Detailed information for compound 835954

Basic information

Technical information
  • TDR Targets ID: 835954
  • Name: 4-diethoxyphosphoryl-N-[(4-fluorophenyl)methy l]-2-(3-nitrophenyl)-1,3-oxazol-5-amine
  • MW: 449.369 | Formula: C20H21FN3O6P
  • H donors: 1 H acceptors: 4 LogP: 4.47 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOP(=O)(c1nc(oc1NCc1ccc(cc1)F)c1cccc(c1)[N+](=O)[O-])OCC
  • InChi: 1S/C20H21FN3O6P/c1-3-28-31(27,29-4-2)20-19(22-13-14-8-10-16(21)11-9-14)30-18(23-20)15-6-5-7-17(12-15)24(25)26/h5-12,22H,3-4,13H2,1-2H3
  • InChiKey: KVTASHRTFBJAJB-UHFFFAOYSA-N  

Network

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Synonyms

  • 4-diethoxyphosphoryl-N-[(4-fluorophenyl)methyl]-2-(3-nitrophenyl)oxazol-5-amine
  • 4-diethoxyphosphoryl-N-[(4-fluorophenyl)methyl]-2-(3-nitrophenyl)-5-oxazolamine
  • [4-diethoxyphosphoryl-2-(3-nitrophenyl)oxazol-5-yl]-(4-fluorobenzyl)amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0067 0.0297 0.1094
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0297 0.6461
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0009 0.0007 0.0031
Giardia lamblia Myb 1-like protein 0.0048 0.02 0.0713
Echinococcus multilocularis Smad4 0.0017 0.0047 0.0101
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2015 1 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.0133 0.0126
Giardia lamblia DINP protein human, muc B family 0.0041 0.0165 0.0583
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0062 0.1878
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0067 0.0297 0.1038
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0009 0.0007 0.0016
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0013 0.0048
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0067 0.0297 0.0641
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0226 0.1086 0.1506
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.0007 0.0027
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0067 0.0297 0.1038
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0289 0.1068
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0011 0.004
Echinococcus multilocularis bloom syndrome protein 0.002 0.0062 0.0133
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0013 0.0054
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0067 0.0297 0.1038
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0289 0.1218
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0034 0.0133 0.0451
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0067 0.0297 0.1038
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0067 0.0297 0.6461
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0048 0.0199 0.6625
Echinococcus multilocularis expressed conserved protein 0.0107 0.0494 0.1068
Loa Loa (eye worm) hypothetical protein 0.006 0.026 0.096
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0013 0.0048
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0067 0.0297 0.0641
Echinococcus multilocularis dnaJ subfamily B 0.0413 0.2018 0.4359
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0067 0.0297 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0047 0.0173
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0297 1
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0067 0.0297 0.6461
Treponema pallidum NADH oxidase 0.0034 0.0133 0.0126
Echinococcus multilocularis sterol regulatory element binding protein 0.0049 0.0205 0.0443
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0067 0.0297 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0013 0.0048
Plasmodium falciparum thioredoxin reductase 0.0099 0.0455 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0249 0.1048
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0297 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0053 0.0195
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0007 0.0025
Trichomonas vaginalis MYB72, putative 0.0048 0.0199 0.6625
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0148 0.0546
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0067 0.0297 0.6461
Plasmodium falciparum glutathione reductase 0.0034 0.0133 0.2803
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0067 0.0297 0.1038
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0133 0.2803
Echinococcus granulosus dna polymerase eta 0.0068 0.0299 0.1103
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0165 0.352
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0067 0.0297 1
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0062 0.0201
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0013 0.0054
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0013 0.0028
Echinococcus granulosus sterol regulatory element binding protein 0.0049 0.0205 0.0758
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0013 0.0048
Entamoeba histolytica recQ family DNA helicase 0.001 0.0013 0.0104
Giardia lamblia Hypothetical protein 0.0067 0.0297 0.107
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0067 0.0297 0.6461
Leishmania major cAMP-specific phosphodiesterase, putative 0.0067 0.0297 0.6461
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0034 0.0133 0.049
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0297 0.6461
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0048
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0025 0.0394
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0067 0.0297 1
Trichomonas vaginalis C-MYB, putative 0.0048 0.0199 0.6625
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0062 0.1213
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0937 0.463 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0552 0.271 0.5853
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0062 0.1213
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.0133 0.0126
Schistosoma mansoni hypothetical protein 0.0354 0.1728 0.6378
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0062 0.0228
Plasmodium falciparum phosphodiesterase delta, putative 0.0067 0.0297 0.6461
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0025 0.0394
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0013 0.0048
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0067 0.0297 0.1248
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0067 0.0297 0.1094
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0289 0.0625
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0009 0.0007 0.0016
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0047 0.0101
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0009 0.0007 0.0027
Echinococcus granulosus Niemann Pick C1 protein 0.0114 0.0529 0.1951
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0027
Echinococcus granulosus smad 0.0017 0.0047 0.0173
Schistosoma mansoni glutamate synthase 0.0009 0.0007 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0013 0.0054
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0067 0.0297 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0011 0.0013
Schistosoma mansoni hypothetical protein 0.0047 0.0197 0.0725
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0013 0.0054
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.0007 0.0027
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0067 0.0297 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0048
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0102 0.2113
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0033
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0013 0.0048
Leishmania major hypothetical protein, conserved 0.0067 0.0297 0.6461
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0297 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0067 0.0297 0.6461
Trichomonas vaginalis MYB, putative 0.0048 0.02 0.6664
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0226 0.1086 0.1506
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0009 0.0007 0.0027
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0067 0.0297 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0013 0.0048
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0013 0.0028
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0048 0.0199 0.6625
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0165 0.5448
Loa Loa (eye worm) hypothetical protein 0.0067 0.0297 0.1094
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0048 0.0199 0.3674
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0013 0.0054
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0048 0.0199 0.6625
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0165 0.352
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.0159 0.3386
Treponema pallidum ATP-dependent DNA helicase 0.001 0.0013 0.0005
Mycobacterium ulcerans hypothetical protein 0.0013 0.0025 0.0018
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0067 0.0297 0.1038
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0568 0.2792 0.2787
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0297 1
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0062 0.1878
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0034 0.0133 0.2803
Mycobacterium tuberculosis Probable reductase 0.0226 0.1086 0.1506
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0067 0.0297 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0053 0.0114
Loa Loa (eye worm) RecQ helicase 0.002 0.0062 0.0228
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0062 0.1213
Echinococcus granulosus geminin 0.0354 0.1728 0.6378
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0251 0.1212 0.1682
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0013 0.0028
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0062 0.026
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0236 0.0819
Schistosoma mansoni glutamate synthase 0.0009 0.0007 0.0027
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0099 0.0455 0.0625
Echinococcus granulosus Protein patched homolog 1 0.0049 0.0205 0.0758
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0067 0.0297 0.1094
Schistosoma mansoni DNA polymerase eta 0.0068 0.0299 0.1103
Schistosoma mansoni sulfide quinone reductase 0.0009 0.0007 0.0027
Trypanosoma cruzi trypanothione reductase, putative 0.0099 0.0455 1
Echinococcus granulosus cpg binding protein 0.0031 0.0115 0.0423
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0067 0.0297 0.1094
Brugia malayi ecdysteroid receptor 0.001 0.0013 0.0054
Brugia malayi MH1 domain containing protein 0.0009 0.0009 0.0038
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0165 0.352
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0165 0.0356
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0226 0.1086 0.1506
Echinococcus granulosus GPCR family 2 0.0018 0.0053 0.0195
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.0165 0.0609
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0133 0.2803
Trypanosoma brucei hypothetical protein, conserved 0.0067 0.0297 0.6461
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0048 0.0199 0.6625
Plasmodium falciparum thioredoxin reductase 0.0034 0.0133 0.2803
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0067 0.0297 0.1038
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0034 0.0133 0.0126
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0067 0.0297 0.1038
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0552 0.271 1
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0568 0.2792 0.2787
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0158 0.0666
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0067 0.0297 0.6461
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0067 0.0297 0.6461
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0013 0.0028
Giardia lamblia NADH oxidase lateral transfer candidate 0.0034 0.0133 0.0464
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0013 0.0122
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0249 0.1048
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0067 0.0297 1
Loa Loa (eye worm) MH2 domain-containing protein 0.025 0.1207 0.4452
Schistosoma mansoni hypothetical protein 0.0009 0.0007 0.0027
Brugia malayi TAR-binding protein 0.0066 0.0289 0.1218
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0013 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0297 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0034 0.0133 0.2803
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0067 0.0297 0.0641
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.0133 0.2803
Trichomonas vaginalis pc-MYB2, putative 0.0048 0.0199 0.6625
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0067 0.0297 0.6461
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0289 0.1068
Echinococcus multilocularis protein patched 0.0049 0.0205 0.0443
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0297 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0062 0.026
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0062 0.026
Brugia malayi glutamate synthase 0.0009 0.0007 0.0031
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0013 0.0028
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0165 0.5448
Plasmodium vivax phosphodiesterase gamma, putative 0.0067 0.0297 0.6461
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0013 0.0048
Schistosoma mansoni nuclear hormone receptor 0.001 0.0013 0.0048
Echinococcus multilocularis smad 0.0017 0.0047 0.0101
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0133 0.2803
Loa Loa (eye worm) hypothetical protein 0.0068 0.0299 0.1103
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0165 0.352
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.0165 0.0609
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0484 0.2376 0.8766
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0297 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0067 0.0297 0.1038
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0297 0.6461
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0165 0.022
Loa Loa (eye worm) hypothetical protein 0.0114 0.0529 0.1951
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0165 0.352
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0025 0.0394
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0025 0.0394
Schistosoma mansoni smad1 5 8 and 0.0017 0.0047 0.0173
Entamoeba histolytica recQ family helicase, putative 0.001 0.0011 0.0067
Brugia malayi MH1 domain containing protein 0.0017 0.0047 0.0197
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.0007 0.0016
Schistosoma mansoni hypothetical protein 0.0018 0.0053 0.0195
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0552 0.271 0.9706
Trichomonas vaginalis C-MYB, putative 0.0048 0.0199 0.6625
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0013 0.002
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0013 0.0048
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0067 0.0297 0.1038
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0034 0.0133 0.2803
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2015 1 1
Schistosoma mansoni smad1 5 8 and 0.0017 0.0047 0.0173
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0048 0.0199 0.3674
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0053 0.0223
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0067 0.0297 1
Brugia malayi glutathione reductase 0.0099 0.0455 0.1915
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0067 0.0297 0.1094
Schistosoma mansoni sulfide quinone reductase 0.0009 0.0007 0.0027
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0067 0.0297 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0062 0.0133
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0226 0.1086 0.1506
Brugia malayi polk-prov protein 0.0013 0.0025 0.0106
Schistosoma mansoni DNA polymerase IV / kappa 0.0013 0.0025 0.0093
Loa Loa (eye worm) hypothetical protein 0.0067 0.0297 0.1094
Echinococcus granulosus thioredoxin glutathione reductase 0.0099 0.0455 0.1679
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0034 0.0133 0.049
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0034 0.0133 0.0126
Schistosoma mansoni hypothetical protein 0.0018 0.0053 0.0195
Echinococcus multilocularis dna polymerase eta 0.0068 0.0299 0.0645
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0067 0.0297 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0047 0.0173
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0013 0.0048
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1447 0.717 1
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0048 0.02 0.0692
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0062 0.0228
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0165 0.352
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0009 0.0007 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0013 0.0054
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0013 0.0048
Echinococcus multilocularis GPCR, family 2 0.0018 0.0053 0.0114
Loa Loa (eye worm) hypothetical protein 0.0058 0.0249 0.0919
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0067 0.0297 0.1094
Schistosoma mansoni hypothetical protein 0.0354 0.1728 0.6378
Echinococcus granulosus FTZ F1 alpha 0.001 0.0013 0.0048
Brugia malayi ImpB/MucB/SamB family protein 0.0068 0.0299 0.1258
Schistosoma mansoni hypothetical protein 0.0039 0.0158 0.0584
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0067 0.0297 0.1094
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0067 0.0297 0.6461
Brugia malayi Thioredoxin reductase 0.0099 0.0455 0.1915
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0009 0.0007 0.0016
Entamoeba histolytica hypothetical protein 0.0037 0.0148 0.2696
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0034 0.0133 0.2803
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0165 0.0694
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0048 0.02 0.6664
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0289 0.1068
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0025 0.0394
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0067 0.0297 0.1094
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0165 0.352
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0067 0.0297 0.1094
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0165 0.0158
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0289 0.1068
Onchocerca volvulus 0.0009 0.0007 0.0699
Schistosoma mansoni hypothetical protein 0.0413 0.2018 0.7447
Trypanosoma brucei unspecified product 0.0028 0.0102 0.2113
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.0088 0.0369
Schistosoma mansoni coup transcription factor 0.001 0.0013 0.0048
Echinococcus granulosus Niemann Pick C1 protein 0.0163 0.0772 0.2849
Loa Loa (eye worm) hypothetical protein 0.0552 0.271 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0165 0.352
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0297 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0297 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0289 0.1068
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0062 0.0195
Brugia malayi MH2 domain containing protein 0.0017 0.0047 0.0197
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0013 0.0054
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0034 0.0133 0.0287
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0067 0.0297 0.6461
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0297 1
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0009 0.0007 0.0027
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0067 0.0297 0.1038
Entamoeba histolytica recQ family helicase, putative 0.002 0.0062 0.1041
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0226 0.1086 0.1506
Echinococcus granulosus expressed conserved protein 0.0107 0.0494 0.1825
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0165 0.0609
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0067 0.0297 0.0641
Trypanosoma brucei unspecified product 0.0041 0.0165 0.352
Loa Loa (eye worm) hypothetical protein 0.002 0.0062 0.0228
Schistosoma mansoni Smad4 0.0017 0.0047 0.0173
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0013 0.0025 0.0063
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0013 0.0048
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0251 0.1212 0.1682
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0297 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0067 0.0297 0.1038
Brugia malayi steroid hormone receptor 0.001 0.0013 0.0054
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0009 0.0007 0.0031
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0552 0.271 0.5853
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0067 0.0297 0.1248
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0484 0.2376 1
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0013 0.1212
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0013 0.0028
Leishmania major DNA polymerase eta, putative 0.004 0.0159 0.3386
Trichomonas vaginalis pc-MYB2, putative 0.0048 0.0199 0.6625
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0047 0.0173
Echinococcus multilocularis protein dispatched 1 0.0056 0.024 0.0518
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0297 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0552 0.271 1
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0048 0.0199 0.3674
Trypanosoma brucei trypanothione reductase 0.0099 0.0455 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0297 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0013 0.0048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0013 0.0048
Brugia malayi Smad1 0.0017 0.0047 0.0197
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0067 0.0297 0.6461
Brugia malayi CHE-14 protein 0.0049 0.0205 0.0864
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0297 1
Loa Loa (eye worm) glutathione reductase 0.0099 0.0455 0.1679
Echinococcus multilocularis glutamate synthase 0.0009 0.0007 0.0016
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0013 0.0054
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0006 0.0026
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0049 0.0205 0.0758
Brugia malayi MH1 domain containing protein 0.0009 0.0009 0.0038
Loa Loa (eye worm) PDE1B protein 0.0067 0.0297 0.1094
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0484 0.2376 0.8766
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0013 0.0048
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0568 0.2792 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0013 0.0028
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0067 0.0297 0.1248
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0067 0.0297 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0013 0.0048
Schistosoma mansoni disulfide oxidoreductase 0.0009 0.0007 0.0027
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0067 0.0297 0.1038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0013 0.0048
Schistosoma mansoni cpg binding protein 0.0029 0.0106 0.0393
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0205 0.6844
Leishmania major DNA polymerase kappa, putative 0.0041 0.0165 0.352
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0067 0.0297 0.1038
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0102 0.2113
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0067 0.0297 1
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0148 0.0546
Brugia malayi MH2 domain containing protein 0.025 0.1207 0.5079
Giardia lamblia hypothetical protein 0.0067 0.0297 0.107
Schistosoma mansoni glutamate synthase 0.0009 0.0007 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0013 0.0054
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0048 0.0199 0.6625
Leishmania major hypothetical protein, conserved 0.0067 0.0297 0.6461
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0067 0.0297 0.6461
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0067 0.0297 0.1094
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0048
Trypanosoma brucei DNA polymerase eta, putative 0.0068 0.0299 0.6512
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.0165 0.3021
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0297 1
Brugia malayi hypothetical protein 0.0037 0.0148 0.0623
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0165 0.352
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0067 0.0297 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0067 0.0297 0.6461
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0067 0.0297 0.0641
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0062 0.0133
Echinococcus granulosus bloom syndrome protein 0.002 0.0062 0.0228
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.0133 0.2803
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0025 0.0394
Schistosoma mansoni hypothetical protein 0.0018 0.0053 0.0195
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0013 0.0054
Leishmania major DNA polymerase eta, putative 0.0068 0.0299 0.6512
Trypanosoma cruzi DNA polymerase eta, putative 0.0068 0.0299 0.6512
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0034 0.0133 0.0126
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0297 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.0133 0.2803
Brugia malayi nuclear hormone receptor 0.001 0.0013 0.0054
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0067 0.0297 0.1038
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0133 0.2803
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0165 0.352
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.0133 0.2803
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0067 0.0297 0.1248
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.0165 0.022
Leishmania major trypanothione reductase 0.0099 0.0455 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0552 0.271 1
Echinococcus granulosus Smad4 0.0017 0.0047 0.0173
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0114 0.0529 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0053 0.0114
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0067 0.0297 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0034 0.0133 0.2803
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0102 0.2113
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0067 0.0297 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0025 0.0093
Plasmodium vivax thioredoxin reductase, putative 0.0099 0.0455 1
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0025 0.0394
Mycobacterium tuberculosis Probable oxidoreductase 0.0251 0.1212 0.1682
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0062 0.1878
Schistosoma mansoni cpg binding protein 0.0031 0.0115 0.0423
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0013 0.0054
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0067 0.0297 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0047 0.0101
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0067 0.0297 0.6461
Toxoplasma gondii thioredoxin reductase 0.0099 0.0455 0.1607
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.0133 0.2803
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0053 0.0195
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1447 0.717 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0268 0.099
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0067 0.0297 0.6461
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0133 0.2803
Echinococcus granulosus dna polymerase kappa 0.0041 0.0165 0.0609
Trypanosoma cruzi trypanothione reductase, putative 0.0034 0.0133 0.2803
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0067 0.0297 0.6461
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0013 0.0054
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0013 0.1212
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0165 0.352
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0067 0.0297 0.1094
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0067 0.0297 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.0165 0.352
Loa Loa (eye worm) hypothetical protein 0.0067 0.0297 0.1094
Schistosoma mansoni patched 1 0.0049 0.0205 0.0758
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0297 0.6461
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0048 0.0199 0.3674
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0067 0.0297 0.1094
Echinococcus granulosus glutamate synthase 0.0009 0.0007 0.0027
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0009 0.0007 0.0031
Trypanosoma brucei unspecified product 0.0028 0.0102 0.2113
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0289 0.1068
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0048
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0053 0.0195
Schistosoma mansoni thyroid hormone receptor 0.001 0.0013 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0013 0.0054
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0034 0.0133 0.0126
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0048 0.0199 0.6625
Echinococcus multilocularis Niemann Pick C1 protein 0.0114 0.0529 0.1142
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0067 0.0297 0.1248
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0048
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0148 0.032
Plasmodium vivax glutathione reductase, putative 0.0099 0.0455 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.0007 0.0016
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0034 0.0133 0.0559
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0013 0.0048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0013 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0013 0.0054
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0067 0.0297 0.0641
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0013 0.0028
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0013 0.0122
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0062 0.0195
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0067 0.0297 0.1094
Toxoplasma gondii NADPH-glutathione reductase 0.0034 0.0133 0.0451
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0013 0.0025 0.0063
Brugia malayi nuclear receptor NHR-88 0.001 0.0013 0.0054
Schistosoma mansoni cpg binding protein 0.0031 0.0115 0.0423
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0067 0.0297 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0053 0.0223
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0165 0.352
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0067 0.0297 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0067 0.0297 0.6461
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0048 0.0199 0.3674
Loa Loa (eye worm) Smad1 0.0017 0.0047 0.0173
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0165 0.352
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0297 1
Giardia lamblia DNA damage repair protein 0.0013 0.0025 0.0065
Brugia malayi CXXC zinc finger family protein 0.0029 0.0106 0.0448
Schistosoma mansoni smad 0.0017 0.0047 0.0173
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0165 0.352
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0009 0.0007 0.0027
Echinococcus multilocularis geminin 0.0354 0.1728 0.3733
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0034 0.0133 0.2803
Echinococcus granulosus dnaJ subfamily B 0.0413 0.2018 0.7447
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0034 0.0133 0.2803
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0034 0.0133 0.2803
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0067 0.0297 0.1248
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.001 0.0011 0.0078
Brugia malayi MH1 domain containing protein 0.0017 0.0047 0.0197
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0067 0.0297 0.1094
Onchocerca volvulus 0.001 0.0013 0.1212
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0048
Plasmodium falciparum phosphodiesterase gamma, putative 0.0067 0.0297 0.6461
Echinococcus multilocularis Niemann Pick C1 protein 0.0163 0.0772 0.1667
Loa Loa (eye worm) programmed cell death 8 0.0009 0.0007 0.0027
Loa Loa (eye worm) hypothetical protein 0.0039 0.0158 0.0584
Plasmodium falciparum DNA repair protein REV1, putative 0.0013 0.0025 0.0394
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0025 0.0394
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0047 0.0173
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.0088 0.0369
Schistosoma mansoni hypothetical protein 0.0018 0.0053 0.0195
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0007 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0297 0.6461
Loa Loa (eye worm) RNA binding protein 0.0066 0.0289 0.1068
Schistosoma mansoni hypothetical protein 0.0047 0.0197 0.0725
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0297 1
Entamoeba histolytica hypothetical protein 0.0037 0.0148 0.2696
Loa Loa (eye worm) transcription factor SMAD2 0.025 0.1207 0.4452
Trichomonas vaginalis mercuric reductase, putative 0.0034 0.0133 0.4339
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0106 0.0393
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0013 0.0048
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0013 0.0054
Loa Loa (eye worm) hypothetical protein 0.0049 0.0205 0.0758
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0062 0.1213
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0013 0.0028
Schistosoma mansoni DNA helicase recq1 0.002 0.0062 0.0228
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0025 0.0394
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.0165 0.0356
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0013 0.0048
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2015 1 1
Brugia malayi MH2 domain containing protein 0.0017 0.0047 0.0197
Mycobacterium tuberculosis Probable dehydrogenase 0.0226 0.1086 0.1506
Toxoplasma gondii ImpB/MucB/SamB family protein 0.004 0.0159 0.0544
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0165 0.352
Trypanosoma brucei chrX additional, unordered contigs 0.0013 0.0025 0.0394
Entamoeba histolytica hypothetical protein 0.0037 0.0148 0.2696
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0048
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0067 0.0297 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0013 0.0048
Leishmania major DNA polymerase kappa, putative 0.0013 0.0025 0.0394
Schistosoma mansoni hypothetical protein 0.0037 0.0148 0.0546
Leishmania major DNA damage repair protein, putative 0.0013 0.0025 0.0394
Schistosoma mansoni hypothetical protein 0.0047 0.0197 0.0725
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0289 0.1068
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0067 0.0297 0.6461
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0067 0.0297 0.1038
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0062 0.0228
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0251 0.1212 0.1682
Brugia malayi RNA binding protein 0.0066 0.0289 0.1218
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0048
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0013 0.0048
Plasmodium vivax DNA repair protein REV1, putative 0.0013 0.0025 0.0394
Trichomonas vaginalis MYB3r3, putative 0.0048 0.0199 0.6625
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.0133 0.2803
Onchocerca volvulus 0.0029 0.0106 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0013 0.0048
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0047 0.0173
Brugia malayi Niemann-Pick C1 protein precursor 0.0114 0.0529 0.2226
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0067 0.0297 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0053 0.0195
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0165 0.352
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0067 0.0297 0.1094
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0067 0.0297 0.1038
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0067 0.0297 0.6461
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0048
Echinococcus multilocularis thioredoxin glutathione reductase 0.0099 0.0455 0.0983
Loa Loa (eye worm) nuclear factor I 0.0009 0.0009 0.0033
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0067 0.0297 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0297 1
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0067 0.0297 0.6461
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0034 0.0133 0.0175
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0048
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0165 0.0158
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0552 0.271 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0067 0.0297 0.1094
Loa Loa (eye worm) thioredoxin reductase 0.0099 0.0455 0.1679
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0007 0.0015
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0484 0.2376 0.5131
Entamoeba histolytica hypothetical protein 0.0037 0.0148 0.2696
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0013 0.0122
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0062 0.1213
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0009 0.0007 0.0016
Schistosoma mansoni thyroid hormone receptor 0.001 0.0013 0.0048
Trichomonas vaginalis glutathione reductase, putative 0.0034 0.0133 0.4339
Schistosoma mansoni DNA helicase recq5 0.002 0.0062 0.0228
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0067 0.0297 0.6461
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0568 0.2792 0.3887
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0249 0.0919
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0297 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0133 0.2803
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0067 0.0297 0.1094
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0297 0.6461
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0025 0.0394
Schistosoma mansoni hypothetical protein 0.0047 0.0197 0.0725
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.0165 0.0609
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0165 0.352
Echinococcus multilocularis cpg binding protein 0.0031 0.0115 0.0248
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0013 0.0048
Schistosoma mansoni smad1 5 8 and 0.0017 0.0047 0.0173
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0067 0.0297 0.6461
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0297 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0013 0.0048
Echinococcus granulosus tar DNA binding protein 0.0066 0.0289 0.1068
Plasmodium falciparum glutathione reductase 0.0099 0.0455 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0067 0.0297 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0048 0.02 0.6664
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0116 0.0538 0.1984
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0013 0.1212

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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