Detailed information for compound 836832

Basic information

Technical information
  • TDR Targets ID: 836832
  • Name: N-(4-chloro-2-fluorophenyl)-3-(1,4-dimethyl-2 ,3-dioxoquinoxalin-6-yl)sulfonylpropanamide
  • MW: 453.872 | Formula: C19H17ClFN3O5S
  • H donors: 1 H acceptors: 5 LogP: 1.58 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1F)Cl)CCS(=O)(=O)c1ccc2c(c1)n(C)c(=O)c(=O)n2C
  • InChi: 1S/C19H17ClFN3O5S/c1-23-15-6-4-12(10-16(15)24(2)19(27)18(23)26)30(28,29)8-7-17(25)22-14-5-3-11(20)9-13(14)21/h3-6,9-10H,7-8H2,1-2H3,(H,22,25)
  • InChiKey: SXAVUHXXYSHKLB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(4-chloro-2-fluoro-phenyl)-3-(1,4-dimethyl-2,3-dioxo-quinoxalin-6-yl)sulfonyl-propanamide
  • N-(4-chloro-2-fluorophenyl)-3-[(1,4-dimethyl-2,3-dioxo-6-quinoxalinyl)sulfonyl]propanamide
  • N-(4-chloro-2-fluoro-phenyl)-3-(2,3-diketo-1,4-dimethyl-quinoxalin-6-yl)sulfonyl-propionamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0498 0.0484
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.0798 0.0784
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0498 0.6188
Brugia malayi intermediate filament protein 0.0054 0.0965 0.1349
Echinococcus granulosus Glycosyl transferase family 35 0.0109 0.277 0.276
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0498 0.0484
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0015 0.0021
Loa Loa (eye worm) hypothetical protein 0.0164 0.4616 0.6535
Loa Loa (eye worm) hypothetical protein 0.0026 0.0011 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.0504 0.0694
Loa Loa (eye worm) blistered cuticle protein 3 0.0026 0.0015 0.0021
Loa Loa (eye worm) hypothetical protein 0.0026 0.0015 0.0021
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0965 0.1367
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.0504 0.0694
Loa Loa (eye worm) hypothetical protein 0.004 0.0504 0.0713
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.0798 0.0784
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0775 0.1078
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.0504 0.1041
Echinococcus multilocularis tumor protein p63 0.0326 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0033 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0504 0.0694
Loa Loa (eye worm) hypothetical protein 0.0026 0.0015 0.0021
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0504 0.1041
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0965 0.1349
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.0504 0.0694
Onchocerca volvulus Bile acid receptor homolog 0.019 0.5469 1
Schistosoma mansoni lipoxygenase 0.0055 0.0992 0.2081
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.0504 0.049
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.0504 0.0713
Chlamydia trachomatis glycogen phosphorylase 0.0109 0.277 0.5
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.0798 1
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0498 0.0484
Loa Loa (eye worm) hypothetical protein 0.019 0.5469 0.7743
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0798 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0498 0.0705
Loa Loa (eye worm) hypoxia-induced factor 1 0.0152 0.4193 0.5937
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.0504 0.1041
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.0504 0.1041
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.0504 0.0694
Trichomonas vaginalis glycogen phosphorylase, putative 0.0109 0.277 1
Onchocerca volvulus 0.0048 0.075 0.1347
Entamoeba histolytica glycogen phosphorylase, putative 0.0109 0.277 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.0504 0.049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.0504 0.0713
Trypanosoma brucei protein kinase, putative 0.0049 0.0798 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0015 0.0021
Loa Loa (eye worm) hypothetical protein 0.0048 0.075 0.1061
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0127 0.3369 0.3359
Echinococcus multilocularis lamin dm0 0.0054 0.0965 0.0952
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0047 0.0723 0.5
Echinococcus granulosus lamin dm0 0.0054 0.0965 0.0952
Loa Loa (eye worm) hypothetical protein 0.0054 0.0965 0.1367
Brugia malayi steroid hormone receptor 0.004 0.0504 0.0694
Loa Loa (eye worm) steroid hormone receptor 0.004 0.0504 0.0713
Onchocerca volvulus 0.004 0.0504 0.0896
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.0504 0.049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.0504 0.0713
Entamoeba histolytica glycogen phosphorylase, putative 0.0109 0.277 1
Schistosoma mansoni glycogen phosphorylase 0.0109 0.277 0.587
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0033 0.0018
Brugia malayi hypothetical protein 0.0238 0.7063 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.004 0.0504 0.0896
Schistosoma mansoni thyroid hormone receptor 0.0167 0.4709 1
Echinococcus multilocularis glycogen phosphorylase 0.0109 0.277 0.276
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0504 0.0694
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0798 0.132
Echinococcus multilocularis musashi 0.0054 0.0965 0.0952
Echinococcus multilocularis FTZ F1 alpha 0.004 0.0504 0.049
Schistosoma mansoni coup transcription factor 0.004 0.0504 0.1041
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.0504 0.1041
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0504 0.0694
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.0798 1
Onchocerca volvulus 0.0049 0.0775 0.1394
Schistosoma mansoni single-minded 0.0049 0.0789 0.1649
Schistosoma mansoni lamin 0.0054 0.0965 0.2025
Loa Loa (eye worm) hypothetical protein 0.0026 0.0015 0.0021
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0366 0.0352
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0015 0.0021
Schistosoma mansoni hypothetical protein 0.0127 0.3369 0.7145
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0015 0.0021
Giardia lamblia Kinase, CMGC MAPK 0.0049 0.0798 0.132
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.0504 0.0694
Echinococcus multilocularis thyroid hormone receptor alpha 0.0167 0.4709 0.4701
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0498 0.1029
Brugia malayi MAP kinase sur-1 0.0049 0.0798 0.1111
Brugia malayi Steroid receptor seven-up type 2 0.004 0.0504 0.0694
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0504 0.049
Echinococcus multilocularis glycogen phosphorylase 0.0109 0.277 0.276
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0129 0.0162
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.0504 0.0896
Schistosoma mansoni glycogen phosphorylase 0.0109 0.277 0.587
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.0798 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0033 0.0018
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0992 0.0978
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.7063 0.7059
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0127 0.3369 0.3359
Echinococcus granulosus lamin 0.0054 0.0965 0.0952
Schistosoma mansoni intermediate filament proteins 0.0054 0.0965 0.2025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.0504 0.0713
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0504 0.0694
Loa Loa (eye worm) hypothetical protein 0.0026 0.0015 0.0021
Entamoeba histolytica glycogen phosphorylase, putative 0.0047 0.0723 0.0991
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0504 0.0694
Loa Loa (eye worm) hypothetical protein 0.004 0.0504 0.0713
Brugia malayi nuclear receptor NHR-88 0.004 0.0504 0.0694
Echinococcus granulosus intermediate filament protein 0.0054 0.0965 0.0952
Schistosoma mansoni retinoic acid receptor RXR 0.004 0.0504 0.1041
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.0504 0.049
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.0798 0.0784
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.7063 0.7059
Giardia lamblia Glycogen phosphorylase 0.0109 0.277 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0504 0.0694
Echinococcus granulosus retinoic acid receptor rxr beta a 0.004 0.0504 0.049
Loa Loa (eye worm) hypothetical protein 0.0026 0.0015 0.0021
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0992 0.0978
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.0504 0.049
Onchocerca volvulus 0.0036 0.0366 0.0645
Brugia malayi carbohydrate phosphorylase 0.0109 0.277 0.3909
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.0798 1
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.0504 0.0694
Schistosoma mansoni lamin 0.0054 0.0965 0.2025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.0504 0.0713
Loa Loa (eye worm) hypothetical protein 0.0026 0.0015 0.0021
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.0798 0.5
Brugia malayi hypoxia-induced factor 1 0.0152 0.4193 0.5928
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0798 1
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0798 0.132
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.0504 0.0713
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0504 0.049
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.0798 0.0784
Schistosoma mansoni survival motor neuron protein 0.0049 0.0775 0.1619
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.0504 0.0694
Brugia malayi nuclear hormone receptor 0.004 0.0504 0.0694
Schistosoma mansoni hypothetical protein 0.0049 0.0775 0.1619
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.0504 0.049
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0798 0.1668
Loa Loa (eye worm) hypothetical protein 0.0053 0.0932 0.132
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0965 0.1367
Schistosoma mansoni glycogen phosphorylase 0.0047 0.0723 0.1509
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.0504 0.049
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0798 0.132
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0498 0.6188
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.0789 0.1649
Loa Loa (eye worm) hypothetical protein 0.004 0.0504 0.0713
Echinococcus granulosus single minded 2 0.0036 0.0366 0.0352
Loa Loa (eye worm) glycogen phosphorylase 0.0109 0.277 0.3922
Schistosoma mansoni nuclear hormone receptor 0.004 0.0504 0.1041
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0498 0.1029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.0504 0.0713
Loa Loa (eye worm) hypothetical protein 0.004 0.0504 0.0713
Echinococcus granulosus glycogen phosphorylase 0.0109 0.277 0.276
Schistosoma mansoni thyroid hormone receptor 0.0167 0.4709 1
Echinococcus granulosus FTZ F1 alpha 0.004 0.0504 0.049
Loa Loa (eye worm) hypothetical protein 0.0026 0.0015 0.0021
Onchocerca volvulus 0.0054 0.0965 0.1743
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.0504 0.1041
Brugia malayi PAS domain containing protein 0.0049 0.0789 0.1098
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0504 0.049
Loa Loa (eye worm) hypothetical protein 0.0026 0.0015 0.0021
Loa Loa (eye worm) hypothetical protein 0.004 0.0504 0.0713
Loa Loa (eye worm) hypothetical protein 0.0026 0.0015 0.0021
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0798 0.132
Loa Loa (eye worm) hypothetical protein 0.0026 0.0015 0.0021
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0047 0.0723 1
Brugia malayi ecdysteroid receptor 0.019 0.5469 0.7738
Trichomonas vaginalis glycogen phosphorylase, putative 0.0109 0.277 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.0798 0.1129
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.0504 0.1041
Echinococcus granulosus glycogen phosphorylase 0.0109 0.277 0.276
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.075 0.1565
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0498 0.0484
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.0504 0.1041
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0015 0.0021
Loa Loa (eye worm) hypothetical protein 0.0026 0.0015 0.0021
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0129 0.0182
Loa Loa (eye worm) hypothetical protein 0.0026 0.0015 0.0021
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.0504 0.049
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0366 0.0499
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.0504 0.049
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0498 0.0484
Loa Loa (eye worm) hypothetical protein 0.004 0.0504 0.0713
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0504 0.049
Echinococcus multilocularis lamin 0.0054 0.0965 0.0952
Loa Loa (eye worm) hypothetical protein 0.0026 0.0015 0.0021
Entamoeba histolytica glycogen phosphorylase, putative 0.0047 0.0723 0.0991
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.0504 0.0694
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0498 0.0685
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.0504 0.049
Entamoeba histolytica glycogenphosphorylase, putative 0.0047 0.0723 0.0991
Loa Loa (eye worm) hypothetical protein 0.004 0.0504 0.0713
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0504 0.0694
Onchocerca volvulus Glycogen phosphorylase homolog 0.0109 0.277 0.5052
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0498 0.0484
Echinococcus multilocularis Glycosyl transferase, family 35 0.0109 0.277 0.276
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.0798 1
Brugia malayi hypothetical protein 0.0164 0.4616 0.6528
Loa Loa (eye worm) hypothetical protein 0.0238 0.7063 1
Onchocerca volvulus 0.0054 0.0965 0.1743

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.