TDR Targets

Basic information

Technical information

TDR Targets ID: 836759
Name: 2-[3-(4-methoxyphenyl)-2-oxo-1,4-diazaspiro[4 .5]dec-3-en-1-yl]-N-(3-methylphenyl)acetamide
MW: 405.489 | Formula: C24H27N3O3
H donors: 1 H acceptors: 2 LogP: 3.88 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)C1=NC2(N(C1=O)CC(=O)Nc1cccc(c1)C)CCCCC2
InChi: 1S/C24H27N3O3/c1-17-7-6-8-19(15-17)25-21(28)16-27-23(29)22(18-9-11-20(30-2)12-10-18)26-24(27)13-4-3-5-14-24/h6-12,15H,3-5,13-14,16H2,1-2H3,(H,25,28)
InChiKey: PTHHCLBVLSLGJI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[2-keto-3-(4-methoxyphenyl)-1,4-diazaspiro[4.5]dec-3-en-1-yl]-N-(3-methylphenyl)acetamide
2-[3-(4-methoxyphenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl]-N-(3-methylphenyl)ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	nuclear receptor NHR-88	0.0046	0.0958	0.1386
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0215	0.0215
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.0215	0.0479
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0046	0.0958	0.1417
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0046	0.0958	0.0958
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0215	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0215	0.0318
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0025	0.0025
Loa Loa (eye worm)	nuclear hormone receptor	0.0022	0.0215	0.0318
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0922	0.2254
Brugia malayi	nuclear hormone receptor	0.0022	0.0215	0.0283
Schistosoma mansoni	thyroid hormone receptor	0.0046	0.0958	0.2345
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0015	0.0025	0.0037
Echinococcus granulosus	thyroid hormone receptor alpha	0.0022	0.0215	0.0215
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0307	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0215	0.0318
Schistosoma mansoni	retinoic acid receptor RXR	0.0145	0.4006	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0307	0.0454
Brugia malayi	hypothetical protein	0.0024	0.0295	0.0401
Echinococcus multilocularis	FTZ F1 alpha	0.0046	0.0958	0.0958
Schistosoma mansoni	nuclear hormone receptor	0.0046	0.0958	0.2345
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0958	0.1417
Loa Loa (eye worm)	hypothetical protein	0.005	0.1081	0.1599
Brugia malayi	nuclear receptor RXR	0.0022	0.0215	0.0283
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0024	0.0024
Brugia malayi	Nuclear hormone receptor-like 1	0.0024	0.0295	0.0401
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0046	0.0958	0.0958
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0046	0.0958	0.1386
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0307	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0046	0.0958	0.1386
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0922	0.2254
Schistosoma mansoni	coup transcription factor	0.0046	0.0958	0.2345
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1045	0.1546
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0046	0.0958	0.1386
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0024	0.0024
Brugia malayi	MH2 domain containing protein	0.0116	0.3128	0.4607
Brugia malayi	isocitrate dehydrogenase	0.0015	0.0025	0.0001
Brugia malayi	hypothetical protein	0.0024	0.0295	0.0401
Schistosoma mansoni	nuclear receptor	0.0022	0.0215	0.0479
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.1045	0.1546
Brugia malayi	ecdysone receptor	0.0022	0.0215	0.0283
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0022	0.0215	0.0283
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0046	0.0958	0.1417
Brugia malayi	Nuclear hormone receptor-like 1	0.0046	0.0958	0.1386
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0307	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0046	0.0958	0.1386
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0572	0.0814
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0046	0.0958	0.1386
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0215	0.0318
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0046	0.0958	0.1386
Brugia malayi	nuclear receptor NHR-67	0.0022	0.0215	0.0283
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0046	0.0958	0.0958
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0922	0.0922
Entamoeba histolytica	hypothetical protein	0.0035	0.0629	0.5
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0024	0.0036
Brugia malayi	Pax transcription factor protein 2	0.0235	0.6761	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0046	0.0958	0.1417
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0215	0.0318
Entamoeba histolytica	hypothetical protein	0.0035	0.0629	0.5
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0215	0.0318
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0022	0.0215	0.0215
Echinococcus granulosus	ecdysone induced protein 78C	0.0046	0.0958	0.0958
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0629	0.152
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0215	0.0215
Echinococcus granulosus	GPCR family 2	0.0015	0.0024	0.0024
Brugia malayi	nuclear receptor NHR-88	0.0022	0.0215	0.0283
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0022	0.0215	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0958	0.1417
Schistosoma mansoni	RAR-like nuclear receptor	0.0046	0.0958	0.2345
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0046	0.0958	0.2345
Brugia malayi	hypothetical protein	0.0016	0.0039	0.0022
Echinococcus multilocularis	nuclear receptor nhr 48	0.0022	0.0215	0.0215
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0046	0.0958	0.0958
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0572	0.0847
Brugia malayi	Isocitrate dehydrogenase	0.0015	0.0025	0.0001
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0074	0.1829	0.1829
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0024	0.0024
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0024	0.0295	0.0679
Echinococcus multilocularis	isocitrate dehydrogenase	0.0015	0.0025	0.0025
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0046	0.0958	0.1386
Echinococcus granulosus	nuclear receptor nhr 48	0.0022	0.0215	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0958	0.1417
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0046	0.0958	0.1386
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0046	0.0958	0.1417
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.3128	0.4626
Schistosoma mansoni	cellular tumor antigen P53	0.005	0.1081	0.2654
Schistosoma mansoni	hypothetical protein	0.0033	0.0572	0.1377
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0046	0.0958	0.0958
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0015	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0295	0.0436
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0015	0.0025	0.0002
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.0215	0.0479
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0046	0.0958	0.1417
Echinococcus multilocularis	tumor protein p63	0.034	1	1
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0022	0.0215	0.0318
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0922	0.1333
Brugia malayi	hypothetical protein	0.0025	0.0307	0.0419
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0958	0.1417
Loa Loa (eye worm)	pax transcription factor protein 2	0.0235	0.6761	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0307	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0024	0.0024
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0922	0.2254
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0295	0.0436
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0022	0.0215	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0024	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0215	0.0318
Loa Loa (eye worm)	DR-78	0.0022	0.0215	0.0318
Onchocerca volvulus	Protein ultraspiracle homolog	0.0046	0.0958	0.1135
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0307	1
Onchocerca volvulus		0.005	0.1081	0.1323
Brugia malayi	ecdysteroid receptor	0.0046	0.0958	0.1386
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0022	0.0215	0.0318
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0046	0.0958	0.2345
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0958	0.1417
Brugia malayi	Nuclear hormone receptor-like 1	0.0024	0.0295	0.0401
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0629	0.0629
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0922	0.0922
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0024	0.0295	0.0295
Onchocerca volvulus		0.0046	0.0958	0.1135
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0046	0.0958	0.0958
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0295	0.0436
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0046	0.0958	0.2345
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0958	0.1417
Entamoeba histolytica	hypothetical protein	0.0035	0.0629	0.5
Brugia malayi	tailless protein	0.0022	0.0215	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0958	0.1417
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0046	0.0958	0.0958
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0215	0.0318
Brugia malayi	hypothetical protein	0.0035	0.0629	0.0898
Onchocerca volvulus	Bile acid receptor homolog	0.0046	0.0958	0.1135
Loa Loa (eye worm)	steroid hormone receptor	0.0046	0.0958	0.1417
Schistosoma mansoni	nuclear receptor nhr-48	0.0022	0.0215	0.0479
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0022	0.0215	0.0215
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0074	0.1829	0.1829
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0025	0.0025
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0046	0.0958	0.0958
Brugia malayi	hypothetical protein	0.0022	0.0215	0.0283
Entamoeba histolytica	hypothetical protein	0.0035	0.0629	0.5
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0295	0.0436
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0046	0.0958	0.0958
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0046	0.0958	0.1386
Brugia malayi	Nuclear hormone receptor E75	0.0022	0.0215	0.0283
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0025	0.0025
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0046	0.0958	0.1135
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0215	0.0318
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0022	0.0215	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0215	0.0318
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.3128	0.4626
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0015	0.0025	0.5
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0215	0.0318
Brugia malayi	steroid hormone receptor	0.0046	0.0958	0.1386
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0046	0.0958	0.1386
Onchocerca volvulus		0.0235	0.6761	1
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0024	0.0295	0.0295
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0046	0.0958	0.2345
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0046	0.0958	0.2345
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0022	0.0215	0.0215
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0046	0.0958	0.1386
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0022	0.0215	0.0479
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0046	0.0958	0.1386
Echinococcus granulosus	FTZ F1 alpha	0.0046	0.0958	0.0958
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0922	0.0922
Echinococcus multilocularis	ecdysone induced protein 78C	0.0046	0.0958	0.0958
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0121	0.3263	0.3263
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0295	0.0436
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0046	0.0958	0.0958
Schistosoma mansoni	thyroid hormone receptor	0.0046	0.0958	0.2345
Brugia malayi	Steroid receptor seven-up type 2	0.0046	0.0958	0.1386
Brugia malayi	orphan nuclear receptor NR2E1	0.0022	0.0215	0.0283
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0024	0.0295	0.0436
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0046	0.0958	0.2345
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0629	0.0629
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0046	0.0958	0.1417
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0046	0.0958	0.2345
Brugia malayi	nuclear hormone receptor	0.0046	0.0958	0.1386
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0215	0.0318
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0046	0.0958	0.1417
Brugia malayi	hypothetical protein	0.0022	0.0215	0.0283
Schistosoma mansoni	nuclear receptor	0.0022	0.0215	0.0479
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0046	0.0958	0.1386
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.1045	0.1515
Schistosoma mansoni	hypothetical protein	0.0035	0.0629	0.152
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0215	0.0318
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0022	0.0215	0.0283
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0046	0.0958	0.0958
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0307	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.1045	0.1515
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0015	0.0025	0.0025
Leishmania major	hypothetical protein, conserved	0.0025	0.0307	1
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0024	0.0295	0.0679
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0046	0.0958	0.0958
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0307	1
Brugia malayi	nuclear hormone receptor family member odr-7	0.0022	0.0215	0.0283
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0922	0.1363
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0922	0.0922
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0046	0.0958	0.0958
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0958	0.1417
Brugia malayi	nuclear receptor RXR	0.0024	0.0295	0.0401
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0022	0.0215	0.0215
Brugia malayi	conserved hypotetical protein	0.0022	0.0215	0.0283
Brugia malayi	Nuclear hormone receptor E75	0.0022	0.0215	0.0283
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0145	0.4006	0.4006
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0046	0.0958	0.1386
Schistosoma mansoni	zinc finger protein	0.0022	0.0215	0.0479

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 836759