TDR Targets

Basic information

Technical information

TDR Targets ID: 837402
Name: N-(2-ethylphenyl)-3-(2,5,7-trimethyl-3-phenyl pyrazolo[1,5-a]pyrimidin-6-yl)propanamide
MW: 412.527 | Formula: C26H28N4O
H donors: 1 H acceptors: 3 LogP: 5.02 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCc1ccccc1NC(=O)CCc1c(C)nc2n(c1C)nc(c2c1ccccc1)C
InChi: 1S/C26H28N4O/c1-5-20-11-9-10-14-23(20)28-24(31)16-15-22-17(2)27-26-25(21-12-7-6-8-13-21)18(3)29-30(26)19(22)4/h6-14H,5,15-16H2,1-4H3,(H,28,31)
InChiKey: MPSRMUQFSPXBDU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2-ethylphenyl)-3-(2,5,7-trimethyl-3-phenyl-pyrazolo[1,5-a]pyrimidin-6-yl)propanamide
N-(2-ethylphenyl)-3-(2,5,7-trimethyl-3-phenyl-6-pyrazolo[1,5-a]pyrimidinyl)propanamide
N-(2-ethylphenyl)-3-(2,5,7-trimethyl-3-phenyl-pyrazolo[1,5-a]pyrimidin-6-yl)propionamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1025	1	1
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0523	0.0412
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0334	0.0334
Echinococcus multilocularis	intestinal type alkaline phosphatase 1	0.0318	0.303	0.303
Leishmania major	tyrosine specific protein phosphatase, putative	0.0026	0.0147	0.021
Schistosoma mansoni	pyruvate kinase	0.0033	0.0213	0.0213
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0026	0.0147	0.0147
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.0249	0.2091
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0147	0.0032
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0026	0.0147	0.0147
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0249	0.1851
Brugia malayi	Carboxylesterase family protein	0.0064	0.0523	0.0477
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0249	0.1851
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0026	0.0147	0.0147
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0026	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0147	0.0032
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0147	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0379	0.3631	0.3557
Echinococcus granulosus	intestinal type alkaline phosphatase	0.0318	0.303	0.303
Loa Loa (eye worm)	carboxylesterase	0.0064	0.0523	0.0412
Echinococcus multilocularis	carboxylesterase 5A	0.0379	0.3631	0.3631
Brugia malayi	Carboxylesterase family protein	0.0379	0.3631	0.3601
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0147	0.01
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0134	0.3441
Plasmodium falciparum	ABC transporter G family member 2	0.004	0.0283	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0134	0.0019
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0064	0.0523	0.0523
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0087	0.0752	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0147	0.0032
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0334	0.0334
Brugia malayi	hypothetical protein	0.0025	0.0134	0.0087
Echinococcus granulosus	para nitrobenzyl esterase	0.0064	0.0523	0.0523
Schistosoma mansoni	hypothetical protein	0.0033	0.0219	0.0219
Plasmodium vivax	ABC transporter G family member 2, putative	0.004	0.0283	1
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.1025	1	1
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.004	0.0283	0.2259
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0147	0.0032
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0064	0.0523	0.0523
Trypanosoma brucei	pyruvate kinase 1	0.0033	0.0213	0.1273
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0147	0.01
Echinococcus multilocularis	pyruvate kinase	0.0033	0.0213	0.0213
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0026	0.0147	0.0147
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0147	0.01
Echinococcus multilocularis	neuroligin	0.0064	0.0523	0.0523
Giardia lamblia	Pyruvate kinase	0.0033	0.0213	0.7053
Echinococcus multilocularis	geminin	0.0166	0.1526	0.1526
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0026	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0147	0.0032
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0026	0.0147	0.0032
Schistosoma mansoni	microtubule-associated protein tau	0.0675	0.6551	0.6551
Leishmania major	pyruvate kinase	0.0033	0.0213	0.1273
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0026	0.0147	0.0147
Leishmania major	ATP-binding cassette protein subfamily G, member 4, putative	0.004	0.0283	0.2406
Mycobacterium tuberculosis	Probable conserved transmembrane ATP-binding protein ABC transporter	0.0033	0.0219	0.0245
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0026	0.0147	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0523	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0147	0.0032
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0026	0.0147	0.0147
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0026	0.0147	0.0147
Echinococcus multilocularis		0.0026	0.0147	0.0147
Brugia malayi	hypothetical protein	0.0026	0.0147	0.01
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0101	0.0891	0.0891
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.004	0.0283	0.2259
Echinococcus granulosus	ATP binding cassette sub family G	0.004	0.0283	0.0283
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0147	0.0032
Chlamydia trachomatis	pyruvate kinase	0.0033	0.0213	0.5
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0026	0.0147	0.0147
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0026	0.0147	0.0147
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0147	0.0032
Echinococcus multilocularis	acetylcholinesterase	0.0379	0.3631	0.3631
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0026	0.0147	0.0147
Echinococcus granulosus	pyruvate kinase	0.0017	0.0056	0.0056
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0379	0.3631	0.3631
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0147	0.01
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0147	0.0032
Schistosoma mansoni	BC026374 protein (S09 family)	0.0064	0.0523	0.0523
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0147	0.0032
Schistosoma mansoni	ABC transporter	0.0034	0.0223	0.0223
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0147	0.01
Brugia malayi	Protein kinase domain containing protein	0.0087	0.0752	0.0708
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0033	0.0213	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0147	0.01
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0026	0.0147	0.0147
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0334	0.0334
Leishmania major	ATP-binding cassette protein subfamily G, member 6, putative	0.004	0.0283	0.2406
Echinococcus multilocularis	ATP binding cassette sub family G	0.004	0.0283	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0523	0.0412
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0213	0.0099
Schistosoma mansoni	alkaline phosphatase	0.0318	0.303	0.303
Echinococcus multilocularis	dual specificity	0.0087	0.0752	0.0752
Trypanosoma cruzi	ATP-binding cassette protein, putative	0.004	0.0283	0.2406
Brugia malayi	Helix-loop-helix DNA-binding domain containing protein	0.0106	0.0933	0.0889
Schistosoma mansoni	protein tyrosine phosphatase	0.0026	0.0147	0.0147
Echinococcus granulosus	intestinal type alkaline phosphatase 1	0.0318	0.303	0.303
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0026	0.0147	0.0147
Echinococcus multilocularis	acetylcholinesterase	0.0379	0.3631	0.3631
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0523	0.0412
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0036	0.0249	0.1152
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0147	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0213	0.0099
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0026	0.0147	0.0147
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0249	0.0249
Trypanosoma brucei	ABC transporter, putative	0.004	0.0283	0.2406
Echinococcus granulosus	ATP binding cassette sub family G	0.004	0.0283	0.0283
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0026	0.0147	0.0147
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0334	0.0334
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0249	0.2699
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0033	0.0213	0.1273
Brugia malayi	Protein-tyrosine phosphatase	0.0026	0.0147	0.01
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0105	0.093	0.093
Echinococcus multilocularis	pyruvate kinase	0.0033	0.0213	0.0213
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0026	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0147	0.0032
Onchocerca volvulus		0.0064	0.0523	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0134	0.3441
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0147	0.0032
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0026	0.0147	0.0147
Onchocerca volvulus		0.0064	0.0523	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0147	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0147	0.0032
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0249	0.0249
Brugia malayi	hypothetical protein	0.0026	0.0147	0.01
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0147	0.01
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0147	0.01
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0026	0.0147	0.0147
Schistosoma mansoni	pyruvate kinase	0.0017	0.0056	0.0056
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0026	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0523	0.0412
Echinococcus multilocularis	transcription factor eb	0.0106	0.0933	0.0933
Entamoeba histolytica	hypothetical protein	0.0087	0.0752	1
Schistosoma mansoni	ATP-binding cassette sub-family g2 (white protein) (abcg2)	0.004	0.0283	0.0283
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0334	0.0221
Entamoeba histolytica	ABC transporter, putative	0.004	0.0283	0.263
Echinococcus granulosus	alkaline phosphatase intestinal gene 2	0.0318	0.303	0.303
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0026	0.0147	0.0147
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0087	0.0752	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.1047	0.0942
Loa Loa (eye worm)	ABC transporter	0.0034	0.0223	0.0109
Echinococcus granulosus	carboxylesterase 5A	0.0379	0.3631	0.3631
Echinococcus multilocularis	hypothetical protein	0.0026	0.0147	0.0147
Giardia lamblia	ABC transporter	0.0039	0.0278	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0026	0.0147	0.0147
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0064	0.0523	0.0523
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0249	0.1851
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0026	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0748	0.064
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0026	0.0147	0.0147
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0064	0.0523	0.0523
Leishmania major	pyruvate kinase	0.0033	0.0213	0.1273
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0147	0.01
Schistosoma mansoni	gliotactin	0.0064	0.0523	0.0523
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0213	0.1748
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1025	1	1
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0033	0.0213	0.0166
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0026	0.0147	0.0147
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0026	0.0147	0.0147
Echinococcus granulosus	pyruvate kinase	0.0033	0.0213	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0147	0.0032
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.1047	0.0942
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0026	0.0147	0.0499
Echinococcus multilocularis	ATP binding cassette sub family G	0.004	0.0283	0.0283
Schistosoma mansoni	serine/threonine protein kinase	0.0087	0.0752	0.0752
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0026	0.0147	0.0032
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0026	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0523	0.0412
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.0249	0.8486
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0147	0.01
Echinococcus multilocularis	intestinal type alkaline phosphatase	0.0318	0.303	0.303
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0026	0.0147	0.0147
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0334	0.0334
Echinococcus granulosus	pyruvate kinase	0.0033	0.0213	0.0213
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0147	0.01
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0213	0.1748
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0026	0.0147	0.0147
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0213	0.1748
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0087	0.0752	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0026	0.0147	0.0147
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0026	0.0147	0.0147
Brugia malayi	ABC transporter family protein	0.0034	0.0223	0.0176
Loa Loa (eye worm)	helix-loop-helix DNA-binding domain-containing protein	0.0105	0.0928	0.0822
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0147	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0147	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0147	0.0032
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0334	0.0287
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0134	0.3441
Echinococcus granulosus	alkaline phosphatase	0.0318	0.303	0.303
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0147	0.0032
Brugia malayi	MH2 domain containing protein	0.0117	0.1047	0.1004
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0147	0.01
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0026	0.0147	0.021
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0026	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0147	0.0032
Plasmodium falciparum	pyruvate kinase	0.0033	0.0213	0.6911
Onchocerca volvulus		0.0064	0.0523	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0147	0.0032
Trypanosoma cruzi	ABC transporter, putative	0.004	0.0283	0.2406
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0026	0.0147	0.0147
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0147	0.0032
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0249	0.0249
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0026	0.0147	0.01
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0026	0.0147	0.0499
Echinococcus granulosus	acetylcholinesterase	0.0379	0.3631	0.3631
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0026	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0147	0.0032
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0026	0.0147	0.0147
Echinococcus granulosus	ATP binding cassette sub family G	0.004	0.0283	0.0283
Schistosoma mansoni	protein tyrosine phosphatase	0.0026	0.0147	0.0147
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0026	0.0147	0.021
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1025	1	1
Echinococcus multilocularis	pyruvate kinase	0.0026	0.0145	0.0145
Trichomonas vaginalis	inositol monophosphatase, putative	0.0036	0.0249	0.2699
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0026	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0147	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0748	0.064
Echinococcus multilocularis	pyruvate kinase	0.0017	0.0056	0.0056
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0026	0.0147	0.0032
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0026	0.0147	0.0032
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0249	0.0249
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0033	0.0213	0.1273
Loa Loa (eye worm)	carboxylesterase	0.0064	0.0523	0.0412
Giardia lamblia	Protein tyrosine phosphatase	0.0026	0.0147	0.4097
Schistosoma mansoni	hypothetical protein	0.0165	0.1522	0.1522
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0087	0.0752	1
Plasmodium vivax	pyruvate kinase, putative	0.0033	0.0213	0.6911
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0147	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0147	0.0032
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0026	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0147	0.0032
Echinococcus granulosus	pyruvate kinase	0.0017	0.0056	0.0056
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0147	0.01
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0026	0.0147	0.0147
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0026	0.0147	0.0147
Loa Loa (eye worm)	acetylcholinesterase 1	0.0379	0.3631	0.3557
Entamoeba histolytica	protein kinase, putative	0.0087	0.0752	1
Echinococcus granulosus	pyruvate kinase	0.0017	0.0056	0.0056
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0026	0.0147	0.0147
Echinococcus multilocularis	ATP binding cassette sub family G	0.004	0.0283	0.0283
Trypanosoma brucei	ATP-binding cassette protein, putative	0.004	0.0283	0.2406
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0064	0.0523	1
Schistosoma mansoni	acetylcholinesterase	0.0064	0.0523	0.0523
Schistosoma mansoni	hypothetical protein	0.0166	0.1526	0.1526
Mycobacterium ulcerans	carboxylesterase, LipT	0.0064	0.0523	1
Entamoeba histolytica	protein kinase, putative	0.0087	0.0752	1
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0026	0.0147	0.0147
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0026	0.0147	0.0147
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0026	0.0147	0.021
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0026	0.0147	0.0499
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0134	0.3441
Loa Loa (eye worm)	inositol-1	0.0036	0.0249	0.0135
Brugia malayi	hypothetical protein	0.0064	0.0523	0.0477
Loa Loa (eye worm)	carboxylesterase	0.0379	0.3631	0.3557
Toxoplasma gondii	pyruvate kinase PyK1	0.0033	0.0213	0.6911
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0147	0.0032
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0147	0.0032
Trichomonas vaginalis	spcc417.12 protein, putative	0.0064	0.0523	1
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0026	0.0147	0.021
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0064	0.0523	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0026	0.0147	0.0147
Echinococcus multilocularis	alkaline phosphatase	0.0318	0.303	0.303
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0026	0.0147	0.0147
Brugia malayi	Protein-tyrosine phosphatase	0.0026	0.0147	0.01
Onchocerca volvulus		0.0064	0.0523	1
Echinococcus multilocularis	microtubule associated protein 2	0.0675	0.6551	0.6551
Echinococcus granulosus	BC026374 protein S09 family	0.0064	0.0523	0.0523
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0334	0.0334
Brugia malayi	hypothetical protein	0.0026	0.0147	0.01
Echinococcus granulosus	dual specificity	0.0087	0.0752	0.0752
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0147	0.01
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0213	0.0099
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0026	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0147	0.0032
Brugia malayi	hypothetical protein	0.0026	0.0147	0.01
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0026	0.0147	0.0147
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0033	0.0213	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0523	0.0412
Schistosoma mansoni	hypothetical protein	0.0166	0.1526	0.1526
Loa Loa (eye worm)	hypothetical protein	0.0379	0.3631	0.3557
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0147	0.0032
Schistosoma mansoni	retinoic acid receptor RXR	0.0105	0.093	0.093
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.0249	0.5
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0064	0.0523	1
Echinococcus granulosus	transcription factor eb	0.0106	0.0933	0.0933
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0147	0.0032
Toxoplasma gondii	ATP-binding cassette G family transporter ABCG84	0.004	0.0283	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0026	0.0147	0.0147
Echinococcus granulosus	microtubule associated protein 2	0.0675	0.6551	0.6551
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0249	0.1851
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0026	0.0147	0.0147
Echinococcus multilocularis	pyruvate kinase	0.0017	0.0056	0.0056
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0026	0.0147	0.0147
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0147	0.01
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0147	0.01
Schistosoma mansoni	pcd6 interacting protein-related	0.0026	0.0147	0.0147
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0147	0.0032
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0147	0.01
Trichomonas vaginalis	pyruvate kinase, putative	0.0033	0.0213	0.1748
Brugia malayi	Inositol-1	0.0036	0.0249	0.0202
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.004	0.0283	0.2259
Brugia malayi	Protein-tyrosine phosphatase 1	0.0026	0.0147	0.01
Entamoeba histolytica	protein kinase domain containing protein	0.0087	0.0752	1
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0026	0.0147	0.0147
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0026	0.0147	0.021
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0147	0.0032
Echinococcus granulosus	acetylcholinesterase	0.0379	0.3631	0.3631
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0249	0.2699
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0147	0.0032
Schistosoma mansoni	alkaline phosphatase	0.0318	0.303	0.303
Trichomonas vaginalis	pyruvate kinase, putative	0.0033	0.0213	0.1748
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0064	0.0523	0.0523
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0147	0.01
Brugia malayi	Carboxylesterase family protein	0.0064	0.0523	0.0477
Brugia malayi	hypothetical protein	0.0026	0.0147	0.01
Onchocerca volvulus		0.0064	0.0523	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0026	0.0147	0.0147
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0147	0.01
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0147	0.01
Brugia malayi	Carboxylesterase family protein	0.0064	0.0523	0.0477
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0064	0.0523	0.0523
Schistosoma mansoni	pyruvate kinase	0.0033	0.0213	0.0213
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0064	0.0523	1
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0026	0.0147	0.01
Brugia malayi	Carboxylesterase family protein	0.0064	0.0523	0.0477
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0213	0.0099
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0087	0.0752	0.0644
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0026	0.0147	0.0147
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0147	0.01
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0928	0.0822
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0147	0.01
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0147	0.0032
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0064	0.0523	0.0523
Trypanosoma brucei	pyruvate kinase 1, putative	0.0033	0.0213	0.1273
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0147	0.0032
Brugia malayi	Carboxylesterase family protein	0.0379	0.3631	0.3601
Schistosoma mansoni	protein tyrosine phosphatase	0.0026	0.0147	0.0147
Echinococcus granulosus	neuroligin	0.0064	0.0523	0.0523
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0147	0.0032
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0026	0.0147	0.0147
Echinococcus multilocularis	pyruvate kinase	0.0017	0.0056	0.0056
Echinococcus multilocularis	alkaline phosphatase, intestinal, gene 2	0.0318	0.303	0.303
Echinococcus multilocularis	para nitrobenzyl esterase	0.0064	0.0523	0.0523
Echinococcus granulosus	geminin	0.0166	0.1526	0.1526
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0033	0.0213	0.0166

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 837402