1542
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0109 0.0711
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0189 0.1214
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0153 0.0979
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0073 0.0318
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0189 0.0256
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0015 0.0037 0.0044
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0116 0.011
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0153 0.0995
Schistosoma mansoni cpg binding protein 0.003 0.0148 0.1173
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.2025 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0153 0.0979
Mycobacterium ulcerans polyketide synthase 0.0024 0.0104 0.0098
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0033 0.0249
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0011 0.0006 0.0001
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0014 0.0027 0.003
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0011 0.0006 0.0001
Mycobacterium tuberculosis Conserved protein 0.0036 0.0189 0.0257
Schistosoma mansoni hypothetical protein 0.0174 0.1212 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0189 0.1214
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0189 0.8496
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0297 0.1394
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0196
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0426 0.3501
Brugia malayi nuclear receptor NHR-88 0.0014 0.0033 0.0214
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0024 0.0104 0.0137
Toxoplasma gondii ABC1 family protein 0.0036 0.0189 0.0663
Mycobacterium ulcerans thioesterase 0.0022 0.009 0.0083
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0153 0.1243
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0011 0.0006 0.0001
Brugia malayi Cytochrome P450 family protein 0.0011 0.0006 0.004
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0029 0.0139 0.0559
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0011 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.0036 0.0189 0.1214
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0153 0.1218
Echinococcus multilocularis geminin 0.0174 0.1212 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0189 0.0257
Onchocerca volvulus 0.0031 0.0153 0.0695
Toxoplasma gondii NADPH-glutathione reductase 0.0014 0.0027 0.0075
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0029 0.0139 0.0559
Trichomonas vaginalis set domain proteins, putative 0.0248 0.1761 0.8676
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0153 0.1243
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0011 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.0026 0.012 0.0766
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0153 0.0995
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.002 0.0073 0.0066
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0383 0.2766 0.3858
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0048 0.028 0.1821
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0153 0.0695
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0014 0.0027 0.0175
Loa Loa (eye worm) hypothetical protein 0.0031 0.0153 0.0979
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0426 0.201
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0033 0.0196
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0161 0.1285
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0196
Trichomonas vaginalis pc-MYB2, putative 0.0029 0.0139 0.0559
Loa Loa (eye worm) hypothetical protein 0.0016 0.0046 0.028
Echinococcus multilocularis thioredoxin glutathione reductase 0.004 0.0222 0.1812
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0153 0.1243
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0787 0.5106
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0189 0.1518
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0014 0.0027 0.0172
Trichomonas vaginalis C-MYB, putative 0.0029 0.0139 0.0559
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0033 0.0214
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.01 0.0667 0.0925
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0153 0.0995
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0033 0.0249
Onchocerca volvulus 0.0248 0.1761 1
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0116 0.0155
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0161 0.131
Mycobacterium ulcerans polyketide synthase Pks9 0.0015 0.0037 0.0031
Echinococcus multilocularis 0.0011 0.0006 0.0028
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.012 0.4894
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0033 0.0196
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0218 0.1401
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0153 0.1243
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0161 0.1285
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0033 0.0196
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0189 0.0257
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0153 0.1218
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0037 0.0201 0.0274
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.2025 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0148 0.0943
Brugia malayi nuclear receptor NHR-67 0.0014 0.0033 0.0214
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0027 0.01
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0189 0.0183
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0116 0.011
Echinococcus granulosus cpg binding protein 0.0032 0.016 0.1302
Mycobacterium ulcerans lipase LipD 0.0036 0.0189 0.0183
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.01 0.0667 0.0925
Loa Loa (eye worm) hypothetical protein 0.0031 0.0153 0.0979
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0046 0.0297
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0196
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0011 0.0006 0.0001
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0383 0.2766 0.2746
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.2025 1
Mycobacterium tuberculosis Probable reductase 0.009 0.0592 0.0821
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.0116 0.0154
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0029 0.014 0.0564
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0013 0.0084
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0153 0.1243
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0037 0.0201 0.0274
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0215 0.1758
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0046 0.0356
Schistosoma mansoni cpg binding protein 0.0032 0.016 0.1278
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0027 0.01
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0014 0.0027 0.02
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0153 0.0995
Onchocerca volvulus 0.0155 0.1073 0.6018
Trypanosoma brucei trypanothione reductase 0.0039 0.0218 0.1014
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0104 0.0098
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0014 0.0027 0.01
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0029 0.014 0.0484
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0953 0.453
Mycobacterium tuberculosis Conserved protein 0.0036 0.0189 0.0257
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0153 0.0695
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0011 0.0006 0.0001
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0426 0.3483
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0017 0.0053 0.0171
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0029 0.0139 0.0559
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0161 0.1285
Leishmania major hypothetical protein, conserved 0.0026 0.012 0.0547
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0014 0.0027 0.0021
Loa Loa (eye worm) hypothetical protein 0.0042 0.0238 0.1531
Mycobacterium ulcerans hypothetical protein 0.0036 0.0189 0.0183
Trypanosoma cruzi trypanothione reductase, putative 0.0014 0.0027 0.01
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0153 0.1218
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0029 0.0139 0.0559
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0006 0.0028
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.01 0.0667 0.0923
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0019 0.0067 0.0086
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.012 0.4894
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0027 0.01
Brugia malayi Pre-SET motif family protein 0.0218 0.1539 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0189 0.0812
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0014 0.0027 0.01
Brugia malayi nuclear receptor RXR 0.0016 0.0046 0.0297
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0033 0.0249
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0027 0.01
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0073 0.0454
Toxoplasma gondii thioredoxin reductase 0.0039 0.0218 0.0767
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0153 0.0995
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0976 0.716 1
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0153 0.1218
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0033 0.0214
Loa Loa (eye worm) DR-78 0.0014 0.0033 0.0196
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0426 0.3501
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0033 0.0214
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.0951 0.1323
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.0116 0.0155
Plasmodium falciparum thioredoxin reductase 0.0039 0.0218 1
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0215 0.1758
Trichomonas vaginalis MYB72, putative 0.0029 0.0139 0.0559

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.