Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.2432 | 0.3432 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0022 | 0.2432 | 0.2432 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0011 | 0.0752 | 0.0752 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 0.5662 | 1 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0042 | 0.5662 | 0.5309 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0035 | 0.4654 | 0.6568 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0022 | 0.2432 | 0.3432 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0022 | 0.2432 | 0.3432 |
Trypanosoma brucei | unspecified product | 0.0015 | 0.1337 | 0.1887 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0068 | 1 | 1 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0042 | 0.5662 | 0.5309 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0752 | 0.1062 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0752 | 0.0752 |
Brugia malayi | nuclear hormone receptor | 0.0011 | 0.0752 | 0.1062 |
Echinococcus multilocularis | dna polymerase eta | 0.005 | 0.7086 | 0.6849 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.2432 | 0.3432 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0011 | 0.0752 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.2432 | 0.3432 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.2432 | 0.3432 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0042 | 0.5662 | 0.5309 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0068 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.005 | 0.7086 | 0.7086 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0752 | 0.1062 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0752 | 0.1062 |
Echinococcus granulosus | dna polymerase kappa | 0.0022 | 0.2432 | 0.1816 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0022 | 0.2432 | 0.2432 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.005 | 0.7086 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0752 | 0.1062 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0752 | 0.1062 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0022 | 0.2432 | 0.2432 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0752 | 0.1062 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0011 | 0.0752 | 0.0752 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0752 | 0.1062 |
Onchocerca volvulus | 0.0011 | 0.0752 | 0.5 | |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0752 | 0.1062 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0752 | 0.1062 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0011 | 0.0752 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.2432 | 0.3432 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0022 | 0.2432 | 0.3432 |
Schistosoma mansoni | nuclear hormone receptor | 0.0011 | 0.0752 | 0.0752 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0022 | 0.2432 | 0.3432 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0752 | 0.1062 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0752 | 0.1062 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0042 | 0.5662 | 0.7991 |
Echinococcus granulosus | dna polymerase eta | 0.005 | 0.7086 | 0.6849 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 1 | 1 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0022 | 0.2432 | 0.1816 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0752 | 0.1062 |
Brugia malayi | steroid hormone receptor | 0.0011 | 0.0752 | 0.1062 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0752 | 0.1062 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0752 | 0.1062 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0022 | 0.2432 | 0.3432 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0022 | 0.2432 | 0.3432 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0752 | 0.1062 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0022 | 0.2432 | 0.2432 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0022 | 0.2432 | 0.3432 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0011 | 0.0752 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0011 | 0.0752 | 0.0752 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0042 | 0.5662 | 0.5309 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.2432 | 0.3432 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0011 | 0.0752 | 0.1062 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0022 | 0.2432 | 0.2432 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0752 | 0.1062 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0022 | 0.2432 | 0.3432 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0752 | 0.1062 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0042 | 0.5662 | 1 |
Plasmodium falciparum | DNA repair protein REV1, putative | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0011 | 0.0752 | 0.0752 |
Brugia malayi | ecdysteroid receptor | 0.0011 | 0.0752 | 0.1062 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0042 | 0.5662 | 0.5662 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0042 | 0.5662 | 0.5309 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0011 | 0.0752 | 0.0752 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.005 | 0.7086 | 1 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0042 | 0.5662 | 0.5662 |
Trypanosoma brucei | unspecified product | 0.0022 | 0.2432 | 0.3432 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0752 | 0.1062 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0752 | 0.1062 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0752 | 0.1062 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0752 | 0.1062 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0022 | 0.2432 | 0.3432 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0022 | 0.2432 | 0.1816 |
Echinococcus multilocularis | dna polymerase kappa | 0.0022 | 0.2432 | 0.1816 |
Plasmodium vivax | DNA repair protein REV1, putative | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.2432 | 0.3432 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.7086 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.005 | 0.7086 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0015 | 0.1337 | 0.1887 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0752 | 0.1062 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0068 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.2432 | 0.3432 |
Leishmania major | DNA polymerase kappa, putative | 0.0022 | 0.2432 | 0.2432 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0042 | 0.5662 | 1 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0042 | 0.5662 | 0.7991 |
Brugia malayi | nuclear receptor NHR-88 | 0.0011 | 0.0752 | 0.1062 |
Trypanosoma brucei | unspecified product | 0.0015 | 0.1337 | 0.1887 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0042 | 0.5662 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.005 | 0.7086 | 0.7086 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0042 | 0.5662 | 0.7991 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0011 | 0.0752 | 0.1062 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0011 | 0.0752 | 0.1062 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0752 | 0.1062 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0011 | 0.0752 | 0.0752 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0011 | 0.0752 | 0.1062 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0042 | 0.5662 | 0.5309 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0035 | 0.4654 | 0.4654 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.5662 | 0.7991 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0011 | 0.0752 | 0.0752 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0752 | 0.0752 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0068 | 1 | 1 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0042 | 0.5662 | 0.5662 |
Leishmania major | DNA polymerase eta, putative | 0.0035 | 0.4654 | 0.4654 |
Giardia lamblia | DINP protein human, muc B family | 0.0022 | 0.2432 | 0.4295 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0011 | 0.0752 | 0.1062 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0011 | 0.0752 | 0.0752 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0752 | 0.1062 |
Schistosoma mansoni | coup transcription factor | 0.0011 | 0.0752 | 0.0752 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0042 | 0.5662 | 0.7991 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0015 | 0.1337 | 0.1887 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0011 | 0.0752 | 0.1062 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0752 | 0.1062 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0042 | 0.5662 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.2432 | 0.3432 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.2432 | 0.3432 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0015 | 0.1337 | 0.1887 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0752 | 0.1062 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0011 | 0.0752 | 0.0752 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.