Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | ABC1 family protein | 0.0038 | 0.1065 | 0.4121 |
Brugia malayi | beta-lactamase | 0.0038 | 0.1065 | 0.4121 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0014 | 0.0029 | 0.0112 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0559 | 0.2162 |
Treponema pallidum | NADH oxidase | 0.0025 | 0.0508 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0025 | 0.0508 | 0.1966 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0029 | 0.0112 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0021 | 0.0321 | 0.1242 |
Mycobacterium ulcerans | hypothetical protein | 0.0038 | 0.1065 | 1 |
Onchocerca volvulus | 0.0038 | 0.1065 | 1 | |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0017 | 0.0129 | 0.0499 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.1065 | 0.4121 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0038 | 0.1065 | 0.4121 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0129 | 0.0499 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0025 | 0.0508 | 0.0384 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0025 | 0.0508 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0073 | 0.2585 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0038 | 0.1065 | 1 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0025 | 0.0508 | 0.1544 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0559 | 0.175 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0025 | 0.0508 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1065 | 0.4121 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0025 | 0.0508 | 0.1966 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0017 | 0.0129 | 0.0499 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0151 | 0.0583 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0025 | 0.0508 | 0.0384 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0559 | 0.175 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0025 | 0.0508 | 0.1966 |
Toxoplasma gondii | thioredoxin reductase | 0.0073 | 0.2585 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0073 | 0.2585 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0073 | 0.2585 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0073 | 0.2585 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0073 | 0.2585 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0017 | 0.0129 | 0.0499 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0025 | 0.0508 | 0.5 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0025 | 0.0508 | 0.1544 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0038 | 0.1065 | 0.4121 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0038 | 0.1065 | 0.0948 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0038 | 0.1065 | 0.3812 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0559 | 0.175 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0559 | 0.2162 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0025 | 0.0508 | 0.1544 |
Plasmodium vivax | hypothetical protein, conserved | 0.0038 | 0.1065 | 0.4121 |
Loa Loa (eye worm) | beta-lactamase | 0.0038 | 0.1065 | 0.4121 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0025 | 0.0508 | 0.0384 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0019 | 0.0216 | 0.0836 |
Mycobacterium ulcerans | lipase LipD | 0.0038 | 0.1065 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1065 | 0.4121 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.1065 | 0.4121 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0559 | 0.175 |
Plasmodium falciparum | glutathione reductase | 0.0073 | 0.2585 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0017 | 0.0129 | 0.0499 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0129 | 0.0499 |
Loa Loa (eye worm) | glutathione reductase | 0.0073 | 0.2585 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0129 | 0.0499 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0559 | 0.2162 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1065 | 0.4121 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0025 | 0.0508 | 0.1544 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.1065 | 0.3812 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.1065 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0073 | 0.2585 | 0.2488 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.1065 | 0.4121 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0025 | 0.0508 | 0.1544 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0073 | 0.2585 | 1 |
Onchocerca volvulus | 0.0038 | 0.1065 | 1 | |
Echinococcus multilocularis | roundabout 2 | 0.0017 | 0.0149 | 0.0575 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0038 | 0.1065 | 0.0948 |
Trypanosoma brucei | trypanothione reductase | 0.0073 | 0.2585 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.1065 | 0.0948 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.1065 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0038 | 0.1065 | 1 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0025 | 0.0508 | 0.1544 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0019 | 0.0216 | 0.0836 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0025 | 0.0508 | 0.1544 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0025 | 0.0508 | 0.1966 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0025 | 0.0508 | 0.1544 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0025 | 0.0508 | 0.0384 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0025 | 0.0508 | 0.1544 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0025 | 0.0508 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0559 | 0.2162 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1065 | 0.4121 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0559 | 0.2162 |
Trichomonas vaginalis | esterase, putative | 0.0038 | 0.1065 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0038 | 0.1065 | 0.0948 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0017 | 0.0129 | 0.0499 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.1065 | 0.4121 |
Brugia malayi | Isocitrate dehydrogenase | 0.0017 | 0.0129 | 0.0499 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0025 | 0.0508 | 0.1966 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0025 | 0.0508 | 0.1966 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0073 | 0.2585 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0025 | 0.0508 | 0.1966 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0014 | 0.0029 | 0.0112 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0025 | 0.0508 | 0.1544 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0014 | 0.0029 | 0.0112 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0321 | 0.1242 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.1065 | 1 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0038 | 0.1065 | 0.0948 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0038 | 0.1065 | 0.4121 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0025 | 0.0508 | 0.1544 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0025 | 0.0508 | 0.1544 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0038 | 0.1065 | 0.4121 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.1065 | 0.3812 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0129 | 0.0499 |
Brugia malayi | glutathione reductase | 0.0073 | 0.2585 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0017 | 0.0129 | 0.0499 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.1065 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0038 | 0.1065 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.1065 | 0.0948 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1065 | 0.4121 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0017 | 0.0129 | 0.0499 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0149 | 0.0575 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1065 | 0.4121 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0025 | 0.0508 | 0.1544 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.1065 | 0.0948 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0038 | 0.1065 | 0.0948 |
Mycobacterium leprae | conserved hypothetical protein | 0.0038 | 0.1065 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0149 | 0.0575 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0025 | 0.0508 | 0.1544 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0017 | 0.0129 | 0.0499 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0067 | 0.0257 |
Onchocerca volvulus | 0.0038 | 0.1065 | 1 | |
Schistosoma mansoni | cell adhesion molecule | 0.0014 | 0.0029 | 0.0112 |
Plasmodium falciparum | thioredoxin reductase | 0.0073 | 0.2585 | 1 |
Echinococcus granulosus | roundabout 2 | 0.0017 | 0.0149 | 0.0575 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0025 | 0.0508 | 0.1966 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.1065 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0025 | 0.0508 | 0.1966 |
Leishmania major | hypothetical protein, conserved | 0.0038 | 0.1065 | 0.3812 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0038 | 0.1065 | 0.0948 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0025 | 0.0508 | 0.1544 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0025 | 0.0508 | 0.1544 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0025 | 0.0508 | 0.1966 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0025 | 0.0508 | 0.1966 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0559 | 0.2162 |
Leishmania major | trypanothione reductase | 0.0073 | 0.2585 | 1 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0025 | 0.0508 | 0.1544 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0017 | 0.0129 | 0.0499 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0025 | 0.0508 | 0.1966 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0038 | 0.1065 | 0.0948 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0038 | 0.1065 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.