Detailed information for compound 837382

Basic information

Technical information
  • TDR Targets ID: 837382
  • Name: 3-(5,7-dimethyl-2-phenylpyrazolo[1,5-a]pyrimi din-6-yl)-N-(3-fluorophenyl)propanamide
  • MW: 388.437 | Formula: C23H21FN4O
  • H donors: 1 H acceptors: 3 LogP: 3.96 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccc(c1)F)CCc1c(C)nc2n(c1C)nc(c2)c1ccccc1
  • InChi: 1S/C23H21FN4O/c1-15-20(11-12-23(29)26-19-10-6-9-18(24)13-19)16(2)28-22(25-15)14-21(27-28)17-7-4-3-5-8-17/h3-10,13-14H,11-12H2,1-2H3,(H,26,29)
  • InChiKey: HZNDXDUZRCHJQJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(5,7-dimethyl-2-phenyl-pyrazolo[1,5-a]pyrimidin-6-yl)-N-(3-fluorophenyl)propanamide
  • 3-(5,7-dimethyl-2-phenyl-6-pyrazolo[1,5-a]pyrimidinyl)-N-(3-fluorophenyl)propanamide
  • 3-(5,7-dimethyl-2-phenyl-pyrazolo[1,5-a]pyrimidin-6-yl)-N-(3-fluorophenyl)propionamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cathepsin L-like precursor 0.0013 0.0126 0.053
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0028 0.0339 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0019 0.0556
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0009 0.0073 0.2906
Plasmodium vivax vivapain-1 0.0007 0.0041 0.1323
Brugia malayi Cathepsin L-like precursor 0.0013 0.0126 0.053
Loa Loa (eye worm) hypothetical protein 0.0004 0.0009 0.0036
Loa Loa (eye worm) hypothetical protein 0.0022 0.0254 0.1065
Onchocerca volvulus 0.0013 0.0126 0.5011
Brugia malayi nuclear receptor RXR 0.0004 0.0008 0.0035
Schistosoma mansoni hypothetical protein 0.001 0.0087 0.0204
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0073 0.0173
Loa Loa (eye worm) hypothetical protein 0.0009 0.0073 0.0307
Loa Loa (eye worm) CXXC zinc finger family protein 0.0022 0.0252 0.1058
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0017 0.0184 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0019 0.0556
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0126 0.3728
Brugia malayi photoreceptor-specific nuclear receptor 0.0009 0.0073 0.0307
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0621 1
Entamoeba histolytica cysteine protease, putative 0.0007 0.0041 0.1212
Trichomonas vaginalis ap endonuclease, putative 0.0017 0.0184 0.5411
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0004 0.0008 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0621 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0009 0.0073 0.0173
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0013 0.0126 0.3728
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0017 0.0184 0.0184
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0015 0.0064
Loa Loa (eye worm) hypothetical protein 0.0004 0.0008 0.0035
Schistosoma mansoni steroid hormone receptor ad4bp 0.0009 0.0073 0.0173
Mycobacterium ulcerans putative regulatory protein 0.0628 0.8547 1
Brugia malayi cathepsin L-like precursor 0.0009 0.0068 0.0286
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0028 0.0339 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0621 1
Brugia malayi ecdysone receptor 0.0004 0.0008 0.0035
Brugia malayi Papain family cysteine protease containing protein 0.0007 0.0041 0.0172
Schistosoma mansoni ap endonuclease 0.0017 0.0184 0.0432
Plasmodium falciparum ataxin-2 like protein, putative 0.0022 0.0254 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0009 0.0073 0.0173
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0009 0.0073 0.0173
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0028 0.0339 0.1422
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0005 0.0019 0.0556
Loa Loa (eye worm) hypothetical protein 0.0004 0.0008 0.0035
Entamoeba histolytica cysteine protease, putative 0.0007 0.0041 0.1212
Trypanosoma cruzi cysteine peptidase, putative 0.0049 0.0621 1
Brugia malayi hypothetical protein 0.0004 0.0008 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0126 0.3728
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0019 0.0556
Onchocerca volvulus 0.0004 0.0008 0.0334
Loa Loa (eye worm) hypothetical protein 0.0009 0.0073 0.0307
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0045 0.0563 0.905
Echinococcus granulosus cathepsin l cysteine peptidase 0.0013 0.0126 0.0298
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0009 0.0073 0.0173
Brugia malayi Cathepsin L-like precursor 0.0004 0.0009 0.0036
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0004 0.0008 0.002
Loa Loa (eye worm) hypothetical protein 0.0028 0.0339 0.1422
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0009 0.0073 0.0307
Onchocerca volvulus 0.0004 0.0008 0.0334
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0084 0.1104 0.4629
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0007 0.0041 0.0097
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0013 0.0126 0.4007
Loa Loa (eye worm) hypothetical protein 0.0005 0.0015 0.0064
Mycobacterium tuberculosis Possible two component transcriptional regulatory protein (probably LuxR-family) 0.0628 0.8547 1
Schistosoma mansoni cpg binding protein 0.0022 0.0252 0.0594
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0009 0.0073 0.0307
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0009 0.0073 0.0307
Loa Loa (eye worm) hypothetical protein 0.0004 0.0008 0.0035
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0028 0.0339 0.514
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0126 0.3728
Loa Loa (eye worm) DR-78 0.0004 0.0008 0.0035
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0009 0.0073 0.0173
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.0015 0.0036
Onchocerca volvulus 0.0022 0.0252 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0007 0.0041 0.0097
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.0126 0.0298
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0126 0.3728
Echinococcus multilocularis ubiquitin specific protease 41 0.0028 0.0339 0.0339
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0073 0.0307
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.0015 0.0036
Loa Loa (eye worm) hypothetical protein 0.0004 0.0008 0.0035
Mycobacterium tuberculosis Probable transcriptional regulatory protein 0.0628 0.8547 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0084 0.1104 0.2598
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0339 1
Trypanosoma cruzi cysteine proteinase, putative 0.0007 0.0041 0.053
Trypanosoma cruzi cysteine protease, putative 0.0007 0.0041 0.053
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0017 0.0184 0.2856
Brugia malayi Cathepsin L-like precursor 0.0013 0.0126 0.053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0009 0.0073 0.0307
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0004 0.0008 0.0008
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0013 0.0126 0.053
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0073 0.0073
Echinococcus multilocularis dnaJ subfamily B 0.0314 0.425 0.425
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0017 0.0184 0.6688
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0073 0.0173
Loa Loa (eye worm) hypothetical protein 0.0004 0.0008 0.0035
Loa Loa (eye worm) hypothetical protein 0.0004 0.0009 0.0036
Echinococcus multilocularis cysteine protease 0.0013 0.0126 0.0126
Echinococcus granulosus mixed lineage leukemia protein mll 0.0005 0.0025 0.006
Plasmodium vivax vivapain-3 0.0007 0.0041 0.1323
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0009 0.0073 0.0307
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0009 0.0073 0.0173
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0084 0.1104 0.1104
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0073 0.0073
Entamoeba histolytica cysteine protease, putative 0.0007 0.0041 0.1212
Loa Loa (eye worm) hypothetical protein 0.0004 0.0008 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0126 0.3728
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0621 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0126 0.3728
Onchocerca volvulus 0.0013 0.0126 0.5011
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0015 0.0036
Schistosoma mansoni RAR-like nuclear receptor 0.0009 0.0073 0.0173
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0084 0.1104 0.2598
Brugia malayi nuclear hormone receptor 0.0004 0.0008 0.0035
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0004 0.0009 0.0036
Mycobacterium tuberculosis Probable transcriptional regulatory protein (LuxR-family) 0.0628 0.8547 1
Onchocerca volvulus 0.0013 0.0126 0.5011
Loa Loa (eye worm) hypothetical protein 0.0009 0.0073 0.0307
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0009 0.0073 0.0173
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0073 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0019 0.0556
Echinococcus granulosus FTZ F1 alpha 0.0009 0.0073 0.0173
Entamoeba histolytica cysteine protease, putative 0.0007 0.0041 0.1212
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0013 0.0126 0.0126
Echinococcus multilocularis cysteine protease 0.0013 0.0126 0.0126
Entamoeba histolytica cysteine protease, putative 0.0007 0.0041 0.1212
Echinococcus multilocularis FTZ F1 alpha 0.0009 0.0073 0.0073
Brugia malayi hypothetical protein 0.0005 0.0015 0.0064
Entamoeba histolytica cysteine proteinase, putative 0.0013 0.0126 0.3728
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.001 0.0087 0.0087
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0621 1
Echinococcus granulosus cathepsin l1 0.0013 0.0126 0.0298
Trypanosoma cruzi cysteine peptidase, putative 0.0049 0.0621 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0009 0.0073 0.0073
Brugia malayi tailless protein 0.0004 0.0008 0.0035
Brugia malayi ecdysteroid receptor 0.0009 0.0073 0.0307
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0068 0.2013
Trypanosoma cruzi cysteine peptidase, putative 0.0007 0.0041 0.053
Brugia malayi nuclear hormone receptor 0.0009 0.0073 0.0307
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.0015 0.0015
Trypanosoma cruzi PAB1-binding protein , putative 0.0022 0.0254 0.4008
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0004 0.0008 0.0008
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0028 0.0339 0.0798
Echinococcus granulosus Nuclear hormone receptor HR96 0.0004 0.0008 0.002
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0044 0.0044
Echinococcus multilocularis cathepsin L cysteine protease 0.0013 0.0126 0.0126
Echinococcus multilocularis cathepsin L 0.0007 0.0041 0.0041
Trypanosoma cruzi cysteine peptidase, putative 0.0013 0.0126 0.1924
Schistosoma mansoni coup transcription factor 0.0009 0.0073 0.0173
Onchocerca volvulus 0.0013 0.0126 0.5011
Onchocerca volvulus Cathepsin L homolog 0.0013 0.0126 0.5011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0126 0.3728
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0041 0.1212
Trypanosoma cruzi cysteine peptidase, putative 0.0049 0.0621 1
Schistosoma mansoni cathepsin s 0.0004 0.0009 0.002
Brugia malayi hypothetical protein 0.0022 0.0254 0.1065
Trypanosoma brucei PAB1-binding protein , putative 0.0022 0.0254 0.3672
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0028 0.0339 0.0798
Echinococcus granulosus cysteine protease 0.0007 0.0041 0.0097
Entamoeba histolytica cysteine proteinase, putative 0.0007 0.0041 0.1212
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0126 0.3728
Brugia malayi hypothetical protein 0.0004 0.0008 0.0035
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0044 0.0103
Trypanosoma cruzi PAB1-binding protein , putative 0.0022 0.0254 0.4008
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.0015 0.0064
Onchocerca volvulus Bile acid receptor homolog 0.0009 0.0073 0.2906
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0009 0.0073 0.0073
Entamoeba histolytica cysteine protease, putative 0.0013 0.0126 0.3728
Onchocerca volvulus 0.0013 0.0126 0.5011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0621 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0621 1
Mycobacterium ulcerans hypothetical protein 0.0628 0.8547 1
Brugia malayi Cathepsin L-like precursor 0.0013 0.0126 0.053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0126 0.3728
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0019 0.0556
Brugia malayi cathepsin F-like cysteine proteinase 0.0004 0.0009 0.0036
Brugia malayi Cathepsin L-like precursor 0.0013 0.0126 0.053
Schistosoma mansoni cpg binding protein 0.0023 0.027 0.0634
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0073 0.0307
Trichomonas vaginalis ap endonuclease, putative 0.0017 0.0184 0.5411
Brugia malayi Nuclear hormone receptor E75 0.0004 0.0008 0.0035
Echinococcus multilocularis nuclear receptor nhr 48 0.0004 0.0008 0.0008
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0073 0.0307
Echinococcus multilocularis ecdysone induced protein 78C 0.0009 0.0073 0.0073
Entamoeba histolytica cysteine protease, putative 0.0007 0.0041 0.1212
Plasmodium vivax vivapain-2 0.0013 0.0126 0.4801
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0009 0.0073 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0009 0.0073 0.0307
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0028 0.0339 1
Loa Loa (eye worm) ctsf protein 0.0013 0.0126 0.053
Brugia malayi Steroid receptor seven-up type 2 0.0009 0.0073 0.0307
Mycobacterium tuberculosis Possible transcriptional regulatory protein 0.0628 0.8547 1
Toxoplasma gondii LsmAD domain-containing protein 0.0022 0.0254 0.3223
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0009 0.0073 0.0307
Brugia malayi orphan nuclear receptor NR2E1 0.0004 0.0008 0.0035
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0005 0.0025 0.0025
Echinococcus multilocularis thyroid hormone receptor alpha 0.0009 0.0073 0.0073
Schistosoma mansoni hypothetical protein 0.0314 0.425 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0019 0.0556
Mycobacterium ulcerans two component transcriptional regulator 0.0628 0.8547 1
Trypanosoma cruzi cruzipain precursor, putative 0.0049 0.0621 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0022 0.0254 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0073 0.0307
Brugia malayi Cathepsin L-like precursor 0.0013 0.0126 0.053
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0004 0.0008 0.0008
Loa Loa (eye worm) fibroinase 0.0013 0.0126 0.053
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0009 0.0073 0.0307
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0084 0.1104 0.2598
Echinococcus granulosus cathepsin L 0.0007 0.0041 0.0097
Plasmodium vivax vivapain-2 0.0013 0.0126 0.4801
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0013 0.0126 0.0126
Entamoeba histolytica cysteine proteinase 1, putative 0.0007 0.0041 0.1212
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0019 0.0556
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0017 0.0184 0.2856
Entamoeba histolytica cysteine proteinase, putative 0.0013 0.0126 0.3728
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0017 0.0184 0.0432
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0004 0.0008 0.0008
Treponema pallidum exodeoxyribonuclease (exoA) 0.0017 0.0184 0.5
Entamoeba histolytica cysteine protease, putative 0.0007 0.0041 0.1212
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0009 0.0073 0.0173
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.0126 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0073 0.0307
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0017 0.0184 0.2456
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0025 0.006
Loa Loa (eye worm) hypothetical protein 0.0013 0.0126 0.053
Brugia malayi nuclear hormone receptor family member nhr-6 0.0004 0.0008 0.0035
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0017 0.0184 0.5411
Loa Loa (eye worm) hypothetical protein 0.0009 0.0073 0.0307
Onchocerca volvulus Cathepsin L homolog 0.0013 0.0126 0.5011
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.001 0.0087 0.0204
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0028 0.0339 0.0339
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0028 0.0339 0.0339
Leishmania major hypothetical protein, conserved 0.0022 0.0254 0.258
Entamoeba histolytica cysteine protease, putative 0.0007 0.0041 0.1212
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0126 0.3728
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0047 0.0591 0.139
Mycobacterium leprae PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN 0.0628 0.8547 0.5
Loa Loa (eye worm) histone methyltransferase 0.0007 0.0044 0.0184
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0007 0.0041 0.053
Loa Loa (eye worm) hypothetical protein 0.0004 0.0008 0.0035
Loa Loa (eye worm) hypothetical protein 0.0009 0.0068 0.0286
Schistosoma mansoni retinoic acid receptor RXR 0.0009 0.0073 0.0173
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0004 0.0008 0.002
Echinococcus granulosus nuclear receptor nhr 48 0.0004 0.0008 0.002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0621 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0068 0.0286
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0028 0.0339 0.0798
Plasmodium vivax ataxin-2 like protein, putative 0.0022 0.0254 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0017 0.0184 0.7126
Entamoeba histolytica cysteine proteinase, putative 0.0007 0.0041 0.1212
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0009 0.0073 0.0307
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0126 0.3728
Entamoeba histolytica cysteine protease, putative 0.0007 0.0041 0.1212
Brugia malayi hypothetical protein 0.0005 0.0015 0.0064
Brugia malayi Cathepsin L-like cysteine proteinase 0.0009 0.0068 0.0286
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0019 0.0556
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0073 0.0307
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0019 0.0556
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0126 0.3728
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0126 0.3728
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0004 0.0009 0.0036
Mycobacterium tuberculosis Probable transcriptional regulatory protein (probably LuxR/UhpA-family) 0.0628 0.8547 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0017 0.0184 0.1154
Loa Loa (eye worm) hypothetical protein 0.0005 0.0015 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0009 0.0073 0.0307
Loa Loa (eye worm) hypothetical protein 0.0004 0.0008 0.0035
Loa Loa (eye worm) hypothetical protein 0.0009 0.0073 0.0307
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0019 0.0556
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0013 0.0126 0.3728
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0073 0.0173
Brugia malayi nuclear receptor NHR-67 0.0004 0.0008 0.0035
Plasmodium vivax unspecified product 0.0007 0.0041 0.1323
Brugia malayi nuclear receptor NHR-88 0.0004 0.0008 0.0035
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0084 0.1104 0.4629
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.0068 0.2013
Schistosoma mansoni zinc finger protein 0.0004 0.0008 0.002
Loa Loa (eye worm) hypothetical protein 0.0004 0.0008 0.0035
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0005 0.0025 0.006
Entamoeba histolytica cysteine proteinase, putative 0.0007 0.0041 0.1212
Entamoeba histolytica cysteine protease, putative 0.0007 0.0041 0.1212
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0019 0.0556
Schistosoma mansoni cpg binding protein 0.0023 0.027 0.0634
Leishmania major cathepsin L-like protease 0.0049 0.0621 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0013 0.0126 0.053
Echinococcus granulosus dnaJ subfamily B 0.0314 0.425 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0073 0.0307
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0126 0.3728
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0126 0.3728
Brugia malayi Papain family cysteine protease containing protein 0.0007 0.0041 0.0172
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0084 0.1104 0.2598
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0009 0.0073 0.0307
Toxoplasma gondii exonuclease III APE 0.0017 0.0184 0.1442
Mycobacterium ulcerans nitrate/nitrite response regulator protein NarL 0.0628 0.8547 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0009 0.0073 0.0307
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0028 0.0339 0.4301
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0004 0.0008 0.0035
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0004 0.0008 0.0008
Schistosoma mansoni nuclear hormone receptor 0.0004 0.0008 0.002
Brugia malayi CXXC zinc finger family protein 0.0022 0.0252 0.1058
Schistosoma mansoni nuclear hormone receptor 0.0004 0.0008 0.002
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0005 0.0025 0.0025
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0178 0.2385 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0004 0.0008 0.002
Onchocerca volvulus 0.0009 0.0073 0.2906
Loa Loa (eye worm) hypothetical protein 0.0009 0.0073 0.0307
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0126 0.3728
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0009 0.0073 0.0307
Echinococcus granulosus ubiquitin specific protease 41 0.0028 0.0339 0.0798
Loa Loa (eye worm) hypothetical protein 0.0004 0.0008 0.0035
Toxoplasma gondii histone lysine methyltransferase SET1 0.0042 0.0522 1
Loa Loa (eye worm) nuclear hormone receptor 0.0004 0.0008 0.0035
Trypanosoma cruzi cysteine proteinase, putative 0.0007 0.0041 0.053
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0019 0.0556
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0621 1
Brugia malayi Cathepsin L-like precursor 0.0009 0.0068 0.0286
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0126 0.3728
Trichomonas vaginalis helicase, putative 0.0005 0.0019 0.0556
Loa Loa (eye worm) hypothetical protein 0.0009 0.0068 0.0286
Leishmania major cathepsin L-like protease 0.0049 0.0621 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0004 0.0008 0.002
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0004 0.0008 0.002
Schistosoma mansoni cathepsin F (C01 family) 0.0009 0.0068 0.0161
Loa Loa (eye worm) hypothetical protein 0.0005 0.0015 0.0064
Onchocerca volvulus Cathepsin F homolog 0.0013 0.0126 0.5011
Brugia malayi conserved hypotetical protein 0.0004 0.0008 0.0035
Onchocerca volvulus 0.0013 0.0126 0.5011
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0019 0.0556
Echinococcus granulosus cathepsin L cysteine proteinase 0.0013 0.0126 0.0298
Echinococcus granulosus cathepsin l1 0.0009 0.0068 0.0161
Trypanosoma cruzi major cysteine proteinase, putative 0.0038 0.0477 0.7656
Schistosoma mansoni nuclear receptor 0.0004 0.0008 0.002
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0015 0.0064
Entamoeba histolytica cysteine protease, putative 0.0007 0.0041 0.1212
Entamoeba histolytica cysteine proteinase, putative 0.0007 0.0041 0.1212
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0009 0.0073 0.0173
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0017 0.0184 0.0769
Brugia malayi exodeoxyribonuclease III family protein 0.0017 0.0184 0.0769
Echinococcus multilocularis cpg binding protein 0.0023 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0005 0.0015 0.0064
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0005 0.0019 0.0556
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0028 0.0339 0.5397
Loa Loa (eye worm) steroid hormone receptor 0.0009 0.0073 0.0307
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0126 0.3728
Loa Loa (eye worm) hypothetical protein 0.0004 0.0009 0.0036
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0009 0.0073 0.0173
Loa Loa (eye worm) cysteine protease 0.0013 0.0126 0.053
Echinococcus multilocularis cathepsin L cysteine protease 0.0013 0.0126 0.0126
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0126 0.3728
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0009 0.0073 0.0073
Onchocerca volvulus 0.0009 0.0068 0.2705
Loa Loa (eye worm) hypothetical protein 0.0004 0.0008 0.0035
Schistosoma mansoni nuclear receptor nhr-48 0.0004 0.0008 0.002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0019 0.0556
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0126 0.3728
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0126 0.3728
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0028 0.0339 0.0798
Brugia malayi F/Y-rich N-terminus family protein 0.0007 0.0043 0.0179
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0073 0.0307
Loa Loa (eye worm) hypothetical protein 0.0004 0.0008 0.0035
Brugia malayi nuclear hormone receptor family member odr-7 0.0004 0.0008 0.0035
Echinococcus granulosus cathepsin L cysteine protease 0.0007 0.0041 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0073 0.0307
Plasmodium falciparum cysteine proteinase falcipain 3 0.0013 0.0126 0.4007
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0009 0.0073 0.0307
Mycobacterium tuberculosis Possible nitrate/nitrite response transcriptional regulatory protein NarL 0.0628 0.8547 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0621 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0084 0.1104 0.2598
Mycobacterium ulcerans two component transcriptional regulatory protein DevR 0.0628 0.8547 1
Echinococcus granulosus cpg binding protein 0.0023 0.027 0.0634
Entamoeba histolytica cysteine proteinase 2 0.0007 0.0041 0.1212
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0073 0.0173
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0126 0.3728
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0004 0.0008 0.0334
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0028 0.0339 0.5397
Brugia malayi hypothetical protein 0.0014 0.0146 0.0614
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0013 0.0126 0.4007
Entamoeba histolytica cysteine protease, putative 0.0007 0.0041 0.1212
Brugia malayi follicle stimulating hormone receptor 0.0178 0.2385 1
Entamoeba histolytica cysteine protease, putative 0.0007 0.0041 0.1212
Leishmania major cathepsin L-like protease 0.0049 0.0621 1
Loa Loa (eye worm) hypothetical protein 0.0004 0.0008 0.0035
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0028 0.0339 1
Brugia malayi nuclear receptor NHR-88 0.0009 0.0073 0.0307
Loa Loa (eye worm) nuclear receptor NHR-67 0.0004 0.0008 0.0035
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0073 0.0173
Schistosoma mansoni ap endonuclease 0.0017 0.0184 0.0432
Echinococcus granulosus thyroid hormone receptor alpha 0.0004 0.0008 0.002
Brugia malayi nuclear receptor RXR 0.0005 0.0015 0.0064
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0126 0.3728
Brugia malayi Nuclear hormone receptor E75 0.0004 0.0008 0.0035
Schistosoma mansoni nuclear receptor 0.0004 0.0008 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0019 0.0556
Onchocerca volvulus 0.0013 0.0126 0.5011
Echinococcus granulosus ecdysone induced protein 78C 0.0009 0.0073 0.0173
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0084 0.1104 0.1104
Brugia malayi steroid hormone receptor 0.0009 0.0073 0.0307
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0621 1
Brugia malayi Cathepsin L-like precursor 0.0009 0.0068 0.0286
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0068 0.2013
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0004 0.0008 0.0334
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0007 0.0041 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0041 0.1212
Brugia malayi Papain family cysteine protease containing protein 0.0013 0.0126 0.053
Loa Loa (eye worm) hypothetical protein 0.0005 0.0015 0.0064
Onchocerca volvulus Protein ultraspiracle homolog 0.0009 0.0073 0.2906

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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