Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tumor protein p53 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | tumor protein p63 | Get druggable targets OG5_140038 | All targets in OG5_140038 |
Echinococcus multilocularis | tumor protein p63 | Get druggable targets OG5_140038 | All targets in OG5_140038 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.3957 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0669 | 0.0734 | 0.0734 |
Brugia malayi | Carboxylesterase family protein | 0.3957 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.3957 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0669 | 0.0734 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.3957 | 1 | 1 |
Onchocerca volvulus | 0.0669 | 0.0734 | 0.5 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0669 | 0.0734 | 0.5 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0669 | 0.0734 | 0.0734 |
Onchocerca volvulus | 0.0669 | 0.0734 | 0.5 | |
Echinococcus granulosus | neuroligin | 0.0669 | 0.0734 | 0.0734 |
Onchocerca volvulus | 0.0669 | 0.0734 | 0.5 | |
Onchocerca volvulus | 0.0669 | 0.0734 | 0.5 | |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0669 | 0.0734 | 0.0734 |
Echinococcus multilocularis | carboxylesterase 5A | 0.3957 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0669 | 0.0734 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3957 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.3957 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.3957 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0669 | 0.0734 | 0.0734 |
Loa Loa (eye worm) | hypothetical protein | 0.3957 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.3957 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.3957 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0669 | 0.0734 | 0.5 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0669 | 0.0734 | 0.0734 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0669 | 0.0734 | 0.0734 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0669 | 0.0734 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.3957 | 1 | 1 |
Onchocerca volvulus | 0.0669 | 0.0734 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0669 | 0.0734 | 0.5 |
Echinococcus multilocularis | neuroligin | 0.0669 | 0.0734 | 0.0734 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 2.5119 um | PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.