Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | amine GPCR | 0.0053 | 0.0047 | 0.0047 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.098 | 0.4012 | 0.4012 |
Echinococcus granulosus | Protein patched homolog 1 | 0.098 | 0.4012 | 0.3984 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0053 | 0.0047 | 0.0047 |
Schistosoma mansoni | amine GPCR | 0.0053 | 0.0047 | 0.0047 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.098 | 0.4012 | 0.3984 |
Echinococcus multilocularis | family S10 non peptidase ue (S10 family) | 0.0058 | 0.007 | 0.0023 |
Schistosoma mansoni | peptide (FMRFamide/neurokinin-3)-like receptor | 0.0053 | 0.0047 | 0.0047 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0053 | 0.0047 | 0.0047 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.238 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.0338 | 0.0292 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.0326 | 0.028 |
Brugia malayi | CHE-14 protein | 0.098 | 0.4012 | 0.3984 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.016 | 0.0504 | 0.0459 |
Schistosoma mansoni | thyrotropin-releasing hormone receptor | 0.0053 | 0.0047 | 0.0047 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0053 | 0.0047 | 0.0047 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.0504 | 0.0459 |
Schistosoma mansoni | patched 1 | 0.098 | 0.4012 | 0.4012 |
Schistosoma mansoni | neuropeptide receptor | 0.0053 | 0.0047 | 0.0047 |
Schistosoma mansoni | growth hormone secretagogue receptor | 0.0053 | 0.0047 | 0.0047 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0047 | 0.0047 |
Schistosoma mansoni | neuropeptide receptor | 0.0053 | 0.0047 | 0.0047 |
Schistosoma mansoni | peptide (allatostatin)-like receptor | 0.0053 | 0.0047 | 0.0047 |
Schistosoma mansoni | biogenic amine receptor | 0.0053 | 0.0047 | 0.0047 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0047 | 0.0047 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0053 | 0.0047 | 0.0047 |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | 0.0053 | 0.0047 | 0.0047 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0053 | 0.0047 | 0.0047 |
Schistosoma mansoni | myosin xvIII | 0.0053 | 0.0047 | 0.0047 |
Schistosoma mansoni | peptide (allatostatin/somatostatin)-like receptor | 0.0053 | 0.0047 | 0.0047 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.098 | 0.4012 | 0.3984 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0053 | 0.0047 | 0.0047 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.0338 | 0.0292 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.238 | 1 | 1 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.238 | 1 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.238 | 1 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.238 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.238 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0097 | 0.005 |
Schistosoma mansoni | biogenic amine receptor | 0.0053 | 0.0047 | 0.0047 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0053 | 0.0047 | 0.0047 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0053 | 0.0047 | 0.0047 |
Schistosoma mansoni | amine GPCR | 0.0053 | 0.0047 | 0.0047 |
Mycobacterium leprae | probable zinc metalloprotease | 0.016 | 0.0504 | 0.5 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0053 | 0.0047 | 0.0047 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0047 | 0.0047 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0053 | 0.0047 | 0.0047 |
Schistosoma mansoni | neuropeptide f receptor 76f | 0.0053 | 0.0047 | 0.0047 |
Schistosoma mansoni | amine GPCR | 0.0053 | 0.0047 | 0.0047 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0053 | 0.0047 | 0.0047 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.0326 | 0.028 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1117 | 0.4597 | 1 |
Brugia malayi | Serine carboxypeptidase F41C3.5 precursor | 0.0064 | 0.0097 | 0.005 |
Onchocerca volvulus | 0.0079 | 0.016 | 1 | |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.016 | 0.0504 | 0.0459 |
Onchocerca volvulus | Uncharacterized serine carboxypeptidase homolog | 0.0064 | 0.0097 | 0.441 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0053 | 0.0047 | 0.0047 |
Brugia malayi | Peptidase family M13 containing protein | 0.016 | 0.0504 | 0.0459 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0081 | 0.0166 | 0.0166 |
Loa Loa (eye worm) | hypothetical protein | 0.098 | 0.4012 | 0.3984 |
Schistosoma mansoni | family S10 non-peptidase homologue (S10 family) | 0.0064 | 0.0097 | 0.0097 |
Schistosoma mansoni | opsin-like receptor | 0.0053 | 0.0047 | 0.0047 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0118 | 0.0326 | 0.028 |
Schistosoma mansoni | biogenic amine receptor | 0.0053 | 0.0047 | 0.0047 |
Schistosoma mansoni | adenoreceptor | 0.0053 | 0.0047 | 0.0047 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.098 | 0.4012 | 0.3984 |
Schistosoma mansoni | alpha-1 adrenergic receptor | 0.0053 | 0.0047 | 0.0047 |
Schistosoma mansoni | neuropeptide receptor | 0.0053 | 0.0047 | 0.0047 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.098 | 0.4012 | 0.3984 |
Echinococcus granulosus | family S10 non peptidase ue S10 family | 0.0058 | 0.007 | 0.0023 |
Schistosoma mansoni | histamine h1 receptor | 0.0053 | 0.0047 | 0.0047 |
Schistosoma mansoni | family S10 unassigned peptidase (S10 family) | 0.0064 | 0.0097 | 0.0097 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.016 | 0.0504 | 0.0504 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.0338 | 0.0292 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0053 | 0.0047 | 0.0047 |
Schistosoma mansoni | opsin-like receptor | 0.0053 | 0.0047 | 0.0047 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0081 | 0.0166 | 0.0166 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.0338 | 0.0292 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.0504 | 0.0459 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.1117 | 0.4597 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.0504 | 0.0459 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0081 | 0.0166 | 0.0166 |
Echinococcus multilocularis | protein dispatched 1 | 0.098 | 0.4012 | 0.3984 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0053 | 0.0047 | 0.0047 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0053 | 0.0047 | 0.0047 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.238 | 1 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0081 | 0.0166 | 0.0166 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.0338 | 0.0292 |
Schistosoma mansoni | neuropeptide receptor | 0.0053 | 0.0047 | 0.0047 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.0338 | 0.0292 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.016 | 0.0113 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.238 | 1 | 1 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0053 | 0.0047 | 0.0047 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0081 | 0.0166 | 0.0166 |
Schistosoma mansoni | histamine-responsive GPCR (AAF21638) | 0.0053 | 0.0047 | 0.0047 |
Echinococcus multilocularis | lysosomal protective protein | 0.0064 | 0.0097 | 0.005 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0118 | 0.0326 | 0.028 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0047 | 0.0047 |
Schistosoma mansoni | opsin-like receptor | 0.0053 | 0.0047 | 0.0047 |
Echinococcus multilocularis | protein patched | 0.098 | 0.4012 | 0.3984 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1117 | 0.4597 | 1 |
Schistosoma mansoni | amine GPCR | 0.0053 | 0.0047 | 0.0047 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.098 | 0.4012 | 0.3984 |
Toxoplasma gondii | peptidase family M13 protein | 0.016 | 0.0504 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1117 | 0.4597 | 1 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0053 | 0.0047 | 0.0047 |
Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | 0.0053 | 0.0047 | 0.0047 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.016 | 0.0504 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.238 | 1 | 1 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0053 | 0.0047 | 0.0047 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.0326 | 0.028 |
Echinococcus granulosus | lysosomal protective protein | 0.0064 | 0.0097 | 0.005 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.0326 | 0.028 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.016 | 0.0504 | 0.0459 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0053 | 0.0047 | 0.0047 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.