Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0237 | 0.1979 | 0.1966 |
Echinococcus multilocularis | c4b binding protein beta chain | 0.0127 | 0.0016 | 0.0016 |
Onchocerca volvulus | 0.0127 | 0.0016 | 0.5 | |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0683 | 1 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0134 | 0.0128 | 0.0112 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0237 | 0.1979 | 0.1966 |
Plasmodium falciparum | thioredoxin reductase | 0.0237 | 0.1979 | 0.1966 |
Onchocerca volvulus | 0.0127 | 0.0016 | 0.5 | |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0683 | 1 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0683 | 1 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0683 | 1 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0683 | 1 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0683 | 1 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0237 | 0.1979 | 0.5 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0237 | 0.1979 | 0.1966 |
Echinococcus multilocularis | C type lectin domian containing protein | 0.0127 | 0.0016 | 0.0016 |
Plasmodium falciparum | glutathione reductase | 0.0237 | 0.1979 | 0.1966 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0237 | 0.1979 | 0.1979 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0237 | 0.1979 | 0.5 |
Schistosoma mansoni | c4b-binding protein beta chain | 0.0127 | 0.0016 | 0.0016 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0237 | 0.1979 | 0.1966 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.0273 | 0.0257 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0237 | 0.1979 | 0.5 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0196 | 0.1256 | 0.1242 |
Toxoplasma gondii | thioredoxin reductase | 0.0683 | 1 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0237 | 0.1979 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0683 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0683 | 1 | 1 |
Treponema pallidum | NADH oxidase | 0.0237 | 0.1979 | 0.5 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0237 | 0.1979 | 0.1966 |
Onchocerca volvulus | 0.0127 | 0.0016 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.0591 | 0.0575 |
Echinococcus multilocularis | roundabout 2 | 0.0159 | 0.0591 | 0.0591 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0683 | 1 | 1 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0237 | 0.1979 | 0.1979 |
Plasmodium falciparum | thioredoxin reductase | 0.0683 | 1 | 1 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0174 | 0.085 | 0.0836 |
Onchocerca volvulus | 0.0127 | 0.0016 | 0.5 | |
Onchocerca volvulus | 0.0127 | 0.0016 | 0.5 | |
Brugia malayi | Thioredoxin reductase | 0.0683 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.0591 | 0.0575 |
Echinococcus granulosus | C type lectin domian containing protein | 0.0127 | 0.0016 | 0.0016 |
Onchocerca volvulus | 0.0127 | 0.0016 | 0.5 | |
Loa Loa (eye worm) | glutathione reductase | 0.0683 | 1 | 1 |
Onchocerca volvulus | 0.0127 | 0.0016 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 0.1256 | 0.1242 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0237 | 0.1979 | 0.5 |
Leishmania major | trypanothione reductase | 0.0683 | 1 | 1 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0237 | 0.1979 | 0.1966 |
Echinococcus granulosus | roundabout 2 | 0.0159 | 0.0591 | 0.0591 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0134 | 0.0128 | 0.0112 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0237 | 0.1979 | 0.5 |
Schistosoma mansoni | cell adhesion molecule | 0.0134 | 0.0128 | 0.0128 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0237 | 0.1979 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0128 | 0.0112 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0134 | 0.0128 | 0.0128 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0237 | 0.1979 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0237 | 0.1979 | 0.5 |
Onchocerca volvulus | 0.0127 | 0.0016 | 0.5 | |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0237 | 0.1979 | 0.1966 |
Onchocerca volvulus | 0.0127 | 0.0016 | 0.5 | |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0237 | 0.1979 | 0.1979 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0174 | 0.085 | 0.0836 |
Onchocerca volvulus | 0.0127 | 0.0016 | 0.5 | |
Echinococcus granulosus | c4b binding protein beta chain | 0.0127 | 0.0016 | 0.0016 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0237 | 0.1979 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.