Detailed information for compound 837188

Basic information

Technical information
  • TDR Targets ID: 837188
  • Name: N-(3-fluorophenyl)-3-[3-(4-fluorophenyl)-2,5, 7-trimethylpyrazolo[1,5-a]pyrimidin-6-yl]prop anamide
  • MW: 420.454 | Formula: C24H22F2N4O
  • H donors: 1 H acceptors: 3 LogP: 4.42 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccc(c1)F)CCc1c(C)nc2n(c1C)nc(c2c1ccc(cc1)F)C
  • InChi: 1S/C24H22F2N4O/c1-14-21(11-12-22(31)28-20-6-4-5-19(26)13-20)16(3)30-24(27-14)23(15(2)29-30)17-7-9-18(25)10-8-17/h4-10,13H,11-12H2,1-3H3,(H,28,31)
  • InChiKey: MQZGIZUYNIPXRD-UHFFFAOYSA-N  

Network

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Synonyms

  • N-(3-fluorophenyl)-3-[3-(4-fluorophenyl)-2,5,7-trimethyl-pyrazolo[1,5-a]pyrimidin-6-yl]propanamide
  • N-(3-fluorophenyl)-3-[3-(4-fluorophenyl)-2,5,7-trimethyl-6-pyrazolo[1,5-a]pyrimidinyl]propanamide
  • N-(3-fluorophenyl)-3-[3-(4-fluorophenyl)-2,5,7-trimethyl-pyrazolo[1,5-a]pyrimidin-6-yl]propionamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0288 0.0656 0.0656
Brugia malayi Muscle positioning protein 4 0.0288 0.0656 0.0656
Brugia malayi basement membrane proteoglycan precursor 0.0137 0.0106 0.0106
Onchocerca volvulus Slit protein homolog 0.0288 0.0656 0.4248
Echinococcus multilocularis chromobox protein 1 0.0142 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0288 0.0656 0.0656
Loa Loa (eye worm) cyclin C 0.0238 0.0474 0.0474
Echinococcus multilocularis Immunoglobulin 0.0137 0.0106 0.0106
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0262 0.0562 0.1415
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0986 0.3208 0.2803
Schistosoma mansoni netrin receptor unc5 0.0137 0.0106 0.0106
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0724 0.2252 0.2252
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0986 0.3208 0.3208
Loa Loa (eye worm) hypothetical protein 0.0137 0.0106 0.0106
Trypanosoma brucei trypanothione reductase 0.2846 1 1
Brugia malayi Prion-like- 0.0244 0.0498 0.0498
Echinococcus multilocularis peroxidasin 0.0244 0.0498 0.0498
Echinococcus granulosus fibropellin Ia 0.0288 0.0656 0.0656
Loa Loa (eye worm) hypothetical protein 0.0818 0.2596 0.2596
Brugia malayi Immunoglobulin I-set domain containing protein 0.0244 0.0498 0.0498
Toxoplasma gondii thioredoxin reductase 0.2846 1 1
Loa Loa (eye worm) hypothetical protein 0.0531 0.1545 0.1545
Brugia malayi Immunoglobulin I-set domain containing protein 0.0137 0.0106 0.0106
Echinococcus multilocularis Immunoglobulin 0.042 0.114 0.114
Brugia malayi Heterochromatin protein 1 0.0142 0.0126 0.0126
Brugia malayi hypothetical protein 0.0531 0.1545 0.1545
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0118 0.0037 0.0037
Brugia malayi Immunoglobulin I-set domain containing protein 0.042 0.114 0.114
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0986 0.3208 0.3208
Echinococcus multilocularis fat cadherin tumor suppressor 0.0288 0.0656 0.0656
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0557 0.164 0.164
Loa Loa (eye worm) hypothetical protein 0.0591 0.1763 0.1763
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0262 0.0562 0.0562
Brugia malayi hypothetical protein 0.0137 0.0106 0.0106
Schistosoma mansoni vesicular amine transporter 0.042 0.114 0.114
Mycobacterium tuberculosis Probable oxidoreductase 0.0986 0.3208 0.2858
Schistosoma mansoni sulfide quinone reductase 0.0262 0.0562 0.0562
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0724 0.2252 0.2252
Echinococcus multilocularis neuroglian 0.0244 0.0498 0.0498
Echinococcus granulosus Immunoglobulin 0.0137 0.0106 0.0106
Echinococcus granulosus C type lectin domian containing protein 0.0531 0.1545 0.1545
Echinococcus granulosus Immunoglobulin subtype 0.0137 0.0106 0.0106
Loa Loa (eye worm) glutathione reductase 0.2846 1 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.0106 0.0106
Brugia malayi hypothetical protein 0.0531 0.1545 0.1545
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0137 0.0106 0.0106
Echinococcus granulosus cyclin dependent kinase 19 0.0152 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0531 0.1545 0.1545
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0262 0.0562 1
Loa Loa (eye worm) hypothetical protein 0.0244 0.0498 0.0498
Schistosoma mansoni nephrin 0.0244 0.0498 0.0498
Schistosoma mansoni septate junction protein 0.0244 0.0498 0.0498
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0986 0.3208 1
Loa Loa (eye worm) hypothetical protein 0.0531 0.1545 0.1545
Loa Loa (eye worm) hypothetical protein 0.0288 0.0656 0.0656
Schistosoma mansoni septate junction protein 0.0244 0.0498 0.0498
Onchocerca volvulus 0.0531 0.1545 1
Schistosoma mansoni hypothetical protein 0.0137 0.0106 0.0106
Loa Loa (eye worm) Notch2 0.0288 0.0656 0.0656
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0262 0.0562 0.0562
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0262 0.0562 0.0562
Brugia malayi Protein kinase domain containing protein 0.0152 0.0162 0.0162
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0262 0.0562 0.0076
Schistosoma mansoni nephrin related 0.0137 0.0106 0.0106
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0262 0.0562 0.0076
Onchocerca volvulus 0.0531 0.1545 1
Schistosoma mansoni cell adhesion molecule 0.0244 0.0498 0.0498
Echinococcus granulosus delta-like protein 1 0.0288 0.0656 0.0656
Brugia malayi Immunoglobulin I-set domain containing protein 0.0244 0.0498 0.0498
Brugia malayi Immunoglobulin domain containing protein 0.0137 0.0106 0.0106
Plasmodium falciparum thioredoxin reductase 0.2846 1 1
Loa Loa (eye worm) hypothetical protein 0.0288 0.0656 0.0656
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0531 0.1545 0.1545
Loa Loa (eye worm) hypothetical protein 0.0244 0.0498 0.0498
Loa Loa (eye worm) hypothetical protein 0.0288 0.0656 0.0656
Schistosoma mansoni peroxidasin 0.0137 0.0106 0.0106
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0262 0.0562 0.0076
Schistosoma mansoni hypothetical protein 0.0288 0.0656 0.0656
Echinococcus granulosus chromobox protein 1 0.0142 0.0126 0.0126
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0244 0.0498 0.0498
Echinococcus granulosus protein jagged 2 0.0288 0.0656 0.0656
Brugia malayi Immunoglobulin I-set domain containing protein 0.0137 0.0106 0.0106
Schistosoma mansoni glutamate synthase 0.0262 0.0562 0.0562
Schistosoma mansoni notch 0.0288 0.0656 0.0656
Echinococcus multilocularis leucine rich repeat containing protein 4 0.0137 0.0106 0.0106
Echinococcus granulosus protein jagged 1 0.0288 0.0656 0.0656
Mycobacterium tuberculosis Probable reductase 0.0262 0.0562 0.0076
Echinococcus multilocularis netrin receptor unc 5 0.0137 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0244 0.0498 0.0498
Onchocerca volvulus 0.0288 0.0656 0.4248
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0986 0.3208 0.2803
Schistosoma mansoni notch 0.0288 0.0656 0.0656
Brugia malayi hypothetical protein 0.0531 0.1545 0.1545
Loa Loa (eye worm) hypothetical protein 0.0531 0.1545 0.1545
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0986 0.3208 0.2803
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0986 0.3208 0.3208
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0262 0.0562 0.0076
Brugia malayi hypothetical protein 0.042 0.114 0.114
Schistosoma mansoni cell adhesion molecule 0.0244 0.0498 0.0498
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0557 0.164 0.164
Brugia malayi Immunoglobulin domain containing protein 0.0137 0.0106 0.0106
Trypanosoma cruzi trypanothione reductase, putative 0.2846 1 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0986 0.3208 0.2803
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0137 0.0106 0.0106
Onchocerca volvulus 0.0531 0.1545 1
Loa Loa (eye worm) hypothetical protein 0.0244 0.0498 0.0498
Plasmodium vivax thioredoxin reductase, putative 0.2846 1 1
Loa Loa (eye worm) hypothetical protein 0.0288 0.0656 0.0656
Schistosoma mansoni chromobox protein 0.0142 0.0126 0.0126
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0986 0.3208 0.3208
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0986 0.3208 1
Echinococcus granulosus neurogenic locus protein delta 0.0288 0.0656 0.0656
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0986 0.3208 0.2858
Loa Loa (eye worm) hypothetical protein 0.042 0.114 0.114
Schistosoma mansoni roundabout 0.0244 0.0498 0.0498
Schistosoma mansoni hypothetical protein 0.0288 0.0656 0.0656
Loa Loa (eye worm) hypothetical protein 0.0288 0.0656 0.0656
Echinococcus granulosus thioredoxin glutathione reductase 0.2846 1 1
Loa Loa (eye worm) hypothetical protein 0.042 0.114 0.114
Schistosoma mansoni glutamate synthase 0.0262 0.0562 0.0562
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0137 0.0106 0.0106
Echinococcus multilocularis neurogenic locus notch protein 0.0288 0.0656 0.0656
Entamoeba histolytica thioredoxin reductase, putative 0.0262 0.0562 1
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0262 0.0562 0.0562
Schistosoma mansoni netrin receptor unc5 0.0137 0.0106 0.0106
Brugia malayi Fibronectin type III domain containing protein 0.042 0.114 0.114
Loa Loa (eye worm) hypothetical protein 0.0288 0.0656 0.0656
Schistosoma mansoni hypothetical protein 0.0137 0.0106 0.0106
Echinococcus granulosus lachesin 0.0244 0.0498 0.0498
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0986 0.3208 0.2803
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.2846 1 1
Loa Loa (eye worm) hypothetical protein 0.042 0.114 0.114
Schistosoma mansoni cell adhesion molecule 0.0244 0.0498 0.0498
Brugia malayi Peroxidasin 0.0244 0.0498 0.0498
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0262 0.0562 1
Leishmania major trypanothione reductase 0.2846 1 1
Onchocerca volvulus 0.0531 0.1545 1
Echinococcus granulosus defective proboscis extension response 0.042 0.114 0.114
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0262 0.0562 0.1415
Brugia malayi Immunoglobulin I-set domain containing protein 0.0244 0.0498 0.0498
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0137 0.0106 0.0106
Echinococcus granulosus c4b binding protein beta chain 0.0531 0.1545 0.1545
Loa Loa (eye worm) hypothetical protein 0.0288 0.0656 0.0656
Echinococcus granulosus roundabout 2 0.0244 0.0498 0.0498
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0244 0.0498 0.0498
Echinococcus granulosus Immunoglobulin 0.0137 0.0106 0.0106
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0137 0.0106 0.0106
Brugia malayi Delta serrate ligand family protein 0.0288 0.0656 0.0656
Brugia malayi Immunoglobulin I-set domain containing protein 0.0244 0.0498 0.0498
Onchocerca volvulus Putative cubilin 0.0288 0.0656 0.4248
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0262 0.0562 1
Toxoplasma gondii EGF family domain-containing protein 0.0288 0.0656 0.01
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0244 0.0498 0.0498
Onchocerca volvulus 0.0288 0.0656 0.4248
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0137 0.0106 0.0106
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0137 0.0106 0.0106
Schistosoma mansoni notch 0.0288 0.0656 0.0656
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0262 0.0562 0.1415
Toxoplasma gondii rhoptry neck protein RON1 0.0531 0.1545 0.1042
Brugia malayi Cyclin, N-terminal domain containing protein 0.0118 0.0037 0.0037
Echinococcus granulosus notch 0.0288 0.0656 0.0656
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0288 0.0656 0.0656
Loa Loa (eye worm) hypothetical protein 0.0288 0.0656 0.0656
Echinococcus granulosus neurogenic locus notch protein 0.0288 0.0656 0.0656
Loa Loa (eye worm) thioredoxin reductase 0.2846 1 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0986 0.3208 1
Loa Loa (eye worm) hypothetical protein 0.0288 0.0656 0.0656
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0262 0.0562 0.1415
Schistosoma mansoni c4b-binding protein beta chain 0.0531 0.1545 0.1545
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0262 0.0562 0.1415
Echinococcus granulosus netrin receptor unc 5 0.0137 0.0106 0.0106
Loa Loa (eye worm) immunoglobulin domain-containing protein 0.0137 0.0106 0.0106
Echinococcus multilocularis notch 0.0288 0.0656 0.0656
Brugia malayi pregnancy-associated plasma protein-A 0.0531 0.1545 0.1545
Brugia malayi Cadherin domain containing protein 0.0288 0.0656 0.0656
Schistosoma mansoni cell adhesion molecule 0.0137 0.0106 0.0106
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0262 0.0562 0.0562
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0986 0.3208 0.2858
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0986 0.3208 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0986 0.3208 0.2803
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0137 0.0106 0.0106
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0986 0.3208 0.2803
Mycobacterium tuberculosis Probable dehydrogenase 0.0262 0.0562 0.0076
Brugia malayi Immunoglobulin I-set domain containing protein 0.0244 0.0498 0.0498
Plasmodium vivax glutathione reductase, putative 0.2846 1 1
Brugia malayi notch-like transmembrane receptor 0.0288 0.0656 0.0656
Echinococcus multilocularis protein jagged 1 0.0288 0.0656 0.0656
Brugia malayi Cyclin C 0.0238 0.0474 0.0474
Brugia malayi EGF-like domain containing protein 0.0288 0.0656 0.0656
Brugia malayi hypothetical protein 0.0531 0.1545 0.1545
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0244 0.0498 0.0498
Toxoplasma gondii rhoptry neck protein RON9 0.0531 0.1545 0.1042
Echinococcus multilocularis roundabout 2 0.0244 0.0498 0.0498
Echinococcus multilocularis Immunoglobulin 0.0137 0.0106 0.0106
Loa Loa (eye worm) notch protein 0.0288 0.0656 0.0656
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0262 0.0562 0.0562
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0986 0.3208 0.2803
Loa Loa (eye worm) hypothetical protein 0.0288 0.0656 0.0656
Loa Loa (eye worm) hypothetical protein 0.0244 0.0498 0.0498
Brugia malayi EGF-like domain containing protein 0.0288 0.0656 0.0656
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0986 0.3208 0.2803
Brugia malayi EGF-like domain containing protein 0.0288 0.0656 0.0656
Schistosoma mansoni nephrin 0.0527 0.1532 0.1532
Schistosoma mansoni cell adhesion molecule 0.0137 0.0106 0.0106
Trichomonas vaginalis apoptosis inducing factor, putative 0.0262 0.0562 0.1415
Echinococcus multilocularis cell adhesion molecule:down regulated by 0.0137 0.0106 0.0106
Brugia malayi EGF-like domain containing protein 0.0288 0.0656 0.0656
Echinococcus multilocularis tyrosine protein kinase otk 0.0244 0.0498 0.0498
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0288 0.0656 0.4248
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0262 0.0562 0.0562
Loa Loa (eye worm) hypothetical protein 0.0288 0.0656 0.0656
Echinococcus multilocularis Immunoglobulin subtype 0.0137 0.0106 0.0106
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0137 0.0106 0.0106
Echinococcus multilocularis hemicentin 1 0.0244 0.0498 0.0498
Echinococcus granulosus 3'partial|cell adhesion molecule:down regulated by 0.0137 0.0106 0.0106
Schistosoma mansoni slit 0.0288 0.0656 0.0656
Schistosoma mansoni hypothetical protein 0.0137 0.0106 0.0106
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0262 0.0562 0.0076
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0986 0.3208 0.2803
Schistosoma mansoni titin 0.0244 0.0498 0.0498
Schistosoma mansoni hypothetical protein 0.0137 0.0106 0.0106
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0262 0.0562 1
Onchocerca volvulus 0.0531 0.1545 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0244 0.0498 0.0498
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0986 0.3208 0.2803
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0244 0.0498 0.0498
Schistosoma mansoni hypothetical protein 0.0288 0.0656 0.0656
Giardia lamblia High cysteine protein 0.0288 0.0656 0.0356
Onchocerca volvulus 0.0262 0.0562 0.3638
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0262 0.0562 0.0562
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0262 0.0562 0.0562
Loa Loa (eye worm) hypothetical protein 0.042 0.114 0.114
Loa Loa (eye worm) hypothetical protein 0.0288 0.0656 0.0656
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0986 0.3208 0.2803
Brugia malayi Immunoglobulin I-set domain containing protein 0.0244 0.0498 0.0498
Loa Loa (eye worm) gastrulation defective protein 1 0.0152 0.016 0.016
Brugia malayi hypothetical protein 0.0531 0.1545 0.1545
Echinococcus multilocularis fibropellin Ia 0.0288 0.0656 0.0656
Plasmodium falciparum glutathione reductase 0.2846 1 1
Loa Loa (eye worm) LAD-2 short isoform 0.0137 0.0106 0.0106
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0137 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0288 0.0656 0.0656
Echinococcus multilocularis cyclin 0.0118 0.0037 0.0037
Schistosoma mansoni sulfide quinone reductase 0.0262 0.0562 0.0562
Plasmodium vivax apical sushi protein, putative 0.0531 0.1545 0.1042
Brugia malayi basement membrane proteoglycan 0.0137 0.0106 0.0106
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0986 0.3208 0.2803
Echinococcus multilocularis protein jagged 1 0.0288 0.0656 0.0656
Loa Loa (eye worm) hypothetical protein 0.0288 0.0656 0.0656
Loa Loa (eye worm) hypothetical protein 0.0137 0.0106 0.0106
Brugia malayi Immunoglobulin I-set domain containing protein 0.0244 0.0498 0.0498
Onchocerca volvulus 0.0288 0.0656 0.4248
Brugia malayi EGF-like domain containing protein 0.0288 0.0656 0.0656
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0986 0.3208 0.2803
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0262 0.0562 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0262 0.0562 0.1415
Echinococcus multilocularis neurogenic locus protein delta 0.0288 0.0656 0.0656
Loa Loa (eye worm) hypothetical protein 0.042 0.114 0.114
Echinococcus granulosus basement membrane specific heparan sulfate 0.0137 0.0106 0.0106
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0986 0.3208 0.2803
Loa Loa (eye worm) hypothetical protein 0.0262 0.0562 0.0562
Loa Loa (eye worm) hypothetical protein 0.0664 0.2032 0.2032
Echinococcus multilocularis protein jagged 2 0.0288 0.0656 0.0656
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0118 0.0037 0.0037
Schistosoma mansoni hypothetical protein 0.0137 0.0106 0.0106
Echinococcus multilocularis neurogenic locus notch protein 4 0.0288 0.0656 0.0656
Echinococcus multilocularis C type lectin domian containing protein 0.0531 0.1545 0.1545
Schistosoma mansoni neuroglian 0.0244 0.0498 0.0498
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0986 0.3208 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0137 0.0106 0.0106
Echinococcus granulosus hemicentin 1 0.0244 0.0498 0.0498
Echinococcus granulosus neurogenic locus notch protein 0.0288 0.0656 0.0656
Brugia malayi Calcium binding EGF domain containing protein 0.0288 0.0656 0.0656
Schistosoma mansoni tyrosine kinase 0.0244 0.0498 0.0498
Echinococcus granulosus low density lipoprotein receptor ldl 0.0137 0.0106 0.0106
Onchocerca volvulus 0.0288 0.0656 0.4248
Entamoeba histolytica disulphide oxidoreductase, putative 0.0262 0.0562 1
Echinococcus granulosus peroxidasin 0.0244 0.0498 0.0498
Loa Loa (eye worm) hypothetical protein 0.0531 0.1545 0.1545
Brugia malayi Immunoglobulin I-set domain containing protein 0.0137 0.0106 0.0106
Echinococcus granulosus protein jagged 2 0.0288 0.0656 0.0656
Onchocerca volvulus 0.0531 0.1545 1
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0262 0.0562 0.0562
Brugia malayi Cadherin domain containing protein 0.0288 0.0656 0.0656
Giardia lamblia NADH oxidase lateral transfer candidate 0.0986 0.3208 1
Plasmodium falciparum glutathione reductase 0.0986 0.3208 0.2803
Schistosoma mansoni laminin gamma-3 chain 0.0288 0.0656 0.0656
Echinococcus multilocularis hemicentin 1 0.0244 0.0498 0.0498
Trichomonas vaginalis glutamate synthase, putative 0.0262 0.0562 0.1415
Schistosoma mansoni hypothetical protein 0.0168 0.022 0.022
Toxoplasma gondii NADPH-glutathione reductase 0.0986 0.3208 0.2803
Echinococcus granulosus neuroglian 0.0244 0.0498 0.0498
Trichomonas vaginalis glutamate synthase, putative 0.0262 0.0562 0.1415
Loa Loa (eye worm) hypothetical protein 0.0288 0.0656 0.0656
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0137 0.0106 0.0106
Treponema pallidum NADH oxidase 0.0986 0.3208 1
Echinococcus multilocularis chromobox protein 1 0.0142 0.0126 0.0126
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0245 0.05 0.05
Echinococcus multilocularis basement membrane specific heparan sulfate 0.042 0.114 0.114
Echinococcus granulosus Immunoglobulin 0.042 0.114 0.114
Schistosoma mansoni septate junction protein 0.0137 0.0106 0.0106
Schistosoma mansoni basigin related 0.0137 0.0106 0.0106
Schistosoma mansoni glutamate synthase 0.0262 0.0562 0.0562
Echinococcus granulosus glutamate synthase 0.0262 0.0562 0.0562
Echinococcus granulosus neural cadherin 0.0288 0.0656 0.0656
Schistosoma mansoni disulfide oxidoreductase 0.0262 0.0562 0.0562
Schistosoma mansoni g1/s-specific cyclin C 0.0238 0.0474 0.0474
Brugia malayi GCC2 and GCC3 family protein 0.0818 0.2596 0.2596
Brugia malayi Immunoglobulin I-set domain containing protein 0.0244 0.0498 0.0498
Loa Loa (eye worm) hypothetical protein 0.0244 0.0498 0.0498
Schistosoma mansoni Neurotrimin precursor (hNT) 0.042 0.114 0.114
Echinococcus multilocularis neuroglian 0.0527 0.1532 0.1532
Echinococcus multilocularis thioredoxin glutathione reductase 0.2846 1 1
Echinococcus granulosus neurogenic locus notch protein 4 0.0288 0.0656 0.0656
Plasmodium falciparum thioredoxin reductase 0.0986 0.3208 0.2803
Brugia malayi Immunoglobulin domain containing protein 0.0137 0.0106 0.0106
Schistosoma mansoni basigin related 0.0137 0.0106 0.0106
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0986 0.3208 0.2803
Echinococcus multilocularis Immunoglobulin 0.042 0.114 0.114
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0986 0.3208 0.2803
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0986 0.3208 0.2803
Echinococcus granulosus slit 2 protein 0.0288 0.0656 0.0656
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0986 0.3208 1
Schistosoma mansoni septate junction protein 0.0137 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0531 0.1545 0.1545
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0244 0.0498 0.0498
Loa Loa (eye worm) hypothetical protein 0.0137 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0288 0.0656 0.0656
Trichomonas vaginalis mercuric reductase, putative 0.0986 0.3208 1
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0262 0.0562 0.0076
Echinococcus multilocularis slit 2 protein 0.0288 0.0656 0.0656
Echinococcus multilocularis neurogenic locus protein delta 0.0288 0.0656 0.0656
Echinococcus granulosus twitchin 0.0528 0.1534 0.1534
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0262 0.0562 0.1415
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0262 0.0562 0.0076
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0262 0.0562 0.0076
Schistosoma mansoni basigin related 0.0137 0.0106 0.0106
Onchocerca volvulus 0.0531 0.1545 1
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0262 0.0562 0.0562
Onchocerca volvulus Neurogenic locus notch homolog 0.0288 0.0656 0.4248
Loa Loa (eye worm) cyclin domain-containing protein 0.0118 0.0037 0.0037
Plasmodium falciparum apical sushi protein 0.0531 0.1545 0.1042
Loa Loa (eye worm) hypothetical protein 0.0288 0.0656 0.0656
Schistosoma mansoni notch 0.0288 0.0656 0.0656
Schistosoma mansoni notch 0.0288 0.0656 0.0656
Schistosoma mansoni hypothetical protein 0.0262 0.0562 0.0562
Brugia malayi EGF-like domain containing protein 0.0288 0.0656 0.0656
Schistosoma mansoni hypothetical protein 0.0168 0.022 0.022
Brugia malayi Immunoglobulin I-set domain containing protein 0.0557 0.164 0.164
Echinococcus multilocularis roundabout 2 0.0244 0.0498 0.0498
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0244 0.0498 0.0498
Echinococcus granulosus roundabout 2 0.0244 0.0498 0.0498
Echinococcus granulosus chromobox protein 1 0.0142 0.0126 0.0126
Schistosoma mansoni cell polarity protein 0.0288 0.0656 0.0656
Loa Loa (eye worm) hypothetical protein 0.0137 0.0106 0.0106
Schistosoma mansoni hypothetical protein 0.0288 0.0656 0.0656
Echinococcus granulosus roundabout 2 0.0664 0.2032 0.2032
Loa Loa (eye worm) hypothetical protein 0.0531 0.1545 0.1545
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0262 0.0562 0.0076
Brugia malayi Thioredoxin reductase 0.2846 1 1
Trypanosoma cruzi trypanothione reductase, putative 0.0986 0.3208 0.2803
Loa Loa (eye worm) programmed cell death 8 0.0262 0.0562 0.0562
Loa Loa (eye worm) hypothetical protein 0.0288 0.0656 0.0656
Trichomonas vaginalis glutathione reductase, putative 0.0986 0.3208 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0986 0.3208 1
Brugia malayi Sushi domain 0.0531 0.1545 0.1545
Schistosoma mansoni chromobox protein 0.0142 0.0126 0.0126
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0262 0.0562 0.0562
Schistosoma mansoni hypothetical protein 0.0288 0.0656 0.0656
Brugia malayi hypothetical protein 0.0531 0.1545 0.1545
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0262 0.0562 0.1415
Echinococcus multilocularis c4b binding protein beta chain 0.0531 0.1545 0.1545
Onchocerca volvulus 0.0531 0.1545 1
Loa Loa (eye worm) hypothetical protein 0.0244 0.0498 0.0498
Onchocerca volvulus 0.0288 0.0656 0.4248
Echinococcus multilocularis roundabout 2 0.0664 0.2032 0.2032
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0262 0.0562 0.1415
Echinococcus granulosus contactin 0.0244 0.0498 0.0498
Schistosoma mansoni notch 0.0288 0.0656 0.0656
Brugia malayi Calcium binding EGF domain containing protein 0.0288 0.0656 0.0656
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0262 0.0562 0.0562
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0244 0.0498 0.0498
Brugia malayi hypothetical protein 0.0531 0.1545 0.1545
Echinococcus multilocularis lachesin 0.0244 0.0498 0.0498
Schistosoma mansoni septate junction protein 0.0288 0.0656 0.0656
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0986 0.3208 0.2803
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0244 0.0498 0.0498
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0244 0.0498 0.3223
Brugia malayi glutamate synthase 0.0262 0.0562 0.0562
Echinococcus multilocularis glutamate synthase 0.0262 0.0562 0.0562
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.042 0.114 0.114
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0262 0.0562 0.1415
Echinococcus granulosus protein jagged 1 0.0288 0.0656 0.0656
Echinococcus granulosus neuroglian 0.0527 0.1532 0.1532
Loa Loa (eye worm) heterochromatin protein 1 0.0142 0.0126 0.0126
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0244 0.0498 0.0498
Loa Loa (eye worm) hypothetical protein 0.0664 0.2032 0.2032
Onchocerca volvulus 0.0531 0.1545 1
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0262 0.0562 0.0076
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0262 0.0562 0.0562
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0986 0.3208 0.2858
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0152 0.0162 0.0162
Schistosoma mansoni hypothetical protein 0.0288 0.0656 0.0656
Loa Loa (eye worm) hypothetical protein 0.0557 0.164 0.164
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0262 0.0562 0.0562
Loa Loa (eye worm) hypothetical protein 0.0244 0.0498 0.0498
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0986 0.3208 0.2803
Schistosoma mansoni hypothetical protein 0.0137 0.0106 0.0106
Schistosoma mansoni serine/threonine protein kinase 0.0152 0.0162 0.0162
Echinococcus granulosus tyrosine protein kinase otk 0.0244 0.0498 0.0498
Echinococcus granulosus cyclin 0.0118 0.0037 0.0037
Echinococcus multilocularis neurogenic locus notch protein 0.0288 0.0656 0.0656
Loa Loa (eye worm) hypothetical protein 0.0288 0.0656 0.0656
Brugia malayi Heparan sulfate 0.0137 0.0106 0.0106
Echinococcus multilocularis cyclin dependent kinase 19 0.0152 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0288 0.0656 0.0656
Schistosoma mansoni hypothetical protein 0.0288 0.0656 0.0656
Echinococcus multilocularis geminin 0.0168 0.022 0.022
Schistosoma mansoni cell adhesion molecule 0.0557 0.164 0.164
Echinococcus multilocularis neural cadherin 0.0288 0.0656 0.0656
Brugia malayi Calcium binding EGF domain containing protein 0.0288 0.0656 0.0656
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0262 0.0562 0.0562
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0986 0.3208 0.2803
Loa Loa (eye worm) hypothetical protein 0.042 0.114 0.114
Brugia malayi Immunoglobulin I-set domain containing protein 0.0244 0.0498 0.0498
Echinococcus granulosus geminin 0.0168 0.022 0.022
Brugia malayi Immunoglobulin I-set domain containing protein 0.0137 0.0106 0.0106
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0137 0.0106 0.0106
Brugia malayi EGF-like domain containing protein 0.0288 0.0656 0.0656
Onchocerca volvulus 0.0531 0.1545 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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