Detailed information for compound 836058

Basic information

Technical information
  • TDR Targets ID: 836058
  • Name: 6-[(4-fluorophenoxy)methyl]-3-(3,4,5-trimetho xyphenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadi azole
  • MW: 416.426 | Formula: C19H17FN4O4S
  • H donors: 0 H acceptors: 3 LogP: 3.44 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(cc(c1OC)OC)c1nnc2n1nc(s2)COc1ccc(cc1)F
  • InChi: 1S/C19H17FN4O4S/c1-25-14-8-11(9-15(26-2)17(14)27-3)18-21-22-19-24(18)23-16(29-19)10-28-13-6-4-12(20)5-7-13/h4-9H,10H2,1-3H3
  • InChiKey: PHXPKIKVGPFNHZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • AO-365/43113511
  • BAS 10123700
  • ZINC02231482
  • STOCK5S-42682

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cpg binding protein 0.0031 0.0289 0.0331
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0532 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0327 0.0327
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0205 0.0205
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0576 1 1
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0067 0.0919 0.1052
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0541 0.062
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0532 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0152 0.2435 0.2788
Giardia lamblia Fructose-bisphosphate aldolase 0.0576 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0041
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0055 0.0063
Echinococcus multilocularis para nitrobenzyl esterase 0.0085 0.1253 0.1434
Loa Loa (eye worm) hypothetical protein 0.0067 0.0919 0.1052
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0063
Brugia malayi acetyltransferase, GNAT family protein 0.0152 0.2435 0.2788
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0085 0.1253 0.1253
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0085 0.1253 0.1434
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0368 0.0368
Loa Loa (eye worm) hypothetical protein 0.0085 0.1253 0.1434
Loa Loa (eye worm) hypothetical protein 0.0049 0.0608 0.0696
Loa Loa (eye worm) hypothetical protein 0.0085 0.1253 0.1434
Schistosoma mansoni BC026374 protein (S09 family) 0.0085 0.1253 0.1434
Echinococcus granulosus inhibitor of apoptosis protein 0.0053 0.0684 0.0783
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0036 0.0041
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0541 0.062
Schistosoma mansoni P2X receptor subunit 0.0066 0.0901 0.1031
Schistosoma mansoni hypothetical protein 0.0021 0.011 0.0126
Onchocerca volvulus 0.0053 0.0684 0.4459
Echinococcus granulosus p2X purinoceptor 4 0.0066 0.0901 0.1031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0085 0.1253 0.1434
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0017 0.0036 0.0041
Loa Loa (eye worm) hypothetical protein 0.0505 0.8735 1
Onchocerca volvulus 0.0085 0.1253 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0145 0.2317 0.2653
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0532 0.0146
Schistosoma mansoni zinc finger protein 0.0025 0.0184 0.0211
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0327 0.0327
Loa Loa (eye worm) hypothetical protein 0.0073 0.1029 0.1179
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0173 0.0198
Loa Loa (eye worm) hypothetical protein 0.0085 0.1253 0.1434
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0576 1 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0064 0.1204
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0153 0.2457 0.2813
Onchocerca volvulus 0.0085 0.1253 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0532 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0205 0.0205
Brugia malayi Carboxylesterase family protein 0.0505 0.8735 1
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0053 0.0684 0.0783
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0505 0.8735 1
Echinococcus granulosus p2X purinoceptor 4 0.0066 0.0901 0.1031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0163 0.0163
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0044 0.0051
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0017 0.0036 0.0041
Giardia lamblia GTOR 0.0045 0.0532 0.0088
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0017 0.0036 0.0041
Loa Loa (eye worm) hypothetical protein 0.0505 0.8735 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0173 0.0198
Echinococcus multilocularis BC026374 protein (S09 family) 0.0085 0.1253 0.1434
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0041
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0557 0.5109
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0541 0.062
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0226 0.0259
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0541 0.062
Schistosoma mansoni inhibitor of apoptosis protein 0.0053 0.0684 0.0783
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0017 0.0036 0.0036
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0017 0.0036 0.0041
Echinococcus multilocularis p2X purinoceptor 4 0.0066 0.0901 0.1031
Loa Loa (eye worm) hypothetical protein 0.0085 0.1253 0.1434
Trichomonas vaginalis spcc417.12 protein, putative 0.0085 0.1253 0.1253
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0017 0.0036 0.0041
Echinococcus multilocularis hyperpolarization activated cyclic 0.0246 0.4118 0.4715
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0053 0.0684 0.0783
Onchocerca volvulus Deterin homolog 0.0053 0.0684 0.4459
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0044 0.0051
Echinococcus multilocularis hypothetical protein 0.0143 0.2276 0.2606
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0053 0.0684 0.0783
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0055 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0368 0.0368
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0153 0.2457 0.2813
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0541 0.062
Echinococcus granulosus hyperpolarization activated cyclic 0.0246 0.4118 0.4715
Brugia malayi PHD-finger family protein 0.0031 0.0282 0.0323
Echinococcus granulosus cpg binding protein 0.0031 0.0289 0.0331
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0392 0.0448
Schistosoma mansoni hypothetical protein 0.0016 0.0012 0.0014
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0017 0.0036 0.0041
Brugia malayi Carboxylesterase family protein 0.0085 0.1253 0.1434
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0017 0.0036 0.0041
Brugia malayi Carboxylesterase family protein 0.0085 0.1253 0.1434
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0163 0.0163
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0541 0.062
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0017 0.0036 0.0041
Echinococcus multilocularis p2X purinoceptor 4 0.0066 0.0901 0.1031
Brugia malayi CXXC zinc finger family protein 0.0028 0.0226 0.0259
Echinococcus multilocularis tumor protein p63 0.0338 0.5754 0.6587
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0017 0.0036 0.0041
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0532 1
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0085 0.1253 0.1434
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0085 0.1253 0.1434
Echinococcus granulosus p2X purinoceptor 4 0.0066 0.0901 0.1031
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0391 0.0448
Loa Loa (eye worm) carboxylesterase 0.0505 0.8735 1
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0153 0.2457 0.2813
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0532 0.0532
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0557 0.0557
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0085 0.1253 0.1434
Trypanosoma cruzi ISWI complex protein 0.0016 0.0012 0.0229
Loa Loa (eye worm) bromodomain containing protein 0.0022 0.0121 0.0138
Loa Loa (eye worm) acetyltransferase 0.0152 0.2435 0.2788
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0532 0.0609
Schistosoma mansoni cpg binding protein 0.0028 0.0226 0.0259
Echinococcus multilocularis carboxylesterase 5A 0.0505 0.8735 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0576 1 1
Echinococcus granulosus acetylcholinesterase 0.0505 0.8735 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0173 0.0198
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0036 0.0041
Schistosoma mansoni hypothetical protein 0.0143 0.2276 0.2606
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0246 0.4118 0.4715
Loa Loa (eye worm) hypothetical protein 0.0049 0.0613 0.0702
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0576 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0164 0.0164
Brugia malayi Bromodomain containing protein 0.0082 0.1201 0.1375
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0017 0.0036 0.0041
Trypanosoma brucei ISWI complex protein 0.0016 0.0012 0.0229
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0921 0.1054
Onchocerca volvulus 0.0085 0.1253 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0152 0.2435 0.2788
Schistosoma mansoni gliotactin 0.0085 0.1253 0.1434
Trypanosoma cruzi ISWI complex protein 0.0016 0.0012 0.0229
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0017 0.0036 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.021 0.021
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0532 0.0146
Brugia malayi Carboxylesterase family protein 0.0085 0.1253 0.1434
Echinococcus multilocularis p2X purinoceptor 4 0.0066 0.0901 0.1031
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0067 0.0919 0.1052
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0044 0.0051
Echinococcus granulosus hyperpolarization activated cyclic 0.0246 0.4118 0.4715
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0153 0.2457 0.2813
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0017 0.0036 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0532 0.0532
Onchocerca volvulus 0.0085 0.1253 1
Schistosoma mansoni hypothetical protein 0.0037 0.0392 0.0448
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0449 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0036 0.0041
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0541 0.062
Brugia malayi hypothetical protein 0.0085 0.1253 0.1434
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0369 0.6934
Schistosoma mansoni bromodomain containing protein 0.007 0.0986 0.1129
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0392 0.0448
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0164 0.0164
Schistosoma mansoni P2X receptor subunit 0.0066 0.0901 0.1031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0327 0.0327
Loa Loa (eye worm) acetylcholinesterase 1 0.0505 0.8735 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0532 0.0609
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0532 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0017 0.0036 0.0041
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0532 0.0609
Echinococcus granulosus Ion_trans_N domain containing protein 0.0143 0.2276 0.2606
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0449 0.0059
Echinococcus multilocularis zinc finger protein 0.0025 0.0184 0.0211
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0576 1 1
Echinococcus granulosus carboxylesterase 5A 0.0505 0.8735 1
Loa Loa (eye worm) carboxylesterase 0.0085 0.1253 0.1434
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0327 0.0327
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0576 1 1
Schistosoma mansoni acetylcholinesterase 0.0085 0.1253 0.1434
Loa Loa (eye worm) hypothetical protein 0.0085 0.1253 0.1434
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0164 0.0164
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0541 0.062
Schistosoma mansoni neuroligin 3 (S09 family) 0.0085 0.1253 0.1434
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0017 0.0036 0.0041
Loa Loa (eye worm) voltage-gated potassium channel 0.0145 0.2326 0.2663
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0053 0.0684 0.0783
Leishmania major hypothetical protein, conserved 0.0016 0.0012 0.0229
Echinococcus granulosus zinc finger protein 0.0025 0.0184 0.0211
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.011 0.0126
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0096 0.1442 0.1651
Echinococcus granulosus tumor protein p63 0.0338 0.5754 0.6587
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0415 0.0415
Echinococcus granulosus BC026374 protein S09 family 0.0085 0.1253 0.1434
Echinococcus multilocularis neuroligin 0.0085 0.1253 0.1434
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0557 0.5
Brugia malayi hypothetical protein 0.0037 0.0392 0.0448
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0777 1
Echinococcus multilocularis voltage gated potassium channel 0.0017 0.0036 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0368 0.0368
Echinococcus multilocularis hyperpolarization activated cyclic 0.0246 0.4118 0.4715
Loa Loa (eye worm) hypothetical protein 0.0053 0.0684 0.0783
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0368 0.0368
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0327 0.0327
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0017 0.0036 0.0041
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0281 0.4748 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0055 0.0063
Echinococcus multilocularis acetylcholinesterase 0.0505 0.8735 1
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0036 0.0041
Brugia malayi Cyclic-nucleotide gated cation channel 0.0017 0.0036 0.0041
Loa Loa (eye worm) hypothetical protein 0.0053 0.0684 0.0783
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0576 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.021 0.021
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0017 0.0036 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0532 0.0532
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0017 0.0036 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0327 0.0327
Schistosoma mansoni P2X receptor subunit 0.0066 0.0901 0.1031
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0557 0.0638
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0164 0.0164
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0036 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0269 0.0269
Echinococcus granulosus acetylcholinesterase 0.0505 0.8735 1
Schistosoma mansoni P2X receptor subunit 0.0066 0.0901 0.1031
Schistosoma mansoni hypothetical protein 0.0053 0.0684 0.0783
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0246 0.4118 0.4715
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0557 0.5109
Schistosoma mansoni zinc finger protein 0.0016 0.0012 0.0014
Brugia malayi Bromodomain containing protein 0.0043 0.05 0.0572
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0532 0.0609
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0921 0.1054
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0053 0.0684 0.0783
Loa Loa (eye worm) hypothetical protein 0.0067 0.0919 0.1052
Echinococcus multilocularis cpg binding protein 0.0031 0.0289 0.0331
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0532 0.0609
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0044 0.0051
Brugia malayi Carboxylesterase family protein 0.0085 0.1253 0.1434
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0576 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.021 0.021
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0103 0.1574 0.1574
Echinococcus multilocularis acetylcholinesterase 0.0505 0.8735 1
Schistosoma mansoni cpg binding protein 0.0031 0.0289 0.0331
Loa Loa (eye worm) carboxylesterase 0.0085 0.1253 0.1434
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0251 0.0251
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0541 0.062
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0576 1 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0281 0.4748 0.5
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0532 1
Brugia malayi Carboxylesterase family protein 0.0505 0.8735 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0055 0.0063
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0392 0.0448
Echinococcus granulosus neuroligin 0.0085 0.1253 0.1434
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0369 0.6934
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0391 0.0448
Treponema pallidum fructose-bisphosphate aldolase 0.0576 1 0.5
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0557 0.0557
Echinococcus granulosus potassium voltage gated channel subfamily KQT 0.0067 0.0919 0.1052
Loa Loa (eye worm) hypothetical protein 0.0039 0.0436 0.0499
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0368 0.0368
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0369 0.6934
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0327 0.0327
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0281 0.4748 1
Echinococcus multilocularis inhibitor of apoptosis protein 0.0053 0.0684 0.0783
Loa Loa (eye worm) hypothetical protein 0.0046 0.0544 0.0623
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0613 0.0702
Onchocerca volvulus 0.0085 0.1253 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.1253 0.1434
Echinococcus granulosus para nitrobenzyl esterase 0.0085 0.1253 0.1434
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0085 0.1253 0.1434
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0246 0.4118 0.4715
Onchocerca volvulus 0.0049 0.0613 0.3767
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0246 0.4118 0.4715
Echinococcus granulosus voltage gated potassium channel 0.0017 0.0036 0.0041
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.011 0.207
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0781 0.0894

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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