Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | peroxidasin | 0.0236 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0236 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.0236 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0205 | 0.8247 | 0.8247 |
Onchocerca volvulus | Peroxidasin homolog | 0.0236 | 1 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0236 | 1 | 1 |
Onchocerca volvulus | 0.0236 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0236 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0236 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0236 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0236 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0236 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.8247 | 0.8247 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.8247 | 0.8247 |
Onchocerca volvulus | Peroxidase homolog | 0.0236 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 1 | 1 |
Onchocerca volvulus | 0.0236 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 1 | 1 |
Onchocerca volvulus | 0.0236 | 1 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0236 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0236 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0236 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0236 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0236 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0236 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 0.8247 | 0.8247 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0236 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0236 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0236 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0236 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0236 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 32.6427 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.