TDR Targets

Basic information

Technical information

TDR Targets ID: 837072
Name: N-(2-methoxyphenyl)-2-[4-oxo-3-(phenylmethyl) pyrido[2,3-d]pyrimidin-2-yl]sulfanylacetamide
MW: 432.495 | Formula: C23H20N4O3S
H donors: 1 H acceptors: 3 LogP: 3.45 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccccc1NC(=O)CSc1nc2ncccc2c(=O)n1Cc1ccccc1
InChi: 1S/C23H20N4O3S/c1-30-19-12-6-5-11-18(19)25-20(28)15-31-23-26-21-17(10-7-13-24-21)22(29)27(23)14-16-8-3-2-4-9-16/h2-13H,14-15H2,1H3,(H,25,28)
InChiKey: JEFAIEUSOBMGJA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2-methoxyphenyl)-2-[4-oxo-3-(phenylmethyl)pyrido[2,3-d]pyrimidin-2-yl]sulfanyl-acetamide
N-(2-methoxyphenyl)-2-[[4-oxo-3-(phenylmethyl)-2-pyrido[2,3-d]pyrimidinyl]thio]acetamide
2-[[3-(benzyl)-4-keto-pyrido[2,3-d]pyrimidin-2-yl]thio]-N-(2-methoxyphenyl)acetamide
N-(2-methoxyphenyl)-2-[4-oxo-3-(phenylmethyl)pyrido[2,3-d]pyrimidin-2-yl]sulfanyl-ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0752	0.1062
Trypanosoma brucei	DNA polymerase kappa, putative	0.0015	0.1337	0.1887
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.2432	0.3432
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.2432	0.3432
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0752	0.0752
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0022	0.2432	0.2432
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0752	0.1062
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.0752	0.1062
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0752	0.0752
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0752	0.1062
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.0752	0.1062
Brugia malayi	ImpB/MucB/SamB family protein	0.0022	0.2432	0.3432
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0752	0.1062
Giardia lamblia	DINP protein human, muc B family	0.0022	0.2432	0.4295
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0042	0.5662	0.5662
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0042	0.5662	0.5662
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0022	0.2432	0.2432
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.0752	0.1062
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.2432	0.3432
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.0752	0.1062
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0042	0.5662	1
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0022	0.2432	0.1816
Trypanosoma cruzi	DNA polymerase eta, putative	0.005	0.7086	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0752	0.1062
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0752	0.1062
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0752	0.1062
Mycobacterium ulcerans	DNA polymerase IV	0.0022	0.2432	0.2432
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0752	0.1062
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0752	0.1062
Echinococcus granulosus	dna polymerase eta	0.005	0.7086	0.6849
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0042	0.5662	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.5662	0.7991
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.2432	0.3432
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0068	1	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0752	0.1062
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0752	0.0752
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.0752	0.1062
Trypanosoma brucei	DNA polymerase kappa, putative	0.0015	0.1337	0.1887
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0752	0.0752
Schistosoma mansoni	aldehyde dehydrogenase	0.0068	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0752	0.1062
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.2432	0.3432
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0752	0.0752
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0752	0.1062
Trypanosoma brucei	unspecified product	0.0015	0.1337	0.1887
Echinococcus granulosus	ubiquitin specific protease 41	0.0042	0.5662	0.5309
Echinococcus multilocularis	ubiquitin specific protease 41	0.0042	0.5662	0.5309
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.2432	0.3432
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0068	1	1
Echinococcus multilocularis	dna polymerase kappa	0.0022	0.2432	0.1816
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0752	0.0752
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0752	0.0752
Brugia malayi	ImpB/MucB/SamB family protein	0.005	0.7086	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.7086	1
Brugia malayi	nuclear hormone receptor	0.0011	0.0752	0.1062
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.2432	0.3432
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0752	0.0752
Echinococcus multilocularis	dna polymerase eta	0.005	0.7086	0.6849
Plasmodium vivax	DNA repair protein REV1, putative	0.0007	0	0.5
Leishmania major	DNA polymerase eta, putative	0.0035	0.4654	0.4654
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.2432	0.3432
Toxoplasma gondii	aldehyde dehydrogenase	0.0068	1	1
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0042	0.5662	0.5309
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0068	1	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.0752	0.1062
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.0752	0.1062
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0752	0.1062
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0752	0.1062
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0042	0.5662	0.5662
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0042	0.5662	0.5309
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0042	0.5662	0.7991
Leishmania major	DNA polymerase eta, putative	0.005	0.7086	0.7086
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0752	0.0752
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.2432	0.3432
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.2432	0.3432
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0042	0.5662	0.5309
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.2432	0.3432
Schistosoma mansoni	aldehyde dehydrogenase	0.0068	1	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0752	0.0752
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0752	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0752	0.1062
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0752	0.1062
Onchocerca volvulus	Protein ultraspiracle homolog	0.0011	0.0752	0.5
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0042	0.5662	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0752	0.1062
Onchocerca volvulus		0.0011	0.0752	0.5
Trypanosoma brucei	DNA polymerase eta, putative	0.005	0.7086	1
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0042	0.5662	1
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.5662	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0752	0.1062
Brugia malayi	steroid hormone receptor	0.0011	0.0752	0.1062
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0035	0.4654	0.4654
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0042	0.5662	0.7991
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.2432	0.3432
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0042	0.5662	0.7991
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0752	0.1062
Trypanosoma brucei	unspecified product	0.0022	0.2432	0.3432
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0752	0.0752
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0752	0.1062
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.2432	0.3432
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.2432	0.3432
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0752	0.1062
Schistosoma mansoni	DNA polymerase eta	0.005	0.7086	0.7086
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.0752	0.1062
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.2432	0.3432
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0022	0.2432	0.3432
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0752	0.1062
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0068	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0752	0.1062
Brugia malayi	ecdysteroid receptor	0.0011	0.0752	0.1062
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0042	0.5662	0.5309
Leishmania major	DNA polymerase kappa, putative	0.0022	0.2432	0.2432
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0011	0.0752	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.0752	0.1062
Onchocerca volvulus	Bile acid receptor homolog	0.0011	0.0752	0.5
Mycobacterium ulcerans	DNA polymerase IV	0.0022	0.2432	0.2432
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0022	0.2432	0.1816
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.2432	0.3432
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.2432	0.3432
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0022	0.2432	0.2432
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0068	1	1
Echinococcus granulosus	dna polymerase kappa	0.0022	0.2432	0.1816
Trypanosoma brucei	DNA polymerase kappa, putative	0.0015	0.1337	0.1887
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0042	0.5662	0.7991
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0068	1	1
Trypanosoma brucei	unspecified product	0.0015	0.1337	0.1887
Trypanosoma cruzi	DNA polymerase eta, putative	0.0035	0.4654	0.6568
Plasmodium falciparum	DNA repair protein REV1, putative	0.0007	0	0.5
Schistosoma mansoni	coup transcription factor	0.0011	0.0752	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0752	0.1062

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 837072