TDR Targets

Basic information

Technical information

TDR Targets ID: 836175
Name: 6-(2-bromophenyl)-3-pyridin-4-yl-[1,2,4]triaz olo[3,4-b][1,3,4]thiadiazole
MW: 358.216 | Formula: C14H8BrN5S
H donors: 0 H acceptors: 4 LogP: 3.21 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Brc1ccccc1c1sc2n(n1)c(nn2)c1ccncc1
InChi: 1S/C14H8BrN5S/c15-11-4-2-1-3-10(11)13-19-20-12(17-18-14(20)21-13)9-5-7-16-8-6-9/h1-8H
InChiKey: IFPYIAGPXCRWTL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

6-(2-bromophenyl)-3-(4-pyridyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
ZINC00641619
AO-365/40105659

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	ornithine decarboxylase, putative	0.021	0.2799	1
Echinococcus granulosus	geminin	0.0169	0.2194	0.2194
Echinococcus multilocularis	lipoxygenase domain containing protein	0.004	0.0269	0.0269
Echinococcus multilocularis	Niemann Pick C1 protein	0.0161	0.2073	0.2073
Trichomonas vaginalis	diaminopimelate decarboxylase, putative	0.021	0.2799	1
Loa Loa (eye worm)	tyrosinase 1	0.0298	0.4119	0.4119
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	0	0.5
Leishmania major	4-coumarate:coa ligase-like protein	0.0051	0.0427	0.1525
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0553	0.0553
Trichomonas vaginalis	pyridoxal-dependent decarboxylase, putative	0.021	0.2799	1
Loa Loa (eye worm)	ShTK domain-containing protein	0.0298	0.4119	0.4119
Plasmodium vivax	S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative	0.021	0.2799	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0411	0.0411
Mycobacterium ulcerans	acyl-CoA synthetase	0.0051	0.0427	0.0748
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0176	0.0176
Trypanosoma brucei	ornithine decarboxylase	0.021	0.2799	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0161	0.2073	0.2073
Leishmania major	4-coumarate:coa ligase-like protein	0.0051	0.0427	0.1525
Loa Loa (eye worm)	hypothetical protein	0.005	0.0411	0.0411
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0048	0.039	0.039
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0693	1	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0051	0.0427	0.0748
Plasmodium vivax	multidomain scavenger receptor, putative	0.004	0.0269	0.096
Plasmodium falciparum	LCCL domain-containing protein	0.004	0.0269	0.096
Schistosoma mansoni	loxhd1	0.004	0.0269	0.0269
Schistosoma mansoni	lipoxygenase	0.004	0.0269	0.0269
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0038	0.0235	0.5
Onchocerca volvulus		0.0298	0.4119	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0051	0.0427	0.0748
Echinococcus multilocularis	sterol regulatory element binding protein	0.0048	0.039	0.039
Mycobacterium leprae	PROBABLE DIAMINOPIMELATE DECARBOXYLASE LYSA (DAP DECARBOXYLASE)	0.0081	0.0876	1
Schistosoma mansoni	polycystin 1-related	0.004	0.0269	0.0269
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0693	1	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0427	0.0427
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0693	1	1
Brugia malayi	Hypothetical tyrosinase-like protein F21C3.2 in chromosome I	0.0298	0.4119	0.4119
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0051	0.0427	0.0858
Loa Loa (eye worm)	hypothetical protein	0.0113	0.1351	0.1351
Plasmodium falciparum	S-adenosylmethionine decarboxylase/ornithine decarboxylase	0.021	0.2799	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0693	1	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0051	0.0427	0.1525
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0051	0.0427	0.0748
Loa Loa (eye worm)	hypothetical protein	0.004	0.0269	0.0269
Echinococcus multilocularis	expressed conserved protein	0.0106	0.1249	0.1249
Brugia malayi	AMP-binding enzyme family protein	0.0051	0.0427	0.0427
Schistosoma mansoni	hypothetical protein	0.0047	0.0364	0.0364
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0176	0.0176
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0113	0.1351	0.4826
Brugia malayi	ShTK domain containing protein	0.0298	0.4119	0.4119
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0411	0.0411
Brugia malayi	AMP-binding enzyme family protein	0.0051	0.0427	0.0427
Echinococcus granulosus	Niemann Pick C1 protein	0.0113	0.1351	0.1351
Trichomonas vaginalis	diaminopimelate decarboxylase, putative	0.021	0.2799	1
Loa Loa (eye worm)	doublecortin family protein	0.004	0.0269	0.0269
Mycobacterium tuberculosis	Diaminopimelate decarboxylase LysA (DAP decarboxylase)	0.021	0.2799	1
Schistosoma mansoni	hypothetical protein	0.004	0.0269	0.0269
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0298	0.4119	0.4119
Echinococcus granulosus	expressed conserved protein	0.0106	0.1249	0.1249
Schistosoma mansoni	lipoxygenase	0.0055	0.0491	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0235	0.0235
Echinococcus granulosus	lipoxygenase domain containing protein	0.004	0.0269	0.0269
Schistosoma mansoni	hypothetical protein	0.0047	0.0364	0.0364
Trichomonas vaginalis	ornithine decarboxylase, putative	0.021	0.2799	1
Entamoeba histolytica	acyl-coA synthetase, putative	0.0051	0.0427	0.1525
Echinococcus granulosus	lipoxygenase domain containing protein	0.004	0.0269	0.0269
Mycobacterium ulcerans	diaminopimelate decarboxylase LysA	0.021	0.2799	1
Brugia malayi	Common central domain of tyrosinase family protein	0.0298	0.4119	0.4119
Echinococcus multilocularis	RUN	0.004	0.0269	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0298	0.4119	0.4119
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0051	0.0427	0.0748
Echinococcus multilocularis	geminin	0.0169	0.2194	0.2194
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0427	0.0427
Onchocerca volvulus		0.0298	0.4119	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0235	0.0235
Schistosoma mansoni	hypothetical protein	0.0169	0.2194	0.2194
Loa Loa (eye worm)	hypothetical protein	0.004	0.0269	0.0269
Echinococcus granulosus	Polycystic kidney disease protein	0.004	0.0269	0.0269
Onchocerca volvulus		0.0298	0.4119	1
Trichomonas vaginalis	ornithine decarboxylase, putative	0.0075	0.0787	0.281
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0235	0.0235
Loa Loa (eye worm)	ShTK domain-containing protein	0.0298	0.4119	0.4119
Onchocerca volvulus		0.004	0.0269	0.0652
Mycobacterium ulcerans	hypothetical protein	0.0051	0.0427	0.0748
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.039	0.1395
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0298	0.4119	0.4119
Mycobacterium ulcerans	acyl-CoA synthetase	0.0051	0.0427	0.0748
Brugia malayi	Doublecortin family protein	0.004	0.0269	0.0269
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0055	0.0491	0.0491
Brugia malayi	AMP-binding enzyme family protein	0.0051	0.0427	0.0427
Schistosoma mansoni	tyrosinase precursor	0.0298	0.4119	0.4119
Brugia malayi	hypothetical protein	0.004	0.0269	0.0269
Plasmodium falciparum	acyl-CoA synthetase	0.0038	0.0235	0.084
Onchocerca volvulus		0.0051	0.0427	0.1036
Brugia malayi	Pyridoxal-dependent decarboxylase, pyridoxal binding domain containing protein	0.021	0.2799	0.2799
Echinococcus multilocularis	protein dispatched 1	0.0055	0.0492	0.0492
Onchocerca volvulus		0.021	0.2799	0.6796
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0235	0.0235
Plasmodium vivax	acyl-CoA synthetase, putative	0.0038	0.0235	0.084
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0115	0.1377	0.1377
Giardia lamblia	Ornithine decarboxylase	0.021	0.2799	0.5
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0051	0.0427	0.1525
Trichomonas vaginalis	conserved hypothetical protein	0.0081	0.0876	0.3131
Schistosoma mansoni	hypothetical protein	0.0034	0.0176	0.0176
Brugia malayi	Niemann-Pick C1 protein precursor	0.0113	0.1351	0.1351
Schistosoma mansoni	tyrosinase precursor	0.0298	0.4119	0.4119
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0235	0.0235
Trypanosoma cruzi	cruzipain precursor, putative	0.0022	0	0.5
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0051	0.0427	0.0858
Onchocerca volvulus		0.0298	0.4119	1
Toxoplasma gondii	diaminopimelate decarboxylase	0.021	0.2799	1
Schistosoma mansoni	hypothetical protein	0.0169	0.2194	0.2194
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0427	0.0427
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0298	0.4119	0.4119
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0051	0.0427	0.1525
Echinococcus multilocularis	lipoxygenase domain containing protein	0.004	0.0269	0.0269
Schistosoma mansoni	patched 1	0.0048	0.039	0.039
Brugia malayi	CHE-14 protein	0.0048	0.039	0.039
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0051	0.0427	0.0748
Entamoeba histolytica	ornithine decarboxylase, putative	0.021	0.2799	1
Echinococcus multilocularis	protein patched	0.0048	0.039	0.039
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0038	0.0235	0.0119
Schistosoma mansoni	hypothetical protein	0.0047	0.0364	0.0364
Loa Loa (eye worm)	pyridoxal-dependent decarboxylase	0.021	0.2799	0.2799
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	0	0.5
Brugia malayi	hypothetical protein	0.004	0.0269	0.0269
Echinococcus granulosus	sterol regulatory element binding protein	0.0048	0.039	0.039
Loa Loa (eye worm)	hypothetical protein	0.0298	0.4119	0.4119
Schistosoma mansoni	rab6-interacting	0.004	0.0269	0.0269
Echinococcus granulosus	Protein patched homolog 1	0.0048	0.039	0.039
Schistosoma mansoni	rab6-interacting	0.004	0.0269	0.0269
Onchocerca volvulus		0.004	0.0269	0.0652
Echinococcus multilocularis	Polycystic kidney disease protein	0.004	0.0269	0.0269
Echinococcus granulosus	RUN	0.004	0.0269	0.0269
Echinococcus multilocularis	Niemann Pick C1 protein	0.0113	0.1351	0.1351
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	0	0.5
Schistosoma mansoni	hypothetical protein	0.0047	0.0364	0.0364
Loa Loa (eye worm)	hypothetical protein	0.0048	0.039	0.039
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0055	0.0491	0.0491
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0411	0.0411
Trichomonas vaginalis	ornithine decarboxylase, putative	0.021	0.2799	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 836175