Detailed information for compound 836734

Basic information

Technical information
  • TDR Targets ID: 836734
  • Name: 9-(3-chlorophenyl)-2-(4-fluorophenyl)-8-oxo-7 H-purine-6-carboxamide
  • MW: 383.764 | Formula: C18H11ClFN5O2
  • H donors: 2 H acceptors: 5 LogP: 3.29 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)c1nc(C(=O)N)c2c(n1)n(c1cccc(c1)Cl)c(n2)O
  • InChi: 1S/C18H11ClFN5O2/c19-10-2-1-3-12(8-10)25-17-14(23-18(25)27)13(15(21)26)22-16(24-17)9-4-6-11(20)7-5-9/h1-8H,(H2,21,26)(H,23,27)
  • InChiKey: LQLQJNQWFLGCAM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 9-(3-chlorophenyl)-2-(4-fluorophenyl)-8-keto-7H-purine-6-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0015 0.0015
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0015 0.0059
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0062 0.0617
Loa Loa (eye worm) carboxylesterase 0.362 1 1
Schistosoma mansoni cpg binding protein 0.0031 0.0061 0.0057
Brugia malayi hypothetical protein 0.0612 0.1669 0.1669
Brugia malayi hypothetical protein 0.0016 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0612 0.1669 0.1669
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0074 1
Echinococcus granulosus solute carrier family 22 0.0014 0.0015 0.0015
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0179 0.0471 0.0471
Onchocerca volvulus 0.0087 0.0217 0.1278
Onchocerca volvulus 0.0014 0.0015 0.0069
Leishmania major protein kinase, putative 0.0031 0.0062 0.7919
Echinococcus granulosus voltage dependent calcium channel subunit 0.0168 0.044 0.044
Onchocerca volvulus 0.0014 0.0015 0.0069
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0039 0.395
Schistosoma mansoni hypothetical protein 0.0102 0.0258 0.0255
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0062 0.7919
Brugia malayi Cation transporter family protein 0.0179 0.0471 0.0471
Loa Loa (eye worm) hypothetical protein 0.0087 0.0217 0.0216
Onchocerca volvulus 0.0612 0.1669 1
Mycobacterium tuberculosis Carboxylesterase LipT 0.0612 0.1669 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0069 0.0065
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0179 0.0471 0.0471
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0062 0.0062
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0015 0.0011
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0046 0.5228
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0087 0.0217 0.0216
Onchocerca volvulus 0.0014 0.0015 0.0069
Brugia malayi nuclear receptor NHR-88 0.001 0.0004 0.0004
Trichomonas vaginalis spcc417.12 protein, putative 0.0612 0.1669 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0015 0.0015
Onchocerca volvulus 0.0014 0.0015 0.0069
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0007 0.0007
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0062 0.0617
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0612 0.1669 0.1666
Onchocerca volvulus 0.0014 0.0015 0.0069
Plasmodium vivax aspartyl proteinase, putative 0.0034 0.0069 0.0377
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0062 0.0062
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0087 0.0217 0.0216
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0179 0.0471 0.0471
Brugia malayi Sugar transporter family protein 0.0102 0.0258 0.0258
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0062 0.0062
Plasmodium falciparum mitogen-activated protein kinase 2 0.0165 0.0432 0.3595
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0004 0.0003
Schistosoma mansoni hypothetical protein 0.0011 0.0007 0.0003
Brugia malayi hypothetical protein 0.0014 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0015
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0165 0.0432 0.2932
Schistosoma mansoni transient receptor potential channel 0.0065 0.0155 0.0152
Trypanosoma brucei glucose transporter 2A 0.0032 0.0063 0.8107
Leishmania major glucose transporter, lmgt2 0.0032 0.0063 0.8107
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0004 0.0004
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0612 0.1669 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0063 0.8107
Brugia malayi nuclear hormone receptor 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0087 0.0217 0.0216
Brugia malayi Sugar transporter family protein 0.0014 0.0015 0.0015
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0062 0.0062
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0062 0.0329
Plasmodium falciparum protein kinase 6 0.0433 0.1176 1
Echinococcus multilocularis carboxylesterase 5A 0.362 1 1
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0034 0.0069 0.0068
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0015
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.0258 0.0258
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0039 0.395
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0087 0.0217 0.0216
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0039 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.0258 0.1469
Schistosoma mansoni sugar transporter 0.0014 0.0015 0.0011
Plasmodium falciparum plasmepsin VI 0.0034 0.0069 0.0462
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0039 0.0164
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0015
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.001 0.001
Onchocerca volvulus 0.0034 0.0069 0.0391
Echinococcus granulosus voltage dependent calcium channel subunit 0.0369 0.0997 0.0997
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0004 0.0004
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0179 0.0471 0.0471
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0015
Echinococcus multilocularis transient receptor potential ion channel A 0.0095 0.0238 0.0238
Brugia malayi Carboxylesterase family protein 0.0612 0.1669 0.1669
Schistosoma mansoni protein kinase 0.0031 0.0062 0.0058
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0039 0.0141
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0062 0.0062
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0015 0.0015
Onchocerca volvulus 0.0092 0.023 0.1357
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0074 0.0416
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0031 0.0094
Loa Loa (eye worm) hypothetical protein 0.0179 0.0471 0.0471
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0179 0.0471 0.0471
Loa Loa (eye worm) hypothetical protein 0.0023 0.0039 0.0038
Schistosoma mansoni glucose transporter 0.0014 0.0015 0.0011
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0062 0.0062
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0004 0.0004
Schistosoma mansoni acetylcholine receptor subunit beta 0.0087 0.0217 0.0213
Schistosoma mansoni acetylcholinesterase 0.0612 0.1669 0.1666
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0062 0.0329
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0087 0.0217 0.0217
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0057 0.0056
Echinococcus multilocularis BC026374 protein (S09 family) 0.0612 0.1669 0.1669
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0004 0.0003
Echinococcus granulosus transient receptor potential ion channel A 0.0095 0.0238 0.0238
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0062 0.0062
Toxoplasma gondii aspartyl protease 0.0034 0.0069 0.0706
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0004 0.0003
Plasmodium vivax aspartyl protease, putative 0.0034 0.0069 0.0377
Loa Loa (eye worm) hypothetical protein 0.0092 0.023 0.023
Schistosoma mansoni hypothetical protein 0.0087 0.0215 0.0212
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0179 0.0471 0.0471
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0069 0.0065
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0179 0.0471 0.0471
Loa Loa (eye worm) hypothetical protein 0.0179 0.0471 0.0471
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0074 0.051
Leishmania major hypothetical protein, conserved 0.0026 0.0046 0.5228
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0039 0.0199
Loa Loa (eye worm) ACC-1 protein 0.0179 0.0471 0.0471
Schistosoma mansoni neurotransmitter gated ion channel 0.0087 0.0217 0.0213
Loa Loa (eye worm) hypothetical protein 0.0179 0.0471 0.0471
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.0217 0.0217
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0612 0.1669 0.1666
Schistosoma mansoni BC026374 protein (S09 family) 0.0612 0.1669 0.1666
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0179 0.0471 0.0471
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0146 0.0143
Trypanosoma brucei glucose transporter, putative 0.0032 0.0063 0.8107
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0179 0.0471 0.0471
Toxoplasma gondii aspartyl protease ASP1 0.0034 0.0069 0.0706
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0128 0.1486
Echinococcus multilocularis glycine receptor subunit beta 0.0179 0.0471 0.0471
Onchocerca volvulus 0.0179 0.0471 0.2806
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0003
Trypanosoma brucei glucose transporter 1E 0.0032 0.0063 0.8107
Loa Loa (eye worm) hypothetical protein 0.0612 0.1669 0.1669
Loa Loa (eye worm) aspartyl protease 6 0.0034 0.0069 0.0068
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.0258 0.0258
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.0258 0.0258
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0165 0.0432 0.5495
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0039 0.3046
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0039 0.395
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0179 0.0471 0.0471
Plasmodium falciparum hexose transporter 0.0102 0.0258 0.2094
Plasmodium falciparum protein kinase 7 0.0289 0.0774 0.6542
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0063 0.8107
Loa Loa (eye worm) hypothetical protein 0.0087 0.0217 0.0216
Loa Loa (eye worm) carboxylesterase 0.0612 0.1669 0.1669
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0063 0.8107
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0179 0.0471 0.0471
Schistosoma mansoni nAChR subunit 0.0179 0.0471 0.0467
Loa Loa (eye worm) hypothetical protein 0.0087 0.0217 0.0216
Loa Loa (eye worm) hypothetical protein 0.0087 0.0217 0.0216
Loa Loa (eye worm) hypothetical protein 0.0063 0.0149 0.0149
Echinococcus multilocularis short transient receptor potential channel 6 0.0065 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0612 0.1669 0.1669
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0179 0.0471 0.0471
Loa Loa (eye worm) hypothetical protein 0.0179 0.0471 0.0471
Plasmodium vivax aspartyl proteinase, putative 0.0034 0.0069 0.0377
Echinococcus granulosus glycine receptor subunit alpha 1 0.0179 0.0471 0.0471
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0005 0.5
Echinococcus multilocularis acetylcholinesterase 0.362 1 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0063 0.8107
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0069 0.0065
Onchocerca volvulus 0.0014 0.0015 0.0069
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0015
Plasmodium falciparum plasmepsin IX 0.0034 0.0069 0.0462
Plasmodium vivax hexose transporter 0.0102 0.0258 0.1708
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.006 0.1135
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0179 0.0471 0.0471
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0003
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0062 0.0058
Toxoplasma gondii aspartyl protease ASP3 0.0034 0.0069 0.0706
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0179 0.0471 0.0471
Loa Loa (eye worm) hypothetical protein 0.0179 0.0471 0.0471
Loa Loa (eye worm) hypothetical protein 0.0087 0.0217 0.0216
Onchocerca volvulus 0.0029 0.0056 0.0313
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0063 0.029
Schistosoma mansoni cpg binding protein 0.0029 0.0056 0.0052
Onchocerca volvulus 0.0014 0.0015 0.0069
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0015 0.0015
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0568 0.1548 0.1548
Brugia malayi CXXC zinc finger family protein 0.0029 0.0056 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0063 0.029
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0015 0.0015
Plasmodium vivax tryptophan-rich antigen (Pv-fam-a) 0.0528 0.1438 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0217 0.0216
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0004 0.0003
Schistosoma mansoni glucose transport protein 0.0102 0.0258 0.0255
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0003
Loa Loa (eye worm) ACC-1 protein 0.0179 0.0471 0.0471
Loa Loa (eye worm) hypothetical protein 0.0092 0.023 0.023
Echinococcus multilocularis solute carrier family 22 0.0014 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0031 0.0062 0.0062
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.0217 0.0217
Brugia malayi aspartic protease BmAsp-1, identical 0.0034 0.0069 0.0069
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0034 0.0069 0.0706
Schistosoma mansoni protein kinase 0.0031 0.0062 0.0058
Loa Loa (eye worm) hypothetical protein 0.0612 0.1669 0.1669
Brugia malayi major facilitator superfamily protein 0.0014 0.0015 0.0015
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0087 0.0217 0.0217
Onchocerca volvulus 0.0087 0.0217 0.1278
Echinococcus granulosus short transient receptor potential channel 6 0.0065 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0179 0.0471 0.0471
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0069 0.0065
Entamoeba histolytica hypothetical protein 0.0092 0.023 1
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0179 0.0471 0.0471
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0039 0.0039
Onchocerca volvulus Putative transporter 0.0014 0.0015 0.0069
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0004 0.0003
Plasmodium falciparum plasmepsin V 0.0034 0.0069 0.0462
Schistosoma mansoni memapsin-2 (A01 family) 0.084 0.2301 0.2298
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0179 0.0471 0.0471
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.006 0.006
Plasmodium vivax aspartyl protease, putative 0.0034 0.0069 0.0377
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0612 0.1669 0.1666
Onchocerca volvulus 0.0014 0.0015 0.0069
Echinococcus granulosus FTZ F1 alpha 0.001 0.0004 0.0003
Onchocerca volvulus 0.0034 0.0069 0.0391
Brugia malayi aspartic protease BmAsp-2, identical 0.0034 0.0069 0.0069
Plasmodium falciparum plasmepsin I 0.0034 0.0069 0.0462
Echinococcus granulosus glycine receptor subunit beta 0.0179 0.0471 0.0471
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.0217 0.0217
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0069 0.0065
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0063 0.029
Loa Loa (eye worm) hypothetical protein 0.0031 0.006 0.006
Brugia malayi hypothetical protein 0.0087 0.0217 0.0217
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0069 0.0065
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0004 0.0003
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0179 0.0471 0.0471
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0179 0.0471 0.0471
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0046 0.5228
Loa Loa (eye worm) hypothetical protein 0.0179 0.0471 0.0471
Brugia malayi Pepsin A precursor 0.0034 0.0069 0.0069
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0004 0.0003
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0004 0.0003
Schistosoma mansoni transient receptor potential channel 0.0065 0.0155 0.0152
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0004 0.0004
Echinococcus granulosus para nitrobenzyl esterase 0.0612 0.1669 0.1669
Loa Loa (eye worm) hypothetical protein 0.0087 0.0217 0.0216
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0179 0.0471 0.0471
Echinococcus multilocularis cpg binding protein 0.0031 0.0061 0.006
Onchocerca volvulus Putative nachr subunit 0.0179 0.0471 0.2806
Brugia malayi hypothetical protein 0.0087 0.0217 0.0217
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0612 0.1669 0.1669
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0092 0.023 0.023
Brugia malayi hypothetical protein 0.0026 0.0046 0.0046
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0063 0.8107
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0004 0.0003
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0179 0.0471 0.0471
Loa Loa (eye worm) hypothetical protein 0.0179 0.0471 0.0471
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0092 0.023 0.023
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0612 0.1669 1
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0063 0.029
Trypanosoma brucei glucose transporter, putative 0.0032 0.0063 0.8107
Brugia malayi Cache domain containing protein 0.0074 0.0181 0.0181
Onchocerca volvulus 0.0014 0.0015 0.0069
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0161 0.0421 0.0418
Schistosoma mansoni transient receptor potential channel 0.0098 0.0248 0.0244
Echinococcus granulosus transient receptor potential gamma protein 0.0098 0.0248 0.0247
Loa Loa (eye worm) carboxylesterase 0.0612 0.1669 0.1669
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0015
Echinococcus multilocularis acetylcholinesterase 0.362 1 1
Echinococcus granulosus nAChR subunit 0.0179 0.0471 0.0471
Loa Loa (eye worm) hypothetical protein 0.0092 0.023 0.023
Onchocerca volvulus 0.0612 0.1669 1
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.006 1
Echinococcus multilocularis General substrate transporter 0.0088 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0034 0.0069 0.0068
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0004 0.0003
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0081 0.02 0.0196
Plasmodium vivax CDK-related protein kinase 6, putative 0.0433 0.1176 0.8155
Echinococcus multilocularis nAChR subunit 0.0179 0.0471 0.0471
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0004 0.0003
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0003
Echinococcus granulosus TRP transient receptor potential channel 0.0037 0.0077 0.0076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0037 0.0077 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0004 0.0004
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0063 0.8107
Brugia malayi Carboxylesterase family protein 0.0612 0.1669 0.1669
Plasmodium falciparum plasmepsin X 0.0034 0.0069 0.0462
Loa Loa (eye worm) hypothetical protein 0.0087 0.0217 0.0216
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0179 0.0471 0.0471
Schistosoma mansoni cpg binding protein 0.0031 0.0061 0.0057
Onchocerca volvulus 0.0612 0.1669 1
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0369 0.0997 0.0997
Schistosoma mansoni nAChR subunit 0.0179 0.0471 0.0467
Schistosoma mansoni neurotransmitter gated ion channel 0.0087 0.0217 0.0213
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0062 0.0062
Entamoeba histolytica protein kinase, putative 0.0031 0.0062 0.1227
Loa Loa (eye worm) hypothetical protein 0.0087 0.0217 0.0216
Plasmodium falciparum plasmepsin III 0.0034 0.0069 0.0462
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0179 0.0471 0.0471
Loa Loa (eye worm) hypothetical protein 0.0092 0.023 0.023
Onchocerca volvulus 0.0179 0.0471 0.2806
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0063 0.029
Schistosoma mansoni cathepsin D (A01 family) 0.0034 0.0069 0.0065
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0069 0.0065
Loa Loa (eye worm) hypothetical protein 0.0031 0.006 0.006
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0039 0.0199
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0004 0.0003
Schistosoma mansoni serine-rich repeat protein 0.0087 0.0215 0.0212
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0015
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0179 0.0471 0.0467
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0062 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0004 0.0004
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0037 0.0077 0.0076
Brugia malayi hypothetical protein 0.0014 0.0015 0.0015
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0069 0.0065
Echinococcus multilocularis dnaJ subfamily B 0.0414 0.1122 0.1122
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0015
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0087 0.0217 0.0216
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0015
Plasmodium falciparum plasmepsin VII 0.0034 0.0069 0.0462
Schistosoma mansoni nAChR subunit 0.0179 0.0471 0.0467
Echinococcus granulosus glycine receptor subunit alpha 1 0.0179 0.0471 0.0471
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0179 0.0471 0.0471
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0092 0.023 0.0226
Echinococcus multilocularis short transient receptor potential channel 6 0.0065 0.0155 0.0155
Echinococcus granulosus acetylcholinesterase 0.362 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0046 0.0046
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0092 0.023 0.023
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0168 0.044 0.044
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0074 1
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0612 0.1669 0.1669
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0179 0.0471 0.0471
Schistosoma mansoni sugar transporter 0.0014 0.0015 0.0011
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0062 0.0617
Loa Loa (eye worm) hypothetical protein 0.0179 0.0471 0.0471
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0655 0.1789 0.1789
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0023 0.1383
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0179 0.0471 0.0467
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0092 0.023 0.023
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0179 0.0471 0.0471
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.006 1
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0039 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0033 0.0068 0.0067
Loa Loa (eye worm) hypothetical protein 0.0612 0.1669 0.1669
Echinococcus granulosus General substrate transporter 0.0088 0.0218 0.0218
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0092 0.023 0.023
Onchocerca volvulus 0.0014 0.0015 0.0069
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0087 0.0217 0.0216
Loa Loa (eye worm) hypothetical protein 0.0612 0.1669 0.1669
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0179 0.0471 0.0471
Plasmodium vivax plasmepsin V, putative 0.0034 0.0069 0.0377
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0179 0.0471 0.0467
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0004 0.0003
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0179 0.0471 0.0471
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0092 0.023 0.023
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0062 0.0283
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0179 0.0471 0.0471
Brugia malayi major facilitator superfamily protein 0.0014 0.0015 0.0015
Schistosoma mansoni glucose transport protein 0.0102 0.0258 0.0255
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0004 0.0003
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0087 0.0217 0.0216
Loa Loa (eye worm) hypothetical protein 0.0074 0.0181 0.0181
Echinococcus multilocularis solute carrier family 22 0.0014 0.0015 0.0015
Onchocerca volvulus 0.0014 0.0015 0.0069
Schistosoma mansoni nAChR subunit 0.0087 0.0217 0.0213
Echinococcus granulosus BC026374 protein S09 family 0.0612 0.1669 0.1669
Schistosoma mansoni protein kinase 0.0031 0.0062 0.0058
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0102 0.0258 0.0258
Brugia malayi excitatory GABA receptor EXP-1A 0.0179 0.0471 0.0471
Brugia malayi steroid hormone receptor 0.001 0.0004 0.0004
Schistosoma mansoni sugar transporter 0.0014 0.0015 0.0011
Schistosoma mansoni gliotactin 0.0612 0.1669 0.1666
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.0258 0.0258
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0179 0.0471 0.0471
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0039 0.5182
Brugia malayi Cation transporter family protein 0.0179 0.0471 0.0471
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0062 0.0062
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0179 0.0471 0.0471
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0063 0.8107
Loa Loa (eye worm) hypothetical protein 0.0612 0.1669 0.1669
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0046 0.0266
Onchocerca volvulus 0.0014 0.0015 0.0069
Onchocerca volvulus 0.0179 0.0471 0.2806
Loa Loa (eye worm) hypothetical protein 0.0179 0.0471 0.0471
Brugia malayi hypothetical protein 0.0034 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0087 0.0217 0.0216
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0034 0.0069 0.0068
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0074 0.0779
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0034 0.0069 0.0324
Loa Loa (eye worm) sugar transporter 0.0102 0.0258 0.0258
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0034 0.0069 0.0068
Loa Loa (eye worm) hypothetical protein 0.0087 0.0217 0.0216
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0179 0.0471 0.0471
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0062 0.0404
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0004 0.0004
Brugia malayi hypothetical protein 0.0087 0.0217 0.0217
Plasmodium vivax aspartyl protease, putative 0.0034 0.0069 0.0377
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0179 0.0471 0.0471
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0092 0.023 0.0226
Brugia malayi Carboxylesterase family protein 0.362 1 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0217 0.0216
Plasmodium vivax plasmepsin IV, putative 0.0034 0.0069 0.0377
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0004 0.0003
Onchocerca volvulus 0.0014 0.0015 0.0069
Brugia malayi Sugar transporter family protein 0.0014 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0179 0.0471 0.0471
Echinococcus granulosus neuroligin 0.0612 0.1669 0.1669
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0039 0.0035
Echinococcus granulosus carboxylesterase 5A 0.362 1 1
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0179 0.0471 0.0471
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0179 0.0471 0.0467
Echinococcus multilocularis transient receptor potential gamma protein 0.0098 0.0248 0.0247
Loa Loa (eye worm) hypothetical protein 0.0778 0.2131 0.2131
Echinococcus multilocularis neuroligin 0.0612 0.1669 0.1669
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.362 1 1
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0179 0.0471 0.0471
Loa Loa (eye worm) hypothetical protein 0.0098 0.0248 0.0247
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0179 0.0471 0.0467
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0046 0.0407
Loa Loa (eye worm) hypothetical protein 0.0179 0.0471 0.0471
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0039 0.0038
Loa Loa (eye worm) hypothetical protein 0.0087 0.0217 0.0216
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0062 0.0404
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0004 0.0003
Schistosoma mansoni hypothetical protein 0.0414 0.1122 0.1119
Echinococcus granulosus short transient receptor potential channel 6 0.0065 0.0155 0.0155
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0179 0.0471 0.0471
Schistosoma mansoni nAChR subunit 0.0179 0.0471 0.0467
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0179 0.0471 0.0471
Entamoeba histolytica protein kinase, putative 0.0031 0.0062 0.1227
Schistosoma mansoni glucose transport protein 0.0102 0.0258 0.0255
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0074 1
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.0015 0.5
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0179 0.0471 0.0467
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.006 0.0273
Echinococcus granulosus solute carrier family 22 0.0014 0.0015 0.0015
Brugia malayi hypothetical protein 0.0034 0.0069 0.0069
Loa Loa (eye worm) acetylcholinesterase 1 0.362 1 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.0258 0.0258
Onchocerca volvulus 0.0014 0.0015 0.0069
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0108 0.0275 0.0271
Echinococcus multilocularis solute carrier family 22 0.0014 0.0015 0.0015
Toxoplasma gondii protein kinase, putative 0.0289 0.0774 1
Leishmania major glucose transporter, lmgt1 0.0032 0.0063 0.8107
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0003
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.006 0.0057
Brugia malayi Cam kinase protein 1 0.0031 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0003
Echinococcus granulosus acetylcholinesterase 0.362 1 1
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0039 0.0201
Schistosoma mansoni neurotransmitter gated ion channel 0.0092 0.023 0.0226
Plasmodium falciparum plasmepsin IV 0.0034 0.0069 0.0462
Loa Loa (eye worm) hypothetical protein 0.0025 0.0044 0.0044
Schistosoma mansoni transient receptor potential channel 4 0.0098 0.0248 0.0244
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0074 1
Onchocerca volvulus 0.0092 0.023 0.1357
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0004 0.0003
Onchocerca volvulus 0.0179 0.0471 0.2806
Onchocerca volvulus 0.0179 0.0471 0.2806
Brugia malayi hypothetical protein 0.0087 0.0217 0.0217
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0179 0.0471 0.0471
Echinococcus granulosus glycine receptor subunit beta 0.0179 0.0471 0.0471
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0046 0.0266
Brugia malayi Transient-receptor-potential like protein 0.0037 0.0077 0.0077
Schistosoma mansoni nAChR subunit 0.0179 0.0471 0.0467
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0074 1
Echinococcus granulosus solute carrier family 22 0.0014 0.0015 0.0015
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0039 0.0308
Echinococcus multilocularis glycine receptor subunit beta 0.0179 0.0471 0.0471
Echinococcus granulosus solute carrier family 22 0.0014 0.0015 0.0015
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.0258 0.0258
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0612 0.1669 1
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0062 0.0404
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0015
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0029 0.0084
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0063 0.029
Mycobacterium ulcerans sugar transporter 0.0014 0.0015 0.0059
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0057 0.0056
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0046 0.5228
Loa Loa (eye worm) hypothetical protein 0.362 1 1
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0179 0.0471 0.0471
Echinococcus multilocularis nAChR subunit 0.0092 0.023 0.023
Onchocerca volvulus 0.0014 0.0015 0.0069
Brugia malayi Carboxylesterase family protein 0.0612 0.1669 0.1669
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0062 0.0404
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0297 0.0797 0.0797
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0004 0.0004
Echinococcus multilocularis para nitrobenzyl esterase 0.0612 0.1669 0.1669
Trypanosoma brucei glucose transporter, putative 0.0032 0.0063 0.8107
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0063 0.8107
Schistosoma mansoni nAChR subunit 0.0179 0.0471 0.0467
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0004 0.0004
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.006 0.0057
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0015 0.0015
Trypanosoma brucei glucose transporter, putative 0.0032 0.0063 0.8107
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0015 0.0059
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0062 0.0329
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0062 0.0062
Schistosoma mansoni acetylcholine receptor-related 0.0087 0.0217 0.0213
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0034 0.0069 0.0068
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0004 0.0003
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0015 0.0059
Brugia malayi Carboxylesterase family protein 0.0612 0.1669 0.1669
Onchocerca volvulus 0.0179 0.0471 0.2806
Loa Loa (eye worm) hypothetical protein 0.0092 0.023 0.023
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0179 0.0471 0.0471
Plasmodium falciparum plasmepsin II 0.0034 0.0069 0.0462
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0062 0.0404
Schistosoma mansoni nAChR subunit 0.0179 0.0471 0.0467
Schistosoma mansoni sugar transporter 0.0014 0.0015 0.0011
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0179 0.0471 0.0471
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0034 0.0069 0.0706
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0015
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0063 0.029
Echinococcus multilocularis solute carrier family 22 0.0014 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0034 0.0069 0.0068
Loa Loa (eye worm) sugar transporter 0.0014 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0179 0.0471 0.0471
Loa Loa (eye worm) LGC-31 protein 0.0179 0.0471 0.0471
Loa Loa (eye worm) GABA receptor subunit 0.0092 0.023 0.023
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0029 0.0084
Loa Loa (eye worm) acetylcholine receptor protein 0.0087 0.0217 0.0216
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.006 0.006
Echinococcus granulosus dnaJ subfamily B 0.0414 0.1122 0.1122
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0003
Echinococcus granulosus nAChR subunit 0.0092 0.023 0.023
Onchocerca volvulus 0.0612 0.1669 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0102 0.0258 0.3201
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0087 0.0217 0.0216
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0004 0.0003
Schistosoma mansoni cathepsin D (A01 family) 0.0034 0.0069 0.0065
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0015
Onchocerca volvulus 0.0014 0.0015 0.0069
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0179 0.0471 0.0471
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0004 0.0003
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.006 0.006
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0069 0.0065
Loa Loa (eye worm) hypothetical protein 0.0034 0.0069 0.0068
Schistosoma mansoni neuroligin 3 (S09 family) 0.0612 0.1669 0.1666
Leishmania major glucose transporter, lmgt3 0.0032 0.0063 0.8107
Trypanosoma brucei glucose transporter, putative 0.0032 0.0063 0.8107
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0015 0.0015
Brugia malayi hypothetical protein 0.0087 0.0217 0.0217
Brugia malayi Eukaryotic aspartyl protease family protein 0.0034 0.0069 0.0069
Plasmodium falciparum plasmepsin VIII, putative 0.0034 0.0069 0.0462
Trypanosoma brucei glucose transporter, putative 0.0032 0.0063 0.8107
Echinococcus granulosus glycine receptor subunit alpha 1 0.0179 0.0471 0.0471
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0062 0.0329
Schistosoma mansoni nAChR subunit 0.0087 0.0217 0.0213
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0087 0.0217 0.0216
Onchocerca volvulus 0.0087 0.0217 0.1278
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0004 0.0003
Brugia malayi hypothetical protein 0.0014 0.0015 0.0015
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0004 0.0003
Trypanosoma cruzi hexose transporter 0.0032 0.0063 0.8107
Loa Loa (eye worm) hypothetical protein 0.0092 0.023 0.023
Mycobacterium ulcerans carboxylesterase, LipT 0.0612 0.1669 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.362 1 1
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0046 0.0217
Trypanosoma brucei glucose transporter, putative 0.0032 0.0063 0.8107
Brugia malayi Cation transporter family protein 0.0179 0.0471 0.0471
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0039 0.0035
Onchocerca volvulus 0.0612 0.1669 1
Brugia malayi ecdysteroid receptor 0.001 0.0004 0.0004
Echinococcus granulosus cpg binding protein 0.0031 0.0061 0.006
Loa Loa (eye worm) hypothetical protein 0.0655 0.1789 0.1789
Loa Loa (eye worm) hypothetical protein 0.0126 0.0323 0.0323
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0179 0.0471 0.0471
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0234 0.0623 0.0622
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0179 0.0471 0.0471
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0087 0.0217 0.0217

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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