Detailed information for compound 836731

Basic information

Technical information
  • TDR Targets ID: 836731
  • Name: N-(4-chlorophenyl)-2-[3-(4-fluorophenyl)-2-ox o-1,4-diazaspiro[4.6]undec-3-en-1-yl]acetamid e
  • MW: 427.899 | Formula: C23H23ClFN3O2
  • H donors: 1 H acceptors: 2 LogP: 4.82 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN1C(=O)C(=NC21CCCCCC2)c1ccc(cc1)F)Nc1ccc(cc1)Cl
  • InChi: 1S/C23H23ClFN3O2/c24-17-7-11-19(12-8-17)26-20(29)15-28-22(30)21(16-5-9-18(25)10-6-16)27-23(28)13-3-1-2-4-14-23/h5-12H,1-4,13-15H2,(H,26,29)
  • InChiKey: HKIHVELOMGFUNU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-chlorophenyl)-2-[3-(4-fluorophenyl)-2-keto-1,4-diazaspiro[4.6]undec-3-en-1-yl]acetamide
  • N-(4-chlorophenyl)-2-[3-(4-fluorophenyl)-2-oxo-1,4-diazaspiro[4.6]undec-3-en-1-yl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni notch 0.0044 0.0369 0.0181
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0077 0.079 0.0699
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0032 0.0215 0.0695
Echinococcus multilocularis protein jagged 1 0.0044 0.0369 0.0308
Schistosoma mansoni nuclear hormone receptor 0.0163 0.1887 0.1729
Onchocerca volvulus 0.0044 0.0369 0.0614
Brugia malayi nuclear hormone receptor 0.0163 0.1887 0.6114
Schistosoma mansoni aldo-keto reductase 0.0032 0.0215 0.0024
Loa Loa (eye worm) hypothetical protein 0.0257 0.3087 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.046 1
Echinococcus multilocularis aldo keto reductase 0.0032 0.0215 0.0133
Schistosoma mansoni notch 0.0044 0.0369 0.0181
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0163 0.1887 0.6114
Loa Loa (eye worm) oxidoreductase 0.0032 0.0215 0.008
Echinococcus granulosus nuclear factor of activated T cells 5 0.0074 0.0749 0.0658
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0215 0.0133
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.046 0.0929
Brugia malayi Animal haem peroxidase family protein 0.0257 0.3087 1
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0044 0.0369 0.0614
Echinococcus multilocularis aldo keto reductase 0.0032 0.0215 0.0133
Brugia malayi Cadherin domain containing protein 0.0044 0.0369 0.1196
Echinococcus granulosus protein jagged 2 0.0044 0.0369 0.0274
Loa Loa (eye worm) DR-78 0.0077 0.079 0.2069
Loa Loa (eye worm) hypothetical protein 0.0163 0.1887 0.5857
Brugia malayi Calcium binding EGF domain containing protein 0.0044 0.0369 0.1196
Loa Loa (eye worm) nuclear receptor NHR-67 0.0077 0.079 0.2069
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0086 0.0908 0.092
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.046 0.0939
Loa Loa (eye worm) hypothetical protein 0.0257 0.3087 1
Schistosoma mansoni microtubule-associated protein tau 0.0689 0.8604 0.8577
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.046 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0077 0.079 0.0611
Loa Loa (eye worm) animal heme peroxidase 0.0257 0.3087 1
Loa Loa (eye worm) hypothetical protein 0.0257 0.3087 1
Echinococcus multilocularis neural cadherin 0.0044 0.0369 0.0308
Schistosoma mansoni hypothetical protein 0.0044 0.0369 0.0181
Echinococcus granulosus hypothetical protein 0.0032 0.0215 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0163 0.1887 0.6114
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0163 0.1887 0.2032
Loa Loa (eye worm) oxidoreductase 0.0032 0.0215 0.008
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0163 0.1887 0.1807
Loa Loa (eye worm) hypothetical protein 0.0077 0.079 0.2069
Loa Loa (eye worm) hypothetical protein 0.0044 0.0369 0.0614
Brugia malayi EGF-like domain containing protein 0.0044 0.0369 0.1196
Onchocerca volvulus Peroxidase homolog 0.0257 0.3087 1
Brugia malayi Peroxidasin 0.0257 0.3087 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0077 0.079 0.0787
Loa Loa (eye worm) Notch2 0.0044 0.0369 0.0614
Loa Loa (eye worm) hypothetical protein 0.0044 0.0369 0.0614
Loa Loa (eye worm) oxidoreductase 0.0032 0.0215 0.008
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0215 0.0133
Loa Loa (eye worm) hypothetical protein 0.0044 0.0369 0.0614
Echinococcus granulosus ecdysone induced protein 78C 0.0163 0.1887 0.1807
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.0215 0.0118
Brugia malayi Nuclear hormone receptor-like 1 0.0163 0.1887 0.6114
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0215 0.0133
Loa Loa (eye worm) hypothetical protein 0.0044 0.0369 0.0614
Brugia malayi photoreceptor-specific nuclear receptor 0.0163 0.1887 0.6114
Loa Loa (eye worm) hypothetical protein 0.0044 0.0369 0.0614
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0077 0.079 0.0699
Brugia malayi hypothetical protein 0.0086 0.0908 0.2941
Brugia malayi GCC2 and GCC3 family protein 0.0044 0.0369 0.1196
Loa Loa (eye worm) hypothetical protein 0.0163 0.1887 0.5857
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.046 1
Loa Loa (eye worm) oxidoreductase 0.0032 0.0215 0.008
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0044 0.0369 0.0181
Loa Loa (eye worm) hypothetical protein 0.0032 0.0215 0.008
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0163 0.1887 0.6114
Loa Loa (eye worm) hypothetical protein 0.0077 0.079 0.2069
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.046 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0369 0.0614
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.0215 0.0118
Brugia malayi hypothetical protein 0.0077 0.079 0.256
Loa Loa (eye worm) animal heme peroxidase 0.0257 0.3087 1
Brugia malayi nuclear hormone receptor 0.0077 0.079 0.256
Schistosoma mansoni cell polarity protein 0.0044 0.0369 0.0181
Toxoplasma gondii aldose reductase, putative 0.0032 0.0215 0.0866
Loa Loa (eye worm) notch protein 0.0044 0.0369 0.0614
Brugia malayi hypothetical protein 0.0086 0.0908 0.2941
Loa Loa (eye worm) hypothetical protein 0.0257 0.3087 1
Schistosoma mansoni notch 0.0044 0.0369 0.0181
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.0215 0.0118
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0215 0.0133
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0163 0.1887 0.6114
Brugia malayi Pre-SET motif family protein 0.0208 0.2463 0.7979
Schistosoma mansoni notch 0.0044 0.0371 0.0183
Brugia malayi Steroid receptor seven-up type 2 0.0163 0.1887 0.6114
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.0215 0.0118
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0712 0.8903 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0163 0.1887 0.1729
Toxoplasma gondii EGF family domain-containing protein 0.0044 0.0369 0.661
Brugia malayi MAP kinase sur-1 0.0051 0.046 0.1491
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0163 0.1887 0.6114
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0191 0.0106
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0191 0.0095
Onchocerca volvulus Chorion peroxidase homolog 0.0257 0.3087 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0191 0.0106
Schistosoma mansoni laminin gamma-3 chain 0.0044 0.0369 0.0181
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0215 0.0133
Schistosoma mansoni coup transcription factor 0.0163 0.1887 0.1729
Schistosoma mansoni slit 0.0044 0.0369 0.0181
Brugia malayi orphan nuclear receptor NR2E1 0.0077 0.079 0.256
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.046 1
Brugia malayi Nuclear hormone receptor E75 0.0077 0.079 0.256
Trichomonas vaginalis set domain proteins, putative 0.0236 0.2829 1
Echinococcus granulosus FTZ F1 alpha 0.0163 0.1887 0.1807
Onchocerca volvulus 0.0077 0.079 0.2069
Brugia malayi EGF-like domain containing protein 0.0044 0.0369 0.1196
Echinococcus granulosus notch 0.0044 0.0369 0.0274
Loa Loa (eye worm) hypothetical protein 0.0044 0.0369 0.0614
Echinococcus granulosus aldo keto reductase 0.0032 0.0215 0.0118
Loa Loa (eye worm) hypothetical protein 0.0044 0.0369 0.0614
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.046 0.0939
Onchocerca volvulus 0.0032 0.0215 0.008
Schistosoma mansoni peroxidasin 0.0257 0.3087 0.2952
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0032 0.0215 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0369 0.0614
Loa Loa (eye worm) steroid hormone receptor 0.0163 0.1887 0.5857
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.0215 0.0118
Brugia malayi hypothetical protein 0.0257 0.3087 1
Schistosoma mansoni hypothetical protein 0.0044 0.0369 0.0181
Loa Loa (eye worm) hypothetical protein 0.0044 0.0369 0.0614
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0163 0.1887 0.2032
Loa Loa (eye worm) hypothetical protein 0.0257 0.3087 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.0908 0.2474
Loa Loa (eye worm) hypothetical protein 0.0044 0.0369 0.0614
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.046 1
Loa Loa (eye worm) hypothetical protein 0.0257 0.3087 1
Brugia malayi nuclear receptor NHR-67 0.0077 0.079 0.256
Echinococcus granulosus neurogenic locus notch protein 0.0044 0.0369 0.0274
Onchocerca volvulus Putative cubilin 0.0044 0.0369 0.0614
Brugia malayi Animal haem peroxidase family protein 0.0257 0.3087 1
Onchocerca volvulus Peroxidasin homolog 0.0257 0.3087 1
Onchocerca volvulus Peroxidase homolog 0.0257 0.3087 1
Schistosoma mansoni hypothetical protein 0.0044 0.0369 0.0181
Loa Loa (eye worm) hypothetical protein 0.0163 0.1887 0.5857
Loa Loa (eye worm) oxidoreductase 0.0032 0.0215 0.008
Mycobacterium ulcerans oxidoreductase 0.0032 0.0215 0.5
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0163 0.1887 0.5857
Loa Loa (eye worm) hypothetical protein 0.0163 0.1887 0.5857
Schistosoma mansoni hypothetical protein 0.0044 0.0369 0.0181
Onchocerca volvulus 0.0044 0.0369 0.0614
Echinococcus granulosus protein jagged 1 0.0044 0.0369 0.0274
Schistosoma mansoni zinc finger protein 0.0077 0.079 0.0611
Loa Loa (eye worm) hypothetical protein 0.0044 0.0369 0.0614
Brugia malayi nuclear hormone receptor family member odr-7 0.0077 0.079 0.256
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0074 0.0749 0.074
Loa Loa (eye worm) hypothetical protein 0.0044 0.0369 0.0614
Echinococcus multilocularis nuclear receptor nhr 48 0.0077 0.079 0.0787
Brugia malayi hypothetical protein 0.0077 0.079 0.256
Onchocerca volvulus 0.0032 0.0215 0.008
Echinococcus multilocularis thyroid hormone receptor alpha 0.0163 0.1887 0.2032
Brugia malayi Animal haem peroxidase family protein 0.0257 0.3087 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.0215 0.0118
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0215 0.0133
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.046 0.0274
Onchocerca volvulus Slit protein homolog 0.0044 0.0369 0.0614
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0163 0.1887 0.2032
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0163 0.1887 0.6114
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0215 0.0133
Echinococcus granulosus slit 2 protein 0.0044 0.0369 0.0274
Echinococcus multilocularis notch 0.0044 0.0369 0.0308
Brugia malayi steroid hormone receptor 0.0163 0.1887 0.6114
Brugia malayi Nuclear hormone receptor-like 1 0.0086 0.0908 0.2941
Onchocerca volvulus 0.0032 0.0215 0.008
Brugia malayi nuclear receptor NHR-88 0.0163 0.1887 0.6114
Loa Loa (eye worm) hypothetical protein 0.0044 0.0369 0.0614
Echinococcus granulosus nuclear receptor nhr 48 0.0077 0.079 0.0699
Schistosoma mansoni steroid hormone receptor ad4bp 0.0163 0.1887 0.1729
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0077 0.079 0.0611
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0163 0.1887 0.5857
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0163 0.1887 0.1729
Echinococcus granulosus protein jagged 2 0.0044 0.0369 0.0274
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0086 0.0908 0.0818
Echinococcus granulosus Nuclear hormone receptor HR96 0.0077 0.079 0.0699
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0032 0.0215 0.0695
Loa Loa (eye worm) hypothetical protein 0.0257 0.3087 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.0215 0.0118
Loa Loa (eye worm) hypothetical protein 0.0163 0.1887 0.5857
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.046 0.0366
Loa Loa (eye worm) hypothetical protein 0.0257 0.3087 1
Echinococcus multilocularis protein jagged 1 0.0044 0.0369 0.0308
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0163 0.1887 0.5857
Onchocerca volvulus 0.0077 0.079 0.2069
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.046 0.0412
Schistosoma mansoni notch 0.0044 0.0369 0.0181
Schistosoma mansoni nuclear hormone receptor 0.0077 0.079 0.0611
Echinococcus multilocularis peroxidasin 0.0257 0.3087 0.3395
Loa Loa (eye worm) hypothetical protein 0.0257 0.3087 1
Loa Loa (eye worm) blistered cuticle protein 3 0.0257 0.3087 1
Schistosoma mansoni nuclear receptor 0.0077 0.079 0.0611
Trypanosoma brucei protein kinase, putative 0.0051 0.046 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0163 0.1887 0.1807
Echinococcus granulosus thyroid hormone receptor alpha 0.0077 0.079 0.0699
Loa Loa (eye worm) hypothetical protein 0.0077 0.079 0.2069
Brugia malayi EGF-like domain containing protein 0.0044 0.0369 0.1196
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0032 0.0215 0.0695
Echinococcus multilocularis FTZ F1 alpha 0.0163 0.1887 0.2032
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0163 0.1887 0.6114
Onchocerca volvulus Bile acid receptor homolog 0.0163 0.1887 0.5857
Loa Loa (eye worm) hypothetical protein 0.0044 0.0369 0.0614
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0163 0.1887 0.1807
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0163 0.1887 0.1729
Loa Loa (eye worm) hypothetical protein 0.0044 0.0369 0.0614
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0163 0.1887 0.1807
Loa Loa (eye worm) hypothetical protein 0.0086 0.0908 0.2474
Echinococcus granulosus protein jagged 1 0.0044 0.0369 0.0274
Loa Loa (eye worm) hypothetical protein 0.0086 0.0908 0.2474
Brugia malayi Nuclear hormone receptor-like 1 0.0086 0.0908 0.2941
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.0215 0.0118
Brugia malayi Animal haem peroxidase family protein 0.0257 0.3087 1
Schistosoma mansoni hypothetical protein 0.0044 0.0369 0.0181
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0163 0.1887 0.6114
Echinococcus multilocularis fibropellin Ia 0.0044 0.0369 0.0308
Echinococcus multilocularis slit 2 protein 0.0044 0.0369 0.0308
Onchocerca volvulus 0.0257 0.3087 1
Loa Loa (eye worm) hypothetical protein 0.0257 0.3087 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0086 0.0908 0.073
Loa Loa (eye worm) hypothetical protein 0.0044 0.0369 0.0614
Echinococcus multilocularis aldo keto reductase 0.0032 0.0215 0.0133
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0163 0.1887 0.5857
Echinococcus granulosus aldo keto reductase 0.0032 0.0215 0.0118
Onchocerca volvulus 0.0163 0.1887 0.5857
Entamoeba histolytica aldose reductase, putative 0.0032 0.0215 0.5
Brugia malayi nuclear receptor RXR 0.0086 0.0908 0.2941
Echinococcus granulosus microtubule associated protein 2 0.0689 0.8604 0.859
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0077 0.079 0.0787
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0163 0.1887 0.5857
Brugia malayi conserved hypotetical protein 0.0077 0.079 0.256
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0077 0.079 0.0787
Brugia malayi Pre-SET motif family protein 0.003 0.0191 0.062
Loa Loa (eye worm) hypothetical protein 0.0077 0.079 0.2069
Loa Loa (eye worm) nuclear hormone receptor 0.0077 0.079 0.2069
Schistosoma mansoni nuclear receptor 0.0077 0.079 0.0611
Brugia malayi nuclear hormone receptor family member nhr-6 0.0077 0.079 0.256
Echinococcus granulosus fibropellin Ia 0.0044 0.0369 0.0274
Onchocerca volvulus Protein ultraspiracle homolog 0.0163 0.1887 0.5857
Echinococcus granulosus peroxidasin 0.0257 0.3087 0.3019
Brugia malayi ecdysone receptor 0.0077 0.079 0.256
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0044 0.0369 0.1196
Brugia malayi EGF-like domain containing protein 0.0044 0.0369 0.1196
Onchocerca volvulus 0.0032 0.0215 0.008
Echinococcus multilocularis neurogenic locus protein delta 0.0044 0.0369 0.0308
Onchocerca volvulus 0.0257 0.3087 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.079 0.2069
Loa Loa (eye worm) hypothetical protein 0.0077 0.079 0.2069
Loa Loa (eye worm) hypothetical protein 0.0077 0.079 0.2069
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0163 0.1887 0.5857
Schistosoma mansoni hypothetical protein 0.0044 0.0369 0.0181
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0163 0.1887 0.1729
Plasmodium vivax SET domain protein, putative 0.003 0.0191 0.5
Brugia malayi notch-like transmembrane receptor 0.0044 0.0369 0.1196
Echinococcus multilocularis ecdysone induced protein 78C 0.0163 0.1887 0.2032
Schistosoma mansoni nuclear hormone receptor 0.0077 0.079 0.0611
Schistosoma mansoni notch 0.0044 0.0369 0.0181
Echinococcus multilocularis neurogenic locus notch protein 0.0044 0.0369 0.0308
Echinococcus multilocularis neurogenic locus protein delta 0.0044 0.0369 0.0308
Giardia lamblia High cysteine protein 0.0044 0.0369 0.6288
Mycobacterium tuberculosis Probable oxidoreductase 0.0032 0.0215 0.5
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0086 0.0908 0.073
Loa Loa (eye worm) hypothetical protein 0.0257 0.3087 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.0908 0.2474
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0163 0.1887 0.2032
Loa Loa (eye worm) hypothetical protein 0.0257 0.3087 1
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.046 0.0412
Loa Loa (eye worm) hypothetical protein 0.0044 0.0369 0.0614
Entamoeba histolytica aldose reductase, putative 0.0032 0.0215 0.5
Brugia malayi Calcium binding EGF domain containing protein 0.0044 0.0369 0.1196
Onchocerca volvulus 0.0044 0.0369 0.0614
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0163 0.1887 0.2032
Schistosoma mansoni retinoic acid receptor RXR 0.0798 1 1
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.046 0.0366
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.0215 0.0118
Onchocerca volvulus Neurogenic locus notch homolog 0.0044 0.0371 0.0619
Schistosoma mansoni peroxidasin 0.0257 0.3087 0.2952
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0086 0.0908 0.2474
Echinococcus granulosus neurogenic locus notch protein 4 0.0044 0.0369 0.0274
Onchocerca volvulus 0.0032 0.0215 0.008
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0163 0.1887 0.5857
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0077 0.079 0.2069
Echinococcus granulosus neurogenic locus protein delta 0.0044 0.0369 0.0274
Brugia malayi Muscle positioning protein 4 0.0044 0.0369 0.1196
Loa Loa (eye worm) hypothetical protein 0.0077 0.079 0.2069
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.046 1
Schistosoma mansoni pol-related 0.0032 0.0215 0.0024
Brugia malayi tailless protein 0.0077 0.079 0.256
Echinococcus granulosus neural cadherin 0.0044 0.0369 0.0274
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.2463 0.7845
Loa Loa (eye worm) hypothetical protein 0.0077 0.079 0.2069
Schistosoma mansoni thyroid hormone receptor 0.0163 0.1887 0.1729
Echinococcus granulosus neurogenic locus notch protein 0.0044 0.0369 0.0274
Loa Loa (eye worm) hypothetical protein 0.0257 0.3087 1
Loa Loa (eye worm) animal heme peroxidase 0.0257 0.3087 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0077 0.079 0.0787
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.046 0.0939
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0163 0.1887 0.6114
Loa Loa (eye worm) hypothetical protein 0.0044 0.0369 0.0614
Brugia malayi Delta serrate ligand family protein 0.0044 0.0369 0.1196
Brugia malayi nuclear receptor NHR-88 0.0077 0.079 0.256
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0077 0.079 0.2069
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0163 0.1887 0.6114
Brugia malayi Animal haem peroxidase family protein 0.0257 0.3087 1
Brugia malayi Nuclear hormone receptor E75 0.0077 0.079 0.256
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0215 0.0133
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0163 0.1887 0.1729
Echinococcus multilocularis fat cadherin tumor suppressor 0.0044 0.0369 0.0308
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.046 0.0939
Schistosoma mansoni aldo-keto reductase 0.0032 0.0215 0.0024
Brugia malayi Cadherin domain containing protein 0.0044 0.0369 0.1196
Brugia malayi ecdysteroid receptor 0.0163 0.1887 0.6114
Onchocerca volvulus 0.0237 0.2831 0.9116
Schistosoma mansoni nuclear receptor nhr-48 0.0077 0.079 0.0611
Echinococcus multilocularis aldo keto reductase 0.0032 0.0215 0.0133
Loa Loa (eye worm) hypothetical protein 0.0044 0.0369 0.0614
Onchocerca volvulus Dual oxidase homolog 0.0257 0.3087 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0215 0.0133
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.046 1
Schistosoma mansoni RAR-like nuclear receptor 0.0163 0.1887 0.1729
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0163 0.1887 0.1807
Loa Loa (eye worm) hypothetical protein 0.0257 0.3087 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0077 0.079 0.256
Onchocerca volvulus 0.0032 0.0215 0.008
Onchocerca volvulus 0.0044 0.0369 0.0614
Loa Loa (eye worm) hypothetical protein 0.0163 0.1887 0.5857
Loa Loa (eye worm) hypothetical protein 0.0077 0.079 0.2069
Schistosoma mansoni septate junction protein 0.0044 0.0369 0.0181
Schistosoma mansoni hypothetical protein 0.0044 0.0369 0.0181
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0163 0.1887 0.6114
Echinococcus multilocularis protein jagged 2 0.0044 0.0369 0.0308
Echinococcus multilocularis microtubule associated protein 2 0.0689 0.8604 0.966
Echinococcus multilocularis neurogenic locus notch protein 0.0044 0.0369 0.0308
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0163 0.1887 0.1807
Onchocerca volvulus 0.0257 0.3087 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.1887 0.5857
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0163 0.1887 0.6114
Brugia malayi EGF-like domain containing protein 0.0044 0.0369 0.1196
Echinococcus multilocularis neurogenic locus notch protein 4 0.0044 0.0369 0.0308
Loa Loa (eye worm) hypothetical protein 0.0086 0.0908 0.2474
Brugia malayi Blistered cuticle protein 3 0.0257 0.3087 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0215 0.0133
Entamoeba histolytica aldose reductase, putative 0.0032 0.0215 0.5
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0215 0.0133
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0163 0.1887 0.1729
Loa Loa (eye worm) hypothetical protein 0.0044 0.0369 0.0614
Brugia malayi EGF-like domain containing protein 0.0044 0.0369 0.1196
Echinococcus granulosus delta-like protein 1 0.0044 0.0369 0.0274
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0077 0.079 0.2069
Loa Loa (eye worm) hypothetical protein 0.0077 0.079 0.2069
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0032 0.0215 0.0695
Loa Loa (eye worm) hypothetical protein 0.0163 0.1887 0.5857
Loa Loa (eye worm) hypothetical protein 0.0077 0.079 0.2069
Schistosoma mansoni thyroid hormone receptor 0.0163 0.1887 0.1729
Echinococcus granulosus Nuclear hormone receptor HR96 0.0077 0.079 0.0699
Echinococcus granulosus aldo keto reductase 0.0032 0.0215 0.0118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0163 0.1887 0.5857
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0163 0.1887 0.2032
Brugia malayi nuclear receptor RXR 0.0077 0.079 0.256
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.046 1
Brugia malayi EGF-like domain containing protein 0.0044 0.0369 0.1196
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0177 0.008
Loa Loa (eye worm) animal heme peroxidase 0.0257 0.3087 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.079 0.2069
Onchocerca volvulus 0.0044 0.0369 0.0614
Onchocerca volvulus Peroxidasin homolog 0.0257 0.3087 1
Brugia malayi Calcium binding EGF domain containing protein 0.0044 0.0369 0.1196
Loa Loa (eye worm) hypothetical protein 0.0044 0.0369 0.0614
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0163 0.1887 0.6114

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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