Detailed information for compound 836398

Basic information

Technical information
  • TDR Targets ID: 836398
  • Name: N-butyl-N-ethyl-4H-chromeno[3,4-d][1,2]oxazol e-3-carboxamide
  • MW: 300.352 | Formula: C17H20N2O3
  • H donors: 0 H acceptors: 2 LogP: 2.99 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCN(C(=O)c1noc2c1COc1c2cccc1)CC
  • InChi: 1S/C17H20N2O3/c1-3-5-10-19(4-2)17(20)15-13-11-21-14-9-7-6-8-12(14)16(13)22-18-15/h6-9H,3-5,10-11H2,1-2H3
  • InChiKey: SSZIKQMUNCXESZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-butyl-N-ethyl-4H-chromeno[3,4-d]isoxazole-3-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni plexin 0.001 0.1488 0.1488
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.4291 0.4291
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.36 0.36
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.4291 0.5
Brugia malayi plexin A 0.002 0.693 0.693
Schistosoma mansoni lamin 0.0026 1 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.4291 0.5
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.4291 0.5
Onchocerca volvulus 0.0026 1 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.4291 0.5
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.4291 0.5
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.4291 0.4291
Onchocerca volvulus 0.0017 0.5272 0.5272
Loa Loa (eye worm) plexin A 0.002 0.693 0.693
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.4291 0.5
Brugia malayi Intermediate filament tail domain containing protein 0.0026 1 1
Echinococcus granulosus plexin a4 0.002 0.693 0.693
Loa Loa (eye worm) hypothetical protein 0.001 0.1488 0.1488
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.4291 0.5
Schistosoma mansoni intermediate filament proteins 0.0026 1 1
Echinococcus granulosus lamin dm0 0.0026 1 1
Brugia malayi Plexin repeat family protein 0.0017 0.5272 0.5272
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.2868 0.2868
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.4291 0.5
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.4291 0.5
Echinococcus multilocularis lamin dm0 0.0026 1 1
Onchocerca volvulus 0.0026 1 1
Brugia malayi isocitrate dehydrogenase 0.0015 0.4291 0.4291
Echinococcus multilocularis lamin 0.0026 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 1 1
Loa Loa (eye worm) intermediate filament protein 0.0026 1 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.2868 0.2868
Echinococcus granulosus intermediate filament protein 0.0026 1 1
Schistosoma mansoni lamin 0.0026 1 1
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.36 0.36
Loa Loa (eye worm) hypothetical protein 0.0012 0.2616 0.2616
Brugia malayi Isocitrate dehydrogenase 0.0015 0.4291 0.4291
Schistosoma mansoni hypothetical protein 0.001 0.1488 0.1488
Schistosoma mansoni plexin 0.0017 0.5272 0.5272
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.4291 0.4291
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.4291 0.4291
Loa Loa (eye worm) hypothetical protein 0.0017 0.5272 0.5272
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 1 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.4291 0.4291
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.4291 0.4291
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.4291 0.4291
Loa Loa (eye worm) hypothetical protein 0.0026 0.9748 0.9748
Echinococcus multilocularis plexin a4 0.002 0.693 0.693
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.4291 0.5
Loa Loa (eye worm) hypothetical protein 0.0013 0.2868 0.2868
Echinococcus granulosus lamin 0.0026 1 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.4291 0.4291
Echinococcus multilocularis musashi 0.0026 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.2616 0.2616

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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