Detailed information for compound 836785

Basic information

Technical information
  • TDR Targets ID: 836785
  • Name: N-(3-chloro-4-methylphenyl)-3-[3-(2-methoxyet hyl)imidazo[5,4-b]pyridin-2-yl]propanamide
  • MW: 372.849 | Formula: C19H21ClN4O2
  • H donors: 1 H acceptors: 3 LogP: 2.58 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCn1c(CCC(=O)Nc2ccc(c(c2)Cl)C)nc2c1nccc2
  • InChi: 1S/C19H21ClN4O2/c1-13-5-6-14(12-15(13)20)22-18(25)8-7-17-23-16-4-3-9-21-19(16)24(17)10-11-26-2/h3-6,9,12H,7-8,10-11H2,1-2H3,(H,22,25)
  • InChiKey: BWOYJQAGXCMBFC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-chloro-4-methyl-phenyl)-3-[3-(2-methoxyethyl)imidazo[5,4-b]pyridin-2-yl]propanamide
  • N-(3-chloro-4-methylphenyl)-3-[3-(2-methoxyethyl)-2-imidazo[5,4-b]pyridinyl]propanamide
  • N-(3-chloro-4-methyl-phenyl)-3-[3-(2-methoxyethyl)imidazo[5,4-b]pyridin-2-yl]propionamide
  • C919-0274
  • NCGC00114586-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus BC026374 protein S09 family 0.0047 0.1034 0.1034
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0033 0.0646 0.0646
Brugia malayi RE15519p 0.0033 0.0646 0.0463
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0942 0.5
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Loa Loa (eye worm) hypothetical protein 0.0029 0.0538 0.0351
Onchocerca volvulus 0.0047 0.1034 1
Loa Loa (eye worm) hypothetical protein 0.0277 0.7482 0.753
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0033 0.0646 0.0646
Echinococcus multilocularis somatostatin receptor 0.0033 0.0646 0.0646
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0033 0.0646 0.0646
Mycobacterium ulcerans carboxylesterase, LipT 0.0047 0.1034 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0538 0.0351
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Entamoeba histolytica transcription factor BTF3, putative 0.0038 0.0776 0.9453
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0646 0.0646
Echinococcus granulosus para nitrobenzyl esterase 0.0047 0.1034 0.1034
Echinococcus granulosus 7TM GPCR rhodopsin 0.0033 0.0646 0.0646
Echinococcus multilocularis neuropeptides capa receptor 0.0033 0.0646 0.0646
Echinococcus granulosus GPCR family 2 0.0017 0.0198 0.0198
Brugia malayi hypothetical protein 0.0033 0.0646 0.0463
Echinococcus granulosus biogenic amine 5HT receptor 0.0033 0.0646 0.0646
Echinococcus multilocularis neuropeptide s receptor 0.0033 0.0646 0.0646
Echinococcus multilocularis acetylcholinesterase 0.0277 0.7482 0.7482
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0362 0.9872 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Loa Loa (eye worm) hypothetical protein 0.0277 0.7482 0.753
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0047 0.1034 0.1034
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0033 0.0646 0.0646
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.1101 0.1101
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0033 0.0646 0.0646
Echinococcus granulosus hypothetical protein 0.0033 0.0646 0.0646
Echinococcus multilocularis fmrfamide receptor 0.0033 0.0646 0.0646
Schistosoma mansoni neuropeptide receptor 0.0033 0.0646 0.0646
Schistosoma mansoni alpha-1 adrenergic receptor 0.0033 0.0646 0.0646
Onchocerca volvulus 0.0033 0.0646 0.2185
Echinococcus granulosus neuropeptide receptor 0.0033 0.0646 0.0646
Schistosoma mansoni neuropeptide f receptor 76f 0.0033 0.0646 0.0646
Echinococcus multilocularis g protein coupled receptor 0.0033 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0047 0.1034 0.0864
Loa Loa (eye worm) hypothetical protein 0.0043 0.0942 0.0769
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0646 0.0646
Brugia malayi Animal haem peroxidase family protein 0.0029 0.0538 0.0351
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0646 0.0646
Brugia malayi putative neuropeptide receptor 0.0033 0.0646 0.0463
Echinococcus granulosus dro:myosuppressin receptor 0.0033 0.0646 0.0646
Onchocerca volvulus 0.0033 0.0646 0.2185
Echinococcus granulosus g protein coupled receptor 0.0033 0.0646 0.0646
Brugia malayi beta-lactamase family protein 0.0043 0.0942 0.0769
Echinococcus multilocularis neuropeptide FF receptor 2 0.0033 0.0646 0.0646
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0646 0.0646
Echinococcus multilocularis allatostatin A receptor 0.0033 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0054 0.1224 0.1061
Echinococcus multilocularis GPCR, family 2 0.0017 0.0198 0.0198
Mycobacterium tuberculosis Carboxylesterase LipT 0.0047 0.1034 0.014
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Echinococcus granulosus neuropeptide Y receptor 0.0033 0.0646 0.0646
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0033 0.0646 0.0463
Brugia malayi beta-NAC-like protein 0.0038 0.0776 0.0598
Onchocerca volvulus 0.0043 0.0942 0.8148
Echinococcus granulosus g protein coupled receptor 0.0033 0.0646 0.0646
Schistosoma mansoni peroxidasin 0.0029 0.0538 0.0538
Brugia malayi Dopamine receptor 0.0033 0.0646 0.0463
Entamoeba histolytica hypothetical protein 0.0039 0.0821 1
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0047 0.1034 0.1034
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0033 0.0646 0.0646
Brugia malayi hypothetical protein 0.0033 0.0646 0.0463
Onchocerca volvulus 0.0033 0.0646 0.2185
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0047 0.1034 0.1034
Onchocerca volvulus 0.0033 0.0646 0.2185
Brugia malayi Melatonin receptor type 1A 0.0033 0.0646 0.0463
Trichomonas vaginalis spcc417.12 protein, putative 0.0047 0.1034 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0033 0.0646 0.0646
Echinococcus multilocularis transcription factor btf3 0.0038 0.0776 0.0776
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0198 0.0198
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0033 0.0646 0.0646
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0776 0.8239
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0033 0.0646 0.0463
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0821 0.0821
Onchocerca volvulus 0.0033 0.0646 0.2185
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0033 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Onchocerca volvulus 0.0033 0.0646 0.2185
Echinococcus granulosus sex peptide receptor 0.0033 0.0646 0.0646
Brugia malayi larval opioid receptor 0.0033 0.0646 0.0463
Schistosoma mansoni opsin-like receptor 0.0033 0.0646 0.0646
Echinococcus granulosus peptide allatostatin:somatostatin 0.0033 0.0646 0.0646
Brugia malayi follicle stimulating hormone receptor 0.0033 0.0646 0.0463
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0646 0.0646
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0942 1
Onchocerca volvulus 0.0033 0.0646 0.2185
Loa Loa (eye worm) hypothetical protein 0.0047 0.1034 0.0864
Brugia malayi hypothetical protein 0.0033 0.0646 0.0463
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0942 0.9111
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Brugia malayi G protein-coupled receptor F59B2.13 0.0033 0.0646 0.0463
Brugia malayi hypothetical protein 0.0033 0.0646 0.0463
Loa Loa (eye worm) hypothetical protein 0.0029 0.0538 0.0351
Echinococcus granulosus neuroligin 0.0047 0.1034 0.1034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0646 0.0646
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0047 0.1034 0.1034
Echinococcus multilocularis fmrfamide receptor 0.0033 0.0646 0.0646
Echinococcus multilocularis acetylcholinesterase 0.0277 0.7482 0.7482
Schistosoma mansoni transcription factor btf3 0.0038 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.0029 0.0538 0.0351
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0942 1
Brugia malayi Carboxylesterase family protein 0.0277 0.7482 0.753
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0821 0.0821
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0646 0.0646
Brugia malayi neuropeptide F receptor 0.0033 0.0646 0.0463
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0033 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0029 0.0538 0.0351
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Loa Loa (eye worm) hypothetical protein 0.0029 0.0538 0.0351
Schistosoma mansoni amine GPCR 0.0033 0.0646 0.0646
Brugia malayi Tachykinin-like peptides receptor 99D 0.0033 0.0646 0.0463
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Echinococcus granulosus fmrfamide receptor 0.0033 0.0646 0.0646
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.1224 0.1061
Echinococcus granulosus orexin receptor type 2 0.0033 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0033 0.0646 0.0646
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0646 0.0646
Echinococcus granulosus biogenic amine 5HT receptor 0.0033 0.0646 0.0646
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0942 0.6436
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0033 0.0646 0.0463
Echinococcus granulosus G protein coupled receptor 139 0.0033 0.0646 0.0646
Echinococcus granulosus acetylcholinesterase 0.0277 0.7482 0.7482
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0646 0.0646
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0033 0.0646 0.0646
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Loa Loa (eye worm) animal heme peroxidase 0.0029 0.0538 0.0351
Schistosoma mansoni acetylcholinesterase 0.0047 0.1034 0.1034
Brugia malayi hypothetical protein 0.0047 0.1034 0.0864
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0646 0.0646
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0033 0.0646 0.0646
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0942 0.9111
Loa Loa (eye worm) hypothetical protein 0.0047 0.1034 0.0864
Echinococcus multilocularis neuropeptide receptor 0.0033 0.0646 0.0646
Schistosoma mansoni hypothetical protein 0.0367 1 1
Echinococcus multilocularis peroxidasin 0.0029 0.0538 0.0538
Loa Loa (eye worm) hypothetical protein 0.0029 0.0538 0.0351
Loa Loa (eye worm) hypothetical protein 0.0029 0.0538 0.0351
Echinococcus granulosus alpha 1A adrenergic receptor 0.0033 0.0646 0.0646
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0646 0.0646
Loa Loa (eye worm) carboxylesterase 0.0047 0.1034 0.0864
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Loa Loa (eye worm) animal heme peroxidase 0.0029 0.0538 0.0351
Loa Loa (eye worm) hypothetical protein 0.0047 0.1034 0.0864
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0033 0.0646 0.0646
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0942 0.6436
Loa Loa (eye worm) hypothetical protein 0.0029 0.0538 0.0351
Entamoeba histolytica hypothetical protein 0.0038 0.0776 0.9453
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0942 0.0769
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0033 0.0646 0.0463
Schistosoma mansoni amine GPCR 0.0033 0.0646 0.0646
Brugia malayi Peroxidasin 0.0029 0.0538 0.0351
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Brugia malayi Animal haem peroxidase family protein 0.0029 0.0538 0.0351
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0942 1
Brugia malayi Serotonin receptor 0.0033 0.0646 0.0463
Echinococcus multilocularis g-protein coupled receptor 0.0033 0.0646 0.0646
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0942 0.0769
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0749 0.057
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0033 0.0646 0.0646
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0033 0.0646 0.0646
Leishmania major hypothetical protein, conserved 0.0043 0.0942 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0821 0.0821
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0033 0.0646 0.0646
Schistosoma mansoni adenoreceptor 0.0033 0.0646 0.0646
Schistosoma mansoni amine GPCR 0.0033 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Brugia malayi ORL1-like opioid receptor 0.0033 0.0646 0.0463
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0029 0.0538 0.0351
Brugia malayi hypothetical protein 0.0033 0.0646 0.0463
Echinococcus multilocularis neuropeptide receptor 0.0033 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Brugia malayi Dopamine receptor protein 2 0.0033 0.0646 0.0463
Loa Loa (eye worm) hypothetical protein 0.0043 0.0942 0.0769
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0362 0.9872 0.9872
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0646 0.0646
Loa Loa (eye worm) acetylcholinesterase 1 0.0277 0.7482 0.753
Echinococcus multilocularis neuroligin 0.0047 0.1034 0.1034
Schistosoma mansoni neuropeptide receptor 0.0033 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0029 0.0538 0.0351
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0646 0.0646
Loa Loa (eye worm) TYRA-2 protein 0.0033 0.0646 0.0463
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0033 0.0646 0.0646
Echinococcus multilocularis orexin receptor type 2 0.0033 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0047 0.1034 0.0864
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0047 0.1034 0.1034
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Brugia malayi beta-lactamase family protein 0.0043 0.0942 0.0769
Loa Loa (eye worm) hypothetical protein 0.0043 0.0942 0.0769
Brugia malayi neuropeptide F receptor 0.0033 0.0646 0.0463
Echinococcus multilocularis geminin 0.0367 1 1
Plasmodium vivax basic transcription factor 3b, putative 0.0038 0.0776 0.8239
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0033 0.0646 0.0463
Onchocerca volvulus 0.0047 0.1034 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0033 0.0646 0.2185
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0646 0.0646
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0942 0.0942
Echinococcus granulosus peroxidasin 0.0029 0.0538 0.0538
Schistosoma mansoni amine GPCR 0.0033 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Onchocerca volvulus 0.0033 0.0646 0.2185
Schistosoma mansoni biogenic amine (5HT) receptor 0.0033 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0033 0.0646 0.0646
Leishmania major basic transcription factor 3a, putative 0.0038 0.0776 0.8239
Brugia malayi hypothetical protein 0.0039 0.0821 0.0644
Echinococcus granulosus neuropeptide FF receptor 2 0.0033 0.0646 0.0646
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1101 0.1101
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0033 0.0646 0.0463
Mycobacterium ulcerans beta-lactamase 0.0043 0.0942 0.9111
Brugia malayi Carboxylesterase family protein 0.0047 0.1034 0.0864
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0033 0.0646 0.0646
Loa Loa (eye worm) beta-lactamase 0.0043 0.0942 0.0769
Toxoplasma gondii NAC domain-containing protein 0.0038 0.0776 0.8239
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0033 0.0646 0.0646
Schistosoma mansoni opsin-like receptor 0.0033 0.0646 0.0646
Echinococcus granulosus allatostatin A receptor 0.0033 0.0646 0.0646
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0942 0.0942
Brugia malayi Dopamine receptor protein 1 0.0033 0.0646 0.0463
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0646 0.0646
Toxoplasma gondii ABC1 family protein 0.0043 0.0942 1
Loa Loa (eye worm) blistered cuticle protein 3 0.0029 0.0538 0.0351
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Schistosoma mansoni BC026374 protein (S09 family) 0.0047 0.1034 0.1034
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.1101 0.0933
Loa Loa (eye worm) ICD-1 protein 0.0038 0.0776 0.0598
Loa Loa (eye worm) G-protein coupled receptor 0.0033 0.0646 0.0463
Onchocerca volvulus 0.0033 0.0646 0.2185
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0033 0.0646 0.0646
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0198 0.0198
Schistosoma mansoni hypothetical protein 0.0033 0.0646 0.0646
Schistosoma mansoni hypothetical protein 0.0017 0.0198 0.0198
Brugia malayi Serotonin receptor 0.0033 0.0646 0.0463
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0942 0.0942
Mycobacterium ulcerans hypothetical protein 0.0043 0.0942 0.9111
Onchocerca volvulus 0.0043 0.0942 0.8148
Loa Loa (eye worm) carboxylesterase 0.0047 0.1034 0.0864
Echinococcus multilocularis neuropeptide Y receptor 0.0033 0.0646 0.0646
Schistosoma mansoni neuroligin 3 (S09 family) 0.0047 0.1034 0.1034
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0362 0.9872 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0033 0.0646 0.2185
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0646 0.0646
Echinococcus multilocularis serotonin receptor 0.0033 0.0646 0.0646
Brugia malayi hypothetical protein 0.0033 0.0646 0.0463
Echinococcus granulosus neuropeptide s receptor 0.0033 0.0646 0.0646
Loa Loa (eye worm) carboxylesterase 0.0277 0.7482 0.753
Brugia malayi hypothetical protein 0.0033 0.0646 0.0463
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.1101 0.1101
Echinococcus granulosus acetylcholinesterase 0.0277 0.7482 0.7482
Onchocerca volvulus 0.0033 0.0646 0.2185
Brugia malayi Carboxylesterase family protein 0.0047 0.1034 0.0864
Echinococcus multilocularis serotonin receptor 0.0033 0.0646 0.0646
Schistosoma mansoni histamine h1 receptor 0.0033 0.0646 0.0646
Loa Loa (eye worm) neuropeptide F receptor 0.0033 0.0646 0.0463
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.1224 0.1061
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Loa Loa (eye worm) hypothetical protein 0.0029 0.0538 0.0351
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0033 0.0646 0.0646
Brugia malayi hypothetical protein 0.0033 0.0646 0.0463
Brugia malayi Carboxylesterase family protein 0.0277 0.7482 0.753
Brugia malayi Blistered cuticle protein 3 0.0029 0.0538 0.0351
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0033 0.0646 0.0646
Echinococcus multilocularis sex peptide receptor 0.0033 0.0646 0.0646
Brugia malayi hypothetical protein 0.0033 0.0646 0.0463
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0033 0.0646 0.0463
Entamoeba histolytica hypothetical protein 0.0039 0.0821 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0033 0.0646 0.0646
Schistosoma mansoni hypothetical protein 0.0367 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Loa Loa (eye worm) hypothetical protein 0.0037 0.0749 0.057
Plasmodium falciparum basic transcription factor 3b, putative 0.0038 0.0776 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0033 0.0646 0.0646
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0942 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0033 0.0646 0.0463
Echinococcus multilocularis G protein coupled receptor 139 0.0033 0.0646 0.0646
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0033 0.0646 0.0646
Echinococcus granulosus tm gpcr rhodopsin 0.0033 0.0646 0.0646
Loa Loa (eye worm) neuropeptide F receptor 0.0033 0.0646 0.0463
Echinococcus multilocularis g protein coupled receptor 0.0033 0.0646 0.0646
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0277 0.7482 0.7482
Echinococcus multilocularis neuropeptides capa receptor 0.0033 0.0646 0.0646
Brugia malayi hypothetical protein 0.0029 0.0538 0.0351
Schistosoma mansoni opsin-like receptor 0.0033 0.0646 0.0646
Schistosoma mansoni neuropeptide F-like receptor 0.0033 0.0646 0.0646
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.1101 0.1101
Trypanosoma brucei transcription factor BTF3, putative 0.0038 0.0776 0.8239
Schistosoma mansoni hypothetical protein 0.0017 0.0198 0.0198
Entamoeba histolytica hypothetical protein 0.0039 0.0821 1
Onchocerca volvulus 0.0043 0.0942 0.8148
Echinococcus granulosus serotonin receptor 0.0033 0.0646 0.0646
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0047 0.1034 0.014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0646 0.0646
Onchocerca volvulus 0.0047 0.1034 1
Echinococcus granulosus neuropeptide Y receptor 0.0033 0.0646 0.0646
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0776 0.8239
Onchocerca volvulus 0.0033 0.0646 0.2185
Brugia malayi sulfakinin receptor protein 0.0033 0.0646 0.0463
Schistosoma mansoni growth hormone secretagogue receptor 0.0033 0.0646 0.0646
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0942 0.0942
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1101 0.1101
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Schistosoma mansoni hypothetical protein 0.0039 0.0821 0.0821
Onchocerca volvulus 0.0033 0.0646 0.2185
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.1101 0.1101
Schistosoma mansoni biogenic amine receptor 0.0033 0.0646 0.0646
Echinococcus granulosus g protein coupled receptor 0.0033 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0033 0.0646 0.0646
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0033 0.0646 0.0463
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0047 0.1034 0.014
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.7512 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Schistosoma mansoni peroxidasin 0.0029 0.0538 0.0538
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0646 0.0646
Echinococcus granulosus neuropeptides capa receptor 0.0033 0.0646 0.0646
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0047 0.1034 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Loa Loa (eye worm) hypothetical protein 0.0029 0.0538 0.0351
Brugia malayi G protein-coupled receptor 0.0033 0.0646 0.0463
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0033 0.0646 0.0646
Trichomonas vaginalis esterase, putative 0.0043 0.0942 0.6436
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0646 0.0646
Schistosoma mansoni hypothetical protein 0.0033 0.0646 0.0646
Echinococcus granulosus somatostatin receptor 0.0033 0.0646 0.0646
Entamoeba histolytica hypothetical protein 0.0039 0.0821 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.1034 0.0864
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0033 0.0646 0.0646
Onchocerca volvulus 0.0047 0.1034 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0033 0.0646 0.0646
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.1224 0.1061
Echinococcus granulosus tm gpcr rhodopsin 0.0033 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Echinococcus granulosus neuropeptides capa receptor 0.0033 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0043 0.0942 0.0769
Loa Loa (eye worm) animal heme peroxidase 0.0029 0.0538 0.0351
Schistosoma mansoni neuropeptide receptor 0.0033 0.0646 0.0646
Echinococcus granulosus tachykinin peptides receptor 99D 0.0033 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Echinococcus multilocularis g protein coupled receptor 0.0033 0.0646 0.0646
Schistosoma mansoni hypothetical protein 0.0037 0.0749 0.0749
Onchocerca volvulus 0.0033 0.0646 0.2185
Echinococcus granulosus carboxylesterase 5A 0.0277 0.7482 0.7482
Mycobacterium leprae Probable lipase LipE 0.0043 0.0942 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Onchocerca volvulus 0.0033 0.0646 0.2185
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0033 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Schistosoma mansoni biogenic amine receptor 0.0033 0.0646 0.0646
Echinococcus multilocularis para nitrobenzyl esterase 0.0047 0.1034 0.1034
Loa Loa (eye worm) melatonin receptor type 1A 0.0033 0.0646 0.0463
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Brugia malayi GnHR receptor homolog 0.0033 0.0646 0.0463
Echinococcus granulosus g-protein coupled receptor 0.0033 0.0646 0.0646
Echinococcus multilocularis carboxylesterase 5A 0.0277 0.7482 0.7482
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0198 0.0198
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0362 0.9872 0.9872
Onchocerca volvulus 0.0047 0.1034 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0033 0.0646 0.0646
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0646 0.0646
Schistosoma mansoni hypothetical protein 0.0017 0.0198 0.0198
Onchocerca volvulus 0.0033 0.0646 0.2185
Brugia malayi hypothetical protein 0.0033 0.0646 0.0463
Loa Loa (eye worm) hypothetical protein 0.0043 0.0942 0.0769
Brugia malayi beta-lactamase 0.0043 0.0942 0.0769
Loa Loa (eye worm) animal heme peroxidase 0.0029 0.0538 0.0351
Onchocerca volvulus 0.0033 0.0646 0.2185
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.1101 0.0933
Brugia malayi Animal haem peroxidase family protein 0.0029 0.0538 0.0351
Loa Loa (eye worm) G-protein coupled receptor 0.0033 0.0646 0.0463
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0942 0.6436
Brugia malayi G-protein coupled receptor 0.0033 0.0646 0.0463
Echinococcus granulosus neuropeptide receptor A26 0.0033 0.0646 0.0646
Echinococcus multilocularis BC026374 protein (S09 family) 0.0047 0.1034 0.1034
Echinococcus multilocularis neuropeptide Y receptor 0.0033 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Onchocerca volvulus 0.0033 0.0646 0.2185
Schistosoma mansoni amine GPCR 0.0033 0.0646 0.0646
Brugia malayi Carboxylesterase family protein 0.0047 0.1034 0.0864
Schistosoma mansoni myosin xvIII 0.0033 0.0646 0.0646
Echinococcus granulosus neuropeptide receptor 0.0033 0.0646 0.0646
Schistosoma mansoni biogenic amine (5HT) receptor 0.0033 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0942 0.6436
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Echinococcus granulosus 7tm_1 domain containing protein 0.0033 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0033 0.0646 0.0463
Schistosoma mansoni hypothetical protein 0.0017 0.0198 0.0198
Schistosoma mansoni neuropeptide F-like receptor 0.0033 0.0646 0.0646
Brugia malayi putative neuropeptide receptor NPR1 0.0033 0.0646 0.0463
Schistosoma mansoni gliotactin 0.0047 0.1034 0.1034
Brugia malayi Animal haem peroxidase family protein 0.0029 0.0538 0.0351
Schistosoma mansoni neuropeptide receptor 0.0033 0.0646 0.0646
Echinococcus granulosus transcription factor btf3 0.0038 0.0776 0.0776
Echinococcus granulosus tm gpcr rhodopsin 0.0033 0.0646 0.0646
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1101 0.1101
Brugia malayi AKH receptor 0.0033 0.0646 0.0463
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0033 0.0646 0.0463
Echinococcus multilocularis neuropeptide receptor A26 0.0033 0.0646 0.0646
Schistosoma mansoni hypothetical protein 0.0033 0.0646 0.0646
Brugia malayi G-protein coupled receptor 0.0033 0.0646 0.0463
Mycobacterium ulcerans lipase LipD 0.0043 0.0942 0.9111
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0033 0.0646 0.0646
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0362 0.9872 0.9872
Brugia malayi Animal haem peroxidase family protein 0.0029 0.0538 0.0351
Loa Loa (eye worm) hypothetical protein 0.0029 0.0538 0.0351
Brugia malayi Carboxylesterase family protein 0.0047 0.1034 0.0864
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0033 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0047 0.1034 0.0864
Loa Loa (eye worm) hypothetical protein 0.0043 0.0942 0.0769
Schistosoma mansoni hypothetical protein 0.0033 0.0646 0.0646
Schistosoma mansoni biogenic amine receptor 0.0033 0.0646 0.0646
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0942 0.6436

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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