Detailed information for compound 836597

Basic information

Technical information
  • TDR Targets ID: 836597
  • Name: N-(4-methoxyphenyl)-3-pyrrol-1-ylpropanamide
  • MW: 244.289 | Formula: C14H16N2O2
  • H donors: 1 H acceptors: 1 LogP: 1.37 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)NC(=O)CCn1cccc1
  • InChi: 1S/C14H16N2O2/c1-18-13-6-4-12(5-7-13)15-14(17)8-11-16-9-2-3-10-16/h2-7,9-10H,8,11H2,1H3,(H,15,17)
  • InChiKey: WZXOVWAWCFKORW-UHFFFAOYSA-N  

Network

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Synonyms

  • N-(4-methoxyphenyl)-3-pyrrol-1-yl-propanamide
  • N-(4-methoxyphenyl)-3-(1-pyrrolyl)propanamide
  • N-(4-methoxyphenyl)-3-pyrrol-1-yl-propionamide
  • MLS000094076
  • N-(4-methoxyphenyl)-3-(1H-pyrrol-1-yl)propanamide
  • SMR000029691
  • ZINC00176599

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0279 0.0977
Onchocerca volvulus 0.0035 0.0129 1
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0154 0.0655
Loa Loa (eye worm) hypothetical protein 0.007 0.0301 0.1759
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0054 0.1023
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0009 0.0058
Schistosoma mansoni smad1 5 8 and 0.0018 0.0048 0.0204
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0044 0.0174 0.0741
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0009 0.0037
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0174 0.3642
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0174 0.3642
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0174 0.6914
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0102 0.2072
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0044 0.0174 0.0741
Brugia malayi MH1 domain containing protein 0.001 0.0009 0.0061
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0009 0.0037
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0174 0.6914
Brugia malayi ImpB/MucB/SamB family protein 0.0042 0.0166 0.1108
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0044 0.0174 0.0741
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.001 0.0008 0.0002
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0009 0.0025
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0585 0.2791 1
Schistosoma mansoni smad1 5 8 and 0.0018 0.0048 0.0204
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0044 0.0174 0.1163
Trypanosoma brucei trypanothione reductase 0.0104 0.0465 1
Leishmania major DNA polymerase kappa, putative 0.0042 0.0166 0.3461
Trichomonas vaginalis DNA helicase recq1, putative 0.0019 0.0054 0.1942
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0059 0.0247 1
Leishmania major hypothetical protein, conserved 0.0044 0.0174 0.3642
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0318 0.1497 0.8755
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0044 0.0174 0.6914
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0174 0.6914
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0009 0.0037
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0174 0.0601
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0036 0.0136 0.0128
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0174 0.6914
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0013 0.0025 0.0064
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0044 0.0174 0.1018
Plasmodium falciparum phosphodiesterase gamma, putative 0.0044 0.0174 0.3642
Plasmodium falciparum glutathione reductase 0.0104 0.0465 1
Echinococcus granulosus FTZ F1 alpha 0.001 0.0009 0.0037
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0174 0.3642
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0009 0.0051
Echinococcus multilocularis GPCR, family 2 0.0017 0.0046 0.0194
Loa Loa (eye worm) hypothetical protein 0.0044 0.0174 0.1018
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0059 0.0247 0.9943
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0036 0.0136 0.2814
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0166 0.0706
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0051
Echinococcus granulosus thioredoxin glutathione reductase 0.0104 0.0465 0.1979
Trichomonas vaginalis MYB3r3, putative 0.0059 0.0247 0.9943
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0174 0.3642
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.001 0.0008 0.0032
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0048 0.028
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.001 0.0008 0.0028
Loa Loa (eye worm) RNA binding protein 0.007 0.03 0.1755
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0044 0.0174 0.3642
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0044 0.0174 0.0741
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0166 0.3461
Treponema pallidum ATP-dependent DNA helicase 0.001 0.0009 0.0001
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0174 0.6914
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2077 1 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0054 0.1023
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0166 0.0158
Plasmodium vivax DNA repair protein REV1, putative 0.0013 0.0025 0.039
Brugia malayi MH1 domain containing protein 0.0018 0.0048 0.032
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.001 0.0008 0.0032
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0044 0.0174 0.6914
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0044 0.0174 0.6914
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0009 0.0058
Brugia malayi Smad1 0.0018 0.0048 0.032
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0044 0.0174 0.6914
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0046 0.0194
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0174 0.6914
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0238 0.111 0.1539
Schistosoma mansoni cpg binding protein 0.0035 0.0129 0.0549
Echinococcus granulosus Smad4 0.0018 0.0048 0.0204
Mycobacterium tuberculosis Probable oxidoreductase 0.0264 0.1238 0.1718
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0048 0.0204
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0264 0.1238 0.1718
Loa Loa (eye worm) thioredoxin reductase 0.0104 0.0465 0.2718
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0009 0.0037
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0044 0.0174 0.3642
Echinococcus granulosus smad 0.0018 0.0048 0.0204
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0003 0.0012
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0174 0.0601
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0009 0.0037
Echinococcus multilocularis tar DNA binding protein 0.007 0.03 0.1278
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0059 0.0249 1
Schistosoma mansoni thyroid hormone receptor 0.001 0.0009 0.0037
Giardia lamblia Myb 1-like protein 0.0059 0.0248 0.1415
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0166 0.3461
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0009 0.0037
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0009 0.0058
Entamoeba histolytica glutamate synthase beta subunit, putative 0.001 0.0008 0.0028
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0042 0.0166 0.097
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0174 0.0601
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0036 0.0136 0.0128
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0166 0.3461
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0059 0.0247 0.9943
Onchocerca volvulus 0.001 0.0008 0.059
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.001 0.0008 0.0032
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0036 0.0136 0.2814
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.016 0.3328
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0585 0.2791 0.2786
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0174 0.0601
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0009 0.0058
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0009 0.0037
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0013 0.0056
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0051
Entamoeba histolytica deoxycytidyl transferase, putative 0.0042 0.0166 0.6616
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0003 0.0012
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0009 0.0037
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0009 0.0037
Loa Loa (eye worm) hypothetical protein 0.0044 0.0174 0.1018
Loa Loa (eye worm) hypothetical protein 0.0019 0.0054 0.0318
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0009 0.0058
Brugia malayi steroid hormone receptor 0.001 0.0009 0.0058
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0042 0.0166 0.0706
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0044 0.0174 0.0741
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0044 0.0174 0.0741
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0174 0.6914
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0238 0.111 0.1539
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0318 0.1497 0.6375
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0054 0.0232
Schistosoma mansoni hypothetical protein 0.0494 0.2349 1
Loa Loa (eye worm) Smad1 0.0018 0.0048 0.028
Brugia malayi MH1 domain containing protein 0.001 0.0009 0.0061
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0009 0.0037
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0044 0.0174 0.1163
Echinococcus multilocularis Smad4 0.0018 0.0048 0.0204
Loa Loa (eye worm) hypothetical protein 0.0055 0.0228 0.1333
Giardia lamblia Hypothetical protein 0.0044 0.0174 0.0978
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0044 0.0174 0.3642
Giardia lamblia DNA damage repair protein 0.0013 0.0025 0.0101
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0009 0.0037
Plasmodium falciparum thioredoxin reductase 0.0104 0.0465 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0009 0.0037
Schistosoma mansoni sulfide quinone reductase 0.001 0.0008 0.0032
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.001 0.0008 0.0051
Brugia malayi MH2 domain containing protein 0.0018 0.0048 0.032
Brugia malayi MH1 domain containing protein 0.0018 0.0048 0.032
Leishmania major DNA polymerase eta, putative 0.0041 0.016 0.3328
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.001 0.0008 0.0032
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0044 0.0174 0.0741
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0013 0.0025 0.0064
Echinococcus multilocularis glutamate synthase 0.001 0.0008 0.0032
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0166 0.3461
Loa Loa (eye worm) TAR-binding protein 0.007 0.03 0.1755
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0054 0.1942
Echinococcus multilocularis cpg binding protein 0.0037 0.0138 0.059
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0059 0.0249 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0362 0.171 0.6117
Mycobacterium tuberculosis Conserved hypothetical protein 0.0042 0.0166 0.0221
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0104 0.0465 0.0639
Brugia malayi hypothetical protein 0.004 0.0154 0.1027
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0044 0.0174 0.6914
Trichomonas vaginalis pc-MYB2, putative 0.0059 0.0247 0.9943
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.001 0.0008 0.0032
Entamoeba histolytica thioredoxin reductase, putative 0.001 0.0008 0.0028
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0044 0.0174 0.1163
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0238 0.111 0.1539
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0009 0.0058
Trichomonas vaginalis pc-MYB2, putative 0.0059 0.0247 0.9943
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0174 0.0601
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0174 0.6914
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0054 0.1942
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0174 0.6914
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0136 0.2803
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0044 0.0174 0.6914
Schistosoma mansoni terminal deoxycytidyl transferase 0.0042 0.0166 0.0706
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0174 0.6914
Leishmania major hypothetical protein, conserved 0.0044 0.0174 0.3642
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0044 0.0174 0.3642
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0044 0.0174 0.0741
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0166 0.6569
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0036 0.0136 0.0578
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0362 0.171 0.7281
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0174 0.0601
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0136 0.2803
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0174 0.3651
Echinococcus granulosus dnaJ subfamily B 0.0494 0.2349 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0044 0.0174 0.6914
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0036 0.0136 0.0578
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0136 0.2803
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.001 0.0008 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0174 0.6914
Schistosoma mansoni DNA polymerase eta 0.007 0.0301 0.1281
Brugia malayi Bloom's syndrome protein homolog 0.0019 0.0054 0.0363
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0044 0.0174 0.3651
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0051
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0003 0.0012
Schistosoma mansoni cpg binding protein 0.0037 0.0138 0.059
Schistosoma mansoni cpg binding protein 0.0037 0.0138 0.059
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0238 0.111 0.1539
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0046 0.0194
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0166 0.0158
Echinococcus granulosus bloom syndrome protein 0.0019 0.0054 0.0232
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0059 0.0248 0.0867
Plasmodium falciparum phosphodiesterase delta, putative 0.0044 0.0174 0.3642
Echinococcus granulosus GPCR family 2 0.0017 0.0046 0.0194
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.001 0.0008 0.0051
Treponema pallidum NADH oxidase 0.0036 0.0136 0.0128
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0174 0.6914
Schistosoma mansoni tar DNA-binding protein 0.007 0.03 0.1278
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0009 0.0058
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0318 0.1497 0.6375
Schistosoma mansoni tar DNA-binding protein 0.007 0.03 0.1278
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0044 0.0174 0.1163
Entamoeba histolytica hypothetical protein 0.004 0.0154 0.6113
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0054 0.0232
Trichomonas vaginalis mercuric reductase, putative 0.0036 0.0136 0.5321
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0044 0.0174 0.0741
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0166 0.3461
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0166 0.3461
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0044 0.0174 0.3642
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0044 0.0174 0.0741
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0136 0.2803
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0044 0.0174 0.3642
Plasmodium vivax phosphodiesterase gamma, putative 0.0044 0.0174 0.3651
Brugia malayi RNA recognition motif domain containing protein 0.007 0.03 0.2005
Leishmania major DNA polymerase kappa, putative 0.0013 0.0025 0.0375
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0009 0.0058
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1491 0.717 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0166 0.3461
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0048 0.0204
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0166 0.3461
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0009 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0009 0.0051
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0174 0.6914
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0166 0.3461
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0046 0.0194
Echinococcus granulosus dna polymerase eta 0.007 0.0301 0.1281
Loa Loa (eye worm) PDE1B protein 0.0044 0.0174 0.1018
Schistosoma mansoni blooms syndrome DNA helicase 0.0009 0.0007 0.003
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0059 0.0247 0.9943
Schistosoma mansoni Smad4 0.0018 0.0048 0.0204
Mycobacterium tuberculosis Probable dehydrogenase 0.0238 0.111 0.1539
Schistosoma mansoni sulfide quinone reductase 0.001 0.0008 0.0032
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0051
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0036 0.0136 0.2803
Trypanosoma brucei hypothetical protein, conserved 0.0044 0.0174 0.3642
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0317 0.1349
Schistosoma mansoni hypothetical protein 0.0017 0.0046 0.0194
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0036 0.0136 0.2803
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0009 0.0039
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0009 0.0037
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.001 0.0008 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0025 0.0375
Plasmodium falciparum DNA repair protein REV1, putative 0.0013 0.0025 0.0375
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0009 0.0037
Schistosoma mansoni hypothetical protein 0.0373 0.1766 0.7519
Schistosoma mansoni hypothetical protein 0.0017 0.0046 0.0194
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0166 0.3461
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0009 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0009 0.0058
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0013 0.0077
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2077 1 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0054 0.0232
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0059 0.0247 0.9943
Brugia malayi nuclear hormone receptor 0.001 0.0009 0.0058
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.001 0.0008 0.0028
Brugia malayi polk-prov protein 0.0013 0.0025 0.0165
Leishmania major cAMP-specific phosphodiesterase, putative 0.0044 0.0174 0.3642
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0174 0.6914
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0174 0.3642
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.001 0.0008 0.0028
Schistosoma mansoni tar DNA-binding protein 0.007 0.03 0.1278
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0174 0.0601
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0009 0.0058
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0362 0.171 0.7281
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0044 0.0174 0.6914
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0051
Entamoeba histolytica glutamate synthase beta subunit, putative 0.001 0.0008 0.0028
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0059 0.0247 0.9943
Echinococcus granulosus geminin 0.0373 0.1766 0.7519
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0009 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0009 0.0058
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0044 0.0174 0.6914
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0362 0.171 0.7281
Plasmodium falciparum thioredoxin reductase 0.0036 0.0136 0.2803
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0174 0.0601
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0025 0.0375
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0042 0.0166 0.0706
Echinococcus multilocularis geminin 0.0373 0.1766 0.7519
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0228 0.1523
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0044 0.0174 0.6914
Echinococcus granulosus tar DNA binding protein 0.007 0.03 0.1278
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0166 0.3461
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0136 0.2803
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0044 0.0174 0.0741
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0174 0.6914
Plasmodium vivax glutathione reductase, putative 0.0104 0.0465 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.03 0.1755
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0048 0.0204
Mycobacterium tuberculosis Probable reductase 0.0238 0.111 0.1539
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0009 0.0037
Schistosoma mansoni hypothetical protein 0.0038 0.0144 0.0611
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0041 0.016 0.0549
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0044 0.0174 0.1163
Loa Loa (eye worm) programmed cell death 8 0.001 0.0008 0.0044
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0012 0.0083
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0048 0.0204
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.001 0.0008 0.0015
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0044 0.0174 0.0741
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0264 0.1238 0.1718
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0009 0.0037
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0054 0.1023
Entamoeba histolytica recQ family helicase, putative 0.0019 0.0054 0.1976
Loa Loa (eye worm) hypothetical protein 0.0362 0.171 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.001 0.0008 0.0032
Leishmania major trypanothione reductase 0.0104 0.0465 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0036 0.0136 0.0179
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.2349 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0228 0.1333
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0174 0.3642
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0044 0.0174 0.0741
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0025 0.0375
Schistosoma mansoni smad1 5 8 and 0.0018 0.0048 0.0204
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0009 0.0037
Loa Loa (eye worm) hypothetical protein 0.0044 0.0174 0.1018
Entamoeba histolytica hypothetical protein 0.004 0.0154 0.6113
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0009 0.0037
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0174 0.3642
Echinococcus granulosus cpg binding protein 0.0037 0.0138 0.059
Trichomonas vaginalis C-MYB, putative 0.0059 0.0247 0.9943
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0044 0.0174 0.6914
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0042 0.0166 0.0706
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0174 0.0601
Leishmania major DNA polymerase eta, putative 0.007 0.0301 0.6413
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0003 0.0012
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0054 0.1023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0009 0.0051
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0174 0.3642
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0046 0.0194
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0051
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.001 0.0008 0.0032
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0025 0.0375
Schistosoma mansoni hypothetical protein 0.0373 0.1766 0.7519
Brugia malayi ImpB/MucB/SamB family protein 0.007 0.0301 0.2009
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0174 0.6914
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0009 0.0679
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0054 0.0275
Brugia malayi Thioredoxin reductase 0.0104 0.0465 0.3105
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0027 0.0089 0.0598
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0044 0.0174 0.6914
Trypanosoma brucei chrX additional, unordered contigs 0.0013 0.0025 0.0375
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0051
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0264 0.1238 0.1718
Schistosoma mansoni tar DNA-binding protein 0.007 0.03 0.1278
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0174 0.6914
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.001 0.0008 0.0044
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0054 0.017
Loa Loa (eye worm) hypothetical protein 0.0017 0.0046 0.0267
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0044 0.0174 0.6914
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0025 0.0375
Trypanosoma brucei unspecified product 0.0029 0.0102 0.2072
Schistosoma mansoni hypothetical protein 0.0017 0.0046 0.0194
Brugia malayi TAR-binding protein 0.007 0.03 0.2005
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0174 0.0601
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.0136 0.2803
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0174 0.0601
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1491 0.717 1
Schistosoma mansoni thyroid hormone receptor 0.001 0.0009 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0166 0.3461
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0174 0.0601
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0102 0.2072
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0154 0.0655
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0044 0.0174 0.0741
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0044 0.0174 0.3642
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0048 0.0204
Schistosoma mansoni smad 0.0018 0.0048 0.0204
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0044 0.0174 0.1163
Onchocerca volvulus 0.001 0.0009 0.0679
Loa Loa (eye worm) hypothetical protein 0.0013 0.0025 0.0145
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0102 0.2072
Trypanosoma brucei DNA polymerase eta, putative 0.007 0.0301 0.6413
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.001 0.0008 0.0032
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0174 0.6914
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0036 0.0136 0.0128
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0136 0.2803
Trypanosoma cruzi DNA polymerase eta, putative 0.007 0.0301 0.6413
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0166 0.6569
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0136 0.0128
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0174 0.6914
Trichomonas vaginalis MYB72, putative 0.0059 0.0247 0.9943
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0054 0.0232
Loa Loa (eye worm) hypothetical protein 0.0038 0.0144 0.084
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.001 0.0008 0.0051
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0228 0.1523
Schistosoma mansoni hypothetical protein 0.001 0.0008 0.0032
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0585 0.2791 0.3887
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0009 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0174 0.3642
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0009 0.0058
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0174 0.6914
Loa Loa (eye worm) RecQ helicase 0.0019 0.0054 0.0318
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0044 0.0174 0.6914
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0036 0.0136 0.0463
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0044 0.0174 0.3642
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0054 0.0318
Brugia malayi MH2 domain containing protein 0.0263 0.1233 0.8234
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0044 0.0174 0.3642
Giardia lamblia NADH oxidase lateral transfer candidate 0.0036 0.0136 0.0753
Schistosoma mansoni glutamate synthase 0.001 0.0008 0.0032
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0059 0.0247 1
Schistosoma mansoni coup transcription factor 0.001 0.0009 0.0037
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0174 0.6914
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0166 0.3461
Toxoplasma gondii NADPH-glutathione reductase 0.0036 0.0136 0.0463
Echinococcus multilocularis dna polymerase eta 0.007 0.0301 0.1281
Entamoeba histolytica hypothetical protein 0.004 0.0154 0.6113
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0044 0.0174 0.0741
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0174 0.6914
Entamoeba histolytica disulphide oxidoreductase, putative 0.001 0.0008 0.0028
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0174 0.6914
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0136 0.2803
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0044 0.0174 0.6914
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0166 0.3461
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0174 0.0601
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0036 0.0136 0.0907
Loa Loa (eye worm) transcription factor SMAD2 0.0263 0.1233 0.7209
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0054 0.0363
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0009 0.0037
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0044 0.0174 0.3642
Echinococcus multilocularis smad 0.0018 0.0048 0.0204
Brugia malayi nuclear receptor NHR-88 0.001 0.0009 0.0058
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0009 0.0037
Schistosoma mansoni hypothetical protein 0.004 0.0154 0.0655
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0009 0.0679
Schistosoma mansoni hypothetical protein 0.0017 0.0046 0.0194
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0025 0.0375
Schistosoma mansoni nuclear hormone receptor 0.001 0.0009 0.0037
Giardia lamblia hypothetical protein 0.0044 0.0174 0.0978
Trypanosoma brucei unspecified product 0.0029 0.0102 0.2072
Brugia malayi glutamate synthase 0.001 0.0008 0.0051
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0044 0.0174 0.0741
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0044 0.0174 0.3642
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.001 0.0008 0.0032
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0009 0.0037
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0036 0.0136 0.2803
Toxoplasma gondii thioredoxin reductase 0.0104 0.0465 0.1645
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0025 0.0375
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0009 0.0051
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0054
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0054 0.1023
Mycobacterium ulcerans hypothetical protein 0.0013 0.0025 0.0017
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0044 0.0174 0.6914
Schistosoma mansoni disulfide oxidoreductase 0.001 0.0008 0.0032
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0174 0.0601
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0166 0.3461
Leishmania major DNA damage repair protein, putative 0.0013 0.0025 0.0375
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0059 0.0247 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0042 0.0166 0.3461
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0044 0.0174 0.3642
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0025 0.0375
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0144 0.0959
Echinococcus multilocularis bloom syndrome protein 0.0019 0.0054 0.0232
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0025 0.0375
Trichomonas vaginalis glutathione reductase, putative 0.0036 0.0136 0.5321
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0174 0.0601
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0044
Loa Loa (eye worm) nuclear factor I 0.001 0.0009 0.0054
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0129 0.0754
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0362 0.171 0.7281
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0136 0.2803
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0318 0.1497 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0136 0.2803
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0166 0.3461
Echinococcus granulosus glutamate synthase 0.001 0.0008 0.0032
Plasmodium falciparum glutathione reductase 0.0036 0.0136 0.2803
Plasmodium vivax thioredoxin reductase, putative 0.0104 0.0465 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0044 0.0174 0.3642
Entamoeba histolytica recQ family DNA helicase 0.001 0.0009 0.0075
Schistosoma mansoni glutamate synthase 0.001 0.0008 0.0032
Schistosoma mansoni tar DNA-binding protein 0.007 0.03 0.1278
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0009 0.0051
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0051
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.001 0.0008 0.0002
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0136 0.2803
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0009 0.0037
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0044 0.0174 0.0741
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0044 0.0174 0.0741
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0048 0.028
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0054 0.0363
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.001 0.0008 0.0002
Schistosoma mansoni DNA helicase recq5 0.0019 0.0054 0.0232
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0009 0.0058
Schistosoma mansoni glutamate synthase 0.001 0.0008 0.0032
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0154 0.0655
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0166 0.3461
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0042 0.0166 0.0221
Schistosoma mansoni DNA helicase recq1 0.0019 0.0054 0.0232
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0174 0.6914
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0174 0.6914
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0013 0.0056
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0009 0.0037
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0009 0.0025
Echinococcus multilocularis thioredoxin glutathione reductase 0.0104 0.0465 0.1979
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0044 0.0174 0.3642
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0044 0.0174 0.0741
Trypanosoma cruzi trypanothione reductase, putative 0.0104 0.0465 1
Brugia malayi ecdysteroid receptor 0.001 0.0009 0.0058
Echinococcus granulosus dna polymerase kappa 0.0042 0.0166 0.0706
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0174 0.6914
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0051
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0136 0.0128
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0027 0.0089 0.0598
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0362 0.171 0.7281
Brugia malayi RNA binding protein 0.007 0.03 0.2005
Trichomonas vaginalis C-MYB, putative 0.0059 0.0247 0.9943
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0362 0.171 1
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.001 0.0008 0.0015
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0136 0.2803
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0046 0.0305
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0136 0.2803
Plasmodium vivax ferrodoxin reductase, putative 0.001 0.0008 0.0015
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0046 0.0267
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0003 0.0012
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0044 0.0174 0.6914
Brugia malayi CXXC zinc finger family protein 0.0035 0.0129 0.0861
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0044 0.0174 0.3642
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0174 0.0601
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0585 0.2791 0.2786
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0009 0.0058
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0174 0.6914
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0044 0.0174 0.0741
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0059 0.0247 1
Brugia malayi glutathione reductase 0.0104 0.0465 0.3105
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0054 0.017
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0025 0.0375
Echinococcus granulosus sulfide:quinone oxidoreductase 0.001 0.0008 0.0032
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0174 0.3651
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0036 0.0136 0.0578
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0046 0.0305
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0009 0.0058
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0174 0.6914
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0044 0.0174 0.0741
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0059 0.0247 0.9943
Loa Loa (eye worm) glutathione reductase 0.0104 0.0465 0.2718
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0059 0.0247 1
Schistosoma mansoni DNA polymerase IV / kappa 0.0013 0.0025 0.0105
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2077 1 1
Toxoplasma gondii selenide, water dikinase 0.001 0.0008 0.0002
Trichomonas vaginalis MYB, putative 0.0059 0.0249 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0009 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0009 0.0058
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0036 0.0136 0.2803
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.001 0.0008 0.0002
Entamoeba histolytica hypothetical protein 0.004 0.0154 0.6113
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0036 0.0136 0.2803
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0238 0.111 0.1539
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0009 0.0679
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0174 0.0601
Giardia lamblia DINP protein human, muc B family 0.0042 0.0166 0.0929
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0009 0.0037
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0036 0.0136 0.2803
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0044 0.0174 0.0741
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0174 0.6914
Brugia malayi MH2 domain containing protein 0.0018 0.0048 0.032
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0174 0.3642
Loa Loa (eye worm) MH2 domain-containing protein 0.0263 0.1233 0.7209
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.001 0.0008 0.0032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0009 0.0051
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0036 0.0136 0.0128
Trypanosoma brucei unspecified product 0.0042 0.0166 0.3461
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0009 0.0006

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.6964 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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