TDR Targets

Basic information

Technical information

TDR Targets ID: 836488
Name: N-(3-diethylaminopropyl)-N,1-dimethyl-4H-thio chromeno[3,4-d]pyrazole-3-carboxamide
MW: 372.528 | Formula: C20H28N4OS
H donors: 0 H acceptors: 2 LogP: 2.9 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCN(CCCN(C(=O)c1nn(c2c1CSc1c2cccc1)C)C)CC
InChi: 1S/C20H28N4OS/c1-5-24(6-2)13-9-12-22(3)20(25)18-16-14-26-17-11-8-7-10-15(17)19(16)23(4)21-18/h7-8,10-11H,5-6,9,12-14H2,1-4H3
InChiKey: IINCSWHILVKFDG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0518	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0518	1	1
Brugia malayi	Cathepsin L-like precursor	0.0518	1	1
Brugia malayi	amidase	0.0439	0.8274	0.8249
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0518	1	1
Giardia lamblia	Hypothetical protein	0.0096	0.0782	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0518	1	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0096	0.0782	0.0782
Giardia lamblia	Cathepsin B precursor	0.0096	0.0782	0.5
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0782	0.0782
Onchocerca volvulus	Cathepsin L homolog	0.0096	0.0782	0.0782
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0267	0.4519	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0518	1	1
Schistosoma mansoni	fatty-acid amide hydrolase	0.0439	0.8274	0.8274
Brugia malayi	Papain family cysteine protease containing protein	0.0267	0.4519	0.4442
Entamoeba histolytica	cysteine proteinase 2	0.0267	0.4519	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0782	0.0782
Brugia malayi	Cathepsin L-like precursor	0.0347	0.6263	0.621
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0096	0.0782	0.0782
Onchocerca volvulus		0.0518	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0267	0.4519	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0347	0.6263	0.5946
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0096	0.0782	0.5
Plasmodium vivax	unspecified product	0.0267	0.4519	0.4054
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0096	0.0782	0.5
Echinococcus multilocularis	tumor protein p63	0.0408	0.7606	0.7572
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0518	1	1
Plasmodium vivax	unspecified product	0.0171	0.2433	0.1791
Onchocerca volvulus		0.0518	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0267	0.4519	0.4054
Onchocerca volvulus		0.0518	1	1
Giardia lamblia	Hypothetical protein	0.0096	0.0782	0.5
Onchocerca volvulus	Cathepsin L homolog	0.0518	1	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0518	1	1
Brugia malayi	cathepsin L-like cysteine proteinase	0.0096	0.0782	0.0652
Onchocerca volvulus		0.0518	1	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0096	0.0782	0.0782
Echinococcus multilocularis	cathepsin L cysteine protease	0.0518	1	1
Onchocerca volvulus		0.0518	1	1
Leishmania major	cathepsin L-like protease	0.0518	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0518	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0267	0.4519	0.4442
Onchocerca volvulus		0.0096	0.0782	0.0782
Loa Loa (eye worm)	cathepsin B	0.0096	0.0782	0.0782
Giardia lamblia	Cathepsin L precursor	0.0096	0.0782	0.5
Schistosoma mansoni	voltage-gated potassium channel	0.0066	0.0139	0.0139
Entamoeba histolytica	cysteine protease, putative	0.0267	0.4519	0.4054
Giardia lamblia	Cysteine protease	0.0096	0.0782	0.5
Giardia lamblia	Cathepsin L precursor	0.0096	0.0782	0.5
Schistosoma mansoni	cathepsin F (C01 family)	0.0518	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0518	1	1
Leishmania major	cathepsin L-like protease	0.0518	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0267	0.4519	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0518	1	1
Brugia malayi	cathepsin L-like precursor	0.0347	0.6263	0.621
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0267	0.4519	0.4519
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0096	0.0782	0.0782
Toxoplasma gondii	cathepsin CPL	0.0518	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0518	1	1
Leishmania major	cathepsin L-like protease	0.0518	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0096	0.0782	0.0782
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0439	0.8274	0.8249
Trypanosoma cruzi	cysteine protease, putative	0.0267	0.4519	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0782	0.0782
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0267	0.4519	0.4519
Giardia lamblia	Cathepsin L precursor	0.0096	0.0782	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0518	1	1
Giardia lamblia	Cathepsin L-like protease	0.0096	0.0782	0.5
Brugia malayi	cathepsin B-like cysteine proteinase	0.0096	0.0782	0.0652
Entamoeba histolytica	cysteine protease, putative	0.0267	0.4519	0.4054
Onchocerca volvulus		0.0347	0.6263	0.6263
Giardia lamblia	Cathepsin B precursor	0.0096	0.0782	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0518	1	1
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0782	0.0782
Echinococcus granulosus	cathepsin L cysteine protease	0.0267	0.4519	0.4442
Entamoeba histolytica	cysteine protease, putative	0.0267	0.4519	0.4054
Giardia lamblia	Cathepsin B precursor	0.0096	0.0782	0.5
Echinococcus granulosus	cathepsin l1	0.0518	1	1
Giardia lamblia	Cathepsin B precursor	0.0096	0.0782	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0518	1	1
Entamoeba histolytica	cysteine protease, putative	0.0267	0.4519	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0347	0.6263	0.6263
Entamoeba histolytica	cysteine proteinase, putative	0.0267	0.4519	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0096	0.0782	0.0782
Onchocerca volvulus		0.0518	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0518	1	1
Giardia lamblia	Cysteine protease	0.0096	0.0782	0.5
Brugia malayi	Papain family cysteine protease containing protein	0.0096	0.0782	0.0652
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0518	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0347	0.6263	0.5946
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0096	0.0782	0.0782
Echinococcus multilocularis	cathepsin L	0.0096	0.0782	0.0652
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0096	0.0782	0.0652
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0518	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0096	0.0782	0.0782
Loa Loa (eye worm)	hypothetical protein	0.0171	0.2433	0.2433
Leishmania major	cathepsin L-like protease	0.0518	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0267	0.4519	0.4054
Trypanosoma cruzi	cysteine proteinase, putative	0.0267	0.4519	0.4054
Plasmodium vivax	vivapain-2	0.0518	1	1
Brugia malayi	cathepsin L precursor	0.0096	0.0782	0.0652
Schistosoma mansoni	voltage-gated potassium channel	0.0249	0.4134	0.4134
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0518	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0518	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0518	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0096	0.0782	0.0652
Giardia lamblia	Cathepsin L-like protease	0.0096	0.0782	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0518	1	1
Echinococcus granulosus	cathepsin l1	0.0347	0.6263	0.621
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0096	0.0782	0.0782
Plasmodium vivax	vivapain-3	0.0267	0.4519	0.4054
Leishmania major	cysteine peptidase A (CPA)	0.0518	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0518	1	1
Schistosoma mansoni	cathepsin s	0.0171	0.2433	0.2433
Brugia malayi	Cathepsin L-like precursor	0.0518	1	1
Loa Loa (eye worm)	cysteine protease	0.0518	1	1
Giardia lamblia	Cathepsin B precursor	0.0096	0.0782	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.0518	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0096	0.0782	0.0782
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0518	1	1
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0439	0.8274	0.8249
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0518	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0518	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0518	1	1
Entamoeba histolytica	cysteine protease, putative	0.0267	0.4519	0.4054
Echinococcus multilocularis	cysteine protease	0.0518	1	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0228	0.3676	0.3587
Schistosoma mansoni	voltage-gated potassium channel	0.0066	0.0139	0.0139
Leishmania major	cathepsin L-like protease	0.0518	1	1
Loa Loa (eye worm)	hypothetical protein	0.0171	0.2433	0.2433
Brugia malayi	cathepsin F-like cysteine proteinase	0.0171	0.2433	0.2326
Trypanosoma cruzi	cysteine proteinase, putative	0.0267	0.4519	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0518	1	1
Entamoeba histolytica	cysteine protease, putative	0.0267	0.4519	0.4054
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0518	1	1
Echinococcus granulosus	tumor protein p63	0.0408	0.7606	0.7572
Schistosoma mansoni	cathepsin B (C01 family)	0.0096	0.0782	0.0782
Brugia malayi	Papain family cysteine protease containing protein	0.0096	0.0782	0.0652
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0518	1	1
Entamoeba histolytica	cysteine protease, putative	0.0267	0.4519	0.4054
Echinococcus granulosus	cathepsin b	0.0096	0.0782	0.0652
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0439	0.8274	0.8249
Giardia lamblia	Cathepsin L precursor	0.0096	0.0782	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.0518	1	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0096	0.0782	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.0267	0.4519	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0518	1	1
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0228	0.3676	0.3587
Onchocerca volvulus	Cathepsin L homolog	0.0518	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0518	1	1
Loa Loa (eye worm)	hypothetical protein	0.0518	1	1
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0096	0.0782	0.5
Loa Loa (eye worm)	hypothetical protein	0.0198	0.3018	0.3018
Trypanosoma cruzi	cysteine peptidase, putative	0.0518	1	1
Entamoeba histolytica	cysteine protease, putative	0.0267	0.4519	0.4054
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0096	0.0782	0.0782
Schistosoma mansoni	amidase	0.0439	0.8274	0.8274
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0782	0.0782
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0518	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0267	0.4519	0.4519
Giardia lamblia	Cathepsin L precursor	0.0096	0.0782	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0518	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0518	1	1
Echinococcus multilocularis	cathepsin L	0.0267	0.4519	0.4442
Giardia lamblia	Cysteine protease	0.0096	0.0782	0.5
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0213	0.3348	0.2784
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0518	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0518	1	1
Giardia lamblia	Cathepsin B precursor	0.0096	0.0782	0.5
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0096	0.0782	0.0652
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0518	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0518	1	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0518	1	1
Echinococcus granulosus	cathepsin b	0.0096	0.0782	0.0652
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0267	0.4519	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0347	0.6263	0.5946
Brugia malayi	Cathepsin L-like precursor	0.0171	0.2433	0.2326
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0518	1	1
Giardia lamblia	Cysteine protease	0.0096	0.0782	0.5
Mycobacterium ulcerans	carboxylesterase, LipT	0.0164	0.228	0.5
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0139	0.0139
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0096	0.0782	0.0782
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0518	1	1
Plasmodium vivax	vivapain-1	0.0267	0.4519	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0518	1	1
Leishmania major	cathepsin L-like protease	0.0518	1	1
Loa Loa (eye worm)	hypothetical protein	0.0347	0.6263	0.6263
Schistosoma mansoni	cathepsin S (C01 family)	0.0096	0.0782	0.0782
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0171	0.2433	0.2433
Giardia lamblia	Encystation-specific protease	0.0096	0.0782	0.5
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0096	0.0782	0.0782
Brugia malayi	Cathepsin L-like precursor	0.0347	0.6263	0.621
Entamoeba histolytica	cysteine proteinase 1, putative	0.0267	0.4519	0.4054
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0518	1	1
Entamoeba histolytica	cysteine protease, putative	0.0267	0.4519	0.4054
Echinococcus multilocularis	cathepsin b	0.0096	0.0782	0.0652
Loa Loa (eye worm)	fibroinase	0.0518	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0096	0.0782	0.0782
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0347	0.6263	0.5946
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0782	0.0782
Brugia malayi	Cathepsin L-like precursor	0.0518	1	1
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0096	0.0782	0.0782
Loa Loa (eye worm)	ctsf protein	0.0518	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0096	0.0782	0.0782
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0096	0.0782	0.0652
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0347	0.6263	0.621
Trypanosoma cruzi	cysteine peptidase, putative	0.0267	0.4519	0.4054
Echinococcus granulosus	cysteine protease	0.0267	0.4519	0.4442
Echinococcus granulosus	cathepsin L	0.0096	0.0782	0.0652
Echinococcus multilocularis	cysteine protease	0.0518	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0096	0.0782	0.0782
Echinococcus granulosus	cathepsin L	0.0267	0.4519	0.4442
Brugia malayi	cathepsin F-like cysteine proteinase	0.0096	0.0782	0.0652
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0518	1	1
Giardia lamblia	Cathepsin B precursor	0.0096	0.0782	0.5
Leishmania major	cathepsin L-like protease	0.0518	1	1
Brugia malayi	fibroinase precursor	0.0096	0.0782	0.0652
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0518	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0518	1	1
Schistosoma mansoni	voltage-gated potassium channel	0.0249	0.4134	0.4134
Giardia lamblia	Cathepsin L precursor	0.0096	0.0782	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0518	1	1
Echinococcus multilocularis	cathepsin b	0.0096	0.0782	0.0652
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0228	0.3676	0.3587
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0518	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0518	1	1
Entamoeba histolytica	cysteine protease, putative	0.0267	0.4519	0.4054
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0228	0.3676	0.3676
Trypanosoma cruzi	cruzipain precursor, putative	0.0518	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0347	0.6263	0.6263
Loa Loa (eye worm)	hypothetical protein	0.0439	0.8274	0.8274
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0267	0.4519	0.4054
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0518	1	1
Onchocerca volvulus	Cathepsin F homolog	0.0518	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0518	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0518	1	1
Entamoeba histolytica	cysteine protease, putative	0.0267	0.4519	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0267	0.4519	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0267	0.4519	0.4054
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0518	1	1
Entamoeba histolytica	cysteine protease, putative	0.0518	1	1
Schistosoma mansoni	cathepsin C	0.0096	0.0782	0.0782
Loa Loa (eye worm)	hypothetical protein	0.0347	0.6263	0.6263
Giardia lamblia	Cathepsin B precursor	0.0096	0.0782	0.5
Onchocerca volvulus		0.0518	1	1
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0439	0.8274	0.8249
Trypanosoma cruzi	cysteine peptidase, putative	0.0171	0.2433	0.1791
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0171	0.2433	0.2326
Leishmania major	cathepsin L-like protease	0.0518	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0171	0.2433	0.1791
Plasmodium vivax	vivapain-2	0.0518	1	1
Entamoeba histolytica	cysteine protease, putative	0.0267	0.4519	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0782	0.0782
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0164	0.228	0.5
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0213	0.3348	0.2784
Loa Loa (eye worm)	hypothetical protein	0.0171	0.2433	0.2433

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 836488