TDR Targets

Basic information

Technical information

TDR Targets ID: 837603
Name: N-(6-fluoro-1,3-benzothiazol-2-yl)-6,7-dimeth yl-4-oxochromene-2-carboxamide
MW: 368.382 | Formula: C19H13FN2O3S
H donors: 1 H acceptors: 3 LogP: 4.21 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc2c(c1)sc(n2)NC(=O)c1cc(=O)c2c(o1)cc(c(c2)C)C
InChi: 1S/C19H13FN2O3S/c1-9-5-12-14(23)8-16(25-15(12)6-10(9)2)18(24)22-19-21-13-4-3-11(20)7-17(13)26-19/h3-8H,1-2H3,(H,21,22,24)
InChiKey: QNHBBKKUGAKNOT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(6-fluoro-1,3-benzothiazol-2-yl)-6,7-dimethyl-4-oxo-chromene-2-carboxamide
N-(6-fluoro-1,3-benzothiazol-2-yl)-6,7-dimethyl-4-oxo-2-chromenecarboxamide
N-(6-fluoro-1,3-benzothiazol-2-yl)-4-keto-6,7-dimethyl-chromene-2-carboxamide
STOCK5S-94677
ZINC05350231

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0046	0.0872	0.1213
Trypanosoma brucei	trypanothione reductase	0.0046	0.0872	1
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0052	0.1108	0.1606
Echinococcus granulosus	jumonji domain containing protein	0.0031	0.0306	0.027
Loa Loa (eye worm)	hypothetical protein	0.003	0.0259	0.0763
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.003	0.0259	0.3018
Brugia malayi	jmjC domain containing protein	0.0027	0.0144	0.0349
Mycobacterium ulcerans	lipase LipD	0.0032	0.0329	0.5
Brugia malayi	beta-lactamase	0.0032	0.0329	0.0899
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0078	0.2132	0.331
Brugia malayi	beta-lactamase family protein	0.0032	0.0329	0.0899
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0032	0.0329	0.0188
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0105	0.3195	0.8613
Brugia malayi	mbt repeat family protein	0.0045	0.0859	0.2473
Plasmodium falciparum	thioredoxin reductase	0.0046	0.0872	1
Brugia malayi	RNA recognition motif domain containing protein	0.011	0.3396	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0078	0.2132	0.6279
Mycobacterium ulcerans	esterase/lipase LipP	0.0032	0.0329	0.5
Trichomonas vaginalis	D-aminoacylase, putative	0.0032	0.0329	0.0739
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0205	0.7169	1
Entamoeba histolytica	hypothetical protein	0.0028	0.0165	0.5
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0032	0.0329	0.0899
Loa Loa (eye worm)	heterochromatin protein 1	0.0054	0.12	0.3534
Leishmania major	hypothetical protein, conserved	0.0032	0.0329	0.3577
Loa Loa (eye worm)	beta-lactamase	0.0032	0.0329	0.0968
Echinococcus multilocularis	jumonji domain containing protein	0.0031	0.0306	0.027
Brugia malayi	RNA binding protein	0.011	0.3396	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0032	0.0329	0.3577
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0329	0.0968
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0078	0.2132	0.331
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0105	0.3195	0.4191
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0032	0.0329	0.0968
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0078	0.2132	0.2018
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0032	0.0329	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0595	0.1752
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0032	0.0329	0.5
Schistosoma mansoni	hypothetical protein	0.0028	0.0165	0.0021
Schistosoma mansoni	sex comb on midleg homolog	0.0045	0.0859	0.0726
Echinococcus multilocularis	geminin	0.0164	0.5557	0.9011
Brugia malayi	glutathione reductase	0.0046	0.0872	0.2512
Schistosoma mansoni	chromobox protein	0.0054	0.12	0.1072
Echinococcus granulosus	chromobox protein 1	0.0054	0.12	0.1758
Echinococcus multilocularis	tar DNA binding protein	0.011	0.3396	0.5413
Plasmodium vivax	glutathione reductase, putative	0.0046	0.0872	1
Trypanosoma brucei	hypothetical protein, conserved	0.0032	0.0329	0.3577
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0116	0.3657	1
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0105	0.3195	0.4191
Schistosoma mansoni	tar DNA-binding protein	0.011	0.3396	0.3299
Mycobacterium tuberculosis	Probable dehydrogenase	0.0105	0.3195	0.4191
Leishmania major	trypanothione reductase	0.0046	0.0872	1
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0179	0.6151	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0032	0.0329	0.0739
Loa Loa (eye worm)	glutathione reductase	0.0046	0.0872	0.2569
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0052	0.1108	0.0979
Trichomonas vaginalis	chromobox protein, putative	0.0033	0.035	0.0969
Onchocerca volvulus		0.0032	0.0329	0.3826
Schistosoma mansoni	tar DNA-binding protein	0.011	0.3396	0.3299
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0074	0.1993	0.3078
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0105	0.3195	0.4191
Trichomonas vaginalis	esterase, putative	0.0032	0.0329	0.0739
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0028	0.0165	0.0035
Trichomonas vaginalis	penicillin-binding protein, putative	0.0032	0.0329	0.0739
Trichomonas vaginalis	D-aminoacylase, putative	0.0032	0.0329	0.0739
Echinococcus granulosus	beta LACTamase domain containing family member	0.0032	0.0329	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1108	0.3263
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0045	0.0859	0.1191
Loa Loa (eye worm)	MBCTL1	0.0052	0.1108	0.3263
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0045	0.0859	1
Onchocerca volvulus		0.0045	0.0859	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0329	0.0968
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0074	0.1993	0.3078
Echinococcus granulosus	tar DNA binding protein	0.011	0.3396	0.5413
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0078	0.2132	0.2018
Schistosoma mansoni	hypothetical protein	0.0164	0.5557	0.5492
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0078	0.2132	0.331
Schistosoma mansoni	tar DNA-binding protein	0.011	0.3396	0.3299
Trypanosoma cruzi	hypothetical protein, conserved	0.0032	0.0329	0.3577
Brugia malayi	hypothetical protein	0.0028	0.0165	0.0412
Echinococcus multilocularis	chromobox protein 1	0.0054	0.12	0.1758
Mycobacterium tuberculosis	Probable oxidoreductase	0.0116	0.3657	0.4865
Trichomonas vaginalis	chromobox protein, putative	0.0033	0.035	0.0969
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0105	0.3195	0.4191
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0329	0.0968
Echinococcus granulosus	chromobox protein 1	0.0054	0.12	0.1758
Echinococcus granulosus	geminin	0.0164	0.5557	0.9011
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0116	0.3657	0.4865
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0045	0.0859	0.0726
Plasmodium vivax	hypothetical protein, conserved	0.0032	0.0329	0.3577
Plasmodium falciparum	glutathione reductase	0.0046	0.0872	1
Brugia malayi	jmjC domain containing protein	0.0074	0.1993	0.5838
Echinococcus granulosus	SAM and MBT domain containing protein	0.0045	0.0859	0.1191
Toxoplasma gondii	thioredoxin reductase	0.0046	0.0872	1
Mycobacterium ulcerans	beta-lactamase	0.0032	0.0329	0.5
Schistosoma mansoni	jumonji domain containing protein	0.0059	0.139	0.1265
Trypanosoma cruzi	trypanothione reductase, putative	0.0046	0.0872	1
Trichomonas vaginalis	chromobox protein, putative	0.0054	0.12	1
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0052	0.1108	0.3212
Loa Loa (eye worm)	mbt repeat family protein	0.0045	0.0859	0.253
Onchocerca volvulus		0.0032	0.0329	0.3826
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0033	0.035	0.4078
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0078	0.2132	0.2018
Entamoeba histolytica	hypothetical protein	0.0028	0.0165	0.5
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0078	0.2132	0.625
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0329	0.0968
Echinococcus granulosus	thioredoxin glutathione reductase	0.0046	0.0872	0.1213
Loa Loa (eye worm)	jmjC domain-containing protein	0.0047	0.0909	0.2676
Brugia malayi	mbt repeat family protein	0.0045	0.0859	0.2473
Brugia malayi	beta-lactamase family protein	0.0032	0.0329	0.0899
Schistosoma mansoni	transcription factor LCR-F1	0.0028	0.0165	0.0021
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0028	0.0165	0.0035
Mycobacterium ulcerans	hypothetical protein	0.0032	0.0329	0.5
Brugia malayi	Thioredoxin reductase	0.0046	0.0872	0.2512
Trichomonas vaginalis	penicillin-binding protein, putative	0.0032	0.0329	0.0739
Toxoplasma gondii	ABC1 family protein	0.0032	0.0329	0.3577
Echinococcus granulosus	polycomb protein SCMH1	0.0045	0.0859	0.1191
Echinococcus multilocularis	polycomb protein SCMH1	0.0045	0.0859	0.1191
Schistosoma mansoni	tar DNA-binding protein	0.011	0.3396	0.3299
Schistosoma mansoni	tar DNA-binding protein	0.011	0.3396	0.3299
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0032	0.0329	0.0188
Entamoeba histolytica	hypothetical protein	0.0028	0.0165	0.5
Loa Loa (eye worm)	thioredoxin reductase	0.0046	0.0872	0.2569
Loa Loa (eye worm)	jmjC domain-containing protein	0.0027	0.0144	0.0423
Echinococcus multilocularis	chromobox protein 1	0.0054	0.12	0.1758
Entamoeba histolytica	hypothetical protein	0.0028	0.0165	0.5
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0026	0.0076
Brugia malayi	Heterochromatin protein 1	0.0054	0.12	0.3484
Schistosoma mansoni	sex comb on midleg homolog	0.0045	0.0859	0.0726
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0179	0.6151	1
Echinococcus granulosus	histone acetyltransferase MYST2	0.0052	0.1108	0.1606
Schistosoma mansoni	hypothetical protein	0.0164	0.5557	0.5492
Loa Loa (eye worm)	TAR-binding protein	0.011	0.3396	1
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0052	0.1108	0.1606
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0116	0.3657	0.4865
Plasmodium vivax	thioredoxin reductase, putative	0.0046	0.0872	1
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0052	0.1108	0.1606
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0078	0.2132	0.331
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0046	0.0872	0.0795
Brugia malayi	chromobox protein homolog 3	0.003	0.0259	0.0693
Brugia malayi	TAR-binding protein	0.011	0.3396	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0329	0.0968
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0859	0.253
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.011	0.3396	1
Onchocerca volvulus		0.0032	0.0329	0.3826
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0329	0.0968
Schistosoma mansoni	chromobox protein	0.0054	0.12	0.1072
Trichomonas vaginalis	chromobox protein, putative	0.0054	0.12	1
Mycobacterium tuberculosis	Probable reductase	0.0105	0.3195	0.4191
Loa Loa (eye worm)	RNA binding protein	0.011	0.3396	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 837603