Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0415 | 1 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0317 | 0.7067 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0415 | 1 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0317 | 0.7067 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0317 | 0.7067 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0317 | 0.7067 | 1 |
Brugia malayi | glutathione reductase | 0.0317 | 0.7067 | 0.7067 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.011 | 0.0872 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.011 | 0.0872 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0415 | 1 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.011 | 0.0872 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0317 | 0.7067 | 0.6787 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0317 | 0.7067 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0317 | 0.7067 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.011 | 0.0872 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0317 | 0.7067 | 0.6787 |
Trichomonas vaginalis | mercuric reductase, putative | 0.011 | 0.0872 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.011 | 0.0872 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0415 | 1 | 1 |
Treponema pallidum | NADH oxidase | 0.011 | 0.0872 | 0.5 |
Loa Loa (eye worm) | glutathione reductase | 0.0317 | 0.7067 | 0.5168 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.011 | 0.0872 | 0.0872 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0317 | 0.7067 | 0.5168 |
Plasmodium falciparum | thioredoxin reductase | 0.0317 | 0.7067 | 1 |
Leishmania major | trypanothione reductase | 0.0317 | 0.7067 | 0.6787 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.011 | 0.0872 | 0.5 |
Trichomonas vaginalis | glutathione reductase, putative | 0.011 | 0.0872 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0317 | 0.7067 | 0.7067 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0317 | 0.7067 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.011 | 0.0872 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.011 | 0.0872 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.